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Castleman disease is a rare and complicated disease. A case of Castleman disease (CD) in a 40⁃year⁃old woman on the neck was reported and literature review was made to understand the occurrence, clinical characteristics, diagnosis and differential diagnosis, treatment, and prognosis of Castleman disease. Because of the rarity of CD, its oc⁃ currence in the general population and the typical clinical manifestations are still lacked. There are two types of CD, namely localized CD and multicentric CD, both of them are not easy to be diagnosised. CT scans in preoperative is help⁃ ful for the clinical diagnosis, while histopathological examination and lymph node biopsy are beneficial for the early di⁃ agnosis. The treatment result is based on the histopathological examination and lymph node biopsy. The prognosis is dif⁃ ferent with the type of CD. For the localized CD, the prognosis is usually good, while for the multicentric CD is bad. Both of localized CD and multicentric CD have a certain reoccurrence rate.

Objective: To study the changes in liver function in patients with epidemic hemorrhagic fever (EHF)., Method: A retrospective analysis of the laboratory tests of liver function in 103 patients with EHF and control subjects was carried out., Results: The alanine aminotransferase (ALT), serum bilirubin (SB) and albumin levels in patients with severe and critical liver damages significantly differed from those in milder cases, and more sever liver damages were found in the death cases of EHF than in survived patients in terms of ALT and SB increment (P=0.000). The liver damage was related to the clinical type, age and the levels of blood platelet , albumin, lactic dehydrogenase and creatinine in EHF cases (P=0.000, 0.000, 0.030, 0.010, 0.000 and 0.013, respectively)., Conclusions: Liver damage is common in patients with EHF and exacerbates with the severity of the disease. Monitoring of ALT, SB and albumin is helpful for evaluating the progression and prognosis of EHF.