1. 大叶山楝根的化学成分及细胞毒活性研究.
- Author
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李 薇, 黄 淼, 梅文莉, 董文化, 王 军, 蔡彩虹, 盖翠娟, and 戴好富
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SILICA gel , *STOMACH cancer , *HUMAN growth , *MELIACEAE , *CANCER cells , *ETHYL acetate - Abstract
Aphanamixis grandifolia belongs to genus Aphanamixis of family Meliaceae. We made the experiment to clarify the constituents from the roots of A. grandifolia in this paper. The chemical constituents were isolated by silica gel, Sephadex LH-20 column chromatographic methods. The structures were identified by spectral analysis and comparing with the previously reported literatures. The results showed that ten compounds were isolated from the ethyl acetate of ethanol extract from A. grandifolia and identified respectively as schleicheol(1), β-rosasterol(2), fregenedadiol(3), isojacareubin(4), syringaresinol(5), episyringaresinol(6), graminone A(7), sylvatesmin(8), methyl-Z-6-nonadecenoate(9), ralmitic acid(10). The compounds 1-4, 7-9 were obtained from A. grandifolia for the first time. The results of cytotoxic activity showed that compounds 1 and 2 had certain inhibitory activity on the growth of human gastric cancer cell SGC-7901. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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