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Objective: To analyze the prevalence of HIV among men who have sex with men (MSM) of inland high school and college students in China, and to analyze the differences between sample size, sampling methods and study period., Methods: Electronic search strategy was carried out, using WanFang database, China Journal Full-text database, VIP database, CBM and PubMed database to collect data on high school and college students, HIV and MSM, among residents in China. Fixed effects model or random effects model was employed according to statistical tests for homogeneity. Publication bias was assessed by funnel plot., Results: Ten studies were selected with a total of 2014 students-MSM and 106 HIV infected. The overall prevalence of HIV was 4.6% (95% CI 2.9%-6.3%). The prevalence of HIV was stratified by factors as sample size, sampling methods and study period of the study. The pooled prevalence rates of HIV were as follows: 4.7% (95% CI 2.5%-7.0%) and 4.7% (95% CI 1.9%-7.4%) for sample size > 200 and sample size 200, 6.1% (95% CI 3.0%-9.1%) and 2.9% (95% CI 1.7%-4.1%) for snow sampling and non-snow sampling, respectively. The pooled prevalence of HIV were 3.0% (95% CI 1.7%-4.2%) in the study year of 2005-2007 and 6.0% (95% CI 3.1%-9.0%) in 2008-2010, respectively. The pooled prevalence of HIV was higher in snow sampling than non-snow sampling, in the study year of in 2008-2010 than in 2005-2007., Conclusion: The prevalence of HIV among MSM of inland high school and college students in China was higher than general population.