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Bronchial asthma is a common chronic inflammatory disease of the lung， which can cause great health problems and socioeconomic burden. In recent decades， the prevalence of asthma in China has been increasing， and multiple factors have synergistically affected the progress of asthma. More and more studies have found that lipid metabolism disorders play an important role in the development of asthma. High density lipoprotein （HDL） has the functions of reverse cholesterol transport （RCT）， regulation of inflammation and anti-oxidation， and is also involved in the regulation of the immune system and lipid metabolism. Previous studies have shown that serum HDL is associated with the occurrence of asthma. The level of HDL in patients with severe asthma and acute exacerbation of asthma is low.