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Background and objective SMARCA4-deficient non-small cell lung cancer (SMARCA4-dNSCLC) is a rare primary lung malignancy. These diseases are not listed separately in the 2021 World Health Organization (WHO) classification of lung neoplasms, but they have special morphological, immunophenotypic and molecular genetic characteristics. This study aims to improve understanding of SMARCA4-dNSCLC by discussing the clinicopathological features, diagonosis and differential diagnosis of the disease. Methods The clinical and imaging data of 9 cases of SMARCA4-dNSCLC diagnosed in Shanghai Changhai Hospital from January 2020 to March 2022 were collected. The clinicopathological features were analyzed by histological and immunohistochemical staining, and the literature was reviewed. Results The median age of 9 patients was 65 years old. Six men were smokers. The average maximum diameter of tumor was 3.3 cm. Six cases had been metastasized. The imaging showed that it was an infiltrating mass with unclear boundary and 3 cases invaded the pleura. Nine cases were diagnosed as SMARCA4-dNSCLC, which mainly showed three pathological forms including classic lung adenocarcinoma, mucinous adenocarcinoma and poorly differentiated carcinoma. Poorly differentiated tumor cells are epithelioid, syncytial or rhabdomyoid, the cytoplasm was rich, the cytoplasm could be completely transparent to eosinophilic, eosinophilic globules or small abscesses could be seen, showing solid flakes, with more inflammatory cells and flake necrosis in the stroma. Immunohistochemistry showed that SMARCA4 was negative in all cases and eight cases demonstrated cytokeratin 5.2 (CAM5.2) and cytokeratin 7 (CK7) was diffusely strongly positive, p40 was negative, thyroid transcription factor-1 (TTF-1) was negative in 6 cases, partially positive in 2 cases and diffusely positive in 1 case. Conclusion SMARCA4-dNSCLC is a rare subtype of lung cancer with complex and diverse pathological morphology. The characteristic of immunohistochemical phenotype can assist in the diagnosis.

Separation of strontium isotope is an important and challenging work. Herein, a novel method was developed for preparing of acid-resistance crown ether pillared zirconium phosphonate (D-AM-ZrP) by a directly one step reacting 4-amino-benzo-18-crown-6 phosphonic acid with zirconium other than the conventional complicated intercalation methods. By suitable control of the ratio of phosphoric acid to phosphonic acid, the D-AM-ZrP sample with perfect flower-like and well-ordered interlayer structure was obtained. More importantly, D-AM-ZrP exhibited high adsorption capacity and excellent selectivity for extracting Sr2+ from complicated system including high concentrated HNO3 media and competing ions, and the maximum adsorption capacity for Sr2+ (136.42 mg·g-1) was better than that of pure α-ZrP (28.17 mg·g-1) at weak acidic media, which could mainly be attributed to the presence of the strong chemical interaction between the intercalated molecule and material, resulting in its excellent stability and abundant adsorption sites.