Objective To analyze the detection of sarcoidosis on 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (,SF-FDG PET/CT). Methods Clinical and pathological data as well as PET/CT of 35 patients (21 women and 14 men, age range: 34-78 years, mean 45 ±10 years) with histologically confirmed sarcoidosis from 2015 to 2019 in our hospital were analyzed retrospectively. Results The clinical manifestations included cough (29), chest tightness and shortness of breath (22), chest pain (4), fever (3), superficial lymph node enlargement (3), and joint pain (1). PET/CT showed bilateral hilar, (34/35, 97.14%), mediastinal (33/35, 94.28%), right hilar (1/35, 2.86%), cervical (2/35, 5.71%), or abdominal (2/35, 5.71%) lymphadenopathy with increased FDG uptake, bilateral multiple or diffuse lung nodules (19/35, 54.29%), lung consolidation (3/35, 8.57%), pulmonary ground glass opacities (2/35, 5.71%), interstitial lung fibrosis (2/35, 5.71 %), enlargement of tracheal blood vessels (16/35, 45.71%), pleural effusion (3/35, 8.57%), pericardial effusion (1/35, 2.86%), increased uptake in the diaphragm cnira (1/35, 2.86%) and hepatic caudate lobe (1/35, 2.86%). Histology showed typical non-caseous necrotizing granulomatous lesions with negative specific staining in all patients by transbronchial lung biopsy (16), endobronchoscopic ultrasound-guided transbronchial needle aspiration (11), percutaneous lung biopsy (3), superficial lymph node biopsy (3), or tlioraco.scopic suigery (2). Conclusion The clinical manifestations of sarcoidosis are diverse and nonspecific. PET/CT can aid diagnosis and depict active lesions. [ABSTRACT FROM AUTHOR]