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As the simplest type of DNA polyhedron, tetrahedral framework nucleic acids(tFNAs)gradually show their potential in stomatology. tFNAs continue to attract attention due to their excellent endocytosis ability, tissue permeability, strong editability, and predictability. This article summarizes the relevant literature, discussing the advantages of tFNAs in preparation and biological behavior regulation. It focuses on the latest research progress and potential application value of framework nucleic acids in stomatology. It provides a theoretical basis for future nucleic acid drugs to achieve broader clinical applications.