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BackgroundHand-arm vibration disease is harmful to human body, but there are no effective diagnosis and treatment so far, and current occupational exposure limits underestimate the health damage caused by high-frequency vibration exposure. ObjectiveTo evaluate and compare the damage to workers' peripheral circulation and peripheral nerve caused by different frequencies of vibration operation. MethodsDrilling workers (n=187) from a mining company in Shandong Province and golf club head grinding workers (n=228) from a sports equipment factory in Guangdong Province were selected as study subjects. Hand symptoms were investigated. SV106 vibration meter was used to measure the target operation-associated vibration frequency spectrum. The 8 h energy-equivalent frequency weighted acceleration, cumulative vibration exposure level (CVEL), and the working age related to causing white finger in 10% of an exposed group were calculated.ResultThe study subjects were all male. More grinding workers reported hand symptoms than the drilling workers, e.g. peripheral circulation injury (52.6% vs 19.3%), peripheral nerve injury (71.5% vs 23.0%), hand stiffness (64.0% vs 7.0%), and deformed fingers (69.7% vs 4.3%) (all P

Objective To explore the value of peripheral blood circulating DNA in predicting the efficacy and prognosis of immunotherapy for advanced non-small cell lung cancer. Method A retrospective study was conducted on 78 NSCLC patients who were admitted to the Respiratory and Critical Care Medicine Department of the First Affiliated Hospital of Hebei North University and were treated with tirelizumab for advanced driver gene negativity from January 2021 to December 2021. After 2 cycles of immunotherapy, the efficacy was evaluated according to the Solid Tumor Efficacy Evaluation Criteria (RECIST 1.1), including complete remission, partial remission, disease stability, and disease progression. CR and PR patients were defined as the experimental group (n = 48) Other patients were defined as the control group (n = 30), and the ctDNA levels in peripheral blood were measured before and after treatment in both groups. ROC curves were used to analyze the predictive value of periph eral blood ctDNA levels for achieving objective remission after immunotherapy.All patients were followed up and their progression free survival were calcutated.Using univariate and multivariate regression analysis identified the factors affecting the prognosis of patients after immunotherapy. Using Spearman correlation coefficient analyzed the correlation between ctDNA levels and PFS. Kalplan Meier survival curve were used for survival analysis. Result The peripheral blood ctDNA levels before and after treatment in the experimental group were (4.47 ± 1.21)ng/μL and (2.65 ± 1.14) ng/μL, respectively (t = 7.559,P < 0.001), while those in the control group were (4.54 ± 1.15)ng/mL and (4.29 ± 1.57) ng/μL, respectively (t = 0.699,P = 0.487). There was no statistically significant difference in peripheral blood ctDNA levels between the two groups before treatment (t = -0.25,P = 0.801). The peripheral blood ctDNA levels in the experimental group decreased compared to the control group after treatment (t = -5.35,P < 0.001). The ROC curve analysis showed that the area under the curve for predicting objective remission after immunotherapy based on peripheral blood ctDNA levels was 0.819, with a sensitivity of 81.3% and specificity of 80%. Peripheral blood ctDNA levels were negatively correlated with progression free survival (r = -0.784,P = 0.000). Single factor COX regression was used to analyze the clinical and pathological characteristics and ctDNA levels of enrolled patients, and the results showed that the maximum tumor diameter was greater than 5 cm (HR = 0.501, 95% CI: 6.731 ~ 35.567) Tumor stage IV (HR = 0.392,95% CI: 0.227 ~ 0.677), treatment approach (HR = 15.473,95% CI: 6.731 ~ 35.567), and ctDNA levels (HR = 4.657,95% CI: 3.182 ~ 6.555) are all influencing factors for PFS in advanced NSCLC patients after immunotherapy. Multiple factor analysis was conducted on the appeal indicators with statistical differences, and the results showed that treatment approach (HR = 2.981,95% CI:1.019 ~ 8.722) and peripheral blood ctDNA levels (HR = 3.918,95% CI: 2.619 ~ 5.861) It is an independent influencing factor of PFS in advanced NSCLC patients. The Kalplan Meier survival curve was used for analysis, and the results showed that the median PFS of the treatment effective group was 8.4 months, while the median PFS of the control group was 5.4 months. (χ² = 49.277, P = 0.000). Conclusion Immunotherapy combined with chemotherapy can enhance the ability to kill tumor cells, and peripheral blood ctDNA levels can evaluate the efficacy and prognosis of immunotherapy, which can be used to guide immunotherapy in advanced NSCLC patients. [ABSTRACT FROM AUTHOR]

Copyright of Science & Technology of Food Industry is the property of Science & Technology of Food Industry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

At pressent, there are many controversies in China about the recommendations in Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome (hereinafter referred to as the “Guidelines”) revised in 2021, and it's believed that some clauses lack theoretical support. Some researches in China have showed that sodium restriction and negative sodium balance are the only reason for hyponatremia. Sodium retention is the stress protective reaction mechanism for hyponatremia, not the basis for sodium restriction treatment. This article dialectically evaluates the relationship between peripheral circulation dysfunction, hepatorenal syndrome pathogenesis and diagnosis and treatment, and believes that the AASLD Guidelines have weakened the clinical guiding significance, and looks forward to the development of ascites and hepatorenal syndrome diagnosis and treatment guidelines with Chinese intellectual property rights and in line with Chinese clinical practice.

This study designs an intermittent pneumatic pressurization device with STM32 series single chip as the core. The working state of the air pump and the plurality of air chambers is controlled by the IO port of the single chip microcomputer, and the circulating inflation of the plurality of air bags is realized. The pressure monitoring system consists of a silicon piezoresistive pressure sensor, a high-precision operational amplifier and a 12-bit AD converter which monitors the gas pressure of each gas path in real time to ensure the safety of the equipment. The system is easy to operate, simple in function, and has strong practicability.

Copyright of Chinese Journal of Arteriosclerosis is the property of Chinese Journal of Arteriosclerosis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background and objective The application of programmed cell death 1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibodies has greatly improved the clinical outcomes of lung cancer patients. Here, we retrospectively analyzed the efficacy of PD-1 antibody therapy in locally advanced non-surgical or metastatic lung cancer patients, and preliminarily explored the correlation between peripheral blood biomarkers and clinical responses. Methods We conducted a single center study that included 61 IIIA-IV lung cancer patients who received PD-1 antibody treatment from March 2020 to December 2021, and collected the medical record data on PD-1 antibody first-line or second-line treatment. The levels of multiple Th1 and Th2 cytokines in the patient's peripheral blood serum, as well as the phenotype of peripheral blood T cells, were detected and analyzed. Results All the patients completed at least 2 cycles of PD-1 monoclonal antibody treatment. Among them, 42 patients (68.9%) achieved partial response (PR); 7 patients (11.5%) had stable disease (SD); and 12 patients (19.7%) had progressive disease (PD). The levels of peripheral blood interferon gamma (IFN-γ) (P=0.023), tumor necrosis factor α (TNF-α) (P=0.007) and interleukin 5 (IL-5) (P=0.002) before treatment were higher in patients of the disease control rate (DCR) (PR+SD) group than in the PD group. In addition, the decrease in absolute peripheral blood lymphocyte count after PD-1 antibody treatment was associated with disease progression (P=0.023). Moreover, the levels of IL-5 (P=0.0027) and IL-10 (P=0.0208) in the blood serum after immunotherapy were significantly increased compared to baseline. Conclusion Peripheral blood serum IFN-γ, TNF-α and IL-5 in lung cancer patients have certain roles in predicting the clinical efficacy of anti-PD-1 therapy. The decrease in absolute peripheral blood lymphocyte count in lung cancer patients is related to disease progression, but large-scale prospective studies are needed to further elucidate the value of these biomarkers. [ABSTRACT FROM AUTHOR]

Objective: To compare the effects of different thermal insulation measures on perioperative body temperature, peripheral circulation and blood coagulation time in patients undergoing vertical hemi laryngectomy. Method: Sixty eligible patients with elective vertical hemi laryngectomy were randomly divided into 3 groups: preoperative inflatable heating blanket group (A group, n=20), warmed irrigation group (B group, n=20), and control group (C group, n=20). The core temperature were recorded after entering the operating room, before induction, 20th minute during operation, entering PACU and 2nd hour after operation respectively. Blood samples were got at the end of operation to test pH, lactic acid, PT and APTT. After waking patients' SpO₂ and thermal comfort were recorded. Result: The core temperatures at time points of 20th minute during operation and entering PACU were significantly different between C group and A group, C group and B group. There were significant difference in lactic acid, PT, APTT and SpO₂ between C group and A group, C group and B group. Patients' thermal comfort in all three groups were different. Conclusion: Inflatable heating blanket during operation combined with using it before operation or fluid warmers during operation for perioperative body temperature protection duringelective vertical partial laryngectomy surgery can effectively prevent perioperative hypothermia, improve peripheral circulation and blood coagulation time changes, improve patients' comfort after operation., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Copyright of Acta Scientiarum Naturalium Universitatis Sunyatseni / Zhongshan Daxue Xuebao is the property of Sun-Yat-Sen University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the influence of synchronous intermittent mandatory ventilation（SIMV） and adaptive support ventilation（ASV） on the peripheral blood circulation and blood gas indexes in patients with chronic obstructive pulmonary disease（COPD） and respiratory failure. Methods: A total of 86 patients with COPD combined respiratory failure, who were treated in First Hospital of Fangshan District from March 2006 to December 2013, were selected and ventilated in ASV and SIMV mode. their The ventilator parameters, peripheral blood circulation parameters and blood gas indexes were recorded respectively. Results: Respiratory rate（RR）, tidal volume（TV）, peak inspiratory pressure（PIP） in ASV group were significantly lower than those in SIMV group（P<0.01）.Peripheral blood heart rate（HR）, systolic blood pressure（SBP）, diastolic blood pressure（DBP）, and central venous pressure（CVP） in ASV group were significantly lower than those in SIMV group（P<0.01）. Arterial partial pressure of oxygen（PaO2）, pH, blood oxygen saturation（SaO2） in ASV group were significantly higher than those in SIMV group（P<0.05）. Conclusion: The improvement of ventilator parameters, peripheral blood circulation parameters and blood gas indexes in ASV mode for patients with COPD combined respiratory failure was better than in SIMV mode. [ABSTRACT FROM AUTHOR]

Objective: To study the combined effect of low temperature and vibration on function of peripheral circulation and nerve., Methods: 64 rabbits were divided into control group, low temperature group, vibration group and combined effect group randomly, 16 each group. The changes of concentration of ET, Ang II, NO in plasma and SCV, amplitude of sensory nerve action potential, latency of sensory nerve action potential, MCV, distal amplitude of motor nerve, and distal latency of motor nerve were measured before and after experiment., Results: After experiment, the concentration of ET, Ang II, NO and SCV, amplitude of sensory nerve action potential, latency of sensory nerve action potential, MCV, distal amplitude of motor nerve, and distal latency of motor nerve were (68.84+/-14.81) pg/ml, (544.01+/-70.20) pg/ml, (123.73+/-9.58) nmol/ml, (25.36+/-6.96) m/s, (1.84+/-0.65) microV, (4.05+/-1.04) m/s, (27.40+/-6.05) m/s, (1.60+/-0.52) microV, (3.51+/-1.30) m/s respectively in low temperature group; (70.22+/-15.02) pg/ml, (540.77+/-68.25) pg/ml, (129.46+/-11.99) nmol/ml, (27.69+/-6.16) m/s, (2.19+/-0.53) microV, (3.86+/-0.89) m/s, (30.03+/-5.21) m/s, (1.65+/-0.49) microV, (3.36+/-l.11) m/s respectively in vibration group; (88.47+/-13.20) pg/ml, (687.38+/-101.44) pg/ml, (70.66+/-4.99) nmol/ml, (20.82+/-3.65) m/s, (1.21+/-0.64) microV, (5.05+/-0.94) m/s, (19.97+/-4.37) m/s, (1.09+/-0.49) microV, (4.49+/-1.26) m/s respectively in combined effect group; compared with pre-experiment, the concentration of ET and Ang II in low temperature group, vibration group and combined effect group were increased after experiment, and the NO was decreased (P<0.05); the nerve conduct velocity and amplitude was decreased and the latency was delayed (P<0.05). After experiment, the concentrations of ET and Ang II in combined effect group were higher than low temperature group and vibration group, and the concentration of NO in combined effect group was lower than low temperature group and vibration group (P<0.05). After experiment, the SCV and MCV in combined effect group were slower than low temperature group and vibration group; the amplitude of sensory nerve action potential and distal amplitude of motor nerve were less than low temperature group and vibration group; the latency of sensory nerve action potential and distal latency of motor nerve in combined effect group was longer than low temperature group and vibration group. The factorial analysis results indicated the synergistic effect between low temperature and vibration (P<0.05)., Conclusion: Vibration-induced peripheral vascular impairment and nerve impairment would be intensified by low temperature.

Objective To observe the dynamic changes of free CD147 and its induced product matrix metalloproteinase-9 (MMP-9) of patients with traumatic brain injury (TBI) in peripheral blood, and to explore the relationship between its expression changes and short-term prognosis. Methods Thirty-nine patients with TBI admitted to the Second Hospital of Tianjin Medical University from May 2014 to December 2016 were included in the study. The expression changes of free CD147 and MMP - 9 in peripheral blood were determined by enzyme-linked immunosorbent assay (ELISA), and the activity of MMP-9 was determined through gelatin zymography. The prognosis was evaluated via Glasgow Outcome Scale (GOS) at discharge. Results There was no significant difference in GOS score between male and female patients at discharge (2.63 ± 1.28 vs. 2.57 ± 1.14; t = 0.161, P = 0.873). There was a statistically significant difference in GOS score between different age groups at discharge (t = 2.191, P = 0.038). The GOS scores of patients over 60 years old were lower than those of patients under 40 years old (t = 2.645, P = 0.014) and those between 40 and 60 years old (t = 2.320, P = 0.029). According to the GOS score, they were divided into a good prognosis group (GOS score ≥ 3, n = 25) and a poor prognosis group (GOS score < 3, n = 14). Free CD147 in peripheral blood of patients with poor prognosis [(5.07 ± 1.89) ng/ml vs. (10.37 ± 1.69) ng/ml; t = 2.080, P = 0.048] and MMP-9 [(41.55 ± 4.67) ng/ml vs. (75.23 ± 5.18) ng/ml; t = 2.512, P = 0.019] were higher than the good prognosis group. Correlation analysis showed that the GOS score at discharge was negatively correlated with free CD147 (r = - 0.473, P = 0.000) and MMP - 9 (r = - 0.435, P = 0.036) in peripheral blood. Conclusions The higher the level of free CD147 and its induced product MMP-9 in peripheral blood of patients with TBI, the worse the prognosis, which indicated that free CD147 and MMP-9 can be used as important indicators for poor prognosis of patients with TBI. [ABSTRACT FROM AUTHOR]

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the polymorphism of T cell receptor β chain variable region (TCRV β) in peripheral blood of clinically isoiated syndrome (CIS) patients. To preliminarily predict the specific TCRV β fragment of CIS and its diagnostic value for CIS. Methods Hospitalized patients of Beijing Xuanwu Hospital from September 2012 to March 2014, were divided into 2 groups including CIS group (experimental pateints, n = 30) and normal control group (healthy volunteers, n = 30). The routine immune indexes and expression of TCRVβ subfamilies were detected by flow cytometry. CELL Quest Pro 5.1 software was used to analyze 24 subfamilies of TCRVβ. Calculated the statistic of amplification rate, amplification number and amplification fraction of the total 24 subfamilies of TCRVβ. Results Compared to the normal control group, the quantitative expression of CD4+ TCRVβ2, 4, 5.2, 5.3, 7.1, 8, 14, 17, 20, 21.3 and CD8+TCRVβ4, 14 were significantly expanded in CIS group, CD4+TCRVβ11 and CD8+TCRVβ9, 11 were significantly reduced in CIS group (P < 0.05 or P < 0.01). The amplification rate of CD4+TCRVβ2 (P = 0.002) and CD8+TCRVβ14 (P = 0.010) in CIS group were higher than those in normal control group, but there was no significant difference in the other subfamilies. There was no statistical difference in the expansion rate of the TCRVβ between CIS group and normal control group. The amplification number (P = 0.001) and amplification fraction (P = 0.006) of the TCRVβ in CIS group were significantly higher than the normal control group. Receiver operating characteristic curve (ROC) analysis indicated that the area under the curve (AUC) of CD4+TCRVβ4 in the diagnosis of CIS was 0.719 (95%CI: 0.592-0.851, P = 0.003). The sensitivity was 83.33%, the specificity was 56.67%. The AUC of CD4+TCRVβ14 in the diagnosis of CIS was 0.713 (95%CI: 0.581-0.845, P = 0.005). The sensitivity was 70%, the specificity was 56.23%. The AUC of CD8+TCRVβ4 in the diagnosis of CIS was 0.727 (95%CI: 0.600-0.854, P = 0.002). The sensitivity was 93.33%, the specificity was 50%. The three fragments have medium diagnostic value for CIS. Conclusions Although the expression levels of CD4+TCRV β4, CD4+TCRV β14 and CD8+TCRV β4 in peripheral blood are increased in CIS group, their diagnostic value is limited. [ABSTRACT FROM AUTHOR]

Background and objective The incidence and mortality of lung cancer often rank first in all malignant tumors. DNA methylation, as one of epigenetics, often participates in the development and progression of tumors. CDO1 as a tumor suppressor gene always undergoes methylation changes early in tumor development. Therefore, this study aims to discuss the value of CDO1 methylation in the early diagnosis of lung cancer. Methods Peripheral blood samples were collected from tumor patients and healthy people. Detection of the methylation level of CDO1 in plasma by sulfite modification and quantitative real-time PCR. Results The level of gene methylation in peripheral blood of lung cancer patients was significantly higher than that of benign lung disease patients and healthy people. The methylation level of CDO1 was significantly different in the stratified comparison of gender, lymph node metastasis and tumor-node-metastasis (TNM) stage (P<0.05). The sensitivity and specificity of CDO1 were 52.2% and 78.6%, respectively. The overall accuracy of the diagnosis was significantly higher than that of the clinical tumor markers, and the sensitivity of CDO1 to stage I and II patients was the highest (40.8%, 47.1%). In addition, CDO1 could effectively increase the sensitivity of diagnosis in multiple joint examinations. Conclusion Detecting the methylation level of CDO1 has a potentially huge advantage for the early diagnosis of lung cancer. [ABSTRACT FROM AUTHOR]

This study analyzed the impact of a cold surge during the East Asian winter monsoon on an extreme flash flood event in Malaysia using satellite observations and reanalysis data including ERA5 from the European Centre for Medium-Range Weather Forecasts and data from the Global Data Assimilation System. The results indicate that, with the East Asian winter monsoon in the Northern Hemisphere, the redevelopment of the East Asian trough, the strengthening of surface cold high pressure, and the development of explosive cyclones over Japan and Northwestern Pacific jointly provided favorable large-scale circulation background for the cold surge formation. The impact of Tropical Cyclone Rai and the continuous influx of cold air from mid and high latitudes prolonged the duration of the cold surge. Interactions between the cold surge, the peripheral circulation of the tropical cyclone, the easterly airflow in tropical regions, and the topography of the western Maritime Continent led to the formation and maintenance of the Borneo Vortex, providing continuous dynamic conditions for heavy precipitation. The convergence between the cold surge and the equatorial easterly airflow, along with the interaction between the cold surge and the topography of the Malay Peninsula ' s coastline, further enhanced low-level dynamic conditions, which then led to the continuous influence of multi-stage dynamic convergence. The water vapor channel established by the cold surge from the South China Sea to the Malay Peninsula was the main source of precipitation moisture, with the easterly component contributing the strongest water vapor input, followed by the northerly component. This pathway created strong water vapor convergence conditions in the lower troposphere near the Malay Peninsula. As the cold surge moved southward, its temperature and humidity conditions are intensified by the vast ocean surface, particularly in the lower layers, leading to the generation and strengthening of unstable conditions. The warm, energetic, and highly humid environment in the lower troposphere was conducive to the development of mesoscale convective systems and the generation of efficient warm-cloud precipitation. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Practical Electrocardiology is the property of Journal of Practical Electrocardiology Editorial Board and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This study aims to explore the changes and clinical significances of T helper 17 (Th17) cells in the peripheral blood of patients with acute cerebral hemorrhage. The percentage of Th17 cells were assessed by flow cytometry. The mRNA levels of retinoid-related orphan receptor γt (RORγt) were detected by real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). The serum levels of interleukin-17 (IL-17) were measured by enzyme-linked immunosorbent assay (ELISA). According to the examination results, the percentage of Th17 cells, the mRNA expression of RORγt and the serum levels of IL - 17 at 24 h, 3 d and 7 d increased significantly in patients with acute cerebral hemorrhage than in normal controls (P = 0.000, for all). Although the patients with acute cerebral hemorrhage had no significant differences in the percentage of Th17 cells, the mRNA expression of ROR γ t comparable with normal controls (P = 0.058, 0.239), the serum levels of IL-17 in patients were statistically higher than those in normal controls at 14 d (P = 0.000). The percentage of Th17 cells and the serum levels of IL-17 increase in the peripheral blood of patients with acute cerebral hemorrhage, suggesting Th17 cells may participate in the occurrence and development of cerebral hemorrhage. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Modern Medicine & Health is the property of Journal of Modern Medicine & Health and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Reproductive Health/Family Planning is the property of Editorial Board of the Journal of International Reproductive Health/Family Planning and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To investigate the regulatory effect of adiponectin on RANKL/OPG in peripheral circulation and its therapeutic effect on diabetic osteoporosis. Methods High fat diet combined with streptozomycin was used to construct diabetic osteoporosis model mice, which were treated with adiponectin and alendronate sodium as positive control. They were divided into control group, model group, treatment group and positive control group. After the intervention, the weight of the mice was measured, the venous blood of the mice was collected, and the fasting glucose level, glucose tolerance test, and serum RANKL/ OPG were detected. The primary bone marrow mesenchymal stem cells were extracted from the femur of mice in each group, induced osteogenic differentiation and stained with alizarin red to detect the expression levels of Opg and Rankl genes. The lumbar 3 vertebrae of mice were obtained, and the changes of bone microstructure in each group were detected. Results After adiponectin treatment, compared with the model group, the body weight, fasting blood glucose level and glucose tolerance test were significantly decreased, serum OPG concentration increased, serum RANKL concentration decreased, and serum RANKL/OPG decreased in the treatment group. Compared with the control group, the bone formation ability of bone marrow mesenchymal stem cells in the model group was significantly weakened, and RANKL/OPG was significantly up-regulated. Compared with the model group, the osteoblastic differentiation ability of bone marrow mesenchymal stem cells in the treatment group was significantly enhanced, and RANKL/OPG was significantly down-regulated. After adiponectin treatment, the number of osteoblasts per unit length, the percentage of trabecular area and the thickness of trabecular were significantly increased. Conclusion Adiponectin can reduce the body weight of diabetic mice, reduce fasting blood glucose, partially restore the body's blood glucose regulation ability, up-regulate Opg gene expression and inhibit Rankl gene expression, promote bone marrow mesenchymal stem cell osteogenic differentiation, and improve bone microstructure, which is a potential choice for the treatment of diabetic osteoporosis. [ABSTRACT FROM AUTHOR]

The blood-brain barrier (BBB) constitutes a unique anatomical and physiological interface between the central nervous system (CNS) and the peripheral circulation. It is of critical importance for maintaining the stability of the CNS. This article provides an overview of the changes in the structure of the BBB during the progression of diseases such as aging, neurological disorders, and cancer, with a focus on the effects of gut microbiota and their metabolites on the BBB. Environmental factor-induced changes in the composition of the gut flora disrupt BBB integrity through multiple pathways, whereas gut microbial metabolites have positive, negative, or bidirectional modulatory effects on the BBB. For example, lipopolysaccharide and hydrophobic bile acids have negative effects on the BBB by disrupting cellular structure, decreasing tight junction protein expression, and exacerbating inflammatory responses. The short chain fatty acids, 3-indolepropionic acid, and hydrophilic bile acids have positive effects on the BBB by regulating the intestinal flora, increasing tight junction protein expression, reducing inflammation and exerting antioxidant effects. The trimethylamine oxide has a two-way regulatory effects on the BBB. In addition, different probiotic strains are described to directly or indirectly improve BBB integrity by altering the composition of the intestinal flora, regulating short chain fatty acid levels, enhancing tight junction protein expression, as well as anti-inflammatory and antioxidant pathways. This article provides new strategies and theoretical materials for the treatment and improvement of neurological diseases.

Copyright of Chinese Journal of Arteriosclerosis is the property of Chinese Journal of Arteriosclerosis Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

This paper summarized the integrated traditional Chinese and western medicine nursing of a patient undergoing toe amputation for diabetic foot ulcers. Comprehensive nursing interventions including low extremity position care, medication care, pain control and health education were enhanced after toe amputation for diabetic foot ulcers. Based on the Traditional Chinese Medicine syndrome differentiation, Traditional Chinese Medicine ointment rubbing, Tuina on meridian and acupoints, five-element music therapy were carried out to relieve pain, eliminate lower limb swelling, promote wound healing, reduce the incidence of local infection and complications, improve peripheral circulation and neurotrophic status, improve patients' self-care ability and quality of life. . (本文总结1例糖尿病足截趾术后患者的中西医结合护理经验。术后在加强下肢体位护理、针对性用药指导、疼痛护理、健康宣教等护理措施基础上, 基于辨证施护, 开展中药膏摩、经穴推拿、五音疗法等中医疗法, 旨在缓解疼痛, 消除下肢肿胀, 促进创面愈合, 降低局部感染及并发症发生率, 改善患者周围循环及神经营养状态, 提高患者自理能力及生活质量。)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Targeted temperature management (TTM) is a complex and sophisticated intensive-care procedure that is included in the American Heart Association guidelines for treating patients who remain unconscious after resuscitation from cardiac arrest. TTM has been demonstrated to reduce brain injury associated with reperfusion after resuscitation and to improve the neurological prognosis in patients with cardiac arrest. The TTM process may be divided into four phases: induction, maintenance, rewarming, and normothermia. The critical element in TTM is the quick lowering and slow raising of body temperature, which should be fine-tuned to maintain temperature stability and minimize variation. Caregivers should monitor the physiological changes caused by core body temperature change closely and manage possible complications such as shivering, hypo- and hyper-glycemia, electrolyte imbalance, skin injury, arrhythmia, and infection. Based on contemporary evidence and clinical experience, this article provides critical care nurses a summary and key points of each stage of TTM when used to take care of resuscitated patients after cardiac arrest. We hope this work may help improve patient safety and quality of care during the TTM procedure. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To explore the relationship of high mobility group box-1 protein (HMGB1) and endogenous secretory receptor for advanced glycation end products (esRAGE) with carotid atherosclerosis (AS) in type 2 diabetes mellitus (T2DM). Methods We recruited 198 hospitalized patients as the patient group. Based on the presence of T2DM and carotid ultrasonography test results, the patients were divided into AS (72 cases), T2DM (56 cases) and T2DM+AS (70 cases) groups; 46 healthy subjects were selected as the normal control group. Serum levels of HMGB1 and esRAGE were determined by enzyme-linked immunosorbent assay (ELISA). Results HMGB1 level was significantly higher (P<0.05) and esRAGE level was lower (P<0.01) in T2DM+AS group than in the other 3 groups. There was a negative correlation between HMGB1 and esRAGE in T2DM with carotid AS (r=-0.317, P=0.002). Logistic regression analysis indicated that HMGB1 and esRAGE levels were independently associated with carotid AS in T2DM (OR=1.202, P=0.021, 95% CI 1.028-1.406; OR=0.301, P=0.046, 95% CI 0.004-0.848). Conclusion Increased HMGB1 and decreased esRAGE level in the peripheral circulation may be involved in the pathogenesis and progression of AS in T2DM. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Oncology is the property of Editorial Board of China Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In this study, the effects of Ganoderma lucidum polysaccharide on the proliferation and apoptosis of human lung cancer A549 cells were investigated. Lung cancer A549 cells were divided into a blank group, drug control group, and low-, medium- and high-concentration groups. The cells in each group were intervened to detect the changes in apoptosis and proliferation ability, as well as the expression of apoptotic proteins Bcl-2, PI3K and Akt. The results showed that, compared with other groups, the high-concentration group had a lower cell proliferation rate, and its cell proliferation rate decreased from 44.37% to 20.11% when the time of intervention with Ganoderma lucidum polysaccharide was extended. Compared with other groups, the high-concentration group had a higher apoptosis rate, and its apoptosis rate increased from 46.52% to 77.93% when the time of intervention with Ganoderma lucidum polysaccharide was extended. Compared with other groups, the high-concentration group had lower relative expression levels of Bcl-2, PI3K and Akt. The intervention with Ganoderma lucidum polysaccharide can inhibit the proliferation of lung cancer A549 cells and promote the apoptosis of lung cancer A549 cells. Its ability has nothing to do with its own cytotoxicity, but may be related to the regulation of the expression of apoptosis-related proteins, Bcl-2, PI3K and Akt. These results indicate that Ganoderma lucidum polysaccharide can inhibit the development and spread of lung cancer A549 cells and regulate the proliferation and apoptosis of human lung cancer A549 cells. [ABSTRACT FROM AUTHOR]

Copyright of Journal of International Obstetrics & Gynecology is the property of TianJin Medical Information Center and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective To investigate the cognitive change in electrical stimulation (ECS) pre-conditioned rats after traumatic brain injury (TBI) and the role of endothelial progenitor cells in brain trauma. Methods Adult male Wistar rats were divided into 4 groups randomly: Sham group (n = 61), TBI group (n = 61), ECS pre-conditioned and TBI group (ECS-TBI group, n = 61), ECS group (n = 61). At 3 h, 6 h, 24 h, 48 h, 72 h after fluid percussion injury (FPI), 6 rats were randomly selected from each group and the number of circulating endothelial progenitor cells was counted by flow cytometry. At the same time, 3 rats from each group were chosen randomly and brain tissue was taken out. Microvascular density (MVD) of injured hippocampus was measured by vWF immunohistochemical staining. Ten rats of each group were subjected to Morris Water Maze Test and escaping latencies were recorded separately at 7-11 days after FPI. Results Compared with TBI group, the number of endothelial progenitor cells in peripheral circulation increased significantly in ECS-TBI group at 3 hours and 6 hours after brain trauma (P = 0.000, for all), and reduced to baseline gradually afterwards. The vWF+ MVD on the injured side of hippocampus in ECS-TBI group was higher than those of other groups 1d after FPI, and reached to a peak at 7 d (P < 0.01). In Morris Water Maze Test, the escaping latency of ECS-TBI rats were reduced significantly compared to that of the TBI group from 3 d to 5 d after brain trauma (P < 0.01). Conclusion Compared to TBI group, there was less cognitive defect in ECS-TBI group after traumatic brain injury. This protective effect may partially due to enhanced angiogenesis induced by increasing circulating endothelial progenitor cells after ECS. Endothelial progenitor cells accumulated in the injured brain may promote post-traumatic angiogenesis and recovery of neurological function. DOI：10.3969/j.issn.1672-6731.2011.06.005

Bevacizumab, the monoclonal antibody of vascular endothelial growth factor (VEGF) has been applied to the therapy of several neoplasms, but an appropriate biomarker to predict the efficacy has not been found. Those markers can originate from peripheral circulation, tumor tissue and genes. Some researches have found that low level of vascular cell adhesion molecule-1 (VCAM-1), E-selectin, angiopoietin 2 (Ang-2) in circulation or carbonic anhydrase 9 (CA9), CD31-microvessel density (CD31-MVD) in tumor tissue can predict better activity of bevacizumab. Moreover, high level of soluble VEGFR2 (sVEGFR2) in circulation or the ratio of phosphorylated-VEGFR2 (p-VEGFR2) and VEGFR2 in tumor tissue increasing has the same predictive function. As to the gene, VEGF-634 CC, VEGF-1498 TT and VEGFR2 H472Q are only related to the side effct. Thus more clinical tirals and basic researches should be performed to find out effective biomarkers in bevacizumab’s therapy.