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3 results on '"Jing-yu Zhang"'

1. Pathophysiological mechanism, clinical classification and treatment strategy of acute progressive large vessel occlusive stroke

Author

Yi⁃ming DENG, Jing⁃yu ZHANG, Xuan SUN, Li⁃gang SONG, Lian LIU, Xiao⁃chuan HUO, Da⁃peng MO, Ning MA, Feng GAO, and Zhong⁃rong MIAO

Subjects
stroke, brain ischemia, arterial occlusive diseases, review, Neurology. Diseases of the nervous system, RC346-429
Abstract

Acute progressive large vessel occlusive stroke (APLVO) is a special kind of acute ischemic stroke with large vessel occlusion (AIS⁃LVO). Adequate medical history inquiry, detailed imaging analysis and appropriate individualized treatment can lead to better therapeutic effect for APLVO patients. This article reviews the pathophysiological mechanism, clinical features, classification and treatment strategy of APLVO, which different from other causes of ischemic stroke. DOI：10.3969/j.issn.1672⁃6731.2020.05.004

Published
2020

2. Role and action mechanism of interstitial cells of Cajal in visceral sensitization in rats with irritable bowel syndrome

Author

Rong ZHANG, Wang LU, Jing-yu ZHANG, Ming QIN, and Jing-jie WANG

Subjects
irritable bowel syndrome, interstitial Cajal cells, lcsh:R5-920, lcsh:R, lcsh:Medicine, mast cells, lcsh:Medicine (General), visceral sensitization
Abstract

Objective To explore the role and action mechanism of interstitial cells of Cajal (ICC) in the visceral sensitization of rats with irritable bowel syndrome (IBS). Methods The experimental rats were divided into 7 groups (10 each), including normal group, normal group with colonic expansion, IBS group, IBS group with colonic expansion, IBS group with colonic expansion and receiving STI-571, IBS group with colonic expansion and receiving DC, IBS group with colonic expansion and receiving both STI-571 and STI-571. Immunofluorescent double staining and electrophysiological method were used to observe the activity of ICC, the electroactivity of the rectus abdominis and the discharge frequency in dorsal commissural nucleus (DCN). Results The discharge frequency and amplitude of the rectus abdominis and DCN in the IBS rats were higher than those in the normal rats (P0.05). After inhibiting ICC proliferation with STI-571, the discharge of the rectus abdominis and DCN in the IBS rats induced by colonic expansion was significantly inhibited (P

Published
2018

3. The relation of Cx43 and NMDA to visceral sensitization in rats with irritable bowel syndrome

Author

Jing-yu ZHANG, Yu-xin HUANG, Ming QIN, Hui-jun GAO, Wei-jia DOU, and Jing-jie WANG

Subjects
irritable bowel syndrome, lcsh:R5-920, lcsh:R, lcsh:Medicine, receptors, N-methyl-D-aspartate, lcsh:Medicine (General), connexin 43
Abstract

Objective To study the relationship between connexin 43 (Cx43) and N-methyl-D-aspartate (NMDA) receptors and visceral sensitization in the rats with irritable bowel syndrome (IBS). Methods Thirty rats were gavaged with Triehinella spiralis to reproduce the IBS model. These rats were randomly divided into IBS group, IBS+colon distension group, and IBS+STI-571+colon distension group, and other groups of normal rats were randomized into normal group and normal+colon distension group, with 10 rats in each group. Immunofluorescent double staining were used to observe the expressions of intestine Cx43 and sacral NMDA re ceptors of rats in all the groups. Results The Cx43 and sacral NMDA expressions in the normal group, normal+colon distension group and IBS group showed no significant changes (P>0.05), however, Cx43 and sacral NMDA expressions were significantly higher in IBS rats with colon distension as compared with those in normal group, normal+colon distension group, and IBS group (P

Published
2016

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