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To address the low recognition accuracy of generic emotion recognition models when faced with different individuals, a multimodal individual emotion recognition technique based on joint labelling with integrated learning and clustering was proposed. The method first trained a generic emotion recognition model based on a public dataset, then anallysed the distributional differences between the data in the public dataset and the unlabelled data of individuals, and established a cross-domain model for predicting and labelling pseudo-labels of individual data. At the same time, the individual data were weighted clustered and labelled with cluster labels, and the cluster labels were used to jointly label with pseudo-labels, and high confidence samples were screened to further train the generic model to obtain a personalized emotion recognition model. Using this method to annotate these data with the experimentally collected data of 3 emotions from 3 subjects, the final optimized personalized model achieved an average recognition accuracy of more than 80% for the 3 emotions, which was at least a 35% improvement compared to the original generic model.

When the grid voltage contains many harmonics, the filtering effect of the phase-locked loop based on dual second-order generalized integrator (DSOGI-PLL) is not ideal, and the frequency of synchronous signal extracted through the DSOGI-PLL fluctuates. A novel phase-locked loop structure based on cascade second order generalized integrator (CDSOGI-PLL) is proposed. The structure utilizes the cascaded SOGI module to simultaneously weaken the harmonics and inter-harmonics that exist in the grid voltage, thus reducing the influence of harmonics on the PLL and accurately extracting the grid voltage's synchronous signal. Matlab simulation and experimental results show that the signal detection technique proposed in the paper can effectively extract the fundamental positive sequence component, frequency and phase when the grid voltage is unbalanced and has many harmonics.

Objectives: Mimic voter is a crucial component under the dynamic heterogeneous redundancy architecture of mimic defense technology,but the existing mimic voting method needs to collect and process the complete output data of heterogeneous redundant executives. In the application scenario where the connection continuously transmits data in chunked transfer encoding,there are problems that the mimic voting efficiency is too low and the memory resource overhead of mimic voting is too significant.This paper designs and implements an adaptive mimic voter oriented to the scenario of the continuous output of chunked transfer encoded data in a persistent connection to reduce the memory resource overhead of the mimic voter and improve voting efficiency. Methods: The proposed mimic voter adaptively divides the chunked-transfer-encoded data arriving at the voter successively from the heterogeneous redundant executives,dynamically votes, and then outputs the data in the form of a sliding window during the continuous data transmission process.Gradually releasing the data of the voted blocks can reduce the memory consumption of the mimic voter and lower the voting processing time while maintaining the continuity of data transmission of the persistent connection.On the one hand,a voting algorithm selection strategy set is constructed to keep the voting accuracy by analyzing the data characteristics in the sliding window.On the other hand,an inventory model of the data voting process of the adaptive mimic voter is established,and an adaptive voting window control strategy is proposed based on the cost optimization of the inventory model to provide the best adaptive segmentation scheme for the data to be voted. Results:A series of comparative experiments between the prototype system of the adaptive mimic voter and the traditional mimic voter is conducted as follows. (1) The evaluation of memory resource occupancy shows that the peak physical memory consumption and the total time of consuming physical memory when the adaptive mimic voter transmits 20MB web resources in chunked transfer encoding are significantly lower than those of the traditional mimic voter. (2) The evaluation of transmission delay shows that the response time of the adaptive mimic voter in the voting processing of 10MB to 320MB chunked transfer-encoded webpage resources is relatively low, indicating that its voting speed has been significantly improved. (3) The concurrency performance evaluation shows that the average of response time of the system applying the adaptive mimic voter under the request concurrency of 1000 to 5000 is lower than that of the traditional mimic voter,and the voting processing throughput is higher than that of the traditional mimic voter.(4)The evaluation of voting accuracy shows that the adaptive mimic voter based on the voting algorithm selects the strategy set is slightly weaker than the semantic feature algorithm and the AHP algorithm while far superior to the character similarity algorithm in the traditional mimic voter, which reveals that the adaptive mimic voter has an acceptable voting accuracy. Conclusions: The design of the adaptive mimic voter effectively solves the problem of service performance degradation caused by the excessive occupation of memory resources in voting chunked transfer encoding data of persistent connection. The memory occupancy experiment shows the improvement effect of the adaptive mimic voter on this problem, and the voting accuracy evaluation experiment shows that the adaptive mimic voter can improve voting efficiency while maintaining acceptable voting accuracy.The experiments under different service pressures give the feasibility analysis of the adaptive mimic voter in general application scenarios with micro-benchmarks. Therefore, the adaptive mimic voter reduces resource overhead and improves voting efficiency with acceptable voting accuracy, which can effectively support the mimic transformation of applications that transmit data in persistent connections.

Objective To investigate the inhibitory effect of cordycepin on immune function injury in lung cancer rats after radiation therapy through JAK2/STAT3 signaling pathway. Methods Fifty rats were used to establish tumor-bearing model and other 10 rats were taken as normal group. After successful modeling, the rats were randomly divided into model group, radiotherapy group, cordycepin group, agonist group and agonist+cordycepin group (10 rats in each group). We compared tumor weight, tumor volume, tumor inhibition rate, IL-6, TNF-α, spleen index and thymus index, the number of T lymphocyte subsets, JAK2, p-JAK2, STAT3 and p-STAT3 protein expression levels among all groups. Results Compared with normal group, IL-6, TNF-α, CD8+, p-JAK2 and p-STAT3 in model group were increased, while spleen index, thymus index, CD4+ and CD4+/CD8+ were decreased (P < 0.05). Compared with model group, tumor weight, tumor volume, spleen index, thymus index, CD4+ and CD4+/CD8+ were decreased in radiotherapy group, while IL-6, TNF-α, CD8+, p-JAK2 and p-STAT3 were increased (P < 0.05). Compared with radiotherapy group, tumor weight, tumor volume, IL-6, TNF-α, CD8+, p-JAK2 and p-STAT3 were decreased in cordycepin group, while tumor inhibition rate, spleen index thymus index, CD4+ and CD4+/CD8+ were increased; tumor weight, tumor volume, IL-6, TNF-α, CD8+, p-JAK2 and p-STAT3 protein expression were increased in agonist group, while tumor inhibition rate, spleen index, thymus index, CD4+ and CD4+/CD8+ were decreased (P < 0.05). Compared with agonist+cordycepin group, tumor weight, tumor volume, IL-6, TNF-α, CD8+, p-JAK2 and p-STAT3 were decreased in cordycepin group, while tumor inhibition rate, spleen index, thymus index, CD4+ and CD4+/CD8+ were increased; tumor weight, tumor volume, IL-6, TNF-α, CD8+, p-JAK2 and p-STAT3 were increased in agonist group, while tumor inhibition rate, spleen index, thymus index, CD4+ and CD4+/CD8+ were decreased (P < 0.05). Conclusion Cordycepin can effectively inhibit the immune function injury in lung cancer rats after radiation therapy, and may play a regulatory role by inhibiting the JAK2/STAT3 signal pathway.

Screw drive is widely used in the focusing mechanisms in space cameras, and the self-locking ability is required to resist the shock and vibration in the process of launching. The paper establishes a non-linear simplified mechanical model of thread fit clearance with two degrees of freedom. The dynamic response of the system under the vibrating inspiration is achieved by numerical simulation method. The result shows that non-dimensional kurtosis indexes can be used as an indicator to evaluate the degree of self-locking failure of screw drive. Finally, The simplified model is verified by finite element simulation analysis, and it shows kurtosis indexes is effective to analyze the influence of thread fit clearance on self-locking ability.

The article presents a study which discusses the construction and immunological characterization of the recombinant adenovirus expressinf multi-genes of foot-and-mouth disease virus (FMDV) serotype O.

In order to reflect the actual working conditions of the gear pair in the steering gear accurately,the mathematical model of the steering system is established,and the calculating formulas of the pitman arm moment and the steering nut displacement are given. A calculation method for the actual working condition of the gear pair in the circulating ball variable transmission ratio steering is proposed. Base on the vehicle steering portability test,the actual steering condition of the gear pair in a certain type of recirculating ball variable ratio is calculated,and the results is verified by simulation. The calculation result of the actual working condition of the variable transmission ratio gear is applied to the finite element analysis which can prove the feasibility of this method. The calculation method provides a loading basis for simulation and test which is closer to the reality.

ObjectiveTo explore the relationship between blood lipid and the risk of mild cognitive impairment (MCI) among community elderly for providing evidence to MCI prevention in the population. MethodsA case-control study was conducted among residents aged 65 years and above in four communities of Tianjin city during March 2016. The cases were 210 MCI patients diagnosed while attending physical examination at community healthcare centers; the controls were 1 : 1 gender- and age (± 1 year)-matched residents with normal cognitive ability. Face-to-face questionnaire interview, physical examination and laboratory detections were carried out among the participants. Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V) was adopted in diagnosis and assessment of MCI. Multivariate conditional logistic regression analysis was used to explore the relationship between blood lipid and MCI in the elderly. ResultsNo significant differences between the cases and controls were detected in total cholesterol (TC: 186.50 [25th, 75th percentile: 160.75, 215.00] vs. 195.50 [168.00, 217.25] mg/dL), low density lipoprotein-cholesterol (LDL-C: 101.00 [77.75, 121.00] vs. 100.00 [79.75, 123.00] mg/dL), high density lipoprotein-cholesterol (HDL-C: 58.50 [46.75, 71.25] vs. 58.00 [47.00, 70.00] mg/dL), and LDL-C/HDL-C (1.71 [1.30, 2.35] vs. 1.66 [1.31, 2.26]) (P > 0.05 for all). The results of conditional multivariate logistic regression analysis showed that after adjusting for education, hypertension, diabetes, heart disease, and stroke, the LDL-C (mg/dL) of higher than 100 was associated with increased risk of MCI (100 – 130: odds ratio [OR] = 2.37, 95% confidence interval [CI]: 1.21 – 4.65; 130 – 160: OR = 3.22, 95% CI: 1.09 – 9.49; > 160: OR = 9.33, 95% CI: 1.59 – 54.61); while, following factors were correlated to decreased risk of MCI: higher TC (200 – 240 vs. < 200 mg/dL: OR = 0.52, 95% CI: 0.27 – 0.99), higher HDL-C (> 40 vs. ≤ 40 mg/dL: OR = 0.30, 95% CI: 0.14 – 0.67), and higher ratio of LDL-C/HDL-C (> 2.30 vs. < 1.31: OR = 0.37, 95% CI: 0.16 – 0.88). ConclusionHigher serum LDL-C is a risk factor of MCI but higher serum HDL-C, LDL-C/HDL-C ratio and moderate TC are protective factors against MCI for community elderly in Tianjin city.

Objective: To study the influence of leukodeplated blood transfusion on cellular immunity of patients with acute leuemia, so as to provide support for application of leuko-deplated blood transfusion in clinic., Methods: A total of 100 AL patients from January 2012 to December 2015 were chosen, and were divided into 2 groups: leukodeplated blood transfusion group(50 cases) and routine blood transfusion group(RBT) as control (50 cases). The effective rate, side effects, peripheral blood T cells and expression level of TLR2 and TLR4 were compared between 2 groups., Results: The expression levels CD3(+), CD4(+), CD8(+), CD4(+)/CD8(+) of TLR2 and TLR4 in control group were (52.18±2.14)%, （27.28±1.19）%,（24.21±1.65）%,1.22±0.18,0.62±0.04 and 0.57±0.05, respectively, after treatment; while these indicators in LdBT group were （52.18±2.14）%,（30.97±2.01）%,（27.08±1.55）%,1.39±0.24,0.91±0.06 and 0.87±0.07, respectively, and above-mentioned indicators in LdBT group were significantly higher than those in control group（P<0.05）. Compared with these indicators before treatment, CD3(+), CD4(+), CD8(+) and CD4(+)/CD8(+) in the patients increased significantly（P<0.05）. The efficiency was 92.00% (46/50) in LdBT group, and 84.00% (42/50) in control group, without statistically significant difference（P>0.05）. The rate of side effects in study group was 6% (3/50), 18% (9/50) in control group, with statistically significance difference （P<0.05）., Conclusion: Leukodeplated blood transfusion can improve the cellular immunity of AL patients, and reduce the rate of side effects.

Objective: To understand the prevalence of thyroid diseases and its influencing factors of iodine on thyroid gland function and autoimmune among fertile women in different iodine intake areas., Methods: Cross-sectional method was used for descriptive epidemiology. 236 women aged 19 to 45 years were sampled in 2011, in Shanxi province. Questionnaire was used to include general data on place, name, age etc. Sample of water from home, one time random urine sample and venous blood were collected to test the iodine contents using arsenic and cerium catalysis spectrophotometric methods. Finally, in blood, free triiodothyronine (FT3), free thyroxine (FT4), thyrotrophin (TSH) in blood were tested under auto-CLIA and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) through radio-immunological methods., Results: 1)The urine iodine's medians were 486.9 µg/L for fertile women in high iodine areas, and 192.6 µg/L in low iodine areas, with difference on urine iodine level statistically significant (Z = -10.676, P = 0.000). 2) Levels of blood FT3 and FT4 in women from high iodine areas were obviously lower than those from proper iodine areas(t = -2.884, P = 0.004; t = -2.862, P = 0.005), but the level of TSH in high iodine areas was higher than that of proper iodine areas(t = 2.332, P = 0.021). 3) In both areas, the rate of the thyroid dysfunction with positive antibodies was obviously higher than those with negative antibodies (χ² = 20.941, P = 0.000;χ² = 5.596, P = 0.018), while the rate of the thyroid dysfunction with positive antibodies and the level of TSH in the blood for high iodine women higher than those in women with proper iodine level(χ² = 5.708, P = 0.37;t = -2.177, P = 0.031). 4)The morbidity rate of inferior clinical hyperthyroidism for women in high iodine areas was obviously higher than those in proper iodine areas(χ² = 9.542, P = 0.003), while the morbidity rate of inferior clinical hypothyroidism for women with positive antibodies in two areas obviously higher than those with negative antibodies (χ² = 17.264, P = 0.000; χ² = 6.002, P = 0.044)., Conclusion: Morbidity rate of inferior clinical hypothyroidism for women in high iodine areas was obviously higher than those in proper iodine areas, suggesting that there were potential risks of hypothyroidism for overdose iodine intake which causing the existence of positive thyroid antibodies. Monitoring programs on iodine nutrition and thyroid function among women living in high iodine areas should be strengthened.

Objective: To understand the changes of schistosomiasis epidemic situation in the Fushui River basin of the Yangtze River., Methods: The data of schistosomiasis epidemic situation were collected and analyzed statistically in Baota Village, a surveillance site in Fushui River basin of the Yangtze River from 2008 to 2012., Results: The schistosome infection rates of residents decreased from 3.83% in 2008 to 0.23% in 2012, and the infection rate of cattle decreased year by year. There were no cattle in the village in 2012. The schistosome infection rate of Oncomelania snails and the density of infected snails decreased obviously. There were no acute schistosomiasis patients and no newly advanced schistosomiasis cases during recent 5 years., Conclusion: The schistosomiasis epidemic situation has been controlled. However, the surveillance still needs to be strengthened

Two manganese peroxidase (MnP) active fractions D1 and D2 were got from the extracellular culture of Trametes versicolor by using ammonium sulfate precipitation, DEAE-cellulose DE52 chromatography. MnP1 was purified to electrophoretic homogeneity from the D2 by Phenyl Sepharose 6 Fast Flow chromatography and MnP2 was purified to electrophoretic homogeneity from the D1 by Sephacryl S-200HR chromatography and Phenyl Sepharose 6 Fast Flow chromatography. The specific activities of two MnP isozymes are 579.1U/mg and 425.0U/mg; purification folds are 17.51 and 12.85 and the yields are 6.17% and 2.47%, respectively. MnP1 and MnP2 have approximate molecular masses of 46.3kD and 43.0kD respectively, as determined by SDS-PAGE. The isoenzymes differed in optimum temperature (60degreesC and 65degreesC) and optimum pH(5.8 and 6.2) for oxidation of DMP (2,6-dimethoxyphenol). MnP1 and MnP2 are stable below 45degreesC and ranging from pH4.0 to pH7.0. DMP is the best substrate, the Km values of MnP1 and MnP2 for DMP are 13.43micromol/L and 12.45micromol/L respectively. Catalysis doesn't occur in the complete absence of Mn. EDTA inhibites the activities of MnP1 and MnP2 at the higher concentration and DTT inhibites the enzyme activities completely.

Objective: To study the method with endoscope-assisted microsurgical technique through the supraorbital keyhole approach to treat aneurysms in the anterior circulation., Methods: According to preoperative diagnostic imagings, to work out of the individual operation planning. Skin incision was made in the eyebrow, and the diameter of supraorbital craniotomy was about 2 cm, endoscope-assisted microsurgical technique was used to clip aneurysm. The technique was used in the most recent 12 consecutive patients., Results: Five different kinds of aneurysms in the anterior circulation were clipped through this method and 12 patients were cured. One patient, intraoperative accidental aneurysm rupture occurred. There were no approach-related complications., Conclusions: This endoscope-assisted microsurgical technique via supraorbital keyhole approach is a safe, minimal invasive and effective way for the treatment of aneurysms in the anterior circulation, and there is more sufficient operating space.

Background: To observe cytopathogenic effect of Hantaan virus (HV) on cultured human bone marrow cells., Methods: Light and transmission electron microscopy and direct immunofluorescent technique were applied to study cellular structure especially ultrastructural changes of bone marrow cells from patients with Hantaan virus infection. Bone marrow cells of one healthy volunteer were also studied as control., Results: The antigen of HV was found in bone marrow cells of 20 of 27 HFRS patients by the aid of direct immunofluorescent technique. It was found that the granulocytes had the highest percentage of HV antigen positive cells (76%), followed by monocytes (65%), lymphocytes (40%), megakaryocytes (20%) and the lowest was found in erythrocytes (3.7%). The injury of cell membrane after infection with HV was significantly more severe than that in the control group under the light and electron microscopy., Conclusion: This study demonstrated that HV could attack human bone marrow cells and cause cytopathogenic effect on them.

Objective: To study endoscope-assisted microsurgical technique with supraorbital keyhole approach for the treatment of suprasellar region tumor so as to maximize tumor removal and minimize operative-trauma., Methods: According to high resolution CT and MR images before operation, individual operation schemes were worked out. Skin incision was made in the eyebrow, and the diameter of supraorbital craniotomy was approximately 2 cm. Endoscope-assisted microsurgical technique was used to resect lesions in 16 consecutive patients., Results: Total Tumors were removed in all of the 16 patients via the supraorbital keyhole approach. No postoperative complications occurred., Conclusions: Supraorbital keyhole approach may diminish tissue injury considerably and has proven to provide sufficient operating space in the suprasellar region for tumor removal.

Objective: To evaluate the application of CT-guided stereotactic evacuation in the treatment of cerebral hemorrhage in hypertensive patients., Methods: A retrospective analysis was conducted of 32 hypertensive patients with cerebral hemorrhage who underwent CT-guided stereotactic evacuation., Results: The hematomas were effectively removed after the surgical procedure. Follow-up visit of the patients lasting for 6 to 10 months found that 31 patients survived, among whom 12 had total recovery and could live independently, 4 lived with tolerable independence while 15 were bedridden and required assistance. Death occurred in 1 case due to neurogenic pulmonary edema., Conclusion: CT-guided stereotactic evacuation is effective to reduce mortality and disability rate of patients with cerebral hemorrhage, improving their quality of life. Due to the merit of minimal invasion and high precision, this technique is most applicable in the treatment of deep cerebral hematoma.