1. Comparative study of 18F-FLT PET and 18F-FDG PET of lung cancer
- Author
-
Xi LIU, Nai-kang ZHOU, Jin-ming ZHANG, Chao-yang LIANG, Tao ZHANG, and Jia-he TIAN
- Subjects
lcsh:R5-920 ,lcsh:R ,lcsh:Medicine ,lung neoplasms; fluorodeoxyglucose F18; deoxy-fluorothymidine F18; positron-emission tomography; Ki-67 antigen ,lcsh:Medicine (General) - Abstract
Objective The current paper aims to investigate the value of 18F-FLT PET in the diagnosis of lung cancer and the monitoring of tumor proliferation.Methods A total of 36 patients received and cured by the General Hospital of Chinese PLA from September 2005 to October 2008(27 males and 9 females,aged 38 years to 74 years) with chest CT suspected lung cancer were examined with 18F-FLT PET.Up to 42 patients(29 males and 13 females,aged 37 years to 75 years) received and cured at the same time also underwent 18F-FDG PET.The current experimental results were compared with that of the tumor pathology.Immunohistochemistry was used to measure the expression of cell nuclear antigen of excisional disease tissues Ki-67.Results The 18F-FDG PET standardize uptake value(SUV) of lung cancer(SUV,5.2±2.9) was higher than that of the 18F-FLT PET SUV(3.2±1.3)(P < 0.05).The sensitivity of 18F-FLT PET for the detection of primary lung cancer was 77%,the specificity was 86%,and the accuracy was 78%.The sensitivity,specificity,and accuracy of 18F-FDG PET were 88%,50%,and 79%,respectively.The sensitivity,specificity,and accuracy for the lymph node staging with 18F-FLT PET were 47%,88% and 75%,respectively,compared with the 68%,84%,and 79% for 18F-FDG PET,respectively.18F-FLT SUV of lung cancer was positively correlated with the Ki-67 index(r=0.8278,P < 0.001) than that of 18F-FDG SUV(r=0.0079,P=0.968).Conclusions 18F-FLT can be made to uptake by specificity of lung cancer tissue,and its uptake value is correlated significantly with the proliferation of lung cancer.Therefore,18F-FLT PET can be applied to assist the diagnosis of lung tumor,and is expected to be a tool to determine the proliferation activity of tumor cells.
- Published
- 2011