1. [Establishment of blood β-hydroxybutyrate threshold for diagnosis of type 2 diabetes ketoacidosis].
- Author
-
Ke P, Zhou H, Wang Z, Wu X, Lin H, and Huang X
- Subjects
- Diabetes Mellitus, Type 2 blood, Humans, Sensitivity and Specificity, Severity of Illness Index, 3-Hydroxybutyric Acid blood, Diabetic Ketoacidosis blood, Diabetic Ketoacidosis diagnosis
- Abstract
Objective: To establish of blood beta hydroxybutyrate (βOHB) threshold for diagnosing type 2 diabetes ketoacidosis (DKA) and explore the relationship between βOHB levels and the severity of DKA., Methods: Correlation analysis was performed between serum βOHB and [HCO(3)] in type 2 diabetic patients admitted in the emergency department in the past year. Regression equation was used to calculate the concentration of βOHB corresponding to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L, and βOHB concentration corresponding to a [HCO(3)] level of 18.0 mmol/l was used as the DKA diagnostic threshold., Results: The serum βOHB level and [HCO3] concentration showed a good correlation (R²=0.7023, P<0.001). βOHB concentrations that corresponded to a [HCO(3)] level of 18.0, 15, and 10.0 mmol/L were 3.0, 4.70, and 7.5 mmol/L, respectively, in accordance with the severity of DKA. Combined with the blood glucose concentration ≥ 13.9 mmol/L, a blood βOHB≥3.0 mmol/L showed a sensitivity of 99%, specificity of 86%, and total effectiveness of 92.81% for diagnosing DKA., Conclusion: A serum βOHB level above 3.0 mmol/L can be used as the diagnostic threshold of DKA. βOHB can serve as an index for assessing the severity of DKA.
- Published
- 2014