[Objective] To overcome the bottleneck of instrument and equipment management in universities, we designed the concept and mode of instrument and equipment management, strengthened system integration and data interaction with information technology, promoted the implementation of a "one network, one door, one time" intelligent management service system for instrument and equipment, and built an intelligent closed-loop management system for the entire life cycle of university instruments and equipment, including real-time information sharing, upstream and downstream collaborative reconciliation, and integrated control. Building a new ecosystem of management services, this article proposes countermeasures and suggestions to overcome management bottlenecks through investigation, in-depth analysis, and combined with the innovative management practices of the instruments and equipment of Shandong University. [Method] Based on the current actual management requirements of the instruments and equipment, universities innovate management models and mechanisms, optimize management processes, innovate service models, overcome the limitations of traditional value-based accounting theory, and provide a theoretical basis for financial transformation management and accounting transformation data services according to the event-based accounting theory. Concurrently, based on the existing instrument and equipment and financial management systems, combined with the professional software development service providers in the industry, we developed an interface using the HTTPS protocol and the WebService technology, which can connect the instrument and equipment management and financial management information systems in management, service, data, and other aspects. We built a comprehensive business chain in the "Internet Plus" mode, a smart finance-based instrument and equipment asset management platform for resource coordination. [Results] A new model of closed-loop management was established by studying the current situation and existing problems of college instrument and equipment management based on smart finance. Internet Plus, big data, and other technologies were used to achieve intelligent management in the entire life cycle of the instruments and equipment, reforming and innovating the management scheme and path, strengthening the internal control of college instruments and equipment in an all-round and multilevel manner, and creating an entire life cycle integration of college instrument and equipment based on smart finance perspective management. Herein, we deeply integrate final financial accounts with asset allocation, use, management, evaluation, and predecision-making; forming an interface between the instrument and equipment management information and financial management systems of the school; achieving integration in data, services, management, and other aspects; and constructing a new service system for instrument and equipment budget, asset, financial management, and other aspects. Concurrently, a conceptual framework for the intelligent instrument and equipment financial management system was constructed, which promotes innovation in the construction, theory, and methodology of intelligent instrument and equipment management systems and provides ideas for developing and practicing instrument and equipment management in an intelligent environment. [Conclusions] The intelligent management of instruments and equipment in universities is a complex system engineering that requires continuous summarization of experiences in practical work, improvement and innovation combined with national and school development plans, strengthening of information empowering asset modernization governance capabilities and levels, improvement of instrument and equipment use and service efficiencies, providing conducive conditions for technological innovation and facilitating high-level scientific and technological self-reliance, boosting the high-quality development of the "Double First Class" construction. [ABSTRACT FROM AUTHOR]