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Powder bed fusion titanium alloys， as an important metallic material， are widely used in aerospace， medical devices and automotive industries.However， due to their unique material properties and processing methods， surface quality and performance remainone of key issues that constrain their application.In this paper， the research progress on surface polishing techniques for powder bed fusion titanium alloys was reviewed.The advancements in chemical polishing， electrochemical polishing， plasma electrolytic polishing， laser polishing and mechanical polishing were introduced.These techniques have provided options for achieving surface quality and performance that meet various application needs for powder bed fusion titanium alloys.Additionally， the development of composite polishing technologies and related advancements were also prospected.

In order to systematically understand the various types of water hazards and standardize the management of water prevention and control work in coal mines, the National Mine Safety Administration in June 2022 extended the “three zones” management methodology for old goaf water prevention and control to more types of water hazards, such as roof water, floor water, and structural water. However, in the process of dividing the “three zones” of water prevention and control in coal mines, it is revealed that the water damage causing factors and water damage management situation are not closely linked with the division standard, and that technically different divisions are not made for different coal seams and mining areas, and there are inconsistencies in the scope of the division area, and the standardization and timeliness of the division results. Accordingly, combined with the purpose of water hazard prevention and control “three zones” division, compared the similarities and differences between the new and old “three zones” division work, this paper clarifies the degree of hydrogeological conditions survey, water hazard analysis, water hazard management as elements of the division principles, and determines the technical path of the division of the “three zones”. Combining the characteristics of five common types of water hazards in coal mines, the paper puts forward the division method of different types of water hazards, that is: surface water hazard should be divided according to the distribution and development characteristics of surface water bodies in the mining area and the degree of influence of atmospheric precipitation, landslides and other geological disasters in mining. The roof water hazard should be divided according to whether there is a strong water-rich aquifer, a medium water-rich but hydrostatic reservoir-rich aquifer, a loose aquifer. The floor water hazard should be divided according to the relationship between the thickness of the floor water barrier and the depth of the floor mine pressure damage zone in the coal seam pressure mining area, as well as the size of the floor water inrush coefficient. The old goaf water hazard should be divided according to the distribution range and amount of water in the mine and the surrounding mines. The structural water hazards should be divided according to the water-richness, water content, and water source conduction of geological structures and bad geological bodies such as faults, trap columns and caves in the mining area. The key points and difficulties of the division work include the clear division of time and space scope, the comprehensive analysis of division standards, the clear management responsibilities for the “three zones”, and the dynamic transformation of division results. On this basis, typical coal mines with various types of water hazards and complex hydrogeological conditions are selected as case studies. Following the principle of division, according to the division standard, the mineable zone, the slow mining zone and no-mining zone are divided by the method of separating coal seams and mining areas, and detailed explanations are given. The significance of carrying out the division of the “three zones” for water hazard prevention and control is clarified, which can enhance the comprehensive detection level, strengthen the prediction ability, and identify the direction of water hazard management in order to guide and standardize the division of the “three zones” for water prevention and control in the coal mines of China.

This study primarily analyzes the coevolution principle and derives the coevolution model of synergistic mining technology to promote change in traditional mining technology and make up for some vacancies in the basic theory of synergetic mining technology. First, the system of synergetic mining technology is improved from technology classification and composition aspects. According to the synergetic mining system subsystems, synergetic mining technology is classified into three types, and the three components of synergetic mining technology are analyzed. Second, drawing on biological coevolution, we provide supporting evidence for the coevolution of synergetic mining technology, showing that its formation and implementation are processes of coevolution. We analyze the self-organized evolution conditions and characteristics and reveal the coevolution principle of synergistic mining technology based on the following principles: the premise is an open and nonequilibrium state; the driving force is the nonlinear interaction generated by competition and synergy; the causative factor is the random uptick and downturn; and the pathway is the phase transition and bifurcation. Because the Haken model can effectively study the self-organized coevolution of complex systems, this study argues that constructing the evolution model of synergistic mining technology based on the Haken model is feasible. Along with analyzing the type of coevolution of synergistic mining, this study constructs a coevolution model based on the Haken model, derives the coevolution equations and the potential function of synergistic mining technology, and highlights its significance. The application of the constructed model is ensured by introducing an empirical analysis based on the Haken model, and the application method of the coevolution model of synergetic mining technology is proposed and divided into three steps: constructing the index system, measuring the state of subsystems, and analyzing the coevolution mechanism. It realizes the precise identification of sequential parameters, the quantitative characterization of the synergy degree, and the analysis of the positive and negative feedback mechanisms of the subsystem on the synergetic mining system based on the parameters of the sequential parameter equation. Finally, the applicability and reliability of the model are verified by combining the example of synergetic mining technology in the No. 105 ore body of the Gao Feng Mine. The innovation of the article primarily lies in the following: the coevolution principle of synergistic mining technology is analyzed in depth concerning biological coevolution, and a coevolution model that can be practically applied is established based on the Haken model, quantitatively manifesting the coevolution mechanism of synergistic mining technology and the synergism degree. The results of this study can provide a theoretical basis for the practice and decision-making of synergetic mining technology.

Background The risk of diabetes mellitus can increase with age, and the prevalence of prediabetes and diabetes mellitus in the middle-aged and elderly adults is 40% and 10%, respectively. Good adherence to blood glucose monitoring improves the rate of glycohemoglobin compliance. However, adherence to blood glucose monitoring is poor in patients with type 2 diabetes mellitus (T2DM) in rural areas. Objective To investigate and understand the blood glucose monitoring situation of middle-aged and elderly patients with T2DM aged 45 to 65 years in rural areas of Zhongmou County, Henan Province, explore the psychological and behavioral factors affecting their adherence to blood glucose monitoring and monitoring frequency, so as to provide a reference for targeted interventions to improve the blood glucose monitoring compliance of the middle-aged and elderly patients with T2DM in rural areas. Methods Middle-aged and elderly T2DM patients in rural areas of Zhongmou County, Henan Province from November 2 to 12, 2021 were selected to conduct for questionnaire survey by using convenience sampling method. A self-designed general information questionnaire was used to investigate their basic information and blood glucose monitoring. Additionally, the Five-item Mindful Awareness Attention Scale (MAAS-5), Generalized Anxiety Disorder Questionnaire (GAD-7), Patient Health Questionnaire (PHQ-9), and Diabetic Self-management Scale (DSMS) were used to investigate their mindfulness, anxiety, depression, and self-management ability, respectively. Univariate analysis, multivariate Logistic regression and negative binomial regressions were used to explore the influencing factors of situation and frequency of blood glucose monitoring and monitoring frequency in middle-aged and elderly T2DM patients. Results A total of 484 questionnaires were collected, and 469 were enrolled in this study, with a recovery rate of 96.9%. Of the 469 patients, 58.8% (276/469) were unable to monitor blood glucose monthly, and the frequency of monthly blood glucose measurements for the 193 patients who monitored blood glucose ranged from 1 to 60 times, with a median of 2 times. Logistic and negative binomial regression analysis showed that depression symptoms (AOR=1.127, P=0.005), high information level (AOR=0.133, P=0.023), and high motivation level (AOR=1.093, P=0.002) were facilitators of blood glucose monitoring; high annual income (AIRR=2.063, P

Objective To explore the feasibility of using autologous platelet-rich plasma (PRP) in the treatment of deep second-degree burns complicated with wound infection. Methods A retrospective analysis was conducted on the treatment process of a patient with deep second-degree burns and bacterial infection on the wound using autologous PRP. Clinical treatment highlights and outpatient follow-up were combined to discuss the feasibility and clinical effects of using autologous PRP in the treatment of burn wounds complicated with infection. Results The patient had a deep second-degree burn with a coagulase-negative Staphylococcus infection on the left lower limb. After one week of conventional wound dressing and antibiotic treatment, the patient's body temperature returned to normal. However, wound healing was slow and yellow secretion persisted. Subsequently, the burn wound was treated combined with topical autologous PRP. The wound pain score gradually decreased from 8 to 1. After 2 weeks, the bacterial culture of the wound secretion was negative, and the wound healed completely after 18 days. The wound scar score decreased from 5 to 2 at 1, 3 and 6 months after PRP treatment, and no obvious scar formation was observed. In the course of PRP treatment, there were no adverse reactions such as increased wound inflammation, abnormal blood routine and liver and kidney function test results. Conclusion For deep second-degree burn patients with localized wound bacterial infections who either refuse surgery or are not suitable for surgery, autologous PRP is a safer alternative that can effectively promote tissue regeneration and wound healing. The patient in this case achieved a curative effect in a short period of time.

In order to improve the service performance of Zr-4 alloy in nuclear industry and avoid introducing impurity elements， the micro-arc oxidation ceramic layer was prepared on the surface of Zr-4 alloy with Li2B4O7 as electrolyte.The effects of lithium tetraborate concentration on phase composition， microstructure， film thickness， hardness， roughness， wear resistance and corrosion resistance of micro-arc oxidation ceramic layer were investigated.Results showed that as the concentration of Li2B4O7 increased in the range of ρ(Li2B4O7)＝3～15 g/L， the conductivity of the electrolyte continued to increase， and the roughness of the ceramic layer continued to increase overall， which only slightly decreased when the electrolyte concentration changed from 6 g/L to 9 g/L.The thickness of micro-arc oxidation ceramic layer first continuously decreased in the range of ρ(Li2B4O7)＝3～9 g/L and then increased in the range of ρ(Li2B4O7)＝9～15 g/L.The hardness of the ceramic layer first decreased in the range of ρ(Li2B4O7)＝3 ～6 g/L， and then increased in the range of ρ(Li2B4O7)＝6 ～15 g/L.In addition， the ceramic layers were all composed of monoclinic zirconia (m-ZrO2).As the concentration of Li2B4O7 in the electrolyte increased， the porosity of the ceramic layer decreased and the micropore size changed little.The friction coefficient of the ceramic layer increased continuously in the range of ρ(Li2B4O7)＝3～12 g/L， and decreased when ρ(Li2B4O7)＝15 g/L.By comprehensive comparison， the ceramic layer with moderate thickness， good hardness， smooth and continuous surface， small porosity and pore size， good wear resistance and corrosion resistance could be obtained in the electrolyte with ρ(Li2B4O7) ＝ 15 g/L.

DC distribution network is the main development direction of the power distribution system. Due to the influence of electronic equipment and other factors, the system is very easy to produce second harmonics, which seriously affects the stability of the system and the safety of electrical equipment. Multi-filter collaborative filtering in DC distribution network has become one of the methods to control the second harmonic. However, due to the coupling interference between the filters, the filtering effect is affected by multiple factors. This paper establishes a Norton equivalent grid-connected model of multiple filters and proposes a method for analyzing the interaction mechanism of multiple filters based on the relative gain matrix theory. This method establishes the matrix relationship between the change in the output current of the filter and the change in the harmonic source current and analyzes the influence of the grid parameters and controller parameters in the multi-filter grid-connected system on the filtering effect of the filter, and proposes a reasonable parameter selection method. Finally, this paper establishes a DC distribution network model with multiple DC filters in PSCAD/EMTDC, and simulates the parameters affecting the filtering effect and verifies the rationality of the analysis in the scenario of multiple harmonic sources. In addition, it builds a semi-physical simulation model in RT-LAB to further verify the effectiveness of the method.

According to the grid point data of precipitation， average temperature， maximum and minimum temperature in Gansu Province from 1962 to 2019， combined with climate zoning， and using the methods of least squares， CEEMDAN analysis， cross wavelet transforms， wavelet coherence and Hurst Index， etc.， analysis of regional differences in climate change and circulation effects in Gansu over the past 58 years. The results showed that： （1） The linear trend analysis shows that the climate of Gansu has been warming and wetting in recent 58 years， and the warming trend is more significant than the precipitation increase trend.Spatial analysis shows that climate change varies greatly in different regions of Gansu province in the past 58 years， with the exception of the Hexi region， the precipitation in other regions shows a decreasing trend.Gannan’s cold and humid regions experienced the largest decreases in precipitation and the largest increases in temperature.（2） According to CEEMDAN analysis， the period of precipitation increase is about 9 years and the period of precipitation decrease is about 12 years in Gansu province.The average temperature rises and fall cycle is about 7 years.The cycle of maximum temperature increase is about 7 years， and the cycle of decrease is about 9 years.The rising cycle of minimum temperature is about 7 years， and the decreasing cycle is about 5 years.Overall， the change of temperature in Gansu province is about 15 years earlier than that of precipitation.The lowest temperature change is the earliest， and it began to increase obviously from 1962， and the precipitation change is the latest and began to increase obviously from 1992.（3） The Hurst index analysis shows that the climate change in each region has a strong continuity， and the future climate change trend in Gansu Province will be roughly consistent with that in 1962 -2019.（4） By monitoring the relationship between the Nino3.4 index and regional climate change in Gansu， the mean annual precipitation and ENSO events in the subtropical humid region of the southern Southern Gansu River Valley， the warm temperate humid region of the northern Southern Gansu Valley， the temperate and semi-humid region of the southern Gansu， and the temperate and semi-arid region of the northern Gansu are all negatively correlated with each other， the negative correlation coefficients were -0.29， -0.27， -0.29 and -0.3， respectively， which passed the reliability test of 0.05.The highest temperature in the temperate semi-arid region of northern Gansu was positively correlated with ENSO events， and the positive correlation coefficient was 0.28， and passed the reliability test of 0.05.（5） Cross wavelet transforms and wavelet coherence analysis show that the cooperative variation relationship between ENSO and rainfall in the temperate sub-humid zone in the southern part of Central Gansu and the temperate semi-arid zone in the northern part of Central Gansu has high consistency.

In this paper, the comprehensive recovery of copper from a magnetic separation tailings in Hubei Province is studied. The process mineralogical study shows that the composition of the tailings is relatively complex, with low copper content of 0.38% and fine disseminated particle size. Copper mainly occurs in primary copper sulfide, with a distribution rate of 74.08%. The copper ore is mainly chalcopyrite, a small amount of copper blue, chalcocite, etc., and the gangue mineral is mainly quartz, the second is calcite, dolomite, sericite, a small amount of feldspar, kaolinite and so on. According to the characteristics of "poor, fine and miscellaneous" copper minerals in tailings, the CCF flotation column was used to carry out the beneficiation test of recovering copper. The results show that after one roughing, one scavenging and two cleaning operations, the copper concentrate with copper grade of more than 16% and copper recovery of more than 76% can be obtained from the tailings containing 0.38% copper. The test index is good, and the comprehensive recovery and utilization of mineral resources can be realized.

In the context of global warming， research on disastrous weather events is conducive to disaster risk management and has a guiding role in agricultural production.The daily SPEI data from 1960 to 2017 was used to study the changes in drought events in Northeast China.The study found that using the daily SPEI can more accurately identify the occurrence of drought events than the monthly SPEI.In contrast， the monthly SPEI is easier to show Underestimate the intensity and duration of drought events.Furthermore， the study found that： First of all， the change of drought in time is expressed as： the turning point of drought events in Northeast China is considered to be 2000， because before 2000， extreme drought events with long duration and high intensity were prone to occur.Severe drought events are prone to occur after 2000， and their duration and intensity are not as severe as extreme drought events.Therefore， they are affected by the increase in the frequency， intensity and duration of severe droughts and the decrease in the frequency， intensity and duration of extreme drought events.In the past 58 years， the frequency of all drought events in the region has shown an upward trend， but the intensity and duration have shown a downward trend； secondly， the spatial change of drought is manifested as： the areas where the drought duration and intensity have been found to increase are concentrated in western Inner Mongolia， and the areas that have decreased It was found to be concentrated in the central and eastern parts of the Northeast region.Finally， the interdecadal changes of drought events were manifested in the fact that the duration and intensity of drought events from 1990 to 1999 were the least in the past 58 years， and the years when the increase was more obvious were mainly in 2000 Years later.Although the influence of drought in Northeast China has weakened after 2010， the impact of drought in the Hunshandake Sandy Land on the north side of Yinshan Mountain in the western part of the study area and a small part of the Hulunbeier Plateau in the northwest is increasing.

【Objective】There are more than 50 kinds of orchid viruses in the world, among which Cymbidium mosaic virus (CymMV) and Odontoglossum ringspot virus (ORSV) are the most common viruses. However, there are no effective measures to control the virus disease. Therefore, the establishment of efficient detection methods for the CymMV and ORSV is of great significance to control infected plants.【Method】CymMV and ORSV were used as experimental materials, and the reverse transcription loop-mediated isothermal amplification method (RT-LAMP) was used to amplify the viral RNA, so as to establish a rapid detection method of CymMV and ORSV. The RT-LAMP primers were designed according to the conserved regions of the cp gene sequences of two viruses. The hydroxylnaphthol blue (HNB, the final concentration of 200 μmol/L)was added to the RT-LAMP reaction system as an indicator of the amplification product. Without opening the tube for gel electrophoresis, the reaction results could be directly interpreted by the color change of the system which could avoid product aerosol pollution.【Result】The detection method could detect the presence of CymMV and ORSV RNA in the samples within 2 h, and its sensitivity was 10 times that of RT-PCR. In order to test the detection effect of RT-LAMP-HNB in actual production, 20 Phalaenopsis samples were detected by one-step RT-LAMP-HNB. According to the results, the detection rates of CymMV and ORSV were 70% and 55%, which were consistent with the results of RT-PCR, indicating that this method was suitable for the detection of field samples.【Conclusion】The one-step RT-LAMP-HNB established in this study is a sensitive, rapid, specific and convenient method for the detection of CymMV and ORSV. Nucleic acid amplification can be carried out only by simple temperature control equipment such as water bath pot, suitable for promotion and use in grass-roots or inconvenient areas.

Objective To investigate the mechanism of cordycepin (Cor) in the inhibition of epithelial-mesenchymal transition in asthmatic rats. Methods Rats were randomly divided into 4 groups (n=10): control group, ovalbumin (OVA) group, OVA+10 mg/kg Cor group, OVA+50 mg/kg Cor group. After 7 days of treatment, the cell counting in bronchoalveolar lavage fluid (BALF) was measured; hematoxylin-eosin (HE) staining was used to evaluate airway inflammation and airway remodeling. Masson's trichrome staining was used to detect epithelial collagen deposition. Human bronchial epithelioid cells 16HBE were divided into 3 groups: control group, TGF-β1 group and TGF-β1+Cor group. Immuno-fluorescence staining was used to detect the expression of c-Jun in the cells. Cell proliferation and migration were examined by cell counting kit-8 (CCK-8) and Transwell. The protein expression of E-cadherin, N-cadherin, α-SMA, vimentin, Smad3, p-Smad3, ERK1/2 and p-ERK1/2 was detected by immuno-histochemical staining or Western blot. Results With comparison with specific control groups, the following results were recorded. The collagen fiber area and cell count of OVA group increased significantly(P＜0.05). The collagen fiber area and cell count of OVA+10 mg/kg Cor group and OVA+50 mg/kg Cor group both decreased (P＜0.05). E-cadherin staining degree and protein expression of OVA group decreased, while the staining degree of α-SMA increased and the protein expression of N-cadherin, α-SMA and vimentin increased (P＜0.05); E-cadherin staining degree and protein expression of OVA+10 mg/kg Cor group and OVA+50 mg/kg Cor group increased, while the staining degree of α-SMA decreased and the protein expression of N-cadherin, α-SMA and vimentin decreased (P＜0.05). Compared with control group, the cell viability and the number of migrating cells in the TGF-β1 group increased (P＜0.05); compared with the TGF-β1 group, the cell viability and the number of migrating cells in the TGF-β1+Cor group were both decreased (P＜0.05). The expression level of E-cadherin protein in TGF-β1 group decreased, while the protein expression of N-cadherin, α-SMA, vimentin, p-Smad3 and p-ERK1/2 increased (P＜0.05). The E-cadherin protein expression level of TGF-β1+Cor group increased, while the N-cadherin, α-SMA, vimentin, p-Smad3 and p-ERK1/2 protein expression levels decreased (P＜0.05). The relative fluorescence intensity of c-Jun in TGF-β1 group increased (P＜0.05); The relative fluorescence intensity of c-Jun in TGF-β1+Cor group decreased (P＜0.05). Conclusions Cordycepin inhibits EMT in asthma by inhibiting Smad3 and ERK1/2 signaling pathway and c-Jun.

Objective To investigate the effect of Raddeanin A （RDA） on the proliferation and apoptosis of cervical cancer HeLa cells and to explore the possible mechanism. Methods HeLa cells were cultured in vitro and treated with RDA at a concentration of 0, 5, 10, 20, and 40 μmol/L for 48 h. Cell proliferation rate was determined by CCK-8. The half-maximal inhibitory concentration （IC50） was calculated to determine the drug concentration. Flow cytometry was used to detect cell apoptosis, and western blot was employed to detect the expression levels of Bcl-2, Bax, Cleaved-caspase-3, p-PI3K, p-Akt, and p-mTOR proteins. Hela cells were divided into four groups： control group, IGF-1 group, RDA group and combined treatment group. The proliferation rate, apoptosis rate, relative expression levels of p-PI3K, p-Akt and p-mTOR proteins were detected and compared among different groups. Results The proliferation rate of HeLa cells was significantly declined, whereas the apoptosis rate was significantly elevated with the increasing concentration of RDA （both P < 0.05）, the relative expression levels of Bax and Cleaved-caspase-3 proteins were significantly up-regulated （both P < 0.05）, whereas those of Bcl-2, p-PI3K, p-Akt and p-mTOR proteins were significantly down-regulated （all P < 0.05）. After the activation of PI3K/Akt/mTOR signaling pathway by IGF-1, RDA could still inhibit the proliferation of HeLa cells and down-regulate the relative expression levels of p-PI3K, p-Akt and p-mTOR proteins （all P < 0.05）. Conclusion RDA can inhibit the proliferation and promote the apoptosis of cervical cancer HeLa cells by suppressing the PI3K/Akt/mTOR signaling pathway.

An unpredictable emergency situation might happen due to the adverse reaction to psychoactive drug plus physiological disease problems. When a first aid incident occurs, psychiatry nurses who are inexperienced and lack confidence might have impared judgements and inefficient division of labor, which can contribute to an issue of first aid. The current analysis confirmed that task assignment is not specific, a lack of recognition of the accurate position of the first aid cart materials and standard operation procedure, and that the education training is deficient. Moreover, the restrictions of the first aid environment is also related to first aid results. This project defined the division of task assignment, developed first aid cart material pairing software, revised standard operation procedure, and conducted first aid simulation training classes. Results indicated a rise in the accuracy of first aid procedure from 63.7% to 95.6%, and the first aid procedure cognition rose from 64.89% to 92.12%. Additionally, the project increased the awareness of first aid procedure, self-confidence, and brought the team together to reduce the misstep of first aid procedure. [ABSTRACT FROM AUTHOR]

The development of the fifth-generation wireless communications (5G) system is promoted by the high requirements of the high reliability and super-high network capacity.However,existing communication techniques are hard to achieve the high requirements due to the more and more complexity design in 5G system.Currently,deep learning is considered one of effective tools to handle the physical layer wireless communications.Several potential applications based on deep learning were reviewed,and their effectiveness were confirmed.Finally,several potential techniques in deep learning based physical layer wireless communications were pointed out.

Objective: To analyze the clinical, epidemiological and microbiological characteristics of subcutaneous fungal infection occurring in Guangdong, China in the last 30 years. Methods: A 30-year retrospective study from January 1990 to December 2019 reviewing 254 patients with subcutaneous fungal infection from our hospital was conducted. General characteristics, histopathology, diagnosis and isolated strains were analyzed. Results: The average annual diagnosis was 8.47 cases. The average patient age was 47.78 years. The male to female ratio was approximately 1.46∶1. The most common anatomical site of involvement was upper extremities (31.10%).These infections were commonly occured in patients from 31 to 60 years old (46.12%).Sporotrichosis was the most common subcutaneous fungal infection, but the number of infection decreased during recent two decades, while chromoblastomycosis increased in recent decade (P

This paper focuses on a migrant worker with schizophrenia including auditory hallucinations and violent behavior. The worker had returned to Taiwan to quarantine and accept medical treatment. The nursing period was from December 16th, 2020 to January 27th, 2021. The author collect data through case history and discussion which was analyzed with five perspectives of psychiatry, and confirmed nursing problems involving a deficiency in self-care, resistance to following instructions, violent behavior, and perceptual alterations. Given the case was in quarantine, and the nature of the disease, an across-team cooperative nursing plan was started. For instance, insure the cleanliness of the body, comply to quarantine measures, build up therapeutic relationship with the case and provide a safe environment to avoid violence, escape, and any problem situations. Additionally, an attempt was made to teach the case to observe mental states to help separate reality and hallucinations to cope with auditory hallucination. Thus, patient education in Filipino was given to increase medicine-taking obedience. Finally, in order to continue the medical treatment after return to Philippines, video calls was made to contact the case's brother in Philippines. [ABSTRACT FROM AUTHOR]

Background and objective The surgical resection for pancoast tumors remains challenging. There are only few reports explaining the use of VATS in the treatment of Pancoast tumors. The aim of this study is to assess whether the use of video-assisted thoracoscopic surgery (VATS) for the surgical treatment of Pancoast tumors was feasible and safe. Methods Between Janunary 2010 and June 2013, ten patients who were diagnosed as Pancoast tumors were recruited. Six patients were accepted for surgical treatment either through an anterior (n=3) or a posterior approach (n=3) combined with VATS. The observation index of this study included: Operation safety and mortality; The integrity of the tumor resection; General data of operation and postoperative complications; Tumor recurrence and metastasis at twelve months after operation.Results There were no perioperative deaths. The average time of operation time was 242 min. The radical en bloc resection of the involved chest wall were done in each patients. The average amount of blood loss was 308 mL and the average time of hospital stay was 14 d. Only one patient had postoperative pneumonia and recovered after use of antibiotics. There was none of severe postoperative complications. No patient developed a local recurrence or distant metastasis within twelve months. Conclusions The use of VATS has practical value in the management of Pancoast tumors. It is useful to make an accurate extent of the resection of chest-wall and provides a better exposure. Anterior or posterior approach with VATS surgery can facilitate the safety management of Pancoast tumors.

In view of the current popular cloud computing technology,some security problems were analyzed.Based on BLP(Bell-LaPadula) model and Biba model,using the access control technology based on behavior to dynamic adjusting scope of subject's visit,it put forward the CCACSM ( cloud omputing access control security model).The model not only guarantees the cloud computing environment information privacy and integrity,and makes cloud computing environment with considerable flexibility and practical.At last,it gives the model's part,safety justice and realization process.

The purpose of this research was to explore the practice and challenge of follow-up service for young offenders leaving reformatory education. A questionnaire survey was used to collect data from 35 organizations. The results show that: (1) service methods are mainly based on phone calls, visiting homes and Internet; (2) main service items include emotional support, job search, school guidance; (3) difficulties in practice include lack of changes and cooperation, building relationships, high case loading, lack of outcome indicators, limited categories of services, and restriction of employment market. Lastly, the results suggest that: (1) elaborate service guideline; (2) enhance the professional supervising system; (3) design core competence-based training; (4) develop evidence-based service; (5) integrate the resources of follow-up service. [ABSTRACT FROM AUTHOR]

Seven kinds of knitting and weaving, wool and wool blended, common and shrink-proof fabrics are selected in this paper. All the fabrics are washed 5 and 10 cycles and their size, surface roughness, bursting strength and sodium hypochiorite solution weight loss rate have been tested. Besides, the mechanism of washing damage to the shrink-proof wool is also studied. The results show that shrink- proof finishing can improve the size stability and surface roughness. However, household care can cause the damage of wool fabrics, such as surface roughness, bursting strength and fiber structure damage. Physical damage is obvious in the first 5 cycle while structural damage changes significantly after washing 5 cycles. Washing process causes obvious change of the warp shrinkage to all fabrics. The resin scouring fabric has the lowest washing damage among the three shrink-proof finishing methods. [ABSTRACT FROM AUTHOR]

Heat shock protein 90 (Hsp90), as a member of the Hsp family and widely found in the gonads of humans and animals, plays an essential role in male reproduction and induces various changes in the process of reproduction. Hsp90 regulates the division of germ cells and participates in spermatogenesis, location of germ cells, formation of sperm microtubes, protection of sperm from oxidative stress, and inducement of acrosomal reaction. Studies showed significant changes in location and expression of Hsp90 in the sperm of oligospermia and asthenospermia patients. This paper presents an overview of Hsp90 in male reproduction and male infertility and a prospect of the treatment of male infertility.

Objective: To explore the protective role of basic fibroblast growth factor (bFGF) on attenuating hydrogen peroxide-induced injury in cultured rat myoblasts., Methods: Cultured rat myoblasts at growth phase were randomly divided into four groups ( n =6):control group (control), bFGF group (bFGF), model group(H 2 O 2 ) and the treatment group (bFGF + H 2 O 2 ). Model group was treated with 100 μ mol/L hydrogen peroxide for 4h. B-cell lymphoma-2 (Bcl-2) positive particles were detected by immunohistochemistry; Reactive oxygen species (ROS) and expression for Bcl-2 associated X protein (Bax), Bcl-2 and Cytochrome C (Cyt. C) fluorescence were observed under the invented microscope; Cyt. C and Poly ADP-ribose polymerase(PARP)protein were assessed by Western blot., Results: Compared with control group, the myoblats in the model group showed low expression of Bcl-2 positive particles, accompanied by high expression of ROS level and Cyt. C fuorescence ( P < 0.05); Compared with model group, bFGF enhanced Bcl-2 activity of the myoblasts, and significantly downregulated Cyt. C and PARP expression ( P < 0.05)., Conclusions: bFGF could attenuate oxidative injury of rat myoblasts induced by hydrogen peroxide, which mechanism might be related to enhanced Bcl-2 and reduced ROS, Cyt. C levels.

Objective: To observe the the expression of endoplasmic reticulum stress (ERS) related factors in deep tissue injury (DTI) at pressure ulcer rat and to investigate the ERS mechanism of DTI in muscle tissue and protective effect of 4-phenylbutyric acid (4-PBA) in local tissue., Methods: Fifty male SD rats were randomly devided into control group, model group, experimental group NS group and PBA group, the experimental groups were divided into 4 d, 7 d, 14 d and 21 d group according to the observation time (n = 5). Rats in the PBA group were administrated with gastric perfusion of 4-PBA after the modeling; the NS group was given normal saline of the same quantity. Using HE staining to observe morphologic character. The expression of glucose regulated protein 78 (GRP78), CHOP, Caspase 12 were detected by immunohistochernical staining. Cell apoptosis was detected by TUNEL assay., Results: HE staining results showed that each group demonstrated compression injury compared with control group: cellular swelling, ompaction of nuclear, and apoptosis in muscle tissue. The new muscle fiber in 4-PBA group fused faster than those in NS group. The number of TUNEL positive cells peaked at 4 day after compression, then got decreased on day 7 in muscle tissue, apoptosis positive cells were diminished after 4-PBA treatment. The immunohistochemical staining results showed that the expression of protein GRP78, CHOP, Caspase 12 peakd 4 d after modeling and decreased gradually. The GRP78, CHOP, Caspase 12 protein expression were significantly higher than those of PBA group at all time points (P < 0.05)., Conclusion: Cell apoptosis induced by endoplasmic reticulum stress took part in deep tissue injury resulting of pressure ulcer, which mechanism might be related to reducing apoptosis mediated by CHOP, Caspase 12.

Objective: To investigate in situ visualization using near-infrared quantum dots (QDs) conjugated with arginine- glycine-aspartic acid (ROD) peptide fluorescent probes in oral squamous cell carcinoma (08CC)., Methods: QDs with emission wavelength of 800 nm (QD800) were conjugated with RGD peptides to produce QD800-RGD fluorescent probes. Human OSCC cell line BcaCD885 was inoculated in nude mice cheeks to establish OSCC mouse models. Frozen BcaCD885 tumor slices were immunofluorescence double stained by using QD800-RGD and CD105 monoclonal antibody and were observed using a laser scanning confocal microscope. QD800-RGD was injected into the OSCC models through the tail veins, and the in situ visualization was analyzed at different time points. The mice were sacrificed 12 h after injection to isolate tumors for the ex vivo analysis of probe localization in the tumors., Results: QD800-RGD specifically targeted the integrin avβ3 expressed in the endothelial cells of tumor angiogenic vessels in vitro and in vivo, producing clear tumor fluorescence images after intravenous injection. The most complete tumor images with maximal signal-to-noise ratios were observed 0.5 h to 6 h after injection of the probe and significantly reduced 9 h after the injection. However, the tumor image was still clearly visible at 12 h., Conclusion: Using intravenously injected QD800-RGD generates high quality OSCC images when integrin avβ3, which is expressed in the endothelial cells of tumor angiogenic vessels, is used as the target. The technique offers great potential in the diagnosis and individual treatment of OSCC.

Objective: To evaluate the changes of tumor necrosis factor-alpha (TNF-alpha) and nuclear factor-kappaB (NF-kappaB) expression in muscle of pressure ulcer rats and explore the relationship with apoptosis., Methods: Fifty-four male SD rats were randomly divided into nine groups (n = 6), the experiment groups were pressed 9 circles (3 circles/day, 3 days), then observed on the 1st, 3rd, hematoxylin and eosin staining under the microscope; the expression of TNF-alpha was detected by Western blot; the expressions of NF-kappaB and caspase-3 were determined by immunohistochemistry, and evaluated the relationship of TNF-alpha with NF-kappaB and caspase-3; the number of apoptotic cells in compressed muscle tissue was detected by Hoechst 33258 staining under the fluorescence microscope., Results: Compared with the control group, histology examination showed that the tissue structure in experiment groups was in disorder, inter-space was wider, cell edema and the number of inflammatory cells were increased, the tissue was arranged in order and inflammatory cell recruitment was gradually attenuated. The expressions of TNF-alpha, NF-kappaB and caspase-3 were higher in the experiment groups than those in the control group (P < 0.05), reached their peak on the first day, gradually decreased on the 3nd day, but still had a significantly higher level than that in the control group (P < 0.01) on the 7th day; The number of apoptotic cells of experiment groups had a downward trend after the first rise under the fluorescence microscope; the expressions of TNF-alpha and NF-kappaB caspase-3 were found to have positive correlationship (P < 0.05), the expressions of NF-kappaB and caspase-3 were found to have positive correlationship (P < 0.01)., Conclusion: Apoptosis is closely correlated with inflammation in deep tissue injury of pressure ulcer, NF-kappaB plays a role not only in the formation of inflammation, but also triggering apoptosis, which may induce the pathological change and clinical progress of pressure ulcer.