Search

Cabazitaxel is a new taxane-based anti-tumor drug, which has a significant effect on hormone refractory meta-static prostate cancer patients who are ineffective to docetaxel. Although cabazitaxel is used as a second-line clinical drug, it has great application potential due to its low adhesion to P-glycoprotein and good pharmacokinetic characteristics. In recent years, researchers are paying more attention to it. Based on the research progress achieved both at home and abroad and with the pharmacological effects and adverse drug reactions as the starting point, a comprehensive review was made in the drug delivery system of cabazitaxel for treatment of prostate cancer. [ABSTRACT FROM AUTHOR]

Objective This study is to investigate the expressions of MACC1 and c-Met genes in prostate cancer tissues and to explore the relationship between these gene expressions with the development, invasion and metastasis of prostate cancer. Methods The expressions of MACC1 and c-Met genes were examined in 30 cases of benign prostatic hyperplasia and 67 cases of prostate cancer using citron acid-microwave-SP immunohistochemical method and analysed with their clinical pathological features. Results Expressions of MACC1 and c-Met in prostate tissues show statistical difference according to Gleason score, PSA level, pathological stages and whether bone metastasis occurs after radical surgery (P < 0.05 or P < 0.01), but their expressions in prostate tissue show no significant difference among different sex, age and whether smoking or not. Expression of MACC1 in prostate tissue of stage III and IV cancer is significantly higher than that in benign prostatic hyperplasia (BPH) tissues (P < 0.05) while the expression of c-Met only shows statistical difference in prostate tissue of stage IV cancer compared with that in BPH (P < 0.05). There is a positive correlation between the expression of MACC1 with expression of c-Met in prostate cancer tissues (P < 0.01). Kaplan-Meier curves revealed that the survival rates was lower and survival time of bone-free metastasis were shorter in patients with high MACC1 and c-Met expressions in prostate tissue than those with low expressions of MACC1 and c-Met in prostate tissue. Conclusion Expression of MACC1 and c-Met is closely related to the development, invasion and metastasis of prostate cancer, so MACC1 and c-Met may be used as promising diagnostic and prognostic markers for prostate tumor, and as new therapeutic targets for prostate cancer. [ABSTRACT FROM AUTHOR]

In order to meet the needs of medical treatment, biomedical metallic materials are implanted into patients' body in modern medicine. Assuming that the patients need to receive radiation treatment, the implants must have a negative effect on the plan of medical radiation dose and must still be interfered with the implementation. Furthermore, this means an obstacle and huge potential security problem for the high precision tumor radiotherapy. For instance, a prostate cancer patient, who received a femoral replacement surgery, now needs to receive radiation therapy. A human simulation model is built with a particular metal implant and specific tumor information, then Monte Carlo code MCNP is employed to research the influence of the radiation dose in human body with metallic implant materials under the condition of external exposure. Research results show that effect on radiation dose of metal implants during radiotherapy is not only existent, but also leads to a considerable degree of dose deviation which includes dose attenuation at the back-end of implant and dose enhancements at its front-end, thus the risks caused by the dose deviation should also be taken into account. [ABSTRACT FROM AUTHOR]

Prostate cancer is one of the life threatening disorders for human being, which has a high incidence over the world. At present, treatments include surgery, radiation therapy, cryosurgery, chemotherapy and hormonal therapy etc. Also, dietary modifications may decrease incidence of developing prostate cancer. This article summarizes current treatments, which may be helpful to prevent life threatening disease. [ABSTRACT FROM AUTHOR]