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Objective The spatial distribution of ground subsidence in the coastal area of Tianjin was predicted using a random forest machine learning model, in which the performance and significance of the variables were evaluated. Methods The random forest model was trained and validated in this study using datasets of ground subsidence in 2020, aquifer lithology, water level differences in aquifers in 2020, and hydrogeological parameters. Results The results demonstrate the effectiveness of the random forest model for fitting and predicting ground subsidence (R2=0.98, RMSE=0.52 mm). Moreover, it is found that water level difference emerges as the most influential factor affecting ground subsidence, followed by lithology and hydrogeological parameters. Conclusion The present study introduces several novel contributions: ① utilization of spatial distribution data for training ground subsidence models; ② identification of significant controlling factors based on physical mechanisms; ③ assessment of the relative importance of these controlling factors. Additionally, this paper highlights the limitations and future directions in ground subsidence research, offering valuable insights for the rapid and accurate prediction of ground subsidence using the random forest model.

ObjectiveTo study the change trend of blood pressure among rural adults in Shanxi province from 2002 to 2019, and to provide evidence for the prevention and control of hypertension in the population. MethodsThe study included 1 095 rural adult residents (≥ 18 years) with normal blood pressure at baseline in four counties of Shanxi province as part of the Provincial Nutrition and Chronic Diseases Household Cohort Study, which began in 2002. Data were collected from participants′ blood pressure measurements in 2015 and 2019, and changes in participants′ blood pressure between 2002 and 2019 were analyzed. ResultsAmong the participants, systolic and diastolic blood pressure (both in mm Hg) showed a significant increasing trend during the period (both P < 0.05). Compared to 122.9 ± 10.4 in 2002, systolic blood pressure increased by 14.8 to 137.7 ± 18.8 in 2015 and by 15.8 to 138.7 ± 18.1 in 2019, with an increase percentage of 12.0% and 12. 9%; while compared to 72.6 ± 6.9 in 2002, diastolic blood pressure increased by 7.3 to 79.9 ± 10.9 in 2015 and by 7.5 to 80.1 ± 10.9 in 2019, with increase percentages of 10.1% and 10.3%, respectively. ConclusionThere was a significant increasing trend in both systolic and diastolic blood pressure levels among rural adults in Shanxi province from 2002 to 2019.

Standards of basic dataset of chronic and noncommunicable diseases behavior risk factors surveillance in adults (T/CPMA 033 — 2023) was published and officially implemented by Chinese Preventive Medicine Association on October 20th, 2023. The standard specifies the metadata attributes and data element attributes of the adult chronic and noncommunicable disease behavioral risk factors.It is suitable for the collection of data related to the monitoring, investigation, intervention and evaluation of chronic disease behavior risk factors conducted by health administrative departments, disease prevention and control institutions, primary-level medical and health care institutions, health examination and management institutions and scientific research institutes. The article interprets the key points of the standard, and provides guidance for medical and health institutions and professionals to deeply understand and promote the application of the standard.

Objective This study was conducted to observe the effect of curriculum ideology and politics in the teaching of medical psychology by integrating curriculum ideology and politics in the teaching of medical psychology in the five-year system of clinical medicine and comparing it with the traditional lecture-based teaching method. Methods A total of 323 students who underwent medical psychology study in the five-year system of clinical medicine of Jilin University from 2016 to 2019 were selected as the study subjects and divided into the control group(traditional teaching method) of 161 students and the observation group(integration of curriculum ideology and politics teaching mode) of 162 students according to different teaching methods.At the end of the course, the evaluation of the teaching effect of the medical psychology course was compared between the two groups of students by a questionnaire. Results The results of questionnaire survey showed that the observation group was higher than the control group in mental health and interpersonal ability, autonomous learning ability, doctor-patient relationship, doctor-patient communication ability and post competence, and the differences were statistically significant(P

Type 2 diabetes mellitus(T2DM) stands as a significant predisposing factor for cardiovascular diseases,potentially doubling the susceptibility to coronary heart disease and stroke,particularly among the elderly population.Current research on hypoglycemic drugs has evolved beyond mere blood glucose reduction to investigating cardiovascular advantages that extend beyond their hypoglycemic effects.Carotid intima-media thickness(CIMT) serves as a surrogate marker for atherosclerosis,carrying considerable predictive value for future cardiovascular events.This article critically examines the impact of innovative hypoglycemic drugs on CIMT,shedding light on the clinical utility of CIMT in the management of T2DM.

Objective To explore the impact of influenza virus co-infection on prognosis of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods We retrieved studies relevant to outcomes of patients with mono-/co-infection of SARS-CoV-2/influenza viruses published from January 2020 through May 2023 through searching Web of Science, PubMed, Scopus, Embase, the Cochrane Library, and China National Knowledge Infrastructure and with supplementation of literature tracing. R 4.2.1 statistical software was used to perform meta-analysis. Results Totally 24 English articles were included in the analysis, which involved 26 610 patients (20 625 SARS-CoV-2 mono-infections, 3 806 mono-influenza virus infections, and 2 179 co-infections of SARS-CoV-2 and influenza virus). The results of meta-analysis showed that the patients with co-infection of SARS-CoV-2 and influenza virus were at increased risk of admission to intensive care unit (odds ratio [OR] = 2.13, 95% confidence interval[95%CI]: 1.15 – 3.94), having mechanical ventilation support (OR = 5.02, 95%CI: 2.38 – 10.59), and mortality ( OR = 4.84, 95%CI: 2.21 – 10.61) compared to the patients with mono-influenza virus infection. No publication bias was observed and the analysis results were relatively stable based on publication bias test and sensitivity analysis on the included literatures. Conclusion The co-infection of SARS-CoV-2 and influenza virus may result in severe outcomes and affect the prognosis of the patients with the co-infection.

Oil spill pollution seriously endangers human and ecosystem health. Therefore, it is urgent to develop oil-absorbing materials to effectively remove oil spill pollution. Among the traditional oil-absorbing materials, natural organic adsorption material has low oil absorption capacity and hydrophilicity; inorganic adsorption materials are difficult to recover and have low oil absorption efficiency and high price; and although the synthetic organic adsorbent has outstanding oil absorption capacity, its biodegradation is poor. Silica aerogel (SA) has the characteristics of high porosity, low density, and high specific surface area, which make it an excellent oil-absorbing material. However, the hydrophilic surface and pearl necklace structure of SA limit its wide applications in the oil absorption field. Hydrophobically modified hydrophobic silica aerogel (HSA) has not only excellent SA characteristics but also good hydrophobic/lipophilic properties. In this paper, focusing on HSA preparation by surface posttreatment modification and coprecursor modification, the research progress on these two methods combined with supercritical drying and ambient pressure drying is systematically introduced, and the advantages and disadvantages of the two methods are analyzed and summarized. The coprecursor modification is mainly combined with a supercritical drying process to prepare HSA, while the surface posttreatment modification is often combined with an ambient pressure drying process. Both methods normally use silylating agents as hydrophobic modifiers. The surface posttreatment modification does not change the formed pore structure, and the pore size and particle size of HSA are relatively uniform. However, the modification process of surface posttreatment is long, the solvent consumption is large, and the cost is high. In addition, incomplete internal modification may be a problem. In the coprecursor modification method, wet gel is formed and modified simultaneously, shortening the modification time and saving costs. The prepared HSA of coprecursor modification has a larger specific surface area and better hydrophobicity, but its pore size is uneven, and the introduced hydrophobic groups are limited. Excessive silylating agents affect the sol–gel process of HSA. In addition, the current methods for strengthening HSA mechanical properties and the research progress on HSA oil absorption properties are reviewed. Finally, based on the current development of HSA as oil-absorbing materials, the development direction of these materials is discussed, for example, developing low-cost and eco-friendly raw materials, shortening the hydrophobic modification process, preparing bulk HSA, strengthening the mechanical properties, and improving the oil-absorbing properties of HSA.

To date, the recycling technology of common solid waste (blast furnace iron slag) in the iron and steel industry has made important progress. However, persisting, stubborn solid waste problems urgently need to be solved. With the continuous growth of stainless steel production in China, the total amount of stainless steel slag has reached more than 10 million tons. This slag contains a lot of CaO, MgO, and SiO2, which are suitable building material additives. However, the harmful element chromium (Cr) in the slag and the dissolution characteristics of Cr6+ ions limit its large-scale application. For a long time, no effective, harmless disposal method has been available for Cr-containing slag, which brings great hidden danger to the environment. Given the characteristics of stainless steel slag, the current detoxification methods mainly include the solidification method, wet reduction, high-temperature ferrosilicon reduction, and high-temperature modification–crystallization control processes. Among these methods, high-temperature modification–crystallization control can promote Cr-containing spinel phase formation by adjusting steel slag compositions (e.g., basicity and oxidation-reduction properties) to improve the enrichment degree of Cr in the spinel phase. At the same time, by adjusting the slag cooling system (e.g., the quenching temperature and holding time) and reducing the slag viscosity, the nucleation and growth of the Cr-containing spinel phase can be improved, the precipitation amounts of the spinel phase are increased, and the occurrence probability of chromium in the matrix phase is reduced; thus, the detoxification of stainless steel slag can be achieved. Compared with the other three detoxification treatment methods, high-temperature modification–crystallization control has the advantages of a simple process, stable treatment effect, and large scale. In particular, solid wastes containing silicon, aluminum, and magnesium can be used as additives to adjust the composition of steel slag to realize a coordinated treatment of various solid wastes, which has very high economic value. In addition, using waste heat to modify steel slag directly after slag picking can substantially reduce energy consumption, should become one of the most promising harmless treatment approaches, and has recently attracted extensive attention. In this paper, the research progress of high-temperature modification and detoxification of stainless steel slag is reviewed according to its thermodynamic mechanism and crystallization kinetics principles. On the basis of the core problem of melt modification-selective crystallization, the methods and measures for improving the detoxification effect are emphasized. In addition, aiming at the existing problems in the high-temperature modification–crystallization control detoxification of stainless steel slag, development directions are proposed.

Over the past decade, the power conversion efficiency of perovskite solar cells has increased from 3.8% to the current 25.5%, which is expected to become the next generation of commercial thin-film solar cells. However, the widely used TiO2 electron transport layer has low electron mobility, requires a high annealing temperature, and has poor UV light stability, limiting the performance of TiO2-based perovskite solar cells, especially long-term stability. SnO2 is expected to be the first choice to replace TiO2 electron transport layers because of its high electron mobility, suitable band structure, low-temperature solution synthesis, and stable chemical structure. Although the certified maximum efficiency of state-of-the-art SnO2-based perovskite solar cells had exceeded 25%, it was still below its theoretical efficiency. Therefore, component engineering, interface engineering, solvent engineering, and other methods to improve the efficiency and stability of SnO2-based perovskite solar cells have become a major research focus. Currently, regulating the SnO2/perovskite and perovskite/hole transport layer interface is key to optimizing the performance of SnO2-based perovskite solar cells. Most studies focused on improving the charge transport performance of SnO2 and modifying the SnO2/perovskite interface, while few studies have addressed defect passivation of the perovskite layer and the modification of the perovskite/SnO2 interface. Therefore, it is essential to summarize the research progress of interface modification and performance optimization of SnO2-based perovskite solar cells. This paper introduces the types and characteristics of defects in the bulk and surface of the SnO2 electron transport layer, as well as defects in the bulk, grain boundaries, and surface of the perovskite film. The research progress of the interface modification (bulk and surface defect passivation) and performance improvement for the SnO2 electron transport layer/perovskite and perovskite/hole transport layer are reviewed. Finally, the research directions of SnO2-based perovskite solar cells on interface modification and performance optimization are presented.

The potential of ultra-high-pressure sterilization combined with olive oil impregnation for the processing of soft canned saury was evaluated in this paper. Five types of treatment were set up: Unsterilized group without olive oil, ultra-high-pressure sterilization group with olive oil impregnation (UHPSO), ultra-high-pressure sterilization group without olive oil (UHPS), conventional retort sterilization group with olive oil impregnation (RSO), and conventional retort sterilization group without olive oil (RS). The indicators related to the nutrition and taste (e.g. basic nutrients, total amino acids, fatty acids, free amino acids, taste-presenting nucleotides, etc.) of the soft canned saury in different treatment groups were compared and analysed. The results showed that crude fat and crude protein content were higher in the UHPSO group than in the other sterilization treatments, which had higher nutritional value. The amino acid composition of sterilization treatments were in accordance with the FAO/WHO recommendations and there were no limiting amino acids, with the UHPSO group recording the highest amino acid scores, especially for as a good source of supplementary sulphur-containing amino acids and lysine. Compared to conventional retort sterilization, ultra-high pressure sterilization inhibited the oxidative degradation of unsaturated fatty acids, making the soft canned saury were a good sources of n-3 polyunsaturated fatty acids in combination with olive oil impregnation. Compared to the unsterilized group, sterilization treatments resulted in free amino acids and flavoring nucleotides increased. Combining the taste activity values and MSG equivalents, glutamic acid, threonine, aspartic acid, alanine and hypoxanthine were found to contribute significantly to the formation of the umami taste of the soft canned saury, with the UHPSO group displaying the strongest umami taste. In summary, the combination of olive oil impregnation and ultra-high-pressure sterilization sulted in a more nutritious and delicious soft canned saury compared to traditional retort sterilization.

Objective: To optimize the ultrasonic extraction process of aqueous extract of Rehmannia glutinosa based on entropy weight method (EWM) together with analytic hierarchy process (AHP) and back propagation neural network (BPNN). Methods: Taking ultrasonic temperature, ultrasonic time, solid-liquid ratio as orthogonal test factors, catalpa, rehmannioside D, ajugol, rehmannioside polysaccharide content, and the yield of water-soluble extract as indexes, EWM-AHP method was used to determine the weight of each index, to obtain the comprehensive score of multiple indexes. Then, the experimental process conditions were used as the input and the synthesis score was used as the output to build and train a BPNN model to find the best process for the extraction process of Rehmannia glutinosa. Results: The preferred process of BPNN was extraction at 60 ℃ with 33 times of water for 70 min. The mean values of catalpa, rehmannioside D, ajugol, rehmannioside polysaccharide content, and the yield of water-soluble extract were 17.04, 3.75, 10.57, 24.86 mg/g and 0.82 g/g, respectively, with a combined score of 97.74; The best process of the orthogonal test was extraction at 50 ℃ with 25 times of water for 1 h. The mean values of catalpa, rehmannioside D, ajugol, rehmannioside polysaccharide content, and the yield of water-soluble extract were 12.72, 2.58, 8.20, 25.02 mg/g and 0.80 g/g, respectively, with a combined score of 97.26. Conclusion: This study determined that the BPNN preferred process was optimal and provided a reference for the application of the EWM-AHP method combined with BPNN in the extraction process.

Objective: To investigate the protective effects of 6′′′-feruloylspinosinon Aβ1-42-induced SH-SY5Y cells injury. Methods: SH-SY5Y cells were pretreated with 6′′′-feruloylspinosin (1、5、10、20 and 40 μmol/L) for 2 h and then co-treated with 5 μmol/L of Aβ1-42 for 24 h. Cell viability was measured by CCK-8 assay; cell morphology was observed by Calcein-AM/PI assay; intracellular reactive oxygen species, malonic dialdehyde level, Glutathione peroxidaseactivity and mitochondrial membrane potential level were detected by the kit; expression of apoptosis-related proteins: Bcl-xL/Bcl-2 associated death promoter, B-cell lymphoma/leukemia-2 were detected by Western Blotting. Results: 6′′′-feruloylspinosin could inhibit Aβ1-42-induced apoptosis and improve cell viability (P

With the rapid development of industrialization and human civilization, the soil polluted by heavy, toxic lead is becoming increasingly severe worldwide. Thus, it is imperative to control soil pollution due to lead. In this paper, the background, status, and harm of lead-polluted soil were introduced, and the source, mode of occurrence, and extraction of lead from the soil were depicted in detail. Based on the current soil remediation technology, three major methods, namely, physical, chemical, and bioremediation, have been systematically reviewed, and their advantages and disadvantages from the aspects of efficiency, applicability, and economy were evaluated and compared. Results reveal that the most preferred remediation method for heavy, toxic, lead-contaminated soil is chemical remediation. The chemical leaching and immobilization/stabilization methods were subsequently introduced in detail, and the remediation mechanism, effect, applicability, and application prospect of the different types of eluants and curing agents were evaluated and discussed. Finally, the prospect of cleaning and efficient remediation of heavy, toxic, lead-contaminated soil was presented. The restoration should minimize the damage to the soil. For the heavy, lead-contaminated soil, the development of the joint remediation technology is the potential development direction. The mechanism of soil remediation and directional remediation should be determined as soon as possible. Meanwhile, the research and development of multifunctional composite materials should be strengthened.

Objective To evaluate the performance of electrochemiluminescence immunoassay (ECLIA) in detecting HIV antigen/antibody in blood screening. Methods A total of 128 donors, reactive to anti-HIV(ELISA)testing, from September 2016 to September 2020 were enrolled, and seven samples were reactive to double anti-HIV reagents, among which 6 were confirmed by WB, 1 confirmed by NAT as negative.Two group of donors, reactive to solo anti-HIV reagent but being confirmed negative by WB(n=121) vs.randomly selected donors non-reactive to ELISA + NAT(June to September 2020, n=1360), were subjected to HIV antigen/antibody testing using ECLIA to compare the testing results, including concordance rate, sensitivity and specificity. Results The ECLIA results remained non-reactive for 1360 samples initially non-reactive to both ELISA and NAT.The concordance rate of anti-HIV reactivity by ECLIA and ELISA+ WB were 100%(6/6). For 122 samples, reactive to ELISA anti-HIV testing but nonreactive to confirmatory testing, 4(3.28%)of them were reactive to HIV antigen/antibody testing and 118(96.72%) nonreactive, with the concordance rate of ECLIA and ELISA at 96.88%(124/128). The sensitivity, specificity and false positive rate of ECLIA and ELISA were 100% vs 100%, 99.73% vs 91.77%, and 0.27% vs 8.23%, respectively. Conclusion ECLIA for HIV antigen/antibody detection has good sensitivity and specificity, which can meet the requirements of blood screening, and the false positive rate is lower than that of ELISA, adopted commonly in blood bank at present.

Organic contaminants such as dyes and antibiotics have become the focus of water treatment research in recent years due to their complex composition, high toxicity, and difficulty in biodegradation. Spinel ferrite heterogeneous Fenton-like catalysts, with a chemical formula of MFe2O4 (MFe2O4, M is a divalent metallic cation or its combination, and the divalent cation is generally Ni, Zn, Mn, Co, Cu, and Mg, etc.), have attracted much attention because of their excellent structural stability and good magnetic recovery performance. However, the catalytic activity of these catalysts is not ideal and almost all the reported catalysts are synthesized by pure chemical reagents, which restrict their industrial application. Therefore, the preparation of highly efficient heterogeneous Fenton-like catalysts with low cost becomes the key to the treatment of refractory organic wastewater. In this study, copper-doped spinel ferrite (Ni, Mg, Cu)Fe2O4 was successfully synthesized from nickel sulfide concentrate by a coprecipitation–calcination method. The effect of copper doping concentration on the structure, micro-morphology, and catalytic performance of as-prepared samples was systematically investigated by X-ray diffraction, scanning electron microscopy, and X-ray photoelectron spectroscopy. The optimal catalytic system was established as the photo-assisted Fenton-like catalytic system, “(Ni, Mg, Cu)Fe2O4 catalyst/H2O2/visible light”, and the enhancement mechanism of copper doping on the catalytic activity of (Mg, Ni)Fe2O4 was revealed. Results showed that all formed products were pure spinel ferrites under the selected synthesis conditions. With 1∶1 molar ratio of Ni to Cu, the formed (Ni, Mg, Cu)Fe2O4 catalyst achieved 94.5% degradation efficiency for 10-mg∙L−1 RhB solution under visible light irradiation for 180 min. This observed behavior may be ascribed mainly to the increased relative contents of Fe3+ and Cu2+ ions at octahedral site. Hydroxyl radical (·OH) reaction accelerated due to increased amount of Fe3+ and Cu2+ exposed on the surface and enhanced synergetic effect between Fe3+ and Cu2+. This improved the degradation efficiency of RhB solution from 73.1% to 94.5%.

China is one of the major antibiotic producing and consuming countries in the world and demand for and output of antibiotics are increasing year by year. The wastewater produced during the production of antibiotics is of complex composition, high chemical oxygen demand, high concentrations of toxic and harmful substances and strong resistance to biodegradation. This is problematic for the process of pharmaceutical wastewater treatment. Additionally, due to the extensive use of antibiotics, a variety of antibiotics are constantly released into the environment, with adverse effects on aquatic organisms. Although antibiotic concentrations in wastewater are low, the accumulation of low-dose, long-duration antibiotics can lead to the development of drug-resistant strains that threaten human health and the entire ecosystem. Therefore, how to effectively remove antibiotic residues in water is an important challenge toward ensuring the safety of water quality, the environment, and ecology. Advanced oxidation technology (AOP), which has an extremely high oxidation potential, can generate hydroxyl radicals in the reaction process, and can degrade organic compounds rapidly without secondary pollution. Therefore, it exhibits clear advantages in the treatment of antibiotics in water. As a kind of AOP, homogeneous Fenton oxidation technology (Fe2+/H2O2 system) has attracted considerable attention owing to its rapid reaction, simplicity, and high degradation efficiency. Heterogeneous Fenton-like oxidation technology using an iron-based solid catalyst instead of Fe2+ ions can effectively reduce the formation of iron-containing sludge and broaden the pH reaction range to overcome the shortcomings of Homogeneous Fenton. Moreover, recycling of the catalyst has been developed rapidly in recent years and has achieved ideal results when applied to the degradation of antibiotics. In this paper, research progress in heterogeneous Fenton-like catalysts for degradation of antibiotics was reviewed. Based on the core issues of heterogeneous Fenton-like catalysts, the methods, measures, and new viewpoints for improving catalytic performance were expounded upon. Aiming at the problems of heterogeneous Fenton-like technology in degrading antibiotics, future development directions were presented.

Viscosity is a physical property of fluids and shows resistance to flow. In metallurgical slag, it directly affects various parameters of a metallurgical process such as reaction rate, separation effect, etc. The estimation of viscosity by models during a production process is considered to be much more effective owing to the production fluctuations and complexities of the slag composition. Many viscosity models have been developed in the past, such as the structural model with a wide range of adaptability and complex calculation process and the empirical and semiempirical models with simple structure and a narrow range of adaptability. The present paper proposed a new method to calculate the structural parameter (NBO/T) ratio (the amount of nonbridging oxygen per tetrahedral-coordinated atom), based on which the relationship between the viscosity of molten slag and (NBO/T) ratio was investigated. First, the viscosity model was applied to SiO2–ΣMxO slags, with the model parameters obtained by fitting the viscosity data of pure oxide and SiO2–MxO binary slag, and the average deviations were in the range of 9%–18.5%. Then, the model was extended to calculate the viscosity of SiO2–Al2O3–ΣMxO, a multicomponent complex aluminosilicate system, and Al2O3 was split into acid and basic oxides. Then the oxides were used for calculating the (NBO/T) ratio and viscosity activation energy based on the amphoteric behavior of Al2O3 in SiO2–Al2O3–MxO ternary slag system. Using the parameters of a SiO2–MxO binary system, the model parameters of the Al2O3-containing slag system were obtained by fitting the viscosity data of the SiO2–Al2O3–MxO ternary slag system with average deviations between 10% and 25%. In addition, the viscosity of a multi-complex system (SiO2–Al2O3–CaO–MgO–FeO–Na2O–K2O–Li2O–BaO–SrO–MnO) and its subsystems were also calculated using the model proposed in this paper, and the average deviations is less than 25%, which shows relatively accurate prediction results. The present model is based on the analysis of a slag structure and processing of data by an empirical method. This method has a better prediction effect and wider application range compared with the traditional empirical model, and it uses a simpler calculation process compared with the structure model.

Three typical ferroalloy slags, namely, silicon–manganese, nickel–iron, and chrome–iron slags, are produced in large quantities as by-products. This is because they are not efficiently utilized, which creates lots of pressure on environmental capacity and development of enterprises. At present, comprehensive utilization of ferroalloy slags is mainly concentrated on the traditional building materials such as cement and concrete. Although the construction industry consumes a large amount of ferroalloy slags, their high-energy consumption and relatively limited product value limit their maximum utilization. With the increasing market demand and improvement of energy and environmental awareness, the research on rational utilization of ferroalloy slags has been changing from its use as raw materials in traditional building materials to use as raw materials to produce new products with comparatively lower energy consumption and higher product value, which explores the possibility of slag reutilization in other fields. Based on the quality requirements of different ferroalloys, there are significant differences in the requirements of the raw materials and different smelting processes. As a result, different types of ferroalloy slags, having different physical and chemical properties, are produced. This study briefly presented the uses of the silicon–manganese, nickel–iron, and chrome–iron slags. It also showed how to classify these three typical ferroalloy slags. The differences of their chemical and mineral phase composition were also systematically analyzed in this study, which discussed different properties of different slags and provided the basic theoretical guidelines on how to efficiently utilize these slags. This study also emphatically summarized the latest domestic and foreign research advancements about their utilization in traditional building materials such as cement and concrete, and in new functional materials such as geopolymer, inorganic mineral fiber, microcrystalline glass, artificial light aggregate, and refractory materials required to build walls and as alternative raw materials to prepare functional ceramics. Based on the results of this study, we summarized the advantages and disadvantages of using the abovementioned ferroalloy slags as raw materials to generate different materials, and put forward the prospects for its future utilization direction and approach. The study also guided the key development areas for further studying and breaking through the bottleneck of the main utilization mode, formulating and improving the relevant application and pollution control standards, and developing and promoting high value-added products.

The Line C of the China–Central Asia Gas Pipeline is a typical gas pipeline characterized by high transmission pressure, large flow, long pipeline span, numerous gas stations and complicated transportation technology. In order to study the changing law of hydrothermal parameters of the pipeline under normal and accident conditions and the self-rescue time of the pipeline under various accidents, a simulation model of the Line C of the China–Central Asia Gas Pipeline was established using SPS software to simulate the pressure and temperature parameters of the whole pipeline under normal conditions. The maximum relative errors of the pressure and temperature, between simulated results and actual operation data are 1.90% and 6.92% respectively, which verifies the reliability of the model. Based on this, the changes in the ambient temperature and the roughness of the pipeline on the gas transmission efficiency over the whole pipeline were analyzed, and the longest self-rescue time of the pipeline under various accident conditions was determined, which can provide a reference for the operation and management of the China–Central Asia long-distance gas pipeline.

Telomere is a special curved cap-like structure at the end of the linear chromosome of eukaryotic cells. It is a nuclear protein complex composed of DNA repeat sequences containing TTAGGG and telomere-binding proteins. Telomere length decreases correspondingly as normal human cells continue to mitosis. When telomeres reach a certain critical length, further cell division is prevented and cells will senile and die. Telomere length determines the number and life span of cell division and is a biomarker of cell senescence. It is controlled by genes and influenced by various external factors. Sleep is a necessary physiological process to maintain life and susceptible to senescence. In recent years, more and more studies have suggested that telomere length is associated with sleep and cell senescence. This article will review the related research in recent years at home and abroad, aiming at exploring the potential relationship between telomere length and sleep and cell senescence, and providing objective basis for promoting healthy sleep and delaying aging. DOI:10.3969/j.issn.1672-6731.2019.10.016

Background and objective It has been proven that Cyclin D1 and Cyclin E are the important positive regulators of cell cycle, they are closely related to the tumor proliferation. The aim of this study is to explore the relationship between Brucine and the proliferation in human lung cancer cell line PC-9, and the effect of it on the expression of Cyclin D1 and Cyclin E. Methods PC-9 cells were divided to 4 groups: the normal control group, the DMSO control group (2‰), the 150 μM Brucine group, and the 300 μM Brucine group. The proliferation rate of PC-9 cells was determined by The CellTiter-Glo Luminescent Cell Viability Assay and Colony Formation assay. The change of cell cycle was detected by Flow cytome try. Expressions of cell cycle regulators Cyclin D1, Cyclin E mRNA were determined by qRT-PCR. Protein expression of cell cycle regulators Cyclin D1, Cyclin E were determined by Western blot. Results Compared with the control, Brucine remarkably inhibited the proliferation of PC-9 cells in a dose- and time-dependent manner (P

Objective: To research the effects of Na-FA on gastrointestinal movement and gastriculcer in mice., Methods: Using charcoal powder as an indicator, the effects of FA-Na on bowel movement of mice was evaluated by determining the propulsive percent-age of charcoal powder in normal mice, inhibition of small intestinal propulsion model induced by Compound Diphenoxylate and spleen asthenia and diarrhea model caused by Rheum officinale Baill; The acute gastric ulcer model was induced by intragastric alcohol given orally, the protective effect of FA-Na given ahead on gastric injury was evaluated, the ulcer index and the inhibition ratio of ulcer was calculated., Results: FA-Na (intragastric administration) had inhibit effect on normal mice and diarrhea model caused by Rheum officinale, significantly synergetic effect on gastrointestinal asynersis induced by Compound Diphenoxylate, and protective effect on mice gastric mucosal injury cause by dehydrated alcohol. Compared with the positive control drug Ranitidine, the ulcer index and ulcer inhibition ratio large doses of FA-Na had no significant difference., Conclusion: The acute toxicity of FA-Na is very low, it has the effects of antidiarrheal and anti-gastric ulcer.