Search

The hypoglycemic effects of white tea were investigated, using a newly developed non-insulin-dependent diabetes mellitus (NIDDM) zebrafish model.. Treatment of the NIDDM zebra fish with 50 and 100 μg/mL of aged white peony tea (AWP), decreased the level of glucose (GLU) by 29.68% and 20.51%, respectively, after 24 h. After 48 h, the GLU values decreased by 42.16% and 51.54%, respectively, and the differences were significant (P<0.05). Moreover, the GLU values in the 25, 50, and 75 μg/mL white peony tea (WP) groups decreased by 40.18%, 52.57%, and 62.11%, respectively, after 24 h of treatment, and the differences were significant (P<0.05). The effect of white tea treatment on GLU levels of insulin-dependent diabetes mellitus (IDDM) zebrafish was also investigated. In this model, the GLU values of the 20 and 30 μg/mL AWP treatment groups (24 h) decreased by 24.92% and 23.66%, respectively, and AWP treatment for 48 h decreased GLU by 54.35% and 38.38%, respectively (P<0.05). The GLU value of the 40 μg/mL WP-treated group decreased by 22.58% (P<0.05) after 24 h, and the corresponding values in the 20 μg/mL WP-treated group, after 48 h of treatment, decreased by 26.51% (P<0.05). After incubation with 30 μg/mL tea polyphenols (TP) for 48 h, the GLU value decreased by 24.53% (P<0.05). Importantly, the hypoglycemic effects of 20 μg/mL of either WP and AWP on NIDDM zebrafish were significantly better than that of 30 μg/mL of tea phenols (TP). The hypoglycemic effect of 30 μg/mL AWP on IDDM zebrafish was slightly better than that of TP, and significantly better than that of WP. Taken together, these results suggest that both white tea and TP have a significant hypoglycemic effect; however, the hypoglycemic effect of white tea was not limited to TP dependence. The identity of the specific active components in white tea warrant further research. [ABSTRACT FROM AUTHOR]

The present study aimed to investigate hypoglycemic effect of polysaccharide from Dolichos lablab L. (named WHBP) involved in hypothalamic-pituitary-adrenal (HPA) axis in a type II diabetic rat model. In this work, Type II diabetic rat model was established by high fat and high sugar diet combined with the tail vein injection of STZ (30 mg/kg BW), and then these rats were received 1.5 mL of WHBP referring to high (100 mg/kg bw), medium (50 mg/kg bw) and low (25 mg/kg bw) dose of WHBP, respectively. Administration for 4 weeks, the main parameters were examined including body weight, fasting blood glucose (FBG), the serum contents of insulin (INS), corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT). Additionally, the levels of sodium-glucose cotransporter 1 (SGLT1）mRNA was also determined in this work. The results showed that WHBP significantly reduced the levels of FBG and serum INS in type II diabetic rats(P0.05). Furthermore, high-dose WHBP significantly reduced serum CRH, ACTH and CORT contents in type II diabetic rats(P

Copyright of Shipin Kexue/ Food Science is the property of Food Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study hypoglycemic effects of different mulberry leaf extracts on diabetic mice., Methods: STZ-induced diabetic mice were intragastricly administrated with different mulberry leaf extracts( water extracts: 800 mg/kg, ethanol extracts: 500 mg/kg, water extracts + ethanol extracts: low dose 150 mg/kg, high dose300 mg/kg) and positive control group( melbine: 227. 5 mg/kg). Four weeks later, serum glucose levels, insulin levels, antioxidase activities were tested. Liver and pancreas pathological changes were observed by HE staining., Results: Compared with model group, each mulberry leaf extracts group could decrease serum glucose and insulin levels and increase antioxidase activities. The mixture of water extracts and ethanol extracts at high dose showed the most obvious effects. In this group, serum glucose levels, insulin levels, insulin resistance index and insulin sensitivity index were 61. 0%, 64. 1%, 42. 9% and 1. 18 times of those in the model group( P < 0. 05), and no significant differences were found between this group and the positive group( P > 0. 05)., Conclusion: The mixture of mulberry leaf water and ethanol extracts showed synergistic hypoglycemic effects by increasing antioxidase activities, repairing pancrea and liver oxidative damages, and improving insulin resistance status.