Search

Objective To explore the effect of integrated medical and nursing enhanced recovery after surgery (ERAS) nursing on postoperative rehabilitation and nutritional status of patients with colorectal cancer. Methods A total of 120 patients with colorectal cancer admitted to the First People's Hospital of Qinzhou from January 2021 to January 2023 were randomly divided into the routine group and the intervention group, with 60 cases in each group. Routine nursing and ERAS nursing integrated medical and nursing were given respectively. The postoperative indwelling catheter, first exhaust, beginning of semi-fluid, ambulation, hospitalization time, postoperative nutritional indicators (serum total protein, albumin, prealbumin), complications and nursing satisfaction were observed in the two groups. Results The time of indwelling catheter, first exhaust, starting semi-liquid, getting out of bed and hospitalization in the intervention group were significantly shorter than those in the routine group. The postoperative nutritional index and nursing satisfaction were significantly higher than those in the routine group, and the incidence of complications was significantly lower than that in the routine group and the differences were statistically significant (P<0.05). Conclusion The application of integrated medical and nursing with ERAS nursing in the perioperative period of colorectal cancer can promote the recovery of gastrointestinal function, increase nutrition, reduce the incidence of complications and shorten the length of hospital stay. [ABSTRACT FROM AUTHOR]

Obejective: To investigate the effects of different doses of protein diet on nutritional status, immune function and oxidative stress in patients with type 2 diabetes mellitus (T2DM) with pulmonary tuberculosis. Methods: 120 T2DM patients with pulmonary tuberculosis who were admitted to Hunan Provincial Chest Hospital from March 2020 to December 2021 were selected as research objects. Patients were randomly divided into high protein group (1.5 g/kg/d protein, total calorie increased by 10%), medium protein group (1.2 g/kg/d protein, total calorie increased by 10%), low protein group (1.0 g/kg/d protein, total calorie increased by 10%). 40 cases in each group. The sputum mycobacterium tuberculosis negative conversion, pulmonary infection, blood glucose, nutritional status, immune function and oxidative stress level in three groups were compared. Results: The sputum mycobacterium tuberculosis negative conversion rate in high protein group and medium protein group was higher than that in low protein group, and high protein group was higher than that of medium protein group (P<0.05). The pulmonary infection rate in high protein group and medium protein group was lower than that in low protein group, and high protein group was lower than that of medium protein group (P<0.05). After treatment, the glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and 2h postprandial blood glucose (2hPG) in high protein group and medium protein group were lower than those in low protein group, and high protein group was lower than that of medium protein group (P<0.05). After treatment, total albumin (TP), prealbumin (PA) and albumin (ALB) in high protein group and medium protein group were higher than those in low protein group, and high protein group was higher than that of medium protein group (P<0. 05). After treatment, CD3+, CD4+ and CD4+ /CD8+ in high protein group and medium protein group were higher than those in low protein group, and high protein group was higher than that of medium protein group (P<0.05). After treatment, CD8+ in high protein group and medium protein group was lower than that in low protein group, and high protein group was lower than that of medium protein group (P<0.05). After treatment, the superoxide dismutase (SOD) in high protein group and medium protein group was higher than that in low protein group, and high protein group was higher than that of medium protein group (P<0.05). After treatment, the malondialdehyde (MDA) in high protein group and medium protein group was lower than that in low protein group, and high protein group was lower than that of medium protein group (P<0.05). Conclusion: High protein diet can improve the nutritional status and immune function of T2DM patients with pulmonary tuberculosis, and reduce the level of oxidative stress. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of induction chemotherapy (IC) on immune function and inflammatory markers in patients with stage Ⅲ-Ⅳ nasopharyngeal carcinoma (NPC). Methods A total of 102 patients with stage Ⅲ-Ⅳ NPC confirmed by pathology were selected to receive TPF regimen (docetaxel, cisplatin and 5-fluorouracil, 72 cases) or GP regimen (gemcitabine and cisplatin, 30 cases). The short-term clinical outcomes of patients were evaluated. The immune function of patients with different clinical characteristics was compared before and after IC treatment. T lymphocyte subsets (CD3+, CD4+, CD8+, CD4+ /CD8+ ), B lymphocyte subsets (CD19+ ) and NK cell percentage in peripheral blood before and after IC were compared. Inflammatory markers interleukin-6, tumor necrosis factor α (TNF- α), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR), and systemic immunoinflammatory index (SII), and changes of total protein (TP), albumin (ALB) and prealbumin (PA) were also compared. The immune function, inflammatory index and nutritional status of patients with different IC regimen and IC cycle number were compared. Results All 102 patients completed IC, of which 0 patient achieved complete response (CR), 87 patients (85.3%) achieved partial response (PR), 13 patients (12.7%) achieved stable response (SD), 2 patients (2.0%) developed PD. The objective response rate (ORR) was 85.3%, and the disease control rate (DCR) was 98.0%. The proportion of CD19+ lymphocytes and NK cells decreased after IC, while the proportion of CD3+, CD4+ and CD8+ lymphocytes increased after IC (P＜0.05). Levels of NLR, SII, TP, ALB and PA were decreased in NPC patients after IC (P＜0.05). After IC, the CD4+ /CD8+ ratio was higher in the GP group than that in the TPF group, and LMR decreased (P＜0.05). There were no significant differences in the immune function, inflammatory indexes and nutritional status before and after IC between the ≤3 cycle group and the > 3 cycle group. Conclusion IC is an effective therapy with high disease control rates for NPC patients, and can improve their cellular immune function, decrease humoral immune function, inflammatory indices and nutritional status. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of enteral nutrition (EN) based on energy metabolism monitoring on intestinal function, nutritional status and immune function in elderly critically ill patients. Methods: According to the random number table method,136 elderly critically ill patients who were admitted to of EICU Department of Nanjing First Hospital from April 2020 to January 2023 were divided into control group (routine EN) and study group (routine EN based on energy metabolism monitoring), with 68 cases in each group. The clinical indexes, nutritional status, immune function indexes, intestinal function indexes and incidence of complications were compared between two groups. Results: The EN compliance rate within 7 days and the success rate of weaning within 7 days in study group were higher than those in control group, the ICU hospitalization time and mechanical ventilation time in study group were shorter than those in control group, and the total incidence of complications was lower than that in control group (P<0.05). 14 days after intervention, the levels of albumin (ALB), serum total protein (TP), prealbumin (PA) and hemoglobin (Hb) in study group were higher than those in control group (P<0.05). 14 days after intervention, the levels of immunoglobulin (Ig) M, IgG and IgA in study group were higher than those in control group (P<0.05). 14 days after intervention, the levels of D-lactic acid and diamine oxidase (DAO) in study group were lower than those in control group (P<0.05). Conclusion: EN intervention based on energy metabolism monitoring in elderly critically ill patients, which can further improve the nutritional status, intestinal function and immune function of patients. [ABSTRACT FROM AUTHOR]

Objective To assess the nutritional status of vitamin D and associated factors among adults of six ethnic minority groups native to Yunnan Province, and provide evidence for policy making. Methods Between May 2019 and August 2020, a total of 690 adults were selected from Jinuo, Bulang, Jingpo, Deang, Achang and Pumi ethnic groups according to the sex and age composition in the 6th national census. A questionnaire survey and an anthropometric examination were conducted by trained health workers, and serum 25 (OH) D levels were determined with high-performance liquid chromatography-tandem mass spectrometry. Results The median of serum 25 (OH) D was 28.7 ( P25～P75: 24.3 ～33.8) ng/mL, and the prevalence of vitamin D sufficiency, insufficiency and deficiency were 44.2%、 47.5% and 8.3%, respectively. There were significant differences in serum 25 (OH) D levels among the six ethnic groups (χ²=139.29, P < 0.01). Multivariate logistic regression showed that ethnic groups living in higher latitude areas (Pumi, Jingpo, Deang, and Achang), women, and those whose BMI≥24.0 were more likely to be vitamin D insufficient or deficient. Conclusion More than half of the ethnic adults suffer from vitamin D malnutrition which also varies across ethnicities. Further surveillance and interventions among key areas and populations are needed. [ABSTRACT FROM AUTHOR]

Objective To explore the effect of a new type of low-protein enteral nutrition on the nutritional status of patients with chronic kidney disease in stage 3-4 under the guidance of individualized diet. Methods Sixty follow-up outpatients in West China Hospital of Sichuan University were randomly divided into the experimental group and the control group. The two groups were followed up on intervention day 0, day 45, and day 90. According to the principle of intentional analysis, the generalized estimation equation was used to analyze the between-group differences, time change trend, and interaction effect, and the principle of data analysis in accordance with the scheme was used to further verify the stability of results. Results There was no significant difference in nutritional adequacy, clinical effectiveness, and anthropometric indexes between the test group and the control group (P > 0.05). During the intervention period, when the energy intake was stable, the intake of protein (於=17.680, P<0,001) and sodium salt (=21.427, P<0»001) decreased significantly, while the total protein (於=18,075, P<0.001), calcium (护=9.43& P=0,009), phosphorus (护=13.866; P=0.001), and uric acid (於=9,005, P=0.011) fluctuated within the normal range. The results of data analysis in accordance with the scheme were basically consistent with those of intentionality analysis. Only the time change trend of upper arm muscle circumference (於=6.435: P=0.040) and the comparison of energy ratio between groups (於=4.47& P=0.034) were significantly different. Conclusion The new low-protein enteral nutrition preparation is not inferior to the total nutritional formula food for special medical use in improving the nutritional status of patients and delaying the progression of the disease. The use of enteral nutrition under dietary guidance is beneficial to the clinical nutrition management of patients with chronic kidney disease. [ABSTRACT FROM AUTHOR]

Objective: To explore the characteristics of L3 skeletal muscle index in patients with cirrhosis of different etiology and its predictive value for nutritional status of patients. Methods: 120 patients with cirrhosis admitted to our hospital from June 2019 to June 2022 were selected for the study, including 40 cases of hepatitis B cirrhosis, 40 cases of alcoholic cirrhosis, and 40 cases of liver cirrhosis with autoimmune hepatitis. Compthe L3 SMI characteristics of hepatitis B cirrhosis, alcoholic cirrhosis, and autoimmune hepatitis cirrhosis. Pearson correlation test was used to analyze the correlation between L3 SMI and nutritional status in patients with cirrhosis. The independent risk factors affecting the nutritional status of cirrhosis were established by Logistics regression model. The predictive value of L3 SMI for nutritional status in cirrhosis was evaluated using receiver operating curve (ROC). Results: The expression levels of L3 SMI, 25 (OH) D, ALB, PA and TRF in autoimmune hepatitis cirrhosis group were significantly lower than those in alcoholic cirrhosis group and hepatitis B cirrhosis group (P<0.05), and alcoholic cirrhosis group was significantly lower than that in hepatitis B cirrhosis group (P<0.05). LSM was significantly positively correlated with 25 (OH) D, ALB, PA and TRF in patients with cirrhosis (P<0.05). The nutritional status of patients with cirrhosis was incorporated into logistics regression model as dependent variable (normal nutrition =0, malnutrition =1). The results showed that 25 (OH) DALB, PA, TRF and L3 SMI were risk factors (P<0.05). The results of multivariate analysis showed that 25 (OH) DALB, PA, TRF and L3 SMI were independent risk factors affecting the nutritional status of patients with cirrhosis (P<0.05). L3 SMI predicted the Youden index of 0.765, sensitivity 85.00 (%), specificity 82.00 (%), AUC value 0.810, 95%CI: 0.685~0.912. Conclusion: There are significant differences in L3 skeletal muscle index in patients with cirrhosis of different etiology, and L3 skeletal muscle index can be used in clinical prediction and evaluation of nutritional status in patients with cirrhosis. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of immune enhanced enteral nutrition on nutritional status, lung function and humoral immunity in elderly patients with severe pneumonia（SP). Methods: 104 elderly SP patients in our hospital from January 2021 to January 2023 were selected as research objects, and were randomly divided into control group and observation group with 52 cases in each group according to random drawing method. The control group received conventional enteral nutrition support, and the observation group received immune enhanced enteral nutrition support. The recovery time of symptoms and signs, severity of disease, pneumonia severity index, lung function, nutritional status, humoral immunity index before and after treatment were compared between the two groups. Results: The disappearance time of fever, cough, lung rales and X-ray shadow in observation group was shorter than that in control group（P＜0.05). After treatment, the Acute Physiology and Chronic Health Evaluation Ⅱ（APACHEⅡ） scores of the observation group were lower than those of the control group（P＜0.05); After treatment, the risk grade of pneumonia in observation group was better than that in control group（P＜0.05). After treatment, the levels of total protein（TP), prealbumin（PA), albumin（ALB） and transferrin（TRF） in observation group were higher than those in control group（P＜0.05); After treatment, the dynamic lung compliance（Cdyn） of observation group was higher than that of control group, and airway resistance（R） was lower than that of control group（P＜0.05). After treatment, the levels of immunoglobulin A（Ig A), immunoglobulin M（Ig M), immunoglobulin G（Ig G), complement C3 and complement C4 in observation group were higher than those in control group（P＜0.05). Conclusion: Immune enhanced enteral nutrition support can accelerate the relief of clinical symptoms and signs in elderly SP patients, improve their condition, pneumonia severity and lung function, and enhance their immune capacity and nutritional level, which has certain clinical application value. [ABSTRACT FROM AUTHOR]

Objective To explore the nutritional status of chronic obstructive pulmonary disease (COPD) patients in Hengshui area and to explore the influencing factors of malnutrition in COPD patients. Methods A total of 321 COPD patients in our hospital from January 2018 to October 2022 were selected, including 189 males and 132 females, aged 49 to 62 years, with an aver- age age of (55.23 ±3.01) years. Patients were divided into normal nutrition group and malnutrition group. Univariate analysis was used to compare the demographic characteristics, clinical data, and laboratory examinations between the two groups. Logistic regression was used to analyze the possible influencing factors of malnutrition in COPD patients. Results Logistic regression analysis showed that age (OR=2.496, 95%CI: 1.204-1.860), annual family income (OR=0.569, 95%CI: 0.386-0.839), COPD Assessment Test (CAT) score (OR=1.917, 95%CI: 1.288-2.854), 6-Minute Walk Test (6MWT) (OR=0.550, 95%CI: 0.350-0.865), modified Medical Research Council Dyspnea Scale (mMRC) score (OR=1.944, 95%CI: 1.076-3.515), number of acute exacerbations of COPD hospitalization (OR=1.788, 95%CI: 1.053-3.035), and sarcopenia (OR=2.782, 95%CI: 1.542-5.018) were independent influencing factors of malnutrition in patients with COPD in Hengshui area. Conclusion In total 47.35% of the 321 COPD patients in Hengshui area had malnutrition, and age, annual family income, CAT score, 6MWT, mMRC score, acute exacerbation of chronic obstructive pulmonary disease, and sarcopenia are the independent influencing factors of malnutrition in COPD patients. It is suggested to formulate feasible and targeted intervention measures according to the above factors in order to reduce the incidence of malnutrition in patients with COPD, reduce the clinical manifestations of sarcopenia, and prolong the survival time. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of total protein enteral nutrition base on nutritional risk screening (NRS) nutritional risk assessment on nutritional status, intestinal flora and peripheral blood T helper cell 17 (Th17) /regulatory T cell (Treg) balance in elderly patients with cirrhosis. Methods: 103 elderly patients with liver cirrhosis admitted to the First Hospital of Changsha from December 2019 to August 2022 were divided into the control group (51 cases were treated with conventional diet) and the study group (52 cases were treated with whole protein enteral nutrition based on NRS nutrition risk assessment on the basis of the control group) according to the method of random number table. The changes of NRS2002 score, nutritional status index, intestinal flora index and peripheral blood Th17/Treg balance were compared between two groups. Result: Three months after treatment, the NRS2002 score decreased in two groups, and study group was lower than that of control group (P＜0.05) . Three months after treatment, serum total protein (TP), albumin (ALB) and prealbumin (PA) increased in two groups, and study group was higher than that of control group (P＜0.05) .Three months after treatment, bifidobacteria, lactobacilli, enterococci and enterobacteria increased in two groups, and study group was higher than that of control group (P＜0.05) . Three months after treatment, yeast like fungi decreased in two groups, and study group was lower than that of control group (P＜0.05) . Three months after treatment, Treg increased in two groups, and study group was higher than that of control group (P＜0.05) . Three months after treatment, Th17 and Th17/Treg decreased in two groups, and study group was lower than that of control group (P＜0.05) . Conclusion: Total protein enteral nutrition base on NRS nutritional risk assessment in elderly patients with cirrhosis, which is beneficial to reduce the risk of malnutrition, may be relate to the improvement of nutritional status, intestinal flora and peripheral blood Th17/Treg balance. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of microecological preparation combined with immune enhanced enteral nutrition in the treatment of patients with severe pneumonia, and its effects on nutritional status, intestinal flora, T lymphocyte subsets and inflammatory response indexes. Methods: A total of 126 patients with severe pneumonia admitted to Handan Central Hospital from October 2018 to January 2022 were randomly divided into observation group and control group, with 63 cases in each group. The control group was treated with immune enhanced enteral nutrition, and the observation group was treated with microecological preparation on the basis of the control group. The clinical efficacy, symptom changes, nutritional indicators[hemoglobin (HGB), albumin (ALB), prealbumin (PA) ], intestinal flora (bifidobacterium, lactobacillus, enterococcus, escherichia coli, campylobacter), T lymphocyte subsets (CD3+,CD4+, CD8+, CD4+/CD8+), inflammatory factor levels [interleukin-6 (IL-6), soluble vascular cell adhesion molecule 1 (s VCAM-1), C-reactive protein (CRP) ] were compared between the two groups before and after treatment. Results: The total effective rate of the observation group (93.65%) was higher than that of the control group (80.95%) (P＜0.05) . The body temperature recovery time, lung shadow disappearance time, cough improvement time and hospitalization time in the observation group were shorter than those in the control group (P＜0.05) . After treatment, the levels of HGB, ALB and PA in the observation group were higher than those in the control group (P＜0.05) .After treatment, bifidobacterium in the observation group was higher than that in the control group, and lactobacillus, enterococcus,es cherichia coli and campylobacter were lower than those in the control group (P＜0.05) . After treatment, CD8+in the observation group was lower than that in the control group, and CD3+, CD4+, CD4+/CD8+were higher than those in the control group (P＜0.05) . After treatment, the levels of serum IL-6, s VCAM-1 and CRP in the observation group were lower than those in the control group (P＜0.05) . Conclusion: Microecological preparation combined with immune enhanced enteral nutrition is effective in the treatment of severe pneumonia. It can effectively improve symptoms, regulate intestinal flora, enhance immune function, improve nutritional status, and reduce inflammatory response, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of different proportions of enteral combined with parenteral nutrition treatment on patients with severe traumatic brain injury (s TBI). Methods: The subjects of study were s TBI patients admitted to the Neurointensive Care Unit of Chongqing Emergency Medical Center from October 2020 to August 2022. 70 patients who met the inclusion and exclusion criteria were randomly divided into the experimental group and the control group with 35 cases each. Calculate the daily caloric requirements of patients and provide nutritional support according to different proportion of enteral and parenteral nutrition programs. The experimental group was given enteral and parenteral nutrition support at a ratio of 2:1, while the control group was given enteral and parenteral nutrition support at a ratio of 1:1. The differences of nutritional status indicators (hemoglobin, albumin, prealbumin, total protein), immune function indicators [CD3, CD4, CD4/CD8, immunoglobulin (Ig)A, Ig M, Ig G], inflammatory indicators [C-reactive protein (CRP), procalcitonin (PCT), interleukin-6 (IL-6)] and complications between the two groups were statistically compared. Results: In terms of immune function, the levels of CD4, CD4/CD8 and Ig A in the experimental group were significantly higher than those in the control group 14 d after nutritional support (P＜0. 05); There was no significant difference between the two groups in nutritional status, inflammatory indicators and complications (P＞0. 05). Conclusions: Enteral nutrition-based combined nutritional support can promote the recovery of immune function in patients with s TBI, but there is no significant difference in nutritional status, inflammatory indicators and complications between different proportions of enteral combined parenteral nutrition treatment. [ABSTRACT FROM AUTHOR]

Parenteral nutrition is one of the important means of clinical nutrition therapy, which can improve the nutritional intake and nutritional status of patients and improve the clinical outcome of patients. The stability and compatibility of total nutrition mixture have been paid much attention due to the complex and diverse prescription components, the wide range of patients and the high risk of drug use. Related fields are worthy of continuous exploration and in-depth study by pharmaceutical workers. In this paper, by referring to the latest Chinese and foreign literature and guidelines, combined with practical work experience, and aiming at the compatibility stability and compatibility of parenteral nutrition solution, relatively clear evaluation methods and research strategies were proposed to provide reference for related studies on parenteral nutrition solution. [ABSTRACT FROM AUTHOR]

The experiment was to understand the nutritional status of ephemeral and quasi-ephemeral plants in the natural grassland of desert areas in early spring, and analyze the nutritional value of different growth stages. A total of 10 species of such plants were collected as research objects to screen the natural forage resources suitable for feeding livestock. The relevant nutrients were determined, and their quality was evaluated by referring to the technical system of roughage grading index (GI). The results showed that the variation range of DM content of the tested plants was not significant, the contents of EE and CP showed a downward trend, while the content of NDF and ADF showed an upward trend. The green grass stage and flowering stage of ephemeral and quasi-ephemeral plants could be used as better forage resources except for Potentilla bifurca Linn. The feeding value was ranked as Astragalus yanerwoensis Podlech & L. R. Xu＞Trigonella arcuata C. A. Meyer＞Astragalus stalinskyi Sirj. ＞Leontice incerta Pall. ＞Corydalis schanginii (Pall.) B. Fedtsch. ＞ Scorzonera sericeo-lanata (Bunge) Krasch. et Lipsch. ＞Diptychocarpus stricus (Fisch. Ex M. Bieb.) Trautv. ＞Alyssum desertorum stapf.＞Koelpinia linearis Pall.＞Potentilla bifurca Linn. The study indicates that the results of the study can improve the efficient utilization of ephemeral and quasi-ephemeral plants, and provide forage resources for the rapid recovery of body condition of grazing livestock in spring. [ABSTRACT FROM AUTHOR]

Objective To investigate the physical growth and sexual development of adolescents in Lancang Lahu Autonomous County, Yunnan Province, and establish a basic database of Lahu female growth and development. Methods　A cluster random sampling method was used to select 2 870 teenage girls from grades 7 to 9 from 5 middle schools in Lancang County. Local doctors measured the physical growth of adolescent girls and analyzed the physical and sexual development. Results　 In 2021, the height development grade evaluation of female adolescents in Lancang County, Yunnan Province was lower in rural areas than in urban areas (P < 0.01), and the height development of Lahu ethnic groups was lower than average, and tended to increase with age. The incidence of growth retardancy in rural areas (3.2%) was higher than that in urban areas (1.8%), P = 0.036, and that in Lahu ethnic groups (5.2%) was higher than that in other ethnic groups (P < 0.01). The incidence of high waist circumference and obesity in urban areas (25.9%, 10.5%) was higher than that in rural areas (16.8%, 4.7%, P < 0.01). The average age of menarche of female Lahu students in rural areas was later than that of female students of other ethnic groups (P < 0.01). Conclusion　Female students of Lahu nationality have lower height development and higher incidence of growth retardation than other ethnic groups. The average age of menarche of Lahu female students living in rural areas was later than that of other female students. It is suggested that individual health education and dietary guidance should be taken according to the different growth and development of adolescents according to their nutritional status. [ABSTRACT FROM AUTHOR]

Objective: To investigate the prevalence of dental caries in children aged 3～5 years in Xuanwu District of Nanjing, and to analyze the influencing factors of dental caries and its effects on growth development and nutrient intake. Methods: From March 2020 to February 2022, 6 kindergartens in Xuanwu District of Nanjing were randomly selected by using the multi-stage stratified equal capacity random sampling method and the sampling method based on childcare institutions. A total of 792 children aged 3～5 years were sampled, and 788 people actually completed the survey, with a response rate of 99.49%. The incidence of dental caries in children aged 3～5 years in Xuanwu District of Nanjing was recorded. They were divided into dental caries group (n=361) and non-dental caries group (n=427) according to the occurrence of dental caries. The influencing factors of dental caries in children aged 3～5 years in Xuanwu District of Nanjing were analyzed by univariate and multivariate Logistic regression. And the effect of caries on children's growth development and nutrition intake were observed. Results: Among 788 children aged 3～5 years, 361 were found to have dental caries, and the incidence rate was 45.81%. Univariate analysis showed that the incidence of dental caries in children aged 3～5 years in Xuanwu District of Nanjing was related to age, feeding mode, sugar intake frequency, dessert consumption before bedtime, tooth brushing times, age at the beginning of tooth brushing, and oral health knowledge level of parents (P<0.05). The results of multivariate Logistic regression analysis showed that age of 5 years, feeding mode of whole breast milk, sugar intake frequency ≥ 2 times/d, and dessert consumption before bedtime were the risk factors for the occurrence of dental caries in children aged 3～5 years in Xuanwu District of Nanjing (P<0.05), while the higher oral health knowledge level of parents was the protective factor for the occurrence of dental caries in children aged 3～5 years in Xuanwu District of Nanjing (P<0.05). The height, weight, chest circumference and vital capacity of the non-dental caries group were higher than those of the dental caries group (P<0.05). The energy, protein, fat, calcium, iron, zinc, vitamin C and folic acid of the dental caries group were lower than those of the non-dental caries group (P<0.05). Conclusion: The incidence of dental caries in children aged 3 ～5 years in Xuanwu District of Nanjing is high. Dental caries has a certain impact on growth development and nutrient intake, while age, feeding mode, sugar intake frequency,dessert consumption before bedtime and oral health knowledge level of parents are all influencing factors. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of probiotic early enteral nutrition on nutritional status and inflammatory factors in patients with severe craniocerebral injury (SCCI) undergoing mechanical ventilation, and to analyze the influencing factors of ventilator-associated pneumonia (VAP). Methods: 102 patients with SCCI who were admitted to our hospital from February 2021 to April 2022 were selected, and they were divided into control group (n=51) and study group (n=51) according to the random number table method. On the basis of conventional treatment, the control group was given early enteral nutrition support treatment, while the study group was given probiotic combined with early enteral nutrition support treatment. The duration of mechanical ventilation, hospital stay, nutritional status and inflammatory factors changes were compared in the two groups, and the occurrence of VAP in the two groups during treatment was recorded. All patients were divided into VAP group and non-VAP group according to the occurrence of VAP. Univariate and multivariate Logistic regression analysis was used to analyze the influencing factors of the occurrence of VAP in mechanical ventilation patients with SCCI. Results: The time of mechanical ventilation and hospital stay in the study group were shorter than those in the control group, and the incidence rate of VAP was lower than that in the control group (P＜0.05). After treatment, the albumin (ALB), transferrin (TF) and hemoglobin (Hb) in the two groups were increased, and the study group was higher than the control group (P＜0.05). After treatment, interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), procalcitonin (PCT) in the two groups decreased, and the study group was lower than the control group (P＜0.05). The results of univariate analysis showed that the incidence of VAP was related to age, the way of establishing artificial airway, the daily number of sputum aspiration, the number of oral care, the daily number of airway humidification, the number of operations, combined with compound injury, aspiration, preoperative GCS score, and the time of mechanical ventilation (P＜0.05). The results of multivariate Logistic regression analysis showed that age greater than or equal to 60 years, high preoperative GCS score, tracheotomy as the way of establishing artificial airway, 2 times of number of operations, daily number of airway humidification less than 3 times, aspiration, and longer time of mechanical ventilation were all risk factors for VAP in patients with SCCI mechanical ventilation (P＜0.05). Conclusion: Probiotic early enteral nutrition can shorten the time of mechanical ventilation and hospital stay in patients with SCCI, promote the improvement of nutritional status, and reduce the level of inflammatory factors. At the same time, the incidence of postoperative VAP in patients with SCCI is high. Age, preoperative GCS score, the way of establishing artificial airway, the number of operations, the average daily number of airway humidification, aspiration, and the time of mechanical ventilation are the influencing factors of VAP in patients with SCCI undergoing mechanical ventilation. [ABSTRACT FROM AUTHOR]

Objective: To observe the changes of the nutritional status calibrated by BMI and serum albumin in early -pregnant women with mild thalassemia, and iron metabolism levels, and to explore the relationship between nutritional status and iron metabolism in these pregnant women. Methods: The levels of serum iron (SI), serum ferritin (SF) and hemoglobin (Hb) in 634 pregnant women with mild thalassemia, from October 2018 to October 2020, were retrospectively analyzed. According to the nutritional status, the pregnant women were divided into the low weight-malnutrition group (group A), the low weight-good nutrition group (group B), the high weight-malnutrition group (group C) and the high weight-good nutrition group (group D). Results: With the increase of gestational age, the levels of SI, SF and Hb of pregnant women in the four groups showed a downward trend. The levels of SF and SI in group D were lower than those in other three groups at different gestational periods (all P＜0.05). The levels of SF in group A were higher than those in the other three groups in the middle and late pregnancy, the levels of SI were higher than those in the other three groups at different gestational periods, while the levels of Hb were lower than those in the other three groups at different gestational periods (all P＜0.05). Conclusions: Pregnant women with mild thalassemia, especially those with low weight - malnutrition and high weight-good nutrition, may have iron deficiency anemia. Therefore, it is necessary to dynamically monitor the level of iron metabolism during the pregnancy of mild thalassemia, and those with high iron load or good nutritional status in the early pregnancy should not be ignored. Nutrition or iron supplementation should be given to different individuals to reduce the risk of iron deficiency anemia. [ABSTRACT FROM AUTHOR]

Objective: To study the influencing factors of high nutritional risk in children with sepsis and their effects on immune function, trace elements and disease outcome. Methods: 168 children with sepsis who were admitted to our hospital from January 2019 to December 2021 were selected, the nutritional status and growth risk screening tool (STRONGkids) was used to screen their nutritional risk, according to the scoring results, the children with nutritional risk were divided into medium-low nutritional risk group and high nutritional risk group. The clinical data of the two groups were compared, and the influencing factors of high nutritional risk were analyzed by Logistic regression model. The indexes of immune function (CD4+, CD8+, CD4+/CD8+), the contents of trace elements [copper (Cu), iron (Fe), zinc (Zn)] and the disease outcome situation were compared between the low and middle nutrition risk group and the high nutrition risk group. Results: The results of STRONGkids nutritional risk screening showed that 151 children with sepsis had nutritional risk, and the incidence of nutritional risk was 89.88%, including 110 cases of medium-low nutritional risk (medium-low nutritional risk group) and 41 cases of high nutritional risk (high nutritional risk group). The acute physiology and chronic health score system II (APACHE II) score, lactic acid, procalcitonin levels and the proportion of severe sepsis in the high nutritional risk group were higher than those in the medium-low nutritional risk group, and the albumin level was lower than that in the medium-low nutritional risk group (P<0.05). Multivariate Logistic regression analysis showed that increased APACHE II score and severe sepsis were risk factors for high nutritional risk in children with sepsis (P<0.05), and increased albumin was a protective factor for high nutritional risk in children with sepsis (P<0.05). CD4+ and CD4+/CD8+ in the high nutritional risk group were lower than those in the medium-low nutritional risk group, and CD8+ was higher than that in the medium-low nutritional risk group (P＜0.05). There was no significant difference in Cu content between the two groups (P>0.05). The Fe and Zn contents in the high nutritional risk group were lower than those in the medium-low nutritional risk group (P＜0.05). There were 74 cases of improvement, 32 cases of unrecovery, and 4 cases of death in the medium-low nutritional risk group, while 19 cases of improvement, 15 cases of unrecovery and 7 cases of death in the high nutritional risk group, the good disease outcome rate in the high nutritional risk group was lower than that in the medium-low nutritional risk group (P＜0.05). Conclusion: The incidence of high nutritional risk is high in children with sepsis. Severe sepsis, APACHE Ⅱ score and albumin level are the influencing factors of high nutritional risk, and high nutritional risk leads to the decline of immune function, the reduction of Fe and Zn content in the body, and poor disease outcome. Early nutritional intervention is recommended to improve the prognosis of children. [ABSTRACT FROM AUTHOR]

Objective To investigate and analyze the body fluid distribution and nutritional status of patients with heart failure (HF) before and after treatment. Methods A total of 100 patients with HF admitted to this hospital from January 2021 to April 2022 were selected as the research objects. The nutritional status of patients (hemoglobin, plasma albumin, prealbumin, triglyceride, total cholesterol, etc. ) was monitored before and after treatment, and the patients were treated by cardiologists. Extracellular fluid volume, intracellular fluid volume (ICW), total body fluid volume (TBW), protein content, skeletal muscle content, body fat, body cell volume, etc., before diuretic treatment (the first day after admission) and after diuretic treatment (HF correction, signs disappearing or alleviating, meeting discharge criteria) were measured by dietitian of nutrition department, and ICW/TBW was calculated. The body fluid distribution and nutritional status of patients before and after treatment were compared. Results The levels of hemoglobin, plasma albumin, prealbumin, triglyceride and total cholesterol of 100 patients were improved after diuretic treatment, but there was no statistical significance compared with before treatment (P >0.05). Both extracellular fluid volume, TBW and ICW/ TBW showed a decreasing trend, with statistical significance (P <0.05). There were no significant differences in ICW, protein content, skeletal muscle content, body fat and body cell volume compared with before treatment (P >0.05). Conclusion Diuretic therapy can effectively improve the body fluid distribution in HF patients. However, due to the short observation time, there is no obvious intervention effect on the improvement of nutritional status of patients. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical value of early application of enteral nutrition emulsion (EN) on nutritional support and infection prevention in patients with severe cerebrovascular disease. Methods: According to the random number table method, 392patients with severe cerebrovascular disease who were treated in our hospital from January 2016 to January 2021 were divided into control group (n=196) and experimental group (n=196). The patients in the control group were given en support treatment 24 hours after the onset of the disease, and the patients in the experimental group were given EN support treatment within 24 hours after the onset of the disease. The nutritional status, immune function, complication rate, condition and self-care ability of the two groups were compared.Results: After treatment, albumin, prealbumin and hemoglobin in experimental group were higher than those in control group (P＜0.05). After treatment, CD3+, CD4+and CD4+/CD8+in experimental group were higher than those in control group, and CD8+was lower than that in control group (P＜0.05). The survival rate in the experimental group was higher than that in the control group, and the incidence of complications was lower than that in the control group (P＜0.05). After treatment, the activity of daily living scale (ADL) score in the two groups was higher than that before treatment, and the National Institutes of Health Neurological Deficit Scale (NIHSS) score was lower than that before treatment, and the degree of change in the experimental group was greater than that in the control group (P＜0.05). Conclusion: Early application of EN can improve the nutritional status of patients with severe cerebrovascular disease, enhance their immunity, reduce the incidence of complications, improve the activities of daily living, and increase the survival rate. [ABSTRACT FROM AUTHOR]

Agrobiodiversity including landraces of crops is extreme significant for global food security and sustainable rural development but it is losing at alarming speed. Only in the remote areas, some of landraces are remained in local agroecosystem. Landraces refer to the traditional resources domesticated by people living in a certain area. They are bred or evolved in the local environments, which can adapt to the local natural and cultural environments. Changmaogu is a unique colored rice landrace planted by Lama people, a branch of Bai, in Lanping Bai and Pumi Autonomous County, Yunnan Province. Changmaogu is a typical representative landrace in China. Due to its lower yield, the cultivation of Changmaogu was controlled in a very limited area in the past few years, which was a very dangerous signal for a major crop. Despite its rare and endangered status, there has been a lack of research on Changmaogu. In order to promote the conservation and sustainable development of this landrace, we investigated and analyzed the quality traits, traditional knowledge and culture, development and utilization status and existing problems of Changmaogu in Lanping, and determined the nutritional components of Changmaogu comparing with those of common rice varieties to explore the nutritional value of Changmaogu, using the methods of ethnobotany and nutrition. The results are as follows:(1)The Lama people, have developed rich traditional knowledge about Changmaogu, including traditional farming knowledge, relevant historical allusions, traditional eating knowledge, seed exchange and conservation culture. They never use chemicals but collect green manures as fertilizer for this landrace. Under the backgrownd of understanding the good characteristics of Changmaogu, the local people continue to grow Changmaogu in the original habitat in a larger scale according to their traditional knowledge and culture.(2)Changmaogu has a high content of available carbohydrates, water, ash, total dietary fiber and anthocyanin, and contains a certain content of procyanidins, indicating that it has excellent nutritional and health care values. This study indicates that the mode of in-situ or on-farm conservation of Changmaogu provides a great reference for the conservation of other landraces, and reveals the fact that the outstanding properties like high nutritional value of Changmaogu will contribute to the sustainable uses of Changmaogu and other landraces. [ABSTRACT FROM AUTHOR]

Objective: To explore the influencing factors of malnutrition in elderly patients with heart failure (HF) and the effects of early enteral nutrition on cardiac function, nutritional status and intestinal mucosal barrier function in patients with malnutrition. 180 elderly patients with HF who were treated in our hospital from February 2021 to April 2022 were selected as the research objects. After admission, the nutritional status of all patients was evaluated according to the short-form mini-nutritional assessment (MNA-SF). According to the MNA-SF score results, they were divided into malnutrition group (n=83) and normal nutrition group (n=97). Univariate and multivariate Logistic regression were used to analyze the risk factors of malnutrition in elderly patients with HF. The elderly patients with HF malnutrition were given early enteral nutrition intervention, and the changes situation of cardiac function, nutritional status and intestinal mucosal barrier function were observed before treatment and 1 week after treatment. There were no significant correlation between malnutrition in elderly patients with HF and gender, residence, drinking history, etiology, occupational category, glutamic-pyruvic transaminase, serum creatinine, systolic blood pressure (SBP) and diastolic blood pressure (DBP) (P>0.05), and were associated with age, medical insurance type, disease course, marital status, New York Heart Association (NYHA) classification, educational level, C-reactive protein (CRP), family per capita monthly income, B-type brain natriuretic peptide (BNP), smoking history, left ventricular ejection fraction (LVEF) (P<0.05). Logistic regression analysis showed that longer disease course, higher CRP, higher BNP, NYHA classification IV, older age and smoking history were risk factors for malnutrition in elderly patients with HF (P<0.05). 1 week after treatment, LVEF was increased in elderly patients with HF with malnutrition group, and BNP was decreased (P<0.05). 1 weekafter treatment, the levels of prealbumin (PA) and transferrin (TRF) in elderly patients with HF in the malnutrition group were increased (P<0.05). 1 week after treatment, D-lactic acid (D-LAC), diamine oxidase (DAO) and intestinal fatty acid binding protein (IFABP) in elderly patients with HF in the malnutrition group were decreased (P<0.05). Malnutrition in elderly patients with HF is affected by the disease course, CRP, BNP, NYHA classification, age, smoking history and other factors. Early enteral nutrition for elderly patients with HF malnutrition is helpful to improve their cardiac function, nutritional status and intestinal mucosal barrier function. [ABSTRACT FROM AUTHOR]

Objective To assess the nutritional status of vitamin A among adults of ethnic minority groups native to Yunnan Province, and provide scientific evidence for healthy eating promotions. Methods Between 2016 and 2020, 841 adults were randomly sampled from seven ethnic minority groups according to the sex and age composition in the 6thnational census. The serum retinol level was determined using high-performance liquid chromatography (HLCP), and judged by the WHO criteria. Vitamin A intake was calculated through a dietary survey and judged by reference to the dietary guidelines. Results The median serum vitamin A concentration was 0.55 mg/L (ranging from 0.44 to 0.68 mg/L) and significant differences were found in sex, race, education and income levels (all P < 0.05). The prevalence of vitamin A deficiency and marginal deficiencies were 0.7% and 3.7%, respectively. The median of dietary vitamin A intake was 406.0 µg retinol equivalents (RE) and 67.0% of the subjects consumed less vitamin A than the Chinese Estimated Average Requirement (EAR). The major food sources of vitamin A were dark vegetables, eggs, light vegetables and meat, accounting for 86.6% of total vitamin A intake. Conclusion The serum vitamin A concentration is relatively good in the population, whereas inadequate vitamin A intake remains a problem, especially for certain ethnic groups, older and poor adults. [ABSTRACT FROM AUTHOR]

The purpose of the experiment was to explore the effects of different fattening stages on serum biochemical indexes, apparent nutrient digestibility and slaughter performance of yak in the growing period. A total of 21 healthy 2.5- year-old yaks with similar body weight were selected and randomly divided into three groups: 0 d slaughter group, 45 d slaughter group and 90 d slaughter group, respectively, with seven replicates in each group and one yak in each group. The pre-trial period was 15 d, and the formal test period was 90 d.The results showed that the apparent digestibility of DM, ADF and OM of yak in 90 d slaughter group was significantly higher than that of 0 d slaughter group (P<0.05), and the apparent digestibility of ADF was significantly higher than that of 45 d slaughter group (P<0.05).The ALP activity and TC content of yak in 0 d slaughter group were significantly higher than those in 90 d slaughter group (P<0.05), and ALP activity was significantly higher than that in 45 d slaughter group (P<0.05). The carcass weight, bone weight, net meat weight, meat to bone ratio, slaughtering rate and carcass meat yield of 90 d slaughter group yak were significantly higher than those of other groups (P<0.05).The weights of head, hooves, intestines, stomach, viscera and fur of yak in 90 d slaughter group were significantly higher than those in 0 d slaughter group (P<0.05), and the weights of head, hoof and fur were significantly higher than those of 45 d slaughter group (P<0.05). The study indicates that in different fattening stages, increasing intake of digestible nutrients can increase the slaughter performance of yak in growing period, promote metabolism of yak body, and gradually stabilize development of viscera, intestine and stomach. [ABSTRACT FROM AUTHOR]

The current situation, causes and solutions of the nutritional imbalance of young football players at home and abroad were summarized. It was pointed out that the imbalance of energy and material intake were mainly caused by insufficient total energy and carbohydrate intake and excessive protein and fat intake, with obvious regional characteristics; The main causes of nutritional imbalance were lack of nutrition knowledge, insufficient nutrition plan and energy intake supervision, failure to form healthy eating habits and necessity to improve suitable training and competition ability supplement, etc; The combination of regulation and induction would help to improve the nutritional status of young football players. In the future, in-depth research can be carried out on the regional differences of nutritional imbalance, the comparison of nutritional status between young football players and adult football players, and the improvement of teenagers' self-awareness from a psychological perspective, so as to further solve the problem of nutritional imbalance of young football players. [ABSTRACT FROM AUTHOR]

Objective: To observe the effects of enteral nutrition on nutritional status, intestinal mucosal barrier function and intestinal flora in patients with active ulcerative colitis（UC） with malnutrition. Methods: 120 patients with active UC with malnutrition who were treated in Shanghai Changzheng Hospital from August 2019 to September 2021 were selected, they were randomly divided into control group（60 cases, treated with total parenteral nutrition） and study group（60 cases, treated with enteral nutrition）. The total clinical effective rate of the two groups 3 weeks after treatment were observed, the nutritional status, intestinal mucosal barrier function index and intestinal flora of the two groups before and 3 weeks after treatment were compared, and the incidence of adverse reactions during the treatment of the two groups were recorded. Results: The total clinical effective rate of the study group（90.00%） was higher than that of the control group（68.33%）（P<0.05）. The levels of D-lactic acid（D-LA）, diamine oxidase（DAO） and endotoxin（ET） in the study group were lower than those in the control group at 3 weeks after treatment（P<0.05）. The levels of serum albumin and hemoglobin in the study group were higher than those in the control group at 3 weeks after treatment（P<0.05）. The number of Lactobacillus and Bifidobacterium in the study group was higher than that in the control group, while the number of Escherichia coli was lower than that in the control group at 3 weeks after treatment（P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. Conclusion: Enteral nutrition can promote the improvement of nutritional status and intestinal mucosal barrier function, regulate the structure of intestinal flora, which is safe and effective. [ABSTRACT FROM AUTHOR]

Objective To explore the expression level of insulin-like growth factor binding protein-2 (IGFBP-2) and its correlations to nutritional status and the prognosis of esophageal cancer patients. Methods A total of 136 esophageal cancer patients treated with surgical resection and chemotherapy/radiotherapy in our hospital were included in this study. The expression level of serum IGFBP-2 was detected by enzyme linked immunosorbent assay (ELISA), and its correlations to clinicopathological characteristics and nutritional parameters were further analyzed. Kaplan-Meier survival curve was plotted to evaluate the impact of serum IGFBP-2 expression on the overall survival (OS) of esophageal cancer patients. Moreover, the Cox multivariate regression analysis was used to determine the prognostic significance of serum IGFBP-2 level for esophageal cancer patients. Results All patients were divided into the high expression (n=68) group and the low expression group (n=68) based on the median value (302.52 μg/L) of serum IGFBP-2 expression. Compared with the low expression group, patients with high expression of serum IGFBP-2 had a higher proportion of weight loss ≥ 5% (χ² = 6.814), serum albumin <35 g/L (χ² =23.702), C-reactive protein ≥10 mg/L (χ² = 4.561), Glasgow prognostic score (GPS) 1-2 (χ² = 17.486) and prognostic nutritional index (PNI) <50.8 (χ² = 51.883), and a lower count of peripheral blood lymphocyte (P＜ 0.05). Kaplan-Meier curves showed that the median OS of patients with high IGFBP-2 expression was significantly shorter than that of patients with low IGFBP-2 expression (22.0 months vs. 36.0 months, Log-rank χ² =5.037，P＜0.05). The results of multivariate Cox analysis indicated that high serum IGFBP-2 expression (HR=1.631, 95%CI: 1.064-2.940, P=0.025) and tumor stage Ⅲ-Ⅳ (HR=1.851, 95%CI: 1.166-2.940, P=0.009) were independent prognostic factors for esophageal cancer patients. Conclusion The elevated serum level of IGFBP-2 expression is an indicator of malnutrition status, suggesting a poor prognosis of esophageal cancer. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between cognitive impairment and nutritional status in maintenance peritoneal dialysis patients. Methods: 172 maintenance peritoneal dialysis patients who were treated in the Affiliated Hospital of Jining Medical University from January 2019 to June 2020 were prospectively included, and the general data of patients were collected. The Montelier Cognitive Assessment Scale（MoCA） was used to assess the cognitive function of the patients. According to MOCA score, they were divided into normal cognitive function group and cognitive impairment group. The nutritional status of patients was assessed by mini nutritional assessment（MNA）. According to MNA score, they were was divided into normal nutrition group, potential malnutrition group and malnutrition group. The proportion of nutritional status in normal cognitive function group and cognitive impairment group was compared, and the correlation between cognitive function and nutritional status and related factors affecting cognitive function in maintenance peritoneal dialysis patients were analyzed. Results: Compared with the normal cognitive function group, the dialysis time in the cognitive impairment group was significantly longer, and the total scores of MNA and MOCA were significantly lower（P<0.05）.Compared with the normal cognitive function group, the proportion of patients with normal nutrition decreased significantly, the proportion of malnutrition increased significantly（P<0.05）, and the proportion of potential malnutrition increased, but the difference was not statistically significant（P>0.05）. Pearson correlation test showed that there was a significant positive correlation between the total score of MOCA and the total score of MNA in maintenance peritoneal dialysis patients（P<0.05）. Logistic regression analysis showed that dialysis time（prolonged） and malnutrition were the risk factors of cognitive impairment in maintenance peritoneal dialysis patients（P<0.05）. Conclusion: The incidence of malnutrition in cognitive impairment in maintenance peritoneal dialysis patients is significantly increased, and there is a significant correlation between cognitive impairment and nutritional status. Strengthening the nutritional status of patients will help to reduce the risk of cognitive impairment. [ABSTRACT FROM AUTHOR]

Objective To investigate the nutritional status of elderly tuberculosis patients in Yunnan and provide evidence for the prevention of malnutrition of elderly tuberculosis patients and nutritional intervention. Methods A total of 1 316 elderly tuberculosis patients aged ≥65 years who were admitted to The Third People’s Hospital of Kunming from June 2019 to June 2021 were selected as the case group, and 520 healthy people who underwent physical examination during the same period were selected as the control group. The nutrition-related indexes of the two groups were compared to analyze the nutritional status of elderly tuberculosis patients. Results Compared with the control group, TB patients’ hemoglobin (Hb) (126.40 + 25.51) g/L, lymphocyte count (LYM) [(1.24 + 0.59) x 109/L], serum total protein (TP) (66.00 + 8.22) g/L, albumin [(36.03) +/ -6.04 g/L), albumin/globulin ratio ( A/g) [1.25 +/-0.33), cholesterol ( TC) [( 4.48 +/-1.18) mmol/L], triglycerides (TG) (1.19 +/-0.70) mmol/L and high-density lipoprotein (HDL -C) [（1.19 ± 0.40) mmol/L] levels were lower than those in the control group (t =15.640, 26.240, 14.770, 35.900, 35.080, 8.272, 7.986, 7.381; P < 0.05); The RBC conut [(4.92 ± 0.52)×1012/L] and globulin level [(29.97 ± 6.06) g/L] were higher than those in the control group (t = 13.060, 15.490; P < 0.05). The prevalence of anemia [10.50% (105/1 000)], hypoproteinemia [30.30% (303/1 000)] and low high-density lipoprotein [27.00% (270/1 000)] in tuberculosis patients were higher than those in control group (χ² = 28.900, 147.900, 53.490; P < 0.05). The prevalence of hypercholesterolemia [11.00% (110/1 000)] and hypertriglyceridemia [7.20% (72/1 000)] were lower than that of the control group (χ² = 56.640, 179.900; P < 0.05). The degree of nutrition-related diseases in TB patients are mild and moderate. The level of Alb [(32.24±6.90) g/L] in patients with tuberculosis combined with diabetes was lower than that in patients with tuberculosis alone [(36.03 ± 6.04) g/L] (t = 3.18; P < 0.01); The levels of Hb[(146±23.23) g/L] and TC[(5.54±0.85) mmol/L] were higher than those of the tuberculosis group [(126.40 ± 25.51) g/L and (4.48 ± 1.18) mmol/L] (t = 3.720, 8.420; P < 0.05). In tuberculosis patients, Hb, Alb, TC, HDL-C levels were correlated with age (r = -0.489, 0.604, -0.526, -0.479; P < 0.05), while TG level was not correlated with age (r = 0.070; P = 0.770). There were no significant differences in the levels of Alb, TC, TG and HDL-C in gender (t = 0.601, 0.942, 0.299, 0.485; P = 0.548, 0.347, 0.765, 0.628). Conclusion The incidence of malnutrition in elderly tuberculosis patients in Yunnan was higher than healthy people, The degree of malnutrition is age-related, and nutrition-related diseases are mainly mild and moderate, in addition, diabetes can aggravate the degree of malnutrition in elderly tuberculosis patients. [ABSTRACT FROM AUTHOR]

To observe the value of sequential parenteral nutrition support in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with respiratory failure. Using random number table method, 90 patients with AECOPD complicated with respiratory failure who were treated in our hospital from January 2019 to December 2020 were randomly divided into enteral group (n=30), parenteral group (n=30) and sequential group (n=30). The nutritional indicators, gastrointestinal mucosal function and immune function of the three groups were compared. The days of use of antibiotics, the days of hospitalization and the incidence of complications of the three groups were observed and recorded. The days of use of antibiotics, the days of hospitalization in sequential group were shorter than those in enteral group and parenteral group (P<0.05). 2 weeks after nutritional support, albumin (ALB), prealbumin (PA) and transferrin (TF) in sequential group were higher than those in enteral group and parenteral group (P<0.05). 2 weeks after nutritional support, the immunoglobulin (Ig)A, IgM and IgG in the sequential group were higher than those in the enteral group and the parenteral group (P<0.05). 2 weeks after nutritional support, D-lactate and diamine oxidase (DAO) in sequential group were lower than those in enteral group and parenteral group (P<0.05). There was no significant difference in the incidence of complications among the three groups (P>0.05). Sequential enteral and parenteral nutrition support in patients with AECOPD complicated with respiratory failure can improve their immune function, improve their nutritional status, promote the recovery of gastrointestinal mucosal function, and shorten the days of use of antibiotics and the days of hospitalization. [ABSTRACT FROM AUTHOR]

To evaluate the current situation of quality of life and psychological status of pediatric recipients after kidney transplantation and analyze the influencing factors. Methods Ninety-six pediatric recipients undergoing kidney transplantation were enrolled in this study. Baseline data of the recipients were collected. The quality of life was assessed by Pediatric Quality of Life Inventory 3.0 (PedsQL吩．0). The psychological status was evaluated by Strengths and Difficulties Questionnaire (SDQ). The influencing factors of postoperative quality of life and psychological status of pediatric kidney transplant recipients were subject to univariate and multivariate analyses. Results The total score of quality of life of pediatric kidney transplant recipients was (71士14) and (12.4土5.8) for the total difficulty score. Univariate analysis showed that gender, postoperative body mass index (BMI) and postoperative complications were the influencing factors of the total score of quality of life of pediatric kidney transplant recipients (all P<0.05). Gender, postoperative complications and follow-up time were the influencing factors of the total difficulty score of pediatric kidney transplant recipients (all P<0.05). Multivariate analysis demonstrated that gender, postoperative BMI, postoperative complications, dialysis type before kidney transplantation were the influencing factors of postoperative quality of life of pediatric kidney transplant recipients, whereas gender, postoperative complications and follow-up time were the influencing factors of postoperative psychological status (all P<0.05). Conclusions The quality of life and psychological status of pediatric kidney transplant recipients are good. In clinical practice, special attention should be paid to those children who are female, with low BMI after kidney transplantation, postoperative complications and short follow-up time. Preventive interventions are recommended to further improve the quality of life of the children. [ABSTRACT FROM AUTHOR]

Objective: To discuss the difference in the quality of life and nutritional status in patients with severe stable chronic obstructive pulmonary disease (COPD) with different phenotypes. Methods: 79 stable patients with severe COPD (grade Ⅲ) from January 2017 to June 2018 in Shidong Hospital of Yangpu District in Shanghai were selected and divided into chronic bronchitis (CB) group (n=48) and non CB group (n=31) according to their clinical phenotypes. The values of pulmonary function, MNA (mini nutritional assessment), CAT(COPD Assessment Test), mMRC (Modified Medical Research Council Dyspnea), ADL (Activity of Daily Living Scale), grip strength and 6-minute walking distance of all patients were collected and analyzed. Results: The values of MNA, CAT, ADL, mMRC in non CB group were better than those in CB group (all P<0.05). And 6-minute walking distance of non CB group is better(t=2.256, P<0.05). In CB group, the value of MNA was positively correlated with FEV1 / predicted value, FVC, 6-minute walking distance, ADL and grip strength (r=0.441, 0.379, 0.442, 0.511, 0.316, all P<0.05), but negatively correlated with CAT and mMRC (r=-0.385, -0.460, all P<0.05). In non CB group, the value of MNA was only negatively correlated with CAT (r=-0.376, P<0.05), but was not correlated with FEV1, FVC, 6-minute walking distance, mMRC and ADL (P>0.05). Conclusion: The quality of life and nutritional status of patients in non CB group with severe stable COPD are better than those in CB group. It suggests that COPD patients with CB phenotype may need more nutritional support to improve their quality of life. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of preoperative reasonable preparation on nutritional status, glucose metabolism,stress response and immune function of elderly patients with lower extremity fracture under general anesthesia. Methods: 120 elderly patients with lower extremity fracture from June 2017 to June 2019 were randomly divided into control group and observation group, 60 cases each. Routine preparation and anesthesia management were adopted in the control group, and reasonable preparation and anesthesia management were adopted in the observation group. The incidence of regurgitation, aspiration, nausea, vomiting, thirst and hunger in the two groups were calculated. Nutritional status indicators (serum prealbumin, albumin, transferrin), glucose metabolism indicators [fasting blood glucose, insulin resistance index (IRI)], stress response indicators [cortisol (Cor), renin (Rn), adrenocorticotropic hormone (ACTH)], immune function indicators [immunoglobulin (IGA, IgM, IgG) and T-lymphoid subsets (CD4+, CD8+, CD4+/ CD8+)] at 12 hours before operation (T0), immediately after operation (T1), 24 hours after operation (T2) between the two groups were compared. Results: The incidence rate of reflux aspiration, thirst and hunger in the study group were significantly lower than those in the control group (P<0.05). When T1 and T2 time point, the levels of serum prealbumin, albumin and transferrin in the two groups were significantly lower than those in the T0 time point. The levels of serum prealbumin, albumin and transferrin in the observation group at T1, T2 time point were significantly higher than those in the control group (P<0.05). The levels of fasting blood glucose, IR index, Cor, Rn and ACTH in the two groups at T1, T2 time point were significantly higher than those in the T0 time point. The levels of fasting blood glucose, IR index, Cor, Rn and ACTH in the observation group at T1, T2 time point were significantly lower than those in the control group (P<0.05). The levels of IgA, IgM, IgG, CD4+ and CD4+/ CD8+ in the two groups at T1, T2 time point were significantly lower than those in the T0 time point, CD8+ were significantly higher than those in the T0 time point. The levels of IgA, IgM, IgG, CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group, CD8+ were significantly lower than those in the control group (P<0.05). Conclusion: Preoperative reasonable preparation can reduce the stress response of elderly patients with lower extremity fracture under general anesthesia, and reduce the influence of operation on nutritional status, glucose metabolism and and immune function of patients after operation, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of lung function rehabilitation training combined with parenteral amino acid nutrition support on nutritional status, cancer-related fatigue and quality of life of patients with non-small cell lung cancer (NSCLC) after chemotherapy. Methods: 137 chemotherapy patients with NSCLC who were admitted to our hospital from June 2016 to October 2019 were selected. According to random number table method, the patients were divided into control group (68 cases, given routine intervention ), observation group (69 cases, parenteral amino acid nutrition support+lung function rehabilitation training on the basis of the control group). The nutritional status, lung function, cancer-related fatigue and quality of life of the two groups before and after intervention were compared. Results: Compared with the control group, albumin, total protein and hemoglobin in the observation group after intervention were higher (P < 0.05). The forced vital capacity (FVC), forced expiratory volume as a percentage of predicted value in the first second (FEV1%) and peak expiratory flow rate (PEF) in the observation group after intervention were higher than those in the control group (P < 0.05). after intervention, the scores of behavioral fatigue, emotional fatigue, physical fatigue and cognitive fatigue of Piper Fatigue Scale (PFS) in the observation group were lower than those in the control group (P < 0.05). The scores of each dimension of life assessment scale (EORTC QLQ-C30) of the observation group were higher than those of the control group after intervention (P < 0.05). Conclusion: Lung function rehabilitation training combined with parenteral amino acid nutrition support in the intervention of NSCLC chemotherapy patients can improve the nutritional status and lung function, relieve cancer-related fatigue and improve the quality of life. [ABSTRACT FROM AUTHOR]

Objective: To explore the effect of preoperative reasonable preparation on nutritional status, glucose metabolism,stress response and immune function of elderly patients with lower extremity fracture under general anesthesia. Methods: 120 elderly patients with lower extremity fracture from June 2017 to June 2019 were randomly divided into control group and observation group, 60 cases each. Routine preparation and anesthesia management were adopted in the control group, and reasonable preparation and anesthesia management were adopted in the observation group. The incidence of regurgitation, aspiration, nausea, vomiting, thirst and hunger in the two groups were calculated. Nutritional status indicators (serum prealbumin, albumin, transferrin), glucose metabolism indicators [fasting blood glucose, insulin resistance index (IRI)], stress response indicators [cortisol (Cor), renin (Rn), adrenocorticotropic hormone (ACTH)], immune function indicators [immunoglobulin (IGA, IgM, IgG) and T-lymphoid subsets (CD4+, CD8+, CD4+/CD8+)] at 12 hours before operation (T0), immediately after operation (T1), 24 hours after operation (T2) between the two groups were compared. Results: The incidence rate of reflux aspiration, thirst and hunger in the study group were significantly lower than those in the control group (P<0.05). When T1 and T2 time point, the levels of serum prealbumin, albumin and transferrin in the two groups were significantly lower than those in the T0 time point. The levels of serum prealbumin, albumin and transferrin in the observation group at T1, T2 time point were significantly higher than those in the control group (P<0.05). The levels of fasting blood glucose, IR index, Cor, Rn and ACTH in the two groups at T1, T2 time point were significantly higher than those in the T0 time point. The levels of fasting blood glucose, IR index, Cor, Rn and ACTH in the observation group at T1, T2 time point were significantly lower than those in the control group (P<0.05). The levels of IgA, IgM, IgG, CD4+ and CD4+/CD8+ in the two groups at T1, T2 time point were significantly lower than those in the T0 time point, CD8+ were significantly higher than those in the T0 time point. The levels of IgA, IgM, IgG, CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group, CD8+ were significantly lower than those in the control group (P<0.05). Conclusion: Preoperative reasonable preparation can reduce the stress response of elderly patients with lower extremity fracture under general anesthesia, and reduce the influence of operation on nutritional status, glucose metabolism and and immune function of patients after operation, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of lung function rehabilitation training combined with parenteral amino acid nutrition support on nutritional status, cancer-related fatigue and quality of life of patients with non-small cell lung cancer (NSCLC) after chemotherapy. Methods: 137 chemotherapy patients with NSCLC who were admitted to our hospital from June 2016 to October 2019 were selected. According to random number table method, the patients were divided into control group (68 cases, given routine intervention ), observation group (69 cases, parenteral amino acid nutrition support+lung function rehabilitation training on the basis of the control group). The nutritional status, lung function, cancer-related fatigue and quality of life of the two groups before and after intervention were compared. Results: Compared with the control group, albumin, total protein and hemoglobin in the observation group after intervention were higher (P < 0.05). The forced vital capacity (FVC), forced expiratory volume as a percentage of predicted value in the first second (FEV1%) and peak expiratory flow rate (PEF) in the observation group after intervention were higher than those in the control group (P < 0.05). after intervention, the scores of behavioral fatigue, emotional fatigue, physical fatigue and cognitive fatigue of Piper Fatigue Scale (PFS) in the observation group were lower than those in the control group (P < 0.05). The scores of each dimension of life assessment scale (EORTC QLQ-C30) of the observation group were higher than those of the control group after intervention (P < 0.05). Conclusions: Lung function rehabilitation training combined with parenteral amino acid nutrition support in the intervention of NSCLC chemotherapy patients can improve the nutritional status and lung function, relieve cancer-related fatigue and improve the quality of life. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of ERAS and Dachengqi Granules on surgical stress in patients after gastrointestinal surgery. Methods: Eighty gastrointestinal surgery patients admitted to our hospital in the past 3 years were randomly divided into a research group and a control group, with 40 patients in each group. ERAS and Dachengqi granules were taken in the two groups, Traditional treatment methods and conventional Western medicine treatment combined with placebo, comparing the effects of different treatment methods on patients' surgical stress during the perioperative period. Results: There was no statistically significant difference in pre-operative psychological (HAMA) and physiological (CRP, epinephrine, cortisol) stress indicators between the two groups of patients (P>0.05). Seven days after surgery, all stress indicators of the study group were obvious Lower than the control group (P<0.05). The first exhaustion time, the first postoperative defecation time, the first time after bed activity, and the average hospital stay of the study group were significantly shorter than those of the control group (P<0.05). There was no statistical difference between the nutritional status of the patients in the group before the operation(P>0.05). The comparison index found that each nutrition index gradually recovered after the stress was reduced, and the decrease in the 3 d postoperative period of the study group was significantly lower than that of the control group (P<0.05), and gradually returned to the preoperative level 7 days after the operation. Conclusion: ERAS and Dachengqi granules after gastrointestinal surgery are more conducive to the recovery of gastrointestinal function of patients after surgery, the postoperative stress response was lighter, and the nutritional status of patients is stable, which can shorten the hospitalization time of patients and encourage patients to postoperatively. Rehabilitation is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To observe the effects of immunoenhanced and common enteral nutrition preparations on nutritional status, intestinal mucosal barrier function and T-cell subsets in elderly with severe pneumonia. Methods: 136 elderly patients with severe pneumonia admitted to our hospital from July 2017 to March 2020 were selected, and randomly divided into study group(n=68), control group (n=68). The control group was treated with common enteral nutrition preparations for intervention, and the study group was treated with immuno enhanced enteral nutrition preparations for intervention. The incidence rarte of intestinal flora imbalance, nutritional status, intestinal mucosal barrier function, T cell subpopulation and complication rate were compared between the two groups. Results: The incidencer arte of intestinal flora imbalance in the study group was lower than that in the control group (P<0.05). No significant difference in incidence rate of complications between two groups (P>0.05). 10 d after intervention, the nutritional status indicators of the two groups: albumin (ALB), prealbumin (PAB) and hemoglobin (HGB) were higher than before intervention, and study group was higher than control group (P<0.05). 10d after intervention, functional indicators of intestinal mucosal barrier in the two groups: endotoxin (ET) and diamine oxidase (DAO) were lower than before intervention, and study group was lower than control group (P<0.05). 10 d after intervention, CD3+, CD4+, CD4+ /CD8+ in two groups were higher than before intervention, and study group was higher than control group (P<0.05), and CD8+ was lower than before intervention, and study group was lower than control group (P<0.05). Conclusion: Compared with common enteral nutrition preparations, immunoenhanced enteral nutrition preparations can improve the nutritional status of elderly patients with severe pneumonia, promote recovery of intestinal mucosal barrier function, improve the body's immune function, and reduce the incidence rate of intestinal flora imbalance [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of intensive enteral nutrition on blood sugar, nutritional status and complications of critically ill emergency patients. Methods: Taking 300 patients who were admitted to the ICU of our hospital from April 2018 to March 2020 as the research objects, they were divided into a control group and a study group, each with 150 cases. Patients in the control group received parenteral nutrition support, and patients in the study group received enteral nutrition therapy. The effects of blood glucose, 24 h insulin usage, total serum protein (Tp), albumin (Alb), creatinine (Scr) and complications, etc., were used to evaluate the impact on the disease. Results: The average blood glucose of the study group within 24 hours was 89.8依38.4 mg/dl, which was significantly lower than the control gro up's 157.6依68.3 mg/dl (P＜0.05), and the insulin usage in the study group within 24 hours was 18.6依12.3 滋, which was significantly lower than the control group 34.7依30.6 滋(P<0.05). Before treatment, there was no significant difference in the levels of Tp, Alb and CCR between the two groups of patients (P>0.05). After treatment, the levels of Tp and Alb in the two groups increased significantly, while the CCR levels decreased significantly (P<0.05). Compared with the control group, the levels of Tp and Alb in the study group were significantly increased, and the level of CCR was significantly decreased (P<0.05). There were different degrees of diarrhea, abdominal distension and upper gastrointestinal bleeding in the two groups. The total incidence of the control group was 23.33 %, and that of the study group was 26.67 % . After comparison, there was no significant difference (P>0.05). Conclusion: Intensified enteral nutrition can effectively improve the blood sugar level of critically ill patients in emergency departments, and improve the nutritional status of patients with high safety. [ABSTRACT FROM AUTHOR]

Objective: Use the nutritional risk screening tool (NRS2002) to assess the nutritional risk of hospitalized patients with esophageal cancer, and analyze the impact of malnutrition on the quality of life and prognosis of patients. Method: Prospectively select our hospital October 2, 2017110 hospitalized patients with esophageal cancer were admitted in October 019. The nutritional risk was analyzed by NRS2002 before treatment, the malnutrition was evaluated by the subjective holistic nutritional assessment method (PG-SGA), and the risk factors of malnutrition were analyzed. According to the PG-SGA score, patients were divided into normal nutrition group, mild malnutrition group, moderate malnutrition group, and severe malnutrition group. The quality of life of the patients was assessed by the Concise Quality of Life Scale (SF-36), and the prognosis was observed for 12 months. The scores and prognosis of the four groups of SF-36 were compared. Results: Among 110 patients, NRS2002 analysis indicated 78 patients with nutritional risk and 32 patients without nutritional risk. The PG-SGA score indicated 37 cases of normal nutrition, 28 cases of mild malnutrition, 25 cases of moderate malnutrition, and 20 cases of severe malnutrition. Multivariate logistic regression analysis showed that age ≥ 60 years old (95%CI: 1.312-3.374, OR=2.104), the number of digestive tract symptoms> 2 (95%CI: 1.052-6.701, OR=2.655), dysphagia (95% CI: 1.052-6.701, OR=2.655) %CI: 1.711-13.601, OR=4.824) and preoperative comorbidities (95%CI: 1.274-10.406, OR=3.641) are risk factors for malnutrition in hospitalized patients with esophageal cancer (P<0.05). The physical pain, energy, physical function, emotional role function, mental health, social function, and overall health scores of the mild, moderate, and severe malnutrition groups were lower than those of the normal nutrition group, and the moderate and severe malnutrition groups were lower than the mild malnutrition group, The severe malnutrition group was lower than the moderate malnutrition group (P<0.05). The survival rate of the normal nutrition group was 94.59%, which was higher than 70.00% of the severe malnutrition group (P<0.05). There was no statistical difference in the survival rate of the normal nutrition group, mild malnutrition group, and moderate malnutrition group (P>0.05). Conclusion: Inpatients with esophageal cancer have a higher nutritional risk and incidence of malnutrition. Their nutritional status is mainly affected by the patient's age, the number of gastrointestinal symptoms, swallowing disorders, and preoperative comorbidities, which have a greater impact on the quality of life and prognosis of patients. Nutrition Evaluation is expected to be an indicator for predicting the quality of life and prognosis of hospitalized patients with esophageal cancer. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of high-throughput hemodialysis (HFHD) combined with Shenshuaining granules on calcium and phosphorus metabolism, inflammatory response, and nutritional status in patients with uremia. Methods: The patients with uremia who underwent hemodialysis treatment in our hospital from January 2017 to October 2019 were selected as research objects, and randomly divided into control group and observation group, with 57 cases in each group. The control group was given HFHD and the observation group received Shenshuaining granules on the basis of the control group. Both groups were treated for 3 months. The renal function indexes, including urea nitrogen (BUN), blood creatinine (Scr), glomerular filtration rate (GFR). Related indexes of calcium and phosphorus metabolism including serum calcium, serum phosphorus and parathyroid hormone (PTH). Inflammatory response indicators, including procalcitonin (PCT), C-reactive protein (CRP), interleukin-6 (IL-6); Nutritional status indicators include albumin (ALB), hemoglobin (Hb), and total serum protein (TP) before and after treatment were compared between the two groups. Results: After treatment, BUN, Scr, GFR, serum phosphorus, PTH, PCT, CRP and IL-6 in the two groups were lower than before treatment, serum calcium, ALB, Hb and TP were higher than before treatment. BUN, Scr, GFR, serum phosphorus, PTH, PCT, CRP and IL-6 in the observation group were lower than those in the control group, Serum calcium, ALB, Hb and TP were higher than control group, with statistical differences (P<0.05). Conclusion: HFHD combine shenshuaning granules in the treatment of uremia, which could effectively improve calcium and phosphorus metabolism and renal function of uremia patients, and improve the inflammatory state and nutritional status of the body. [ABSTRACT FROM AUTHOR]

Objective: To observe the changes in immune function, intestinal mucosal barrier function and nutritional status of patients with severe head injury after the intervention of dietary fiber enteral nutrition combined with probiotics. Methods: A total of 136 patients with severe head injury admitted to our hospital from June 2016 to May 2020 were selected. According to the odd-even method of admission order, they were divided into 68 cases in the control group and 68 cases in the study group. The control group was given dietary fiber enteral nutrition intervention, and the study group was combined with probiotic intervention on the basis of the control group. The two groups were compared with the Glasgow Coma Scale (GCS). ) Score, nutritional status, immune function, intestinal mucosal barrier function and complications. Results: The albumin (ALB), hemoglobin (Hb), and transferrin (TR) of the two groups were higher than before the intervention for 14 days, and the study group was higher than the control group (P<0.05). After 14 days of intervention, the levels of immunoglobulin G (IgG), immunoglobulin A (IgA), and immunoglobulin M (IgM) were higher in the two groups than before the intervention, and the study group was higher than the control group (P<0.05). After 14 days of intervention, the total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-PX) of the two groups were higher than before the intervention, and the study group was higher than the control group (P<0.05), Malondialdehyde (MDA) was lower than before the intervention, and the study group was lower than the control group (P<0.05). The GCS scores of the two groups increased after 14 days of intervention, and the study group was higher than the control group (P<0.05). The incidence of complications in the study group was lower than that in the control group (P<0.05). Conclusion: The enteral nutrition intervention of probiotics combined with dietary fiber can effectively improve the nutritional status, immune function and intestinal mucosal barrier function of patients with severe head injury after surgery. At the same time, it can also reduce the incidence of complications and improve the prognosis of patients. [ABSTRACT FROM AUTHOR]

To investigate the effect of enhanced recovery after surgery (ERAS) on nutritional status, immune function and inflammatory factors in patients with laparoscopic radical gastrectomy for gastric cancer. 166 patients with gastric cancer who underwent laparoscopic radical gastrectomy in our hospital from January 2016 to January 2020 were included in this study. They were randomly divided into ERAS group(n=83) and control group(n=83). The control group was treated with routine treatment, and the ERAS group was treated with ERAS. The nutritional indexes such as Hemoglobin(Hb), Retinol binding protein(RbP), Transferrin(TRF), Prealbumin (PRE), Albumin(ALB), Immunoglobulin indexes such as Immunoglobulin A(IgA), Immunoglobulin G(IgG), Immunoglobulin M (IgM), T cell subsets such as CD3+, CD4+, CD8+, CD4+/CD8+, inflammatory factors such as Interleukin-6 (Il-6), Interleukin-8(Il-8), Interleukin-10 (Il-10) at 1 d and 7 d after operation and postoperative complications were observed. The Hb, RbP,TRF, PRE, ALB, IgA, IgG, IgM, CD3+, CD4+, CD4+/CD8+ levels in the two groups increased and CD8+, Il-6, Il-8, Il-10 levels decreased 7 d after the operation compared with 1d after the operation (P<0.05). 7 d after the operation, the levels of Hb, RbP, TRF, PRE, ALB, IgA, IgG, IgM, CD3+, CD4+, CD8+, CD4+/CD8+ in ERAS group were higher than those in Control group, while CD8+, Il-6, Il-8, Il-10 were lower than those in Control group (P<0.05). The incidence of postoperative complications in ERAS group (8.43%) was lower than that in Control group (22.89%),the difference was statistically significant (P<0.05). The application of ERAS in laparoscopic radical gastrectomy for gastric cancer can effectively reduce the stress response of patients, improve nutritional status, relieve immunosuppression, eliminate inflammatory factors, reduce postoperative complications and help patients recover. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between malnutrition risk and cancer-related fatigue and quality of life in patients with lung cancer, and to analyze the influencing factors of malnutrition risk. Methods: 98 patients with lung cancer who were admitted to our hospital from July 2019 to July 2020 were selected as the research objects. The nutritional status, cancer-related fatigue and quality of life of all subjects were evaluated by nutritional risk screening scale 2002 (NRS-2002), cancer-related fatigue scale (CRF) and quality of life assessment scale (QLQ-C30). Pearson correlation analysis was used to analyze the correlation between NRS-2002 score, CRF score and QLQ-C30 score. Single factor and multivariate logistic regression were used to analyze the risk factors of malnutrition in lung cancer patients. Results: 24 patients without malnutrition risk (NRS-2002 score 0~2) were included in the non malnutrition risk group, and 74 patients with malnutrition risk (NRS-2002 score 3~7) were included in the malnutrition risk group. The malnutrition risk rate of the subjects was 75.51% (74/98). The scores of emotional fatigue, physical fatigue, cognitive fatigue and QLQ-C30 in malnutrition risk group were higher than those in non malnutrition risk group (P<0.05). Pearson correlation analysis showed that NRS-2002 score was positively correlated with CRF score and QLQ-C30 score (P<0.05). The results of single factor analysis showed that there were significant differences in family monthly income, age, clinical stage, nutrition management and living place between the non malnutrition risk group and the malnutrition risk group (P<0.05). Multivariate logistic regression analysis showed that the risk factors of malnutrition in lung cancer patients were clinical stage Ⅳ, family monthly income < 5000 yuan, age > 40 years old, no nutrition management, residence in rural areas (P<0.05). Conclusion: The risk of malnutrition in patients with lung cancer is high, and the risk of malnutrition is related to cancer-related fatigue and quality of life, and there are many factors influencing the risk of malnutrition. Therefore, we should formulate relevant intervention measures for these factors in clinical work. [ABSTRACT FROM AUTHOR]

Objective: To detecte the tol receptor 9 (TLR9), glycosylated hemoglobin (HbA1c) and 25 hydroxyvitamin D[25-(OH) D3] levels in patients with type 2 diabetic foot ulcer complicated with malnutrition, and to analyze their clinical significance. Methods: 81 patients with type 2 diabetic foot ulcer who were admitted to our hospital from March 2018 to March 2019 were selected. The nutritional status of the patients was evaluated and grouped according to the prognostic nutritional index (PNI). 27 patients with PNI≤ 50 were treated as malnutrition group, and 54 patients with PNI>50 were treated as normal nutrition group. Nutritional indicators, body mass index (BMI), PNI, blood glucose, blood lipids, TLR9, HbA1c, 25- (OH)D3 were measured and compared between the two groups. Results: PNI value, BMI, serum total protein (TP), serum albumin (ALB) and serum prealbumin (PA) in the malnutrition group were significantly lower than those in the normal nutrition group (P<0.05). Fasting blood glucose (FBG) and 2 h postprandial blood glucose (PBG) in the malnutrition group were significantly higher than those in the normal nutrition group (P<0.05). There were no significant differences in total cholesterol (TC) and triacylglycerol (TG) levels between the two groups (P>0.05). Serum TLR9 and HbA1c levels in the malnutrition group were significantly higher than those in the normal nutrition group (P<0.05), while the 25-(OH)D3 level was significantly lower than that in the normal nutrition group (P<0.05). Serum TLR9 and HbA1c were significantly negatively correlated with PNI, BMI, TP, ALB and PA (P<0.05), while serum FBG and PBG were significantly positively correlated (P<0.05). Serum 25-(OH)D3 was significantly positively correlated with PNI, BMI, TP, ALB and PA (P<0.05), while significantly negatively correlated with FBG and PBG (P<0.05). Conclusion: Serum TLR9, HbA1c and 25-(OH)D3 levels in patients with type 2 diabetic foot ulcer complicated with malnutrition are closely related to nutritional status and blood glucose control, and which are expected to be potential indicators for disease monitoring and nutritional risk assessment in patients. [ABSTRACT FROM AUTHOR]

Nitrogen is a large number of elements required by crop life and is closely related to crop yield and quality. Accurate diagnosis and dynamic monitoring of crops are important contents of precision agriculture research. With the advantages of high timeliness, high resolution, and low cost, Unmanned Aerial Vehicle (UAV) remote sensing is developing rapidly in the diagnosis and monitoring of nitrogen nutrition in winter wheat. In this study, Nitrogen Nutrition Index (NNI) was selected as an indicator of the nitrogen nutritional status of winter wheat. In order to quantitatively estimate the nitrogen nutrition index of winter wheat at a regional scale, hyperspectral images of the winter wheat experimental plots in Qianxian, Shaanxi province during the year 2016-2017 was obtained by the Cubert UHD185 imaging spectrometer boarded on the UAV. Meanwhile, the above-ground biomass and plant nitrogen concentration data were collected during the flying and were used to calculate the NNI according to the local critical nitrogen concentration dilution model of wheat. Three types of spectral parameters were selected, including trilateral parameters, any two bands spectral indices, and vegetation indices. According to the correlation analysis between spectral parameters and plant nitrogen content, aboveground biomass, and nitrogen nutrition index, ten spectral parameters significantly related to each of the three indicators were screened out, including red-edge area, green peak reflectance maximum, red valley reflectivity minimum, difference spectral index, normalized spectral index, ratio spectral index, red-edge position by linear interpolation, red-edge normalized difference vegetation index, Vogelmann red-edge index, and photochemical reflectance index. Finally, nitrogen nutrition index estimation models of winter wheat at the heading stage were established based on the ten spectral parameters above with simple regression, Multiple Linear Stepwise Regression (MLSR), Partial Least Squares Regression (PLSR), and Random Forest Regression (RFR) algorithms respectively. The coefficient of determination, Root Mean Square Error (RMSE), and Relative Prediction Deviation (RPD) were used to compare the accuracy of each model. The results showed that any two bands’ spectral indices were sensitive to the nitrogen nutrition index. The correlation coefficients between any two bands spectral indices and nitrogen nutrition index were dramatically superior to trilateral parameters and typical vegetation indices. The optimal any two bands spectral index was the ratio spectral index made up of the reflectance at 718 and 738 nm. Of all the nitrogen nutrition index estimation models by simple regression, Difference Spectral Index (DSI) and Red-edge Normalized Difference Vegetation Index (RNDVI) had rough estimation capabilities of nitrogen nutrition index, the relative prediction deviation of which were 1.53 and 1.56 respectively. Among the nitrogen nutrition index estimation models of winter wheat established through ten spectral parameters based on multiple linear stepwise regression, partial least squares regression and random forest regression, the model based on the random forest algorithm had the highest precision, strong reliability, and excellent prediction ability. The validation results showed that the coefficient of determination of the model was 0.79, the root mean square error was 0.13, and the relative prediction deviation was 2.25. The second was the model through the partial least squares regression method, the relative prediction deviation of which was1.54. The model by multiple linear stepwise regression methods could not be used to estimate the nitrogen nutrition index correctly. Overall, the model with the random forest algorithm was considered as the best estimation model of the nitrogen nutrition index, which could be used for the remote sensing mapping of the winter wheat nitrogen nutrition index at a regional scale. It would provide a scientific basis for the diagnosis of nitrogen nutrition, monitoring of yield and quality, and late field management of winter wheat. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy of hydrolyzed protein oral solution(HPOS) treatment in patients with liver cirrhosis hypoproteinemia. Methods From Jul. 2017 to Jul. 2019, 100 patients with liver cirrhosis hypoproteinemia treated in this hospital were enrolled and randomly divided into control group and o bservation group. The control group was given conventional treatment, while the observation group was given HPOS as complementary treatment . On the 3rd, 7th and 14th day of treatment, related indexes were compared between the two groups. Results There were no statistical differences in body m ass index(BMI), white blood cells(WBC), total protein (TP), albumin (ALB), prealbumin (PAB), alanine aminotransferase(ALT), total bilirubin (TBil),serum creatinine(Scr) and blood urea nitrogen(BUN) between the two groups on t he 3rd day(P >0. 05). The levels of ALB and PAB in observation group were significantlyhig her than control group on the 7th day(P < 0. 05). On t he 14th day,the values of TP, ALB and PAB in obse rvation group were statistically different with those in control group (P <0. 05),while the differences of the remaining indicators were not significant(P>0. 05) . Conclusion HPOS treatment could remarkably correct the hypoproteinemia in patients with liver cirrhosis and improve the short term nutritional status. [ABSTRACT FROM AUTHOR]

To investigate the effect of laparoscopic and open wedge resection on the nutritional status, T cell subsets and prognosis of patients with gastric stromal tumor (GIST). The clinical data of 97 patients with GIST in our hospital from January 2013 to February 2014 were retrospectively selected. According to the different operation methods, the patients were divided into the control group (n=47, open stomach wedge resection) and study group (n=50, laparoscopic stomach wedge resection). The operation related indexes, nutritional status, T cell subsets and prognosis of the two groups were compared. The time of hospitalization, anal exhaust, incision length and operation in the study group were shorter than those in the control group, and the amount of bleeding in the operation was less than that in the control group (P<0.05). The prealbumin, transferrin and albumin in the two groups at 7 days after operation were lower than those before operation, but those in the study group were higher than those in the control group (P<0.05). The CD4+ /CD8+, CD3+, CD4+ in the two groups at 7 days after operation were lower than those before operation, while CD8+ was higher than that before operation (P<0.05). The CD4+ /CD8+, CD3+, CD4+ in the study group at 7 days after operation were higher than those in the control group, while CD8+ was lower than that in the control group (P<0.05). The total incidence rate of complications in the study group was lower than that in the control group (P<0.05). There were no differences in the postoperative recurrence rate and 5-year survival rate between the two groups (P>0.05). Compared with open stomach wedge resection, the long-term prognosis of GIST patients treated with laparoscopic gastric wedge resection is similar, it can effectively improve the perioperative related indicators, it has less impact on the nutritional status and T cell subsets of patients, and reduce the incidence of postoperative complications. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of laparoscopic and open wedge resection on the nutritional status, T cell subsets and prognosis of patients with gastric stromal tumor (GIST). Methods: The clinical data of 97 patients with GIST in our hospital from January 2013 to February 2014 were retrospectively selected. According to the different operation methods, the patients were divided into the control group (n=47, open stomach wedge resection) and study group (n=50, laparoscopic stomach wedge resection). The operation related indexes, nutritional status, T cell subsets and prognosis of the two groups were compared. Results: The time of hospitalization, anal exhaust, incision length and operation in the study group were shorter than those in the control group, and the amount of bleeding in the operation was less than that in the control group (P<0.05). The prealbumin, transferrin and albumin in the two groups at 7 days after operation were lower than those before operation, but those in the study group were higher than those in the control group (P<0.05). The CD4+/CD8+, CD3+, CD4+ in the two groups at 7 days after operation were lower than those before operation, while CD8+ was higher than that before operation (P<0.05). The CD4+/CD8+, CD3+, CD4+ in the study group at 7 days after operation were higher than those in the control group, while CD8+ was lower than that in the control group (P<0.05). The total incidence rate of complications in the study group was lower than that in the control group (P<0.05). There were no differences in the postoperative recurrence rate and 5-year survival rate between the two groups (P>0.05). Conclusion: Compared with open stomach wedge resection, the long-term prognosis of GIST patients treated with laparoscopic gastric wedge resection is similar, it can effectively improve the perioperative related indicators, it has less impact on the nutritional status and T cell subsets of patients, and reduce the incidence of postoperative complications. [ABSTRACT FROM AUTHOR]