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1. [Influences of 3,4,5-trihydroxystibene-3-beta-mono-D-glucoside on rabbits' platelet aggregation and thromboxane B2 production in vitro].

Author

Shan CW, Yang SQ, He HD, Shao SL, and Zhang PW

Subjects
Animals, Dose-Response Relationship, Drug, Female, In Vitro Techniques, Male, Rabbits, Glucosides pharmacology, Platelet Aggregation drug effects, Platelet Aggregation Inhibitors pharmacology, Stilbenes pharmacology, Thromboxane B2 biosynthesis
Abstract

Platelet aggregation and thromboxane B2 (TXB2) production induced by arachidonic acid (AA) or Adenosine diphosphate (ADP) were studied by turbidimetry and radioimmunoassay in rabbits. 3,4,5-tri-hydroxystibene-3-beta-mono-D-glucoside (PD) 6.7-107.2 mumol/L inhibited platelet aggregation and the production of TXB2 as well. The inhibitions by PD were dose-dependent: 48-90% (AA-induced) and 43-69% (ADP-induced) for platelet aggregation; 50-87% (AA-induced) and 43-68% (ADP-induced) for TXB2. There were positive correlations between the inhibition of platelet aggregation and production of TXB2.

Published
1990

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