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The transmembrane protein(TMEM) family exhibits widespread distribution across both the plasma membrane and organelle membranes, actively participating in the intricate regulation of diverse pathophysiological processes. Contemporary investigations have uncovered the pivotal involvement of the TMEM family in the human reproductive system. This family is found to play a crucial role in regulating spermatogenesis, sperm-egg fusion, endometrial receptivity, as well as tumor invasion and migration. These findings highlight its intricate association with the onset and progression of various diseases. A comprehensive identification of the function of TMEM family in human reproductive system holds significant importance, offering profound insights into the nuanced biological functions of this protein family. This in-depth examination not only supports our understanding about the complex mechanisms controlling reproductive processes but also lay a foundation for potential advancements in medical research.

Treatment effect is widely used in microeconomics, especially in the literature of program evaluation. In order to estimate the treatment effect consistently, there usually imposed strong restrictions (for example, conditional mean independence) or adopt instrumental variable method. There are few researchers on treatment effect model under less restrictive assumptions. In this paper, we consider nonparametric identification and estimation of conditional treatment effect model under joint symmetry re-striction, and further estimate the average treatment effect. Our model relaxes restriction of the functional form, and also considers a more general form of heteroscedasticity, which greatly reduces the possibility of model misplacement and expands the applicability of the existing model. The proposed estimator is shown to be consistent and asymptotically normally distributed, and it also performs well in the simulation. Finally, we apply our approach to estimate the return of college education and gender difference to explain the practical value. [ABSTRACT FROM AUTHOR]