1. [Manipulation of NADH metabolism in industrial strains].
- Author
-
Qin Y, Dong Z, Liu L, and Chen J
- Subjects
- Energy Metabolism genetics, Fermentation, Lactococcus lactis metabolism, NAD physiology, Saccharomyces cerevisiae metabolism, Streptococcus mutans metabolism, Bacteria metabolism, Energy Metabolism physiology, Industrial Microbiology, NAD metabolism
- Abstract
Nicotinamide adenine nucleotide (NADH), the key cofactor in the metabolic network, plays an essential role in biochemical reaction and physiological function of industrial strains. Manipulation of NADH availability and form is an efficient and easy way to redirect the carbon flux to the target metabolites in industrial strains. We reviewed the physiological function of NADH. Detailed strategies to manipulate NADH availability are addressed. NADH manipulation to enhance metabolic function of industrial strains was discussed and potential solutions were suggested.
- Published
- 2009