1. [Effects of Salvia miltiorrhizae compositae on phosphoinositides metabolism in acute myocardial ischemia].
- Author
-
Tao YY
- Subjects
- Animals, Drugs, Chinese Herbal therapeutic use, Male, Myocardial Ischemia metabolism, Myocardium metabolism, Phosphatidylinositol 4,5-Diphosphate, Plant Extracts, Rats, Rats, Sprague-Dawley, Salvia miltiorrhiza, Drugs, Chinese Herbal pharmacology, Inositol 1,4,5-Trisphosphate metabolism, Myocardial Ischemia drug therapy, Phosphatidylinositol Phosphates metabolism
- Abstract
The effects of Salvia miltiorrhizae compositae (SMC) on phosphoinositides metabolism of acute myocardial ischemia in rats were studied. The results showed that the function of the phosphoinositide signaling system was enhanced 10 min. after acute myocardial ischemia. Both of the accumulations of phosphatidylinositol-4,5-biphosphate (PIP2) and inositol-1,4,5-triphosphate (IP3) were higher than those of the non-ischemic control group (P < 0.01, n = 7). The rise of the levels of PIP2 and IP3 caused by acute myocardial ischemia was remarkably inhibited by the SMC (2g/kg body wt.), and the levels of PIP2 and IP3 were lower than those of the ischemic group (P < 0.01, n = 7).
- Published
- 1993