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A case of Cronkhite-Canada syndrome is reported. A 68-year-old man presented with stomachache and diarrhea for 3 months. The dermatological examination revealed diffuse hair thinning, especially on the frontal region, symmetrical distribution of brown pigmentation covered with green bean-sized maculopapules on the upper and lower lips, hands, and soles. Two-thirds of distal part of the toenails were missing, with rough and uneven dull surface. Pitted edema was observed on the upper eyelids and legs. Laboratory examination showed anemia and hypoproteinemia. Electronic colonoscopy revealed multiple polyps in the colon. Diagnosis: Cronkhite-Canada syndrome. Following high protein nutritional support and symptomatic treatment, anemia and hypoproteinemia were significantly improved. The patient is still under follow-up.