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Objective: To investigate the effect of gonadotropin releasing hormone agonist (GnRH-a) pretreatment combined with high intensity focused ultrasound in the treatment of adenomyosis. Methods: 298 patients with adenomyosis admitted to our hospital from January 2019 to May 2021 were randomly divided into the control group and the experimental group using a random number table method, with 149 patients in each group. The control group received high intensity focused ultrasound treatment, while the experimental group received GnRH-a pretreatment, after 2 consecutive menstrual cycles, high intensity focused ultrasound treatment was combined. Both groups were followed up for 2 years after treatment. The lesion volume, uterine volume, menstrual volume, pain level, levels of hormones, serum cytokine before and 3 months after treatment, adverse reactions during treatment, recurrence and pregnancy outcomes during followed up between the two groups were compared. Results: Compared with before treatment, after 3 months of treatment, the lesion volume and uterine volume of the two groups decreased, experimental group was smaller(P<0.05); the menstrual volume, score of numeric rating scale (NRS), serum levels of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), and transforming growth factor β2(TGF-β2), vascular endothelial growth factor(VEGF) of the two groups decreased, the experimental group compared to the control group was lower (P<0.05); the level of serum adiponectin (ADP) increased in both groups, experimental group was higher (P<0.05). There was no significant difference in the incidence of sacrococcygeal pain, radiating pain, lower abdominal pain, and irregular vaginal bleeding between the experimental group and the control group during the treatment period(P>0.05); the recurrence rate and abortion rate during the followed up period in the experimental group were 6.04% and 10.58%, respectively, lower than the control group's 17.45% and 35.21% (P<0.05); the clinical pregnancy rate during the followed up period in the experimental group was 69.80%, which was higher than 47.65% in the control group(P<0.05). Conclusion: GnRH-a pretreatment combined with high intensity focused ultrasound could regulate levels of hormone and serum cytokine in patients with adenomyosis, reduce lesion volume and uterine volume, reduce menstrual flow, alleviate pain, and improve pregnancy outcomes, with good safety. [ABSTRACT FROM AUTHOR]

Objective To evaluate the efficacy and safety of high intensity focused ultrasound (HFIU) combined with endometrial ablation in the treatment of adenomyosis (AM) patients with heavy menstrual bleeding (HMB). Method A total of 199 patients with AM combined with HMB who underwent HIFU treatment at the Obstetrics and Gynecology Center of Affiliated Hospital of Chengdu University of TCM from July 2020 to September 2022 were selected and divided into two groups according to the ablation range. The combined ablation group included 80 cases with lesion and endometrial ablation (endometrial ablation rate ≥ 30%), while the lesion ablation group 119 cases with simple lesion ablation. A 1:1 propensity score matching was performed on the two groups, resulting in 59 patients in each group. A 6-month follow-up was conducted. The clinical manifestations (menstrual volume, degree of dysmenorrhea, uterine and lesion volume), quality of life (MS-QOL, UFS-QOL), and postoperative adverse reactions between the two groups before and 6 months after surgery was compared. Results Menstrual volume, degree of dysmenorrhea, uterine and lesion volume, MS-QOL score, and UFS-QOL score of the both groups were improved 6 months after surgery, when compared to those before surgery (P < 0.05). Significantly reduced menstrual volume, degree of dysmenorrhea, and lower MS-QOL score were observed in the combined ablation group when compared with the lesion ablation group (P < 0.05), but there was no statistical significance in uterine and lesion volume and UFS-QOL score (P > 0.05). There was no difference in the incidence of adverse reactions between the two groups (P > 0.05), but the combined ablation group had longer vaginal bleeding and fluid flow time (P < 0.05). Conclusion The combined HIFU and endometrial ablation can effectively reduce menstrual flow, alleviate dysmenorrhea, and improve quality of life in patients with AM combined with HMB. Although it increases vaginal bleeding and fluid flow time, reasonable symptomatic management can effectively prevent the occurrence of adverse consequences such as infection. [ABSTRACT FROM AUTHOR]

Objective: To investigate the changes of immunological status and imaging evaluation of high intensity focused ultrasound(HIFU) in the treatment of adenomyosis(AM). Methods: 186 patients with AM admitted to Shijiazhuang People’s Hospital from December 2020 to December 2021 were selected. Before and after HIFU ablation, serum complement C3, C4, the ratio of helper T cell17 to regulatory T cell(Th17/Treg) and magnetic resonance imaging(MRI) were detected.Compare the differences of ultrasound characteristics, MRI measurement parameters, serum complement C3, C4, Th17/Treg levels in AM patients before and after treatment; Spearman correlation was used to analyze the correlation between the levels of serum complement C3, C4, Th17/Treg and the ablation rate and MRI parameters of the non-perfusion area after treatment. Results: Before HIFU treatment in AM patients, ultrasound showed that the echo of the myometrium of the uterine wall was uneven, the blood flow signal of the myometrium was rich, and the blood flow of the focus was rich; MRI showed that the uterus was non-uniformly enlarged, the uterine wall was significantly thickened, the boundary with the uterine junction was unclear, and the signal was uneven. The dynamic enhancement scan showed that the focus was non-uniformly enhanced, and the degree of enhancement was slightly lower than that of the normal myometrium nearby. VAS score of AM patients after HIFU treatment was significantly lower than that before treatment(P＜0.05); Ultrasound showed that the echo of the myometrium of the uterus was uneven, and the blood supply of the myometrium was significantly reduced. MRI showed that the thickening of the uterine wall was reduced, and the signal was uneven. The enhancement scan showed that the central perfusion area was not enhanced, and the peripheral nodular or irregular enhancement was the residual focus, and the ablation rate was about 90%. After HIFU treatment, the levels of serum complement C3 and C4, ADC value and MSI value of residual lesions increased significantly(P＜0.05), while Th17/Treg,ADC value and MSI value of non-perfusion zone decreased significantly(P＜0.05). After HIFU treatment, serum complement C3 and C4levels were significantly negatively correlated with ablation rate, ADC value and MSI value in non-perfusion zone(P＜0.05), while Th17/Treg was significantly positively correlated with ablation rate, ADC value and MSI value in non-perfusion zone(P＜0.05). Conclusion: The changes of immunologic status and MRI evaluation after HIFU treatment of AM patients can help predict the prognosis of AM patients, and guide clinicians to provide objective and realistic basis for the choice of follow-up treatment plan for AM patients. [ABSTRACT FROM AUTHOR]

This study deals with a numerical simulation of the growth of bubble nuclei and the corresponding bubble cloud formation in a pressure field given by high intensity focused ultrasound (HIFU) backscattered from a laser-induced bubble interface. In the present paper, using a multiscale numerical method (Tamura et al., Japanese J. Multiphase Flow, 2022) in which the ghost fluid method is coupled with bubble dynamics, the growth of the bubble cloud which consists of multiple bubble layers is simulated continuously as observed in the experiments. It is shown that the distance between the first cavitation inception point and a laser-induced bubble interface is about 0.27λ, where λ, is the wavelength of HIFU; the distance between bubble layers in the cloud is also about 0.35λ: these distances in the simulation are in good agreement with the experiments. The influence of the configuration of bubble nuclei on the final form of a cone-shaped bubble cloud is investigated. It is also shown that the shape of each bubble layer, which depends on the initial configuration of bubble nuclei, affects the final formation of bubble clouds. This is because that the negative pressure due to the backscattering of HIFU is dependent on the shape of each bubble layer. The results also show that the averaged final shape of bubble clouds quantitively matches the results as observed in the experiment by Horiba et al. (J. Acoust. Soc. Am., 2020). [ABSTRACT FROM AUTHOR]

Copyright of Journal of Computer-Aided Design & Computer Graphics / Jisuanji Fuzhu Sheji Yu Tuxingxue Xuebao is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

With the widespread use of serum PSA level screening and multi-parameter magnetic resonance imaging, the number of diagnoses of prostate cancer has increased. Traditionally. prostate cancer is mainly treated through active monitoring. radical prostatectomy or radiotherapy. Local treatment is a relatively new method the main feature is the local ablation of prostate cancer lesions and the preservation of surrounding healthy tissues. Compared with total gland therapy. local therapy has relatively satisfactory mid-term efficacy and a lower incidence of complications. At present the most discussed local treatment methods mainly include cryotherapy, high-intensity focused ultrasound. laser ablation. photodynamic therapy, and irreversible electroporation. This article combines the existing literature reports at home and abroad to review the local treatment of prostate cancer. [ABSTRACT FROM AUTHOR]

Polyethersulfone (PES) and hollow glass microspheres (HGB) were used as fillers to modify the epoxy resin, and its effect on the mechanical and thermal properties of the epoxy polymer phase was studied. The research found that when epoxy polymer phase was prepared with 1 Owt% PES or HGB loadings, the shear strength increased from 39 MPa to 52 MPa? the thermal expansion coefficient decreased from 8.8 X 1 ()_r)/K to 5.8 X 10_5/K? and the mechanical and thermal properties of the material were significantly improved. Using PZT-4 as the piezoelectric phase? a 1 -3 type piezoelectric composite material with a PES and HGB filling content of 10% by weight was prepared by a cutting and filling method. The influence of temperature on resonance frequency /s and electromechanical coupling coefficient kt was measured by impedance analyzer. The results show that the /s of 1-3 piezoelectric composites was 885 kHz and kt was ().65. The change rate of /s and kt of the material within the range of 15-5() °C was less than 1% which showed good temperature stability. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Medical Equipment Journal is the property of Chinese Medical Equipment Journal Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In the research field of high intensity focused ultrasound (HIFU) against tumor, ideal multi-modal and multi-functional nano-theranostic agents not only can reach the target site specifically which realize the purpose of diagnostic imaging, but also can effectively realize local targeting therapy. HIFU combined with nano-biotechnology as a new cancer treatment has great advantages and terrific diversified functions. Recent progress in the research of nano-biomaterials in HIFU field is reviewed in this paper. [ABSTRACT FROM AUTHOR]

Objective To investigate the safety and effectiveness of high intensity focused ultrasound (HIFU) in the treatment of giant uterine fibroids (GUF) to provide evidence for its clinical rational treatment. Methods Totally 50 patients with GUF treated with HIFU in the Chongqing Haifu Hospital from June 2011 to May 2015 were selected. The enhanced MRI was reexamined on 1 d after treatment for measuring and calculating the fibroids ablation rate. Follow up was performed for 6 months after treatment. The change of tumor size was compared between before and after treatment, the improvement situation of clinical symptoms was followed up. The adverse reactions situation of pain after treatment, radiating pain of lower limbs and vaginal abnormal discharge was performed the statistics. The treatment related adverse reactions were evaluated according to the criteria of the International Society for Interventional Radiotherapy (SIR). The effectiveness and safety of treatment were evaluated. Results Total 52 GUF in 50 cases were smoothly received the HIFU ablation therapy, the grey scale change was observed during treatment, the postoperative ablation rate was (77.8±14.9)%. The tumor volume was smaller than before treatment by 6-month follow up with the shrinkage rate of (59.6 ±20.8)%, and the difference was statistically significant (P<0.05), the clinical symptoms were improved in different degrees. No serious complications occurred after treatment. Conclusion HIFU is safe and effective for the treatment of GUF and can be used as one of treatment schemes in clinic. [ABSTRACT FROM AUTHOR]