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Objective To investigate the current registration rate of tuberculosis in each county and district of Linyi City, Shandong Province, China and its spatial local relationship with related influencing factors. Methods Related data were collected for the incidence rate of tuberculosis and related influencing factors in 12 counties and districts of Linyi City from January to December 2019. Geoda 4.02 software was used to analyze spatial autocorrelation; GWR 4.09 software was used to construct an ordinary least squares regression (OLS) model and a geographic weighted regression (GWR) model; ArcGIS 10.2 software was used to plot the spatial distribution map of influencing factors based on the GWR model. Results In 2019, there were 3 261 cases of tuberculosis in Linyi City, with an overall incidence rate of 32.39/100 000. There was a significant difference in the incidence rate of tuberculosis between different counties, sexes, and age groups (χ2=71.257-1 532.464, P