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ObjectiveTo investigate the clinicopathological features and prognostic factors of periampullary carcinomas (PACs) in the pre-jaundice stage. MethodsA retrospective analysis was performed for the clinical data of 518 patients with PACs who were admitted from January 2012 to December 2017, and according to jaundice symptom and serum total bilirubin on admission, they were divided into pre-jaundice group with 125 patients and jaundice group with 393 patients. The two groups were compared in terms of clinical data, pathological features, and 5-year survival rate, and prognostic factors were analyzed. The independent samples t-test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between two groups. The Kaplan-Meier method was used to calculate survival rates and plot survival curves. The log-rank test was used for univariate analysis, and the Cox proportional-hazards regression model was used for multivariate analysis. ResultsCompared with the jaundice group, the pre-jaundice group had a significantly higher proportion of patients with the manifestation of abdominal distension and pain, a significantly longer duration of abdominal distension and pain, and significant increases in red blood cell count, albumin, and prealbumin (χ2=14.786, Z=-6.023, t=-2.247, -4.688, and -3.873, all P