1. [Expressions of matrix metalloproteinase 9 in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus infection].
- Author
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Feng ZY, Mo XL, Shao CK, and Su ZL
- Subjects
- Female, Humans, Lymphoma, T-Cell pathology, Male, Mucous Membrane virology, Natural Killer T-Cells virology, Gene Expression Regulation, Neoplastic, Herpesvirus 4, Human physiology, Lymphoma, T-Cell genetics, Lymphoma, T-Cell virology, Matrix Metalloproteinase 9 metabolism, Mucous Membrane pathology, Natural Killer T-Cells pathology
- Abstract
Objective: To investigate the expression of matrix metalloproteinase 9 (MMP9) in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus (EBV) infection., Methods: The expression of MMP9 and EBV-encoded RNA (EBER) were detected by immunohistochemistry and in situ hybridization in 59 cases of mucosal natural killer/T cell and mature T cell lymphomas., Results: The positivity rates of MMP9 and EBERs were 83.05% and 72.88% respectively. The positivity rate of EBERs was correlated with histopathological subtype (P<0.05), but not with clinical stage, vascular invasion or the patients' survival time (P>0.05). The expression level of MMP9 was not correlated with the clinical stage, vascular invasion or survival time (P>0.05). No significant correlation was found between MMP9 expression and EBV infection., Conclusion: EBV may play an important role in the development of mucosal natural killer/T cell and mature T cell lymphomas and promote disease progression by up-regulating MMP9 expression indirectly. Elimination of EBV infection may be helpful to prevent the development of lymphoma.
- Published
- 2007