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Background and objective Leptomeningeal carcinomatosis is a rare type of metastatic tumors of the central nervous system. In recent years, with the improvement of neoplasms therapies and longer survival of patients by better systemic control, incidence of leptomeningeal metastases has increased every year. However, there is still lack of effective therapies. The aim of this study is to investigate the efficacy, security and prognosis of intrathecal chemotherapy with methotrexate (MTX) in the treatment of neoplastic meningitis. Methods A total of 27 patients were enrolled. We investigated clinical features and cerebrospinal fluid (CSF) examination results retrospectively, and analyzed the adverse reactions as well as prognosis after intrathecal chemotherapy. Results All 27 patients were treated by intrathecal MTX, 70.4% had clinical remission, however, there was no significant difference in CSF pressure and CSF biochemical changes. We observed that 55.6% patients were all appropriate, 25.9% appeared lower limb numbness and mild pain, no serious irreversible adverse reactions occurred. Median overall survival was 4 months. Conclusion We suggest that intrathecal administration of MTX is associated with improvement of symptoms of leptomeningeal metastasis patients and no severe adverse events observed.

Objective: This study aimed to explore the period of endodontic treatment and the effects of periodontal-endodontic treatment for advanced periodontitis., Methods: A total of 180 patients with advanced periodontitis participated in this clinical multicenter study. The respondents were randomly divided into an endodontic combined treatment (experimental) group and a periodontal treatment alone (control) group; each group consisted of 90 teeth. The control group received periodontal therapy only. The experimental group received periodontal therapy and root-canal treatment, and then pulp status was recorded. The cases were followed up at 1, 3, 6, and 12 months after treatment., Results: Out of 90 teeth in the test group, 22 teeth had completely necrotic pulps, 45 teeth had partial necrosis (coronal pulp necrosis or root pulp necrosis), and 23 had vital pulp. Differences between clinical parameters in the control and experimental groups were not significant (P>0.05) before treatment but were significant after three months (P<0.05)., Conclusions: Pulp treatment for teeth with advanced periodontitis and dull pulp vitality can control the development of inflammation and thus benefit the healing of periodontal tissue.