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Objective: To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) on postoperative olfactory memory disorder in patients with general anesthesia of sevoflurane and to explore its possible mechanism., Methods: Forty patients who were scheduled to have gynecological and urological procedures under general anesthesia were randomly divided into an observation group and a control group, 20 cases in each group. The patients in the observation group were treated with TEAS (dilatational wave, 2 Hz/100 Hz) at Yingxiang (LI 20) and Yintang (GV 29) 10 min before anesthesia induction until the end of operation; the patients in the control group received general anesthesia directly. The changes of mean arterial pressure (MAP), heart rate (HR) and blood oxygen saturation (SpO 2 ) were recorded before treatment, 30 min after operation and at the end of operation; smell identification score was measured by Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test before treatment (T 0 ) and when Aldrete recovery score reached 10 points at the end of anesthesia (T 1 ); the concentration of melatonin in plasma was measured by ELISA method in the two groups., Results: The between-group differences and within-group differences of MAP, HR and SpO 2 were not significant at each time point ( P >0.05). Compared with T 0 , the score of smell identification and plasma concentration of melatonin were not significantly different at T 1 in the observation group ( P >0.05), however, the score of smell identification and plasma concentration of melatonin were reduced in the control group ( P <0.05). At T 1 , the score of smell identification and plasma concentration of melatonin in the observation group were higher than those in the control group ( P <0.05)., Conclusion: TEAS could improve the postoperative olfactory memory disorder in patients with general anesthesia of sevoflurane, and its mechanism may be related to the increase of plasma concentration of melatonin.