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Heart rate recovery, a widely used indicator in clinical evaluation of the autonomic nervous system, refers to the difference between maximum heart rate during exercise and the heart rate after 1 or a few minutes of cessation. It possesses advantages of being noninvasive and repeatable. Currently, heart rate recovery is extensively applied in cardiovascular diseases for evaluating disease severity, prognosis, risk of cardiovascular events, and mortality. This article primarily discusses the application value and current research progress of heart rate recovery in cardiovascular diseases. [ABSTRACT FROM AUTHOR]

Objective: To investigate the diagnostic value of real-time three-dimensional transthoracic echocardiography (RT3D-TTE) combined with serum B type brain natriuretic peptide (BNP) and soluble growth stimulation expressed gene 2 protein (sST2) in heart failure (HF) after myocardial infarction. Methods: 88 HF patients after myocardial infarction (HF group) who were hospitalized for the first time in Zhongshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Traditional Chinese Medicine from June 2020 to November 2022 were selected, patients were divided into grade II group (21 cases), grade III group (39 cases) and grade IV group (28 cases) according to Killip classification. And 88 healthy volunteers who underwent physical examination in our hospital during the same period were selected as control group. All subjects underwent RT3D-TTE examination, and serum BNP and sST2 levels were detected. The correlation between Killip classification and RT3D-TTE parameters, serum BNP and sST2 were analyzed by Spearman rank correlation analysis, the correlation between RT3D-TTE parameters and serum BNP and sST2 were analyzed by Pearson analysis. The value of RT3D-TTE parameters combined with BNP and sST2 in the diagnosis of HF after myocardial infarction was analyzed by receiver operating characteristic (ROC) curve. Results: The left ventricular end-systolic volume (ESV), left ventricular end-diastolic volume (EDV), the percentage of standard difference correction value of the time from the beginning of QRS wave to the minimum systolic volume of the left ventricular 16 myocardial segment of the left ventricle to the cardiac cycle (Tmsvl6-SD%) and the percentage of maximum difference correction value to the cardiac cycle (Tmsvl6-Dif%), serum BNP and sST2 levels in HF group were higher than those in control group(P<0.05), and the left ventricular ejection fraction (LVEF) was lower than that in control group (P < 0.05) The levels of ESV, EDV, Tmsvl6-SD%, Tmsvl6-Dif%, serum BNP and sST2 in grade IV group were higher than those in grade II group and grade III group (P < 0.05) and LVEF was lower than that in grade II group and grade III group (P < 0.05) ; The levels of ESV, EDV, Tmsvl6-SD%, Tmsvl6-Dif%, serum BNP and sST2 in grade III group were higher than those in grade II group (P < 0.05), and LVEF was lower than that in grade II group (P < 0.05) Killip classification was positively correlated with ESV, EDV, Tmsvl6-SD%, Tmsvl6-Dif%, serum BNP and sST2 levels in HF group (P < 0.05), and negatively correlated with LVEF (P < 0.05) ESV, EDV, Tmsvl6-SD% and Tmsvl6-Dif% were positively correlated with serum BNP and sST2 levels (P < 0.05) and LVEF was negatively correlated with serum BNP and sST2 levels (P < 0.05) The area under the curve (AUC) of ESV, EDV, Tmsvl6-SD%, Tmsvl6-Dif%, LVEF, BNP and sST2 in the diagnosis of HF after myocardial infarction was 0.908, which was higher than that of each factor alone. Conclusion: The RT3D-TTE parameters ESV, EDV, Tmsvl6-SD%, Tmsvl6-Dif%, serum BNP and sST2 levels increased and LVEF decreased in HF patients after myocardial infarction, and combined detection of RT3D-TTE parameters, serum BNP and sST2 could improve the diagnostic value of HF after myocardial infarction. [ABSTRACT FROM AUTHOR]

Cardiac CT, or coronary CT, is a medical imaging technique that involves injecting iodine contrast agents into blood vessels to visualize the heart's coronary arteries. Cardiovascular specialists utilize these images to diagnose coronary artery blockages and assess blood flow velocity. Prior to the examination, patients are required to maintain a stable heart rate, typically not exceeding 60 beats per minute. Medications such as β-receptor blockers and nitroglycerin may be administered to reduce heart rate if necessary. This technology offers rapid imaging, minimal side effects, and low rates of false negatives and false positives. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical effect of heart rate corrected QT (QTc), heart rate corrected Tp-Te (Tp-Tec) interval combined with serum brain natriuretic peptide (BNP) and galectin-3 (Gal-3) in predicting ventricular arrhythmia (VA) after acute myocardial infarction (AMI). Methods: 182 AMI patients who were treated in Jinan People's Hospital from January to July 2023 were select- ed as study subjects. Group based on whether VA occurred during hospitalization, with 71 patients with VA as the observation group and 111 patients without VA as the control group. The levels of QTc, Tp-Tec, serum BNP and Gal-3 were detected and compared between two groups. The influencing factors of VA after AMI were analyzed by multivariate Logistic regression analysis, the predictive efficacy of QTc, Tp-Tec combine with serum BNP and Gal-3 on VA after AMI were analyzed by receiver operating characteristic (ROC) curve. Results: The levels of QTc, Tp-Tec, serum BNP and Gal-3 in observation group were higher than those in control group (P<0.05). Multi- variate Logistic regression analysis showed that elevated QTc, Tp-Tec, BNP and Gal-3 and double/multiple vascular lesions were risk factors for VA after AMI. ROC curve analysis showed that, the combined detection of QTc, Tp-Tec, BNP and Gal-3 had the best predictive efficacy for VA after AMI, with AUC of 0.864, sensitivity of 92.50%, specificity of 79.83% and Youden index of 0.723. Conclusion: The levels of QTc, Tp-Tec, BNP and Gal-3 in VA patients after AMI are increase, and are risk factors for VA after AMI. The combine detection of QTc, Tp-Tec, BNP and Gal-3 has a good predictive value for VA after AMI. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation between DC, DRs, AC and prognosis in patients with CHF. Methods: 120 patients with CHF (observation group) admitted to cardiology department of the hospital from October 2021 to October 2022 were divided into grade Ⅱ group (n=40), grade Ⅲ group (n=50), and grade IV group (n=30) based on cardiac function classification. 69 healthy volunteers who received physical examination in the hospital during the same period were selected as the control group. General data of the two groups were compared. DC, DRs and AC were analyzed. Patients in the observation group were followed up for one year, and cardiovascular events were recorded. The value of DC, DRs and AC in evaluating cardiovascular events was discussed. Results: Comparison between the observation group and the control group found that DC, DR2, DR4, DR8 and LVEF of the former group were lower. LVEDD and AC of the former group were greater (P＜0.05). As the grade of cardiac function increased, DC, DR2, DR4, DR8 and LVEF decreased. LVEDD and AC increased (P＜0.05). Comparison between the event group and the non-event group found that DC, DR2, DR4, DR8 and LVEF in the former group were lower. LVEDD and AC in the former group were greater (P＜0.05). The occurrence rates of malignant arrhythmia, readmission due to heart failure, cardiogenic shock, and cardiogenic death were higher in the high-risk group than in the intermediate-risk group and the low-risk group (P＜0.05), and higher in the intermediate-risk group than in the low-risk group (P＜0.05). Conclusion: DC, DRs and AC are of guiding significance in cardiac function classification and prognosis evaluation of patients with CHF. Clinically, monitoring the changes in above indicators in patients with CHF can provide an objective basis for the treatment and prevention of cardiovascular events. [ABSTRACT FROM AUTHOR]

Poor ovarian response (POR) is a pathological condition in which the ovary responds poorly to gonadotropins, and is a major constraint on the unsatisfactory outcome of in vitro fertilization-embryo transfer (IVF-ET). Follicular growth, development, maturation, and expulsion are all affected by the yin-yang balance between heart and kidney, as well as the elevation exchange. If the heart and kidney essence and blood are insufficient, water and fire are out of harmony, and qi movement is not smooth, fewer high-quality follicles will be recruited and acquired during the ovarian stimulation cycle, resulting in a low transferable embryo rate and unacceptable pregnancy result. Sympathetic treatment of heart and kidney should be based on the following principles at different stages of the IVF-ET cycle: replenishing the heart, kidney, essence, and blood before entering the cycle, in order to nourish the essence and assist in the growth of the follicles; nourishing renal water, and clearing heart fire during the pituitary down-regulation period, in order to lessen the negative effects of the down-regulation medicinals; regulating the depression of the heart, liver, spleen, and kidney meridians during the follicle's retrieval period, in order to encourage the smooth release of the ova; and warming heart and kidney fire to improve endometrial tolerance during the implantation period. The application of the theory of intercourse of heart and kidney to elucidate the pathogenesis of POR is critical to the development of clinical strategies for fertility enhancement, as well as providing new ideas for the clinical application of traditional Chinese medicine in the field of reproduction. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Aiming at the limitations of traditional train comfort research in the long-term service monitoring of subway train comfort, this paper presents a comprehensive evaluation method of subway train comfort based on mobile terminals. By investigating the types of sensors integrated in mobile terminals, it is determined that the factors affecting the comfort of subway trains are vibration, noise and illuminance. Combined with questionnaire survey and analytic hierarchy process, the weight coefficients of each factor's influence on the comfort of subway trains are determined. The evaluation models and evaluation standards of each factor are established based on the existing standards and simulation experiments, and then the evaluation method of subway train comfort is determined. The proposed method is integrated into the self-developed mobile terminal APP to realize large-scale collection of train comfort data. In order to objectively verify the feasibility of this method, the experimental data from professional measuring instruments, mobile terminals and wearable devices are collected in the subway line experiment. The results of the analysis show that: when the train is running smoothly, the relative errors of the vibration, noise and illuminance comfort evaluation values collected by the mobile terminal shall not exceed 5%, 15% and 18% respectively; the noise comfort evaluation value accounts for 67.8% and 76.5% of the total evaluation value under two working conditions, therefore the greatest influence on train comfort is noise; the evaluation results of subway train comfort based on the proposed method tend to be consistent with the analysis results of heart rate variability frequency domain indicators (LF, HF and LF / HF ), which objectively verify the feasibility of the evaluation method. The mobile terminal-driven subway train comfort evaluation method can provide new ways and ideas for large-scale monitoring of subway train comfort and long-term service performance evolution analysis. [ABSTRACT FROM AUTHOR]

Objective: To explore the application effect of different doses of remifentanil combined with remifentanil in painless gastroscopy in children. Methods: 165 pediatric patients who underwent painless gastroscopy from May 2023 to November 2023 were selected as the study subjects. They were randomly divided into four groups using a random number table method, namely R1 (n=40), R2 (n=40), R3 group (n=40), and Matched group (n=45). Patients in the Matched group were intravenously injected with 2 mg/kg propofol and 7% fentany l μg/kg, R1, R2, R3 groups intravenous injection of fentanyl 7 μg/kg and Remazolam, R1 group Remazolam is 0.2 mg/kg. The R2 group is 0.3 mg/kg, and the R3 group is 0.4 mg/kg. Gastroscopy should be performed when all patients have improved alertness/calmness (MOAA/S) scores ≤ 1. Compare the success rate of sedation, onset time of sedation, awakening time, gastroscopy examination time, and number of times of remedial sedation among four groups of children. Evaluate the degree of sedation using MOAA/S scores before administration, after initial administration, before endoscopy, and immediately after examination. Record the changes in heart rate, blood pressure, oxygen saturation, heart rate (HR), and blood oxygen saturation (SpO2) of the four groups of children before anesthesia induction (T0), at entry (T1), and after anesthesia induction (T2), Finally, compare the incidence of adverse reactions among the four groups of children. Results: There was no difference in the recovery time and gastroscopy examination time among the four groups of patients(P>0.05). The success rate of sedation in the R3 group was higher than that in the R1 group, R2 group, and Matched group. The onset time of sedation and the number of times of remedial sedation were lower than those in the R1 group, R2 group, and Matched group (P<0.05); There was no difference in MOAA/S scores among the four groups of patients before administration and immediately after examination(P>0.05). After the first administration and before endoscopy, the MOAA/S scores of R3 group patients were lower than those of R1 group, R2 group, and Matched group (P<0.05); There was no change in blood oxygen saturation (SpO2) levels and heart rate (HR) levels at T0, T1, and T2 time in the four groups of patients, and there was no difference between the four groups(P>0.05). The HR levels of patients in the T2 and R3 groups were stable, but there were fluctuations between the R1 and R2 groups and the Matched group. The T1 and R3 group was lower than the R1 and R2 groups and the Matched group (P<0.05); The incidence of adverse reactions such as injection pain, laryngeal spasm, hypoxemia, hypotension, and bradycardia in patients in R1, R2, and R3 groups was lower than that in the Matched group (P<0.05), but there was no difference in the comparison of R1, R2, and R3 groups(P>0.05). Conclusion: The combination of Remazolam and Alfentanil can improve the sedative effect during gastroscopy in children, and Remazolam at a dose of 0.4 mg/kg is more effective. It can further improve the success rate of sedation, reduce the number of times of remedial sedation, and do not increase the awakening time. The sedative effect is better, and it can stabilize the heart rate level during the examination of children, with higher safety. [ABSTRACT FROM AUTHOR]

Objective: To compare the effects of dexmedetomidine and propofol on hemodynamics, stress response and immune function in children undergoing liver mass resection. Methods: The random number table method was used, 90 children who underwent elective liver mass resection in our hospital from May 2021 to April 2023 were divided into dexmedetomidine group (dexmedetomidine anesthesia) and propofol group (propofol anesthesia), 45 cases in each group. The changes of hemodynamics [heart rate (HR), mean arterial pressure (MAP)], stress response [cortisol (Cor), adrenocorticotropic hormone (ACTH)] and T lymphocyte subsets [CD4+, CD8+, CD4+/CD8+] were compared between two groups, and the incidence of adverse reactions during anesthesia was observed. Results: MAP in dexmedetomidine group was lower than that in propofol group at 10 min after anesthesia induction (T1) to the end of operation (T4), and HR was higher than that in propofol group(P<0.05). Cor and ACTH in dexmedetomidine group were lower than those in propofol group at T4 and 1 day after operation (T5) (P<0.05). CD8+ in dexmedetomidine group was lower than that in propofol group at T4 and T5, while CD4+ and CD4+/CD8+ were higher than those in propofol group (P<0.05). There was no difference in the incidence of adverse reactions between two groups(P>0.05). Conclusion: Compare with propofol anesthesia, dexmedetomidine can better stabilize hemodynamics, reduce stress response, and reduce immunosuppression in children undergoing liver mass resection. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of China Sciencepaper is the property of China Sciencepaper and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Deltamethrin (DM) has been widely used as a type II pyrethroid insecticide. Its high lipophilicity allows it to easily pass through the blood-brain barrier and affect the nervous system. However, its impact on the early neural development of zebrafish and the mechanism of toxicity remains unclear. In this study, zebrafish (Danio rerio) embryos were exposed to DM with different concentration of 0,10, 20 and 50 µg⋅L-1 to analyze the development and movement ability. The neurotoxicity of DM to zebrafish larvae was evaluated on the development of the nerve cells of transgenic zebrafish line. The results showed that the frequency of spontaneous coiling decreased 41.2% (P<0.001) by 50 µg⋅L-1 DM exposure at 24 hpf. The hatching rate of all the DM exposure groups was higher than the control group and heart rate were significantly increased in 20 and 50 µg⋅L-1 groups (P<0.01, P< 0.0001), and the body length was significantly reduced (P<0.01) at 36 hpf. These results showed that the effect of DM on embryo development was dose-dependent. Through the analysis of the spontaneous swim, light-dark stimulus and open field behavior of zebrafish larvae, it was found that zebrafish larvae became sluggish in those three scenarios, indicating that DM exposure affected the mobility of zebrafish, and the ability to respond to external environmental stimuli and the ability to actively explore new environments was weakened. Further analysis of transgenic zebrafish strains with specific markers for neural cell systems found that DM exposure caused a significant decrease in the number of nerve stem/progenitor cells in zebrafish (P<0.01, P<0.001), neuronal cell activity was enhanced, and the number of apoptotic cells was significantly increased (P<0.0001). The results suggested that the neurotoxicity of zebrafish larvae induced by DM is related to the nerve cell viability. DM is toxic to the central nervous system of zebrafish by destroying the number of nerve stem / progenitor cells, over-activating neurons and promoting apoptosis of nerve cells, thus affecting the behavior of zebrafish embryos and larvae. [ABSTRACT FROM AUTHOR]

Objective To investigate the perioperative analgesic effect of ultrasound-guided bilateral thoracolumbar interfascial plane block (TLIPB) in patients with discogenic low back pain (DLBP) undergoing percutaneous transforaminal endoscopic discectomy (PTED). Methods Fifty-seven patients with discogenic low back pain admitted to the First Affiliated Hospital of Anhui Medical University from January 2022 to April 2022 were randomly divided into group A (control group)with 28 patients and group B (ultrasound-guided bilateral thoracolumbar interfascialinterfacial plane block group) with 29 patients. The differences of visual analogue scale (VAS) at rest and turning over were compared between the two groups preoperative (t0), 2 hours postoperative (t1), 6 hours postoperative (t2), 12 hours postoperative (t3) and 24 hours postoperative (t4). The differences of quality of recovery-15 scores (QoR-15) were compared between the two groups preoperative and 24 hours postoperative. The changes of mean arterial pressure (MAP) and heart rate (HR) were compared between the two groups after entering the operating room (T0), at the time of skin incision (T1), at the time of foraminoplasty (T2), at the time of the most severe pain recognized by the surgeon (T3), and at the end of the operation (T4). Adverse events were recorded during the operation and within 24 hours postoperative. Results All patients successfully completed the operation and ultrasound-guided bilateral TLIPB, without intervertebral space infection, spinal cord, nerve root and vascular injury, and serious complications such as nausea and vomiting. VAS scores at rest and turning over and QoR-15 scores at 24 hours postoperative were significantly lower than preoperative in the two groups (P < 0.05). There was no significant difference in VAS scores between the two groups at rest at preoperative and postoperative time points (P > 0.05). There were significant differences in VAS scores at 2 hours, 6 hours and 12 hours postoperative between the two groups (P < 0.05). There were significant difference in QoR-15 scores between the two groups at preoperative and 24 hours postoperative (P > 0.05). There was a significant difference in QoR-15 scores between the two groups at 24 hours postoperative (P > 0.05). There were significant differences in MAP and HR between the two groups at the time of foraminoplasty (T2) and at the time of the most severe pain recognized by the surgeon (T3) (P< 0.05). Conclusions Ultrasound-guided bilateral thoracolumbar interfascial plane block can effectively relieve the pain after PTED, reduce the occurrence of perioperative stress response and adverse events, accelerate the postoperative rehabilitation of patients, and shorten the postoperative duration of hospitalization. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] When evacuating people during accidents in high-plateau environments, those affected by high-altitude reactions are prone to physical and cognitive problems, such as slow behavior and slow response, which affect their cognitive response and independent decision-making. Therefore, studying evacuation problems in a high-plateau environment is significant for a more efficient emergency evacuation. However, environmental variations such as altitude and oxygen concentrations in plateau areas are difficult to control, and large experimental costs make it difficult to conduct evacuation field tests. Therefore, a low-oxygen experimental platform was designed to simulate a high-plateau environment. [Methods] Through literature research and laboratory experiments, three control experimental schemes, an up-and-down step experiment, a 90 s running experiment, and a reaction ability experiment, were designed to simulate evacuation scenarios based on physiology and cognition. The control experiments were conducted on a low-oxygen experimental platform and a high-altitude field. Heart rate, blood oxygen levels, and reaction speed were collected as evaluation indices of physiological and psychological dimensions. Statistically, the differences in experimental data between the high-plateau field and low-oxygen experimental platform were compared. The experimental data of the three groups were tested for normality. To analyze the difference between the two groups, non-normally distributed experimental data were analyzed using the independent sample Mann-Whitney U test, while normally distributed experimental data were analyzed using the independent sample T-test. [Results] In the up-and-down step experiments, the progressive significance of the heart rate and blood oxygen levels obtained from the low-oxygen experimental platform and Lhasa Gongga Airport were 0.052 and 0.112, respectively, which were greater than the significance level (P = 0.05), and no significant difference was found between the two experimental results. In the 90 s running experiment, the progressive significance of the heart rate and blood oxygen levels obtained from the low-oxygen experimental platform and Lhasa Gongga Airport were 0.953 and 0.780, respectively, which were significantly greater than the significance level (P = 0.05). No significant difference was found between the two experimental results. In the reaction ability experiment, the T-test results had P-values of 0.211 and 0.204, which were >0.05. No significant difference was noted between the experimental results obtained in the high-altitude field experiment (Nyingchi Airport and Lhasa Gongga Airport) and the low-oxygen experimental platform simulation. [Conclusions] By integrating statistical ideas and analyzing datasets, the low-oxygen experimental platform can simulate the field environment of a high-plateau airport within a certain range of error tolerance based on the results of an up-and-down step experiment, 90 s running experiment, and reaction ability experiment. The experimental platform can serve as a basic support for experimental research and innovation for man-machine safety and occupational health. [ABSTRACT FROM AUTHOR]

Dong qi, referring to beating beside the navel, was proposed for the first time by Nan Jing. "Beating above the navel" " beating below the navel", and "beating below the heart" in Shanghan Lun all belong to the category of Dong qi. The pathogenesis of Dong qi can be learned from Shanghan Lun. Yang deficiency of the heart, spleen, and kidney, with qi failing to transform body fluids, results in fluid retention. Fluid retention is the key etiological factor of Dong qi. Although there is an exterior pattern with Dong qi, the exterior-releasing and purgative method cannot be used for treatment, or the patient will be impaired of yang and exhausted of yin, fluid circulation will be disturbed, and so on. Reinforcing yang qi to drain water retention is the treatment principle of Dong qi. The coupled medicines of Fuling and Guizhi were commonly used by ZHANG Zhongjing to treat Dong qi. This reflects the treatment principle of strengthening the spleen and warming yang for transforming qi to circulate body fluids. ZHANG Bi, a physician from the Yuan Dynasty who learned from ZHANG Zhongjing, thought that the treatment of Dong qi was based on the method of cultivating earth to restrain water and taking into account the ascending, descending, entering, and exiting of qi of the liver, heart, lung, and kidney while tonifying the spleen, and then created Baoming Siqi Powder (Zhiqiao, Fuling, Fangkui, and Qianhu Powder) for the treatment of Dong qi, which is of great significance to the clinic. [ABSTRACT FROM AUTHOR]

Objective.To evaluate the therapeutic efficacy and safety of perioperative electroacupuncture on postoperative abdominal pain in patients undergoing general anesthesia laparoscopic surgery. Methods.A total of 130 patients undergoing general anesthesia laparoscopic surgery were randomly divided into control group and experimental group. The control group received surgery under endotracheal intubation general anesthesia, while the experimental group received one session of electroacupuncture analgesia before and during anesthesia in addition to routine general anesthesia. The preoperative and postoperative pain Numerical rating scale (NRS), Pain Catastroph- izing Scale (PCS), Bruggrmann comfort scale (BCS), heart rate, and blood pressure were compared between the two groups. The occurrence of common adverse reactions after surgery, such as significant itching, rash, nausea, and vomiting, was observed. Results.No significant difference in activity NRS score was found between the two groups after surgery (P = 0.618). Compared with the control group, the experimental group had lower resting NRS score (2.05 ± 1.138),(1.62 ± 0.878), P = 0.017, lower PCS score (20.57 ± 8.538),(17.09 ± 8.291), P = 0.020, and higher BCS score after surgery (2.08 ± 1.035),(2.55 ± 1.046), P = 0.010, and decreased heart rate (76.17 ± 14.500),(70.85 ± 11.990), P = 0.024. There was no significant difference in systolic blood pressure between the two groups 12 and 24 hours after surgery (P > 0.05). A decrease in systolic blood pressure 24 hours after surgery was found in the experimental group when compared to that before surgery (125.6 ± 15.725), (123.60 ± 16.781), P = 0.040. Conclusion.Perioperative electroacupuncture stimulation can relieve postoperative abdominal pain, reduce heart rate and blood pressure, but does not increase the occurrence of adverse reactions. [ABSTRACT FROM AUTHOR]

To investigate the developmental effects of combined exposure of azoxystrobin and selenomethionine on aquatic organisms, a semi-static test method was used to determine the developmental toxicity of combined exposure of azoxystrobin and selenomethionine in equitoxicity ratios on embryo and larvae of zebrafish as aquatic model species, as well as the effects on related enzyme activities. These results showed that: after the combined exposure of azoxystrobin and selenomethionine with different concentrations (0.1+0.2, 0.25+0.5, 0.5+1.0 and 1.0+2.0 mg/L) (the mass of selenomethionine was calculated as the mass of selenium, and the same below), the embryos showed a decrease in the autonomic movement frequency, a decrease in hatching rate, an increase in mortality rate, and a decrease in heart rate. At the same time, and body length of hatching larvae was significantly inhibited with an obvious time-dose-effect relationship. Compared with the control group, the activity of catalase (CAT) was significantly decreased in different combined exposure groups (0.0005+0.001, 0.005+0.01 and 0.05+0.1 mg/L), and the high concentration combined exposure group (azoxystrobin 0.05 mg/L and selenomethionine 0.1 mg/L) showed the most significant inhibitory effect (P < 0.01), while it had no significant effects on the activity of superoxide dismutase (SOD). Compared with the control group, the combined exposure group of the highest concentration (0.05+0.1 mg/L) significantly inhibited the activity of the mitochondrial respiratory chain complex Ⅲ(P < 0.05), while the combined exposure groups of other concentrations had no significant difference. The results suggested that the combinations of azoxystrobin and selenomethionine (0.1+0.2, 0.25+0.5, 0.5+1.0 and 1.0+2.0 mg/L) could cause developmental toxicity effects on zebrafish embryo and larvae, however, the combinations of azoxystrobin and selenomethionine at actual environment-related concentrations will not cause any developmental toxicity effects except for inhibiting the activity of CAT. These results can provide data support for monitoring the concentrations of azoxystrobin and selenomethionine in aquatic environment and the ecological risk assessment of their combined exposure in the future. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: During a badminton game, athletes need to perform high-intensity tasks such as jumping, lunging, changing direction quickly, and hitting the ball. The tactics are highly different between singles and doubles games. Understanding the difference in match load between singles and doubles games could help in the design of proper training plans and recovery strategies. The aims of this study were to quantify the work load of badminton players and to compare the differences in match load between singles and doubles players. Methods: Fifteen junior college men's badminton team players were recruited as experiment participants. Each player wore two Capture.U inertial sensors (wrist and lower back), a Polar H10 heart rate sensor (chest), and a Global T1 local positioning system sensor (shoulder). Each participant played one singles and one doubles simulated match and then recorded their work load during the match. The difference in singles and doubles match loads was analyzed using the dependent sample t-test. Results: Banister's TRIMP, average heart rate, maximal heart rate, distance covered, and average speed of singles players were higher than those of doubles players. However, sRPE and player load were not significantly different. Singles players also played a higher number of shots and had a greater stroke frequency and sum of acceleration peaks. The number of shots, stroke frequency, and sum of acceleration peaks were higher in doubles combinations than in singles. Conclusion: The higher heart rate and average speed of singles players and the greater distance they covered indicate that singles matches had a higher physical load. In doubles matches, the number of shots was higher and stroke frequency and sum of acceleration peaks were greater, suggesting that they had a higher hitting load. In conclusion, singles matches impose higher physical demands, whereas doubles matches require focus on technical and tactical skills. [ABSTRACT FROM AUTHOR]

Copyright of Psychological Science is the property of Psychological Science Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Liquid Crystal & Displays is the property of Chinese Journal of Liquid Crystal & Displays and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: A prospective study of the effect of intraoperative intercostal nerve block (IINB) on body stress response, hemodynamics and quality of life in patients with rib fracture (RF). Methods: 70 RF patients who underwent thoracoscopic surgery in the First Affiliated Hospital of Chengdu Medical College from January 2017 to December 2021 were selected and divided into IINB group (n=35) and control group (n=35) according to the random number table. The control group was given intravenous and inhalation combined general anesthesia, and the IINB group was given IINB on the basis of the control group. The hemodynamic indexes such as mean arterial pressure (MAP) and heart rate (HR) before operation (T0), 5 min (T1), 15 min (T2), 30 min (T3) and at the end of operation (T4); Postoperative recovery; Pain at 6 h, 12 h, 24 h and 48 h after operation and pain relief rate; Quality of life at 1 d, 3 d and 7 d after operation; Postoperative complications and other indicators were observed. Results: MAP and HR of IINB group were lower than those of control group at all time points (P<0.05). The feeding recovery time, first time to get out of bed, time of indwelling chest tube and the postoperative hospitalization time in IINB group were shorter than those in the control group(P<0.05). The VAS score of IINB group was lower than that of control group at 6 h, 12 h, 24 h and 48 h after operation (P<0.05); The pain relief rate of IINB group was 20.00% (7/35) lower than that of control group (42.86% (15/35) (P<0.05). The quality of life scores in IINB group were higher than those in the control group on the 1 d, 3 d and 7 d after operation(P<0.05). The incidence of complications in IINB group was 2.86%(1/35) lower than that 22.86%(8/35) in control group(P<0.05). Conclusion: IINB can effectively relieve the pain and body stress response of RF patients, maintain the stability of hemodynamics during operation, effectively relieve postoperative pain,promote postoperative recovery, improve their quality of life and reduce postoperative complications. [ABSTRACT FROM AUTHOR]

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of anterior serserus plane and intercostal nerve block under intravenous anesthesia combined with ultrasound guidance in thoracoscopic cuneform resection of lung. Methods: 60 patients with thoracoscopic wedge-shaped pulmonary resection admitted to our hospital from October 2021 to December 2022 were selected and divided into control group(30 cases)and observation group(30 cases) according to random number table method.30 patients in the control group received general anesthesia combined with thoracic paravertebral block+intercostal nerve block, and 30 patients in the observation group received general anesthesia combined with serratus anterior+intercostal nerve block. The mean arterial pressure and heart rate of the two groups were compared at the time of monitoring home invasion(T0), immediately after intubation(T1), at the time of operation sectioning(T2) and immediately after extubation(T3), the pain scores at resting and coughing at 2 h, 4 h, 12 h, 24 h and 48 h after surgery, and the stress response indexes at T0-T3 points were compared between the two groups. The intraoperative dose of vasoactive drugs was compared between the two groups, and the incidence of perioperative adverse reactions was compared between the two groups. Results: Compared with T0, the mean arterial pressure and heart rate at T1, T2 and T3 increased significantly(P＜0.05), while there was no difference between the two groups at T1(P＞0.05); the mean arterial pressure and heart rate in the observation group at T2 and T3 were significantly lower than those of the control group(P＜0.05). With the extension of postoperative time, the pain scores in resting and coughing state of the two groups were significantly decreased(P＜0.05), but there was no statistical significance between the two groups at the same time point(P＞0.05).Compared with T0 point, tumor necrosis factor, interleukin 6 and interleukin 10 levels in the observation group were significantly increased at T1, T2 and T3(P＜0.05), but there was no statistical significance between the observation group and control group at the same time point(P＞0.05). The dose of vasoactive drugs used in the observation group was significantly lower than that in the control group(P＜0.05). The incidence of adverse reactions in observation group was 16.77 % lower than that in control group(23.33 %), but there was no statistical significance between groups(P＞0.05). Conclusion: The hemodynamics of thoracoscopic wedge resection patients who underwent intravenous general anesthesia combined with ultrasound-guided anterior serration plane + intercostal nerve block were more stable, and the amount of vasoactive drugs required during the operation was significantly reduced. [ABSTRACT FROM AUTHOR]

PAHS are a kind of organic chemical pollutants with high melting point and boiling point, low vapor pressure, insoluble in water and easily soluble in benzene aromatic solvents, which seriously harm the survival and growth of fish. PAHS can induce neurodegeneration and affect neurodevelopment, damage gill tissue and affect the physiological function of respiratory system, affect the heart contraction and change the heart rate, so that the heart shape changes, damage the physiological structure of digestive organs and affect metabolic activities. It can affect the expression of non-specific immune functional genes and inhibit the proliferation of specific immune cells. It can also hinder the secretion of sex hormones and reduce the gonadal index. In the paper, the research progress on the physiological harm of PAHS to fish in recent years was reviewed, in order to provide reference for controlling PAHS pollution and healthy fishery production. [ABSTRACT FROM AUTHOR]

To investigate the value of AIMS65 score combined with serum gastrin (GAS), prostaglandin E2 (PGE2) and urea nitrogen/albumin ratio (BAR) in assessing clinical outcomes after endoscopic hemostatic treatment in patients with acute non-variceal upper gastrointestinal bleeding (ANVUGIB). A total of 108 ANVUGIB patients, who were admitted to the Gastroenterology Department of Beijing Hepingli Hospital between May 2020 and may 2022, were selected and divided into poor prognosis and good prognosis groups according to the prognosis of the patients within 28 d of hospitalization. Patients' clinical data were collected, serum GAS and PGE2 levels were measured and AIMS65 score and BAR were calculated. Multi-factor logistic regression was used to analyze the factors influencing poor prognosis after endoscopic hemostasis treatment in patients with ANVUGIB. The value of the AIMS65 score, GAS, PGE2 and BAR in assessing poor prognosis after endoscopic hemostasis treatment in patients with ANVUGIB was analyzed using receiver operating characteristic (ROC) curves. The incidence of poor prognosis in 108 patients with ANVUGIB after endoscopic hemostasis treatment was 37.96%(41/108). Univariate analysis showed that the poor prognosis group was older than the good prognosis group, with higher heart rate, shock index, AIMS65 score, GAS and BAR than the good prognosis group, and lower PGE2 levels than the good prognosis group (all P<0.05). Multivariate logistic regression analysis showed that increasing age and shock index, aims65 score, gas and bar elevation were independent risk factors for poor outcome after endoscopic hemostatic therapy in ANVUGIB patients, and increasing PGE2 was an independent protective factor(all P<0.05). ROC curve analysis showed that the area under the curve for the AIMS65 score combined with GAS, PGE2 and BAR to assess poor prognosis after endoscopic hemostasis treatment in patients with ANVUGIB was greater than for the AIMS65 score, GAS, PGE2 and BAR alone (all P<0.05). The AIMS65 score, GAS and BAR of patients with poor prognosis of ANVUGIB were higher than those with good prognosis. The AIMS65 score combined with GAS, PGE2 and BAR is of high value in assessing clinical outcomes after endoscopic hemostatic treatment in patients with ANVUGIB. [ABSTRACT FROM AUTHOR]

Objective: To investigate the changes of blood micrometastasis, gastrointestinal function recovery and cognitive function in elderly patients undergoing radical resection of rectal cancer during anesthesia with dexmedetomidine and etomidate. Methods: 112 cases of elderly patients undergoing radical resection of rectal cancer who were treated in our hospital from April 2020 to February 2022 were divided into control group (n=56, etomidate anesthesia) and study group (n=56, dexmedetomidine combined with etomidate anesthesia) according to the random number table method. The blood micrometastasis situation, hemodynamics, anesthetic effect, gastrointestinal function recovery situation and cognitive function situation were compared between the two groups, and the incidence of adverse reactions in the two groups was counted. Results: The positive expression rate of cyctokeratin-20 (CK20) in the two groups at 24 h after operation was decreased, and study group was lower than control group (P<0.05). There was no difference in incidence rate of adverse reactions between two groups (P>0.05). The heart rate (HR) and mean arterial pressure (MAP) in the study group at immediately intubation, immediately after operation and immediately extubation were higher than those in the control group (P<0.05). There were no significant differences in the tracheal extubation time, respiratory recovery time and anesthesia recovery time in both groups (P>0.05). The feeding time, intestinal sound recovery time and first exhaust time in the study group were shorter than those in the control group (P<0.05). The Mini-Mental State Examination (MMSE) scores in the study group at 1 d after operation and 3 d after operation were higher than those in the control group, the incidence rate of postoperative cognitive dysfunction (POCD) was lower than that in control group (P<0.05). Conclusion: Etomidate combined with Dexmedetomidine in elderly patients undergoing radical resection of rectal cancer has a good anesthetic effect, which can maintain hemodynamic stability, reduce blood micrometastasis, improve gastrointestinal function and cognitive function. [ABSTRACT FROM AUTHOR]

Copyright of South China Fisheries Science is the property of South China Fisheries Science Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective We aimed to construct an animal model of combining disease with syndrome of yin deficiency and yang hyperactivity with attention deficit hyperactivity disorder (ADHD) in children, so as to promote the development of new drugs for the treatment of ADHD. Methods Young spontaneously hypertensive rats (SHR) were used as ADHD model rats. SHR were randomly divided into four groups according to body mass( n = 8): the SHR group, the model group, the Xiaoer Huanglong Granule low dose (XEHL-L) group (1. 88 g / kg) and the Xiaoer Huanglong Granule high dose (XEHL-H) group (3. 75 g / kg). The WKY group and the Wistar group were also set up (n = 8). Rats in the model group, the XEHL-L group and the XEHL-H group were subcutaneously injected with levothyroxine sodium (0. 3 μg / g) daily for 14 days, and rats in the other groups were subcutaneously injected with normal saline. From the 11th day, rats in the XEHL-L group and the XEHL-H group were given drugs by gavage for 21 days, and rats in the other groups were given normal saline by gavage. The diet volume, water volume, defecation volume, urine volume, heart rate, respiratory rate, and specific values of the tongue image red vector (R), green vector (G) and blue vector (B) were used as evaluation indicators of the syndrome of yin deficiency and yang hyperactivity. The degree of autonomous activity, the degree of social preference, the ability of attention set transfer and the degree of irritability were used as the behavioral indexes of ADHD to evaluate the model. Results Compared with the model group, the heart rate of rats in the other groups was decreased (P<0. 05), the respiratory rate of rats in the SHR group and the XEHL-H group was decreased (P<0. 05, P<0. 01), and the G and B values of tongue images of rats in the WKY group and the XEHL-H group were decreased (P< 0. 05). The degree of autonomic activity showed that except for the central area residence time, all indexes in the model group were higher than those in the WKY group (P<0. 05), and the distance in the central region was higher than that in the SHR group (P<0. 05). The degree of social preference showed that compared with the Wistar group, rats in the model group spent less time with strangers and the ratio of time with strangers was lower (P< 0. 01). The attention set transfer ability test showed that the error rate in the EDS reverse learning stage was lower in the XEHL-L group than in the model group (P<0. 05). The irritation experiment showed that the aggressive behavior in the model group was increased compared with that in the WKY group (P< 0. 05). Conclusion A more stable and reliable model of ADHD syndrome with yin deficiency and yang hyperactivity can be obtained by injecting young SHR with levothyroxine sodium. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of dexmedetomidine combined with sevoflurane under bispectral index (BIS) monitoring on quality of awakening serum oxidative stress indexes and nerve injury markers in patients undergoing interventional embolization for intracranial aneurysms. Methods: Using the random number table method, 80 patients with interventional embolization for intracranial aneurysms who were admitted to our hospital from March 2019 to June 2021 were divided into the study group (dexmedetomidine combined with sevoflurane under BIS monitoring, n = 40 ) and the control group (sevoflurane under BIS monitoring, n = 40 . The changes of hemodynamics, recovery quality, serum oxidative stress indexes and nerve injury markers in the two groups were observed. The occurrence of adverse reactions during perioperative period in the two groups was recorded. Results: From 1 min after endotracheal intubation (T1) to 10 min after extubation (T4), the mean arterial pressure (MAP) and heart rate (HR) in the two groups increased and then decreased, but the study group was lower than the control group at the same time (P < 0.05) . Compared with the control group, the awakening time, recovery breathing time and extubation time in the study group were shorter (P < 0.05) At T1~T4, the levels of superoxide dismutase (SOD) and catalase (CAT) in the two groups decreased and then increased, but the study group was higher than the control group at the same time point (P < 0.05) 1 d after operation, the levels of myelin basic protein (MBP), neuron-specific enolase (NSE) and $100ẞ in the two groups were increased, but the study group was lower than the control group at the same time (P < 0.05) . There was no significant difference in the incidence of adverse reactions in the control group and the study group (P > 0.05) Conclusion: Sevoflurane combined with dexmedetomidine under BIS monitoring can improve the quality of awakening, reduce the level of oxidative stress and the degree of nerve injury, and stabilize hemodynamic fluctuations in patients undergoing interventional embolization for intracranial aneurysms [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of dexmedetomidine combined with dexamethasone on awakening quality, stress response and peripheral blood T cell subsets in patients with colorectal cancer. Methods: 132 patients with colorectal cancer who were received in our hospital from April 2020 to March 2021 were selected, and they were divided into control group (dexmedetomidine, n=66) and study group (dexmedetomidine combined with dexamethasone, n=66) by random number table method. Hemodynamics, awakening quality, stress response, T cell subsets and adverse reactions were observed of the two groups. Results: The mean arterial pressure (MAP) and heart rate(HR) of the study group were lower than those of the control group at the time point from 10min (T1) to the time point from the operating room (T4) after administration (P<0.05). The norepinephrine (NE) and epinephrine (E) of the study group were lower than those of the control group at T1~T4(P<0.05). There were no differences in eye opening time, recovery time of spontaneous respiration after operation and extubation time of the two groups (P>0.05). CD3+, CD4+, CD4/CD8+of the study group at 3 d after operation were higher than those of the control group, and CD8+ was lower than that of the control group (P<0.05). There was no difference in the incidence of adverse reactions of the two groups (P>0.05). Conclusion: Dexmedetomidine combined with dexamethasone in patients with coorectal cancer can maintain good awakening quality, reduce body's stress response and immune suppression, and improve hemodynamic fluctuations. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of sevoflurane combined with remifentanil on neurologic function, cognitive function and inflammatory factors in patients with intracranial aneurysms undergoing interventional therapy. Methods: 80 patients with intracranial aneurysms who underwent interventional surgery in our hospital from January 2020 to June 2022 were selected and divided into group A(sevoflurane combined with remifentanil) and group B(propofol combined with remifentanil) according to different anesthesia methods, with 40 patients in each group. Neurological function, cognitive function and inflammatory factor level were compared between the two groups. Results: The heart rate(HR) and mean arterial pressure(MAP) of group A were better than those of group B from T1 to T3(P＜0.05). The national institutes of health stroke scale(NIHSS) score of group A was significantly lower than that of group B at 24 h and 7 d after operation(P＜0.05), and the mini-mental state examination(MMSE) score was higher than that of group B(P＜0.05).Serum tumor necrosis factor-α(TNF-α), C-reactive protein(CRP), and interleukin-6(IL-6) levels at 24 h and 3 d after operation in group A were lower than those in group B(P＜0.05). The recovery time of spontaneous respiration, recovery time, extubation time and the incidence of agitation after extubation in group A were lower than those in group B(P＜0.05). The adverse effects were not different(P＞0.05).Conclusion: The application of sevoflurane combined with remifentanil maintenance anesthesia in interventional IA patients can smooth hemodynamics, improve postoperative neurological function and cognitive function, reduce inflammatory response, and improve the quality of anesthesia awakening. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into application effect of remazolam toluenesulfonate combined with remifentanil on painless gastroscopy in elderly patients. METHODS: A total of 90 elderly patients underwent painless gastroscopy in the endoscopy center of Taizhou People’ s Hospital from Aug. 2020 to Aug. 2022 were enrolled and divided into P group, R1 group and R2 group via random number table method. Three groups were firstly given remifentanil hydrochloride 0. 5 μg / kg intravenously; then the P group was given propofol 1. 5 mg / kg intravenously for anesthesia, the R1 group was given remazolam toluenesulfonate 0. 15 mg / kg intravenously for anesthesia, and the R2 group wasgiven remazolam toluenesulfonate 0. 2 mg / kg intravenously for anesthesia. The sedation onset time, awakening time, modified alertness/ sedation scale (MOAA/ S) score after 2 minutes of drug administration and the number of remedial sedation were compared among the three groups, the hemodynamic indicators [heart rate (HR), mean arterial pressure (MAP) and pulse oxygen saturation (SpO2)], were recorded before surgery (T0), at 1 min after administration (T1), at the time of endoscopic insertion (T2), at the end of the examination (T3) and at the time of awakening from anesthesia (T4), the incidence of adverse drug reactions during and after surgery were counted. RESULTS: Compared with P group, patients in R1 group and R2 group had longer sedation onset time but shorter awakening time, with statistically significant differences (P<0. 05), while the difference between R1 group and R2 group was not statistically significant (P>0. 05). There was no statistically significant difference in the MOAA/ S sedation scores among the three groups at 2 min after drug administration (P>0. 05). The incidence of remedial sedation (additional sedative drugs ≥1 time) and the mean number of drug additions were higher in R1 group and R2 group than those in P group, with statistically significant differences (P<0. 05), while the difference between R1 group and R2 group was not statistically significant (P>0. 05). The HR and MAP from T1 to T4 and SpO2 at T1 to T2 were higher in R1 group and R2 group than those in P group, with statistically significant differences (P<0. 05), while the difference between R1 group and R2 group was not statistically significant (P>0. 05). Compared with P group, the incidences of hypotension, hypoxemia and injection pain were reduced in R1 group, and the incidence of injection pain was reduced in R2 group, with statistically significant differences (P < 0. 05). CONCLUSIONS: The 0. 15 mg / kg remazolam toluenesulfonate combined with 0. 25 μg / mg remifentanil for painless gastroscopy in elderly patients is safer while ensuring the anesthetic effect. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Chongqing University of Technology (Natural Science) is the property of Chongqing University of Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of edaravone and dexamethasone combined with BIS monitoring before anesthesia induction on lung protection and postoperative recovery after thoracoscopic lobectomy. Methods: A total of 80 patients who came to our hospital for thoracoscopic lobectomy from January 2021 to August 2022 were selected. Before induction of anesthesia, group A was given 100 m L of 0.9 % normal saline, group B was given 30 mg edaravone, group C was given 4 mg dexamethasone injection, and group D was given 30 mg edaravone Bong and 4 mg dexamethasone, and relevant indicators were compared between the four groups. Results:There was no difference in the operation time, anesthesia time, fluid volume and blood loss among the four groups (P＞0.05). The heart rate and mean arterial pressure of the four groups of patients were not significant at points T1-T4 (P＞0.05); the oxygenation index and respiratory index of the four groups of patients were not significant at points T1, T2, and T4 (P＞0.05); the oxygenation index of group D was higher than that of groups A, B, and C, and the respiratory index was lower than that of groups A, B, and C. There was no significance between group B and group C (P＞0.05), but the oxygenation index was lower than that of group A, B, and C. The index was higher than that of group A, and the respiratory index was lower than that of group A (P＜0.05). At T1, T2, and T4, the serum IL-8, IL-10,TNF-α, SP-A levels and the number of polymorphic neutrophils in the four groups were not significant (P＞0.05); group D Compared with groups A, B and C, the level of SP-A was higher, and the numbers of IL-8, IL-10, TNF-α and polymorphic neutrophils were lower than those in groups A, B and C (P＜0.05). There was no statistical comparison between group B and group C (P＞0.05). However, the level of SP-A was higher than that of group A, and the number of IL-8, IL-10, TNF-α and polymorphic neutrophils was lower than that of group A (P＜0.05). The postoperative hospital stay in group D was lower than that in groups A, B and C, and there was no difference between group B and group C (P＞0.05), but the postoperative hospital stay was lower than that in group A (P＜0.05). There was no significance in the incidence of pneumonia and atelectasis among the four groups (P＞0.05). Conclusion: Edaravone combined with dexamethasone before induction of anesthesia and BIS monitoring can improve the pulmonary protective effect and promote postoperative recovery after thoracoscopic lobectomy. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study was to investigate the risk factors and Logistic regression analysis of interscalenus brachial plexus block affecting heart rate variability. Methods: Selection in May 2021 to March 2022 in our hospital in patients with shoulder joint open surgical treatment of 60 cases as the research object, according to the different anesthesia were randomly divided into experimental group and control group in two groups, one group patients give between scalene muscle under the guidance of ultrasound brachial plexus block, between the control group patients with pure scalenus brachial plexus block. General clinical data of the patients were collected, and heart rate variation index, SpO2, heart rate and mean arterial pressure level before and after block were compared and analyzed. The relationship between risk factors and heart rate variability was also studied. Results: Univariate analysis of interbrachial plexus block affecting heart rate variability showed that risk factors were not related with sex, mean age, BMI, total cholesterol, triglycerides, HDL, LDL, chronic diseases (diabetes, hypertension), smoking and alcohol history (P>0.05), and interanginal brachial plexus block with shorter analgesic maintenance, longer exercise recovery and fewer blocks were more likely to show heart rate variability (P<0.05). After the block, LF, HF, LF/HF, RMSSD, SDNN and PNN50% were significantly lower than those in the control group (P<0.05), how- ever, there was no difference in SpO, heart rate, and mean arterial pressure after the block (P>0.05). The multiple factors affecting the risk factors of HEART rate variability were maintenance time of analgesia (OR-6.224, P 0.001 <0.05), exercise recovery time (OR=9. 556, P=0.002<0.05), number of blocks (OR=7.591, P-0.001 <0.05). Conclusion: The heart rate variability in brachial plexus block was related to the maintenance time of analgesia, the recovery time of exercise and the number of blocks. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of ultrasound-guided nerve block anesthesia on anesthetic effect and postoperative cognitive function in senile patients undergoing femoral head replacement. Methods: 150 senile patients scheduled for Ifemoral head replacement admitted to our hospital from January 2019 to December 2021 were randomly divived into control group and observation group, each group has 75 patients. The control group received general anesthesia, the observation group received ultrasound-guided nerve block anesthesia combined with general anesthesia. The hemodynamics indexes, extubation, recovery and PACU stay time, VAS scores, postoperative cognitive function and adverse reactions of two groups were compared. Results: The heart rate (HR) and mean arterial pressure(MAP) of observation group were lower than control group at each time point (P<0.05). The extubation, recovery and PACU stay time of observation group were shorter as compared with control group (P<0.05). The VAS scores of observation group were lower than control group at each time point postoperative (P<0.05). Comparing with control group, the mini-mental state examination (MMSE) scores of observation group at 1 h, 12 h and 24 h postoperative were higher, the incidence of postoperative cognitive dysfunction (POCD) of observation group at 1 h, 12 h and 24 h postoperative were lower than control group (P<0.05). There were no significant differences of adverse reactions of two groups (P>0.05). Conclusion: Ultrasound-guided nerve block anesthesia could stabilize hemodynamic, shorten extubation, recovery and PACU stay time, relieve postoperative pain, improve postoperative cognitive function, which deserves the clinical expansion. [ABSTRACT FROM AUTHOR]

Objective: To observe the clinical effect of different doses of oxycodone combined with dexmedetomidine anesthesia in patients undergoing radical resection of lung cancer. Methods: Used the random number table method, patients with lung cancer (n=140) who underwent radical resection of lung cancer in our hospital from March 2017 to December 2020 were divided into group A (1.0 mg/kg oxycodone) and group B (2.5 μg/kg dexmedetomidine, 1.0 mg/kg oxycodone), group C (2.5 μg/kg dexmedetomidine, 0.75mg/kg oxycodone), group D (2.5 μg/kg dexmedetomidine, 0.5 mg/kg oxycodone), 35 cases in each. Hemodynamics, immune response,satisfaction of analgesic effect and incidence of adverse reactions were observed in the four groups. Results: The heart rate (HR) and mean arterial pressure (MAP) at 2 h after operation (T1) to 6 h after operation (T2) time points in the group C and group D were lower than those in the group A and group B (P<0.05). There were no significant differences in HR and MAP at T1 and T2 time points between the between group A and group B, group C and group D (P>0.05). The satisfaction of analgesic effect in the group A and group D was lower than that in the group C and group B (P<0.05). There were no significant differences in the satisfaction of analgesic effect between the between the group A and group D, group C and group B (P>0.05). CD3+, CD4+, CD4+/CD8+in group C and group D were higher than those in group A and group B. CD8+was lower than that in the group A and group B (P<0.05). There were no significant differences in CD3+, CD4+, CD8+, CD4+/CD8+ between the group C and group D, between the group A and group B (P>0.05). The incidence of adverse reactions in the group C was lower than that in the group A, group B and group D (P<0.05). Conclusion: Oxycodone combined with dexmedetomidine anesthesia is used in patients undergoing radical resection of lung cancer with 0.75 mg/kg oxycodone combined with 2.5 μg/kg dexmedetomidine has the best effect, can obtain better satisfaction with analgesic effect, stabilize hemodynamics, reduce immunosuppression, and which is safe and reliable. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To explore the intervention effects of Ligusticum Chuanxiong extract on rats with chronic heart failure and explore its mechanism through Wnt/β-catenin signaling pathway. METHODS: The rat model of chronic heart failure was established by abdominal aortic constriction combined with strenuous swimming. Electrocardiogram was used to detect the changes of electrocardiogram before and after modeling. After successful modeling, the rats were divided into the model group (n =10) and experimental group (n =10), and 10 rats without model were set as the control group. The experimental group was given Ligusticum Chuanxiong extract (100 mg/kg) once a day for 4 weeks, and the control group and model group received the same amount of 0. 9% sodium chloride solution gavage. At the end of the experiment, the heart rate and respiratory rate of rats in each group were detected, and LVIDd, LVIDS, LVEF and LVFS were detected. The pathological state of rat heart tissue was detected by hematoxylin-eosin (HE) staining. Ultrastructural changes of heart tissues were detected by electron microscope, and the expression of key molecules Dvl3, GSKβ, β-catenin in heart tissues was detected by Western blotting. RESULTS: Ultrasound results showed that LVIDd and LVIDS of the model group were significantly higher than those of control group, LVEF and LVFS were significantly lower than those of control group, LVIDd and LVIDs of experimental group were significantly lower than those of model group, LVEF and LVFS were significantly higher than those of model group, the differences were statistically significant (P <0. 01). HE staining and electron microscopy results showed that heart tissues of the model group were damaged, while the experimental group was less than the model group. Western blotting results showed that expression levels of Dvl3, GSKβ and β-catenin in the model group were significantly higher than those in the experimental group, and there was a significant downward trend compared with the model group (P<0. 01). CONCLUSIONS: Ligusticum Chuanxiong extract has protective effects on the heart of chronic heart failure rats, and its mechanism is related to the inhibition of Wnt/β-catanin signaling pathway. [ABSTRACT FROM AUTHOR]

As a broad-spectrum antibiotic, sulfamethoxazole (SMX) has been widely used and frequently detected in various water bodies. In order to study the developmental toxicity of SMX to zebrafish ( Danio rerio), embryos within 3 hours after fertilization (hpf) were treated with different concentrations (CK: 0 μg·L-1, S4: 4 μg·L-1, S40: 40 μg·L-1, S400: 400 μg·L-1 ) of SMX solution until 120 hpf. The hatchability of zebrafish embryos, the mortality rate, heart rate, body length and malformation rate of larvae and other developmental parameters were observed. Besides, the contents of growth hormone (GH) and insulin-like growth factor (IGF-1) and the transcriptional levels of genes involved in GH/IGF-axis in zebrafish were detected. The results showed that exposure to 40 μg·L-1 and 400 μg·L-1 of SMX significantly resulted in increased mortality and malformation (pericardium cyst, spinal curvature, tail deformity, etc.), and shortened body length. SMX stress exhibited no significant effects on the hatchability of zebrafish, but decreased the heart rates of embryos and larvae. In addition, under SMX exposure, the levels of GH and IGF-1 in larval fish were significantly increased, while SMX exposure down-regulated the transcription of several genes along GH/IGF-axis, including gh1 (0.30-, 0.17- and 0.10-fold), ghrb (0.74-, 0.36- and 0.39-fold), igf1(0.75-, 0.23- and 0.33-fold) and igf1ra(0.49-, 0.22- and 0.72-fold). It seemed that the response of hormones had a delay compared with the transcriptional change of genes. The current results indicate that SMX induces embryo developmental toxicity in zebrafish, and may inhibit the early growth of zebrafish via slowing heart beat and/or interfering with GH/IGF axis. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background: The continuous monitoring of body surface temperature has been proven to help detect potential fever events in hospitalized patients. However, the efficacy of using body surface temperature to detect fever in older adults remains unclear due to the relatively low and slower-to-change body surface temperature in this population. Purpose: This study was designed to investigate 1) the relationship between changes in body surface and routine tympanic temperatures, 2) the correlation between body surface temperature measurement frequency and detection of fever, and 3) the factors related to the incidence of fever in hospitalized older adults. Methods: A prospective study was conducted on 33 hospitalized older adults aged 65 years or older who were suspected to have or diagnosed with an infection in an infectious disease and medical ward at a medical center in southern Taiwan from March to November 2020. Demographic, routine tympanic temperature, and heart rate data were collected by reviewing the participants' medical records. Body surface temperatures were monitored continuously using HEARThermo every 10 seconds until one of the following conditions were met: hospital discharge, no fever for three continuous days, and HEARThermo was removed. Descriptive analysis was used to compare the variations in body surface temperature and routine tympanic temperature measurements. Pearson correlation was used to analyze the correlation between different measurement frequencies and fever events. Finally, mixed effects logistic regression was used to analyze the factors significantly related to fever events. Results: Seven hundred and twenty routine body temperature measurements were taken, with 209 (29.0%) fever events detected in 23 (69.7%) of the participants. The body surface temperatures were more closely correlated with tympanic temperatures during fever events than non-fever events (r = .260, p < .001). More fever events were detected using body surface temperature monitoring frequencies of every 10 seconds and every 1 minute. After controlling for demographic factors, the results of the mixed effect model indicate that body surface temperature and heart rate are significant factors related to fever events in hospitalized older adults (odds ratio, OR: 1.74, p < .001; OR: 1.11, p < .001). Conclusions/ Implications for Practice: The continuous monitoring of body surface temperature may improve the detection of fever events in hospitalized older adults. The application of wearable devices and cloud platforms may further facilitate the real-time assessment and care capabilities of nurses, thus reducing their workload and improving care quality. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Railway Science & Engineering is the property of Journal of Railway Science & Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OBJECTIVE: To probe into the effects of Huangqi Guizhi Wuwu decoction on heart rate recovery from bradyarrhythmia, serum fatty acid binding protein levels and plasma Ang Ⅱ, Adropin and galectin (Gal) 3. METHODS: A total of 120 patients with bradyarrhythmias admitted into the hospital from Apr. 2020 to Apr. 2021 were extracted to be divided into the control group and the observation group via the random number table method, with 60 cases in each group. The control group was treated with routine treatment, while the observation group received Huangqi Guizhi Wuwu decoction based on the control group. The levels of Gal-3, vasoactive intestinal peptide (VIP), nitric oxide (NO) and Ang Ⅱ, Adropin, growth differentiation factor (GDF)-15, creatine kinase isoenzyme (CK-MB), heart-type fatty acid binding protein (H-FABP), endogenous nociceptin / orphanin FQ (N/ OFQ), left ventricular ejection fraction (LVEF), heart rate (HR), root mean square of the difference between successive NN intervals (RMSSD), every 5 min NN standard deviation of mean interval (SDANN) and total NN interval (SDNN) before and after treatment in two groups were detected. Clinical efficacy of two groups were compared. RESULTS: After treatment, the level of Ang Ⅱ of the observation group was lower than that of the control group, the levels of VIP, Adropin and NO were higher than those of the control group, the levels of Gal-3, GDF-15 was lower than that of the control group, the levels of H-FABP, CK-MB and N/ OFQ were lower than those of the control group, the levels of LVEF and HR were higher than those of the control group, the levels of RMSSD and SDANN were lower than those in the control group, the level of SDNN was higher than that of the control group, with statistically significant differences (P<0. 05). The total effective rate of the observation group was 96. 67% (58 / 60), higher than 83. 33% (50 / 60) of the control group, the difference was statistically significant (P < 0. 05). CONCLUSIONS: Huangqi Guizhi Wuwu decoction in the treatment of patients with bradyarrhythmias can improve vascular endothelial function, inhibit inflammation, reduce myocardial damage, improve heart rate, heart rate variability and cardiac function, and improve the clinical efficacy. [ABSTRACT FROM AUTHOR]

Objective: To observe the effect of dexmedetomidine combined with fentanyl on cellular immune function and cardioprotective effect in patients undergoing heart valve replacement. Methods: 97 patients with heart valve replacement under cardiopulmonary bypass (CPB） received in our hospital from April 2019 to June 2021 were included. According to the envelope lottery method,the patients were divided into control group (fentanyl, 48 cases） and observation group (dexmedetomidine combined with fentanyl, 49cases). The hemodynamic indexes [mean arterial pressure (MAP), heart rate (HR）], myocardial injury indexes [troponin (cTnI), creatine kinase isoenzyme (CK-MB), heart fatty acid binding protein (HFABP）], brain injury indexes [neuron specific enolase (NSE), S-100β],cellular immune function, analgesia situation and incidence of adverse reactions of the two groups were compared. Results: The HR and MAP in the observation group were lower than those in the control group at 10 min (T2） after the beginning of CPB, but higher than those in the control group at the end of CPB (T3） and the end of operation (T4) (P＜0.05). Visual analogue scale (VAS） scores in the two groups increased and then decreased before operation (T1), 24 h after operation and 48 h after operation (P＜0.05), and VAS scores in the observation group were lower than those in the control group at 24 h after operation and 48 h after operation (P＜0.05). 48 h after operation,CD4+and CD4+/CD8+in the observation group were higher than those in the control group, while CD8+was lower than that in the control group (P＜0.05). The cTnI, CK-MB and HFABP in the observation group at 48 h after operation were lower than those in the control group (P＜0.05). NSE and S100B in the observation group were lower than those in the control group at 48 h after operation (P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05). Conclusion: Dexmedetomidine combined with fentanyl anesthesia scheme for patients undergoing cardiac valve replacement can help relieve pain, stabilize hemodynamics, reduce immune suppression, and also play a protective effect on the heart and brain, reducing the incidence of adverse reactions,which is a reliable anesthesia program. [ABSTRACT FROM AUTHOR]

Objective: To investigate the value of dexmedetomidine and sevoflurane combined anesthesia in elderly patients undergoing radical resection of esophageal cancer, and to observe the changes of cellular immune function, stress response and cognitive function. Methods: 96 elderly patients with esophageal cancer who were treated in our hospital from January 2021 to June 2022 were included. The patients were divided into group A (32 cases, sevoflurane), group B (32 cases, sevoflurane combined with propofol) and group C (32 cases, sevoflurane combined with dexmedetomidine) by random number table method. The changes of hemodynamic indexes,stress response indexes, cellular immune function and cognitive function in the three groups were observed, and the occurrence of adverse reactions in the three groups was recorded. Results: The heart rate (HR) and mean arterial pressure (MAP) at immediate endotracheal intubation (T1) ～operation completion (T3) time points in group B and group C were lower than those in group A, and the group C was lower than the group B (P＜0.05). The epinephrine (E), norepinephrine (NE) and dopamine (DA) in group B and group C at 3 d after operation were lower than those in group A, and the group C was lower than the group B (P＜0.05). The CD4+, CD3+and CD4+/CD8+in group B and group C at 3 d after operation were higher than those in group A, and the group C was higher than the group B (P＜0.05). 3 d after operation, CD8+in group B and group C was lower than that in group A, and the group C was lower than the group B (P＜0.05). The Montreal Cognitive Assessment (MoCA) score and Mini-Mental State Examination (MMSE) score in group B and group C were higher than those in group A, and the group C was higher than the group B (P＜0.05). The incidence of postoperative cognitive dysfunction (POCD) in group C was lower than that in group A and group B (P＜0.05). There was no significant difference in the incidence of POCD between group A and group B (P＞0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P＞0.05). Conclusion: Combined anesthesia with sevoflurane and dexmedetomidine in elderly patients with esophageal cancer undergoing radical surgery can maintain hemodynamic stability, improve stress response, immunosuppression and cognitive impairment, and the effect is good. [ABSTRACT FROM AUTHOR]

Objective: To investigate the diagnostic value of serum INH-A expression combined with transabdominal ultrasound in ectopic pregnancy. Methods: 60 patients with ectopic pregnancy treated in our hospital from January 2018 to August 2021 were selected as the research object and divided into the observation group. Another 60 normal pregnant women who came to our hospital for physical examination in the same period were selected as the control group. All pregnant women were treated with serum inhibin-A (inh-a), alkaline phosphatase (ALP) β-Human chorionic gonadotropin(β-All pregnant women were diagnosed by transabdominal ultrasound. The expression levels of ALP, β-HCG and INH-A in serum of the two groups were compared, and the diagnostic results of transabdominal ultrasound were compared between the two groups. The diagnostic value of single diagnosis and combined diagnosis of serum INH-A and transabdominal ultrasound in ectopic pregnancy of the two groups were analyzed. Results: ALP of pregnant women in the observation group β-The level of hCG was lower than that of the control group, and the level of INH-A was higher than that of the control group (P＜0.05). In the observation group, the incidence of no fetal heart beat, no intrauterine pregnancy sac, adnexal mass and endometrial thickness less than 10 mm were higher than those in the control group (P＜0.05). By comparing the detection rate of ectopic pregnancy in72 patients, it was found that the detection rate of combined diagnosis was significantly higher than that of serum INH-A and transabdominal ultrasound, and the misdiagnosis rate and missed diagnosis rate of combined diagnosis were lower than that of serum INH-A and transabdominal ultrasound (P＜0.05）; By comparing the detection value of different tests, it was found that the accuracy and sensitivity of combined diagnosis were significantly higher than those of the other two single test methods (P＜0.05), and there was no difference in the detection value of specificity, positive predictive value and negative predictive value among the three diagnostic methods (P＞0.05). Conclusion: The application of serum INH-A expression combined with transabdominal ultrasound diagnosis can improve the accuracy and sensitivity of ectopic pregnancy diagnosis, so it can be considered for patients with suspected clinical symptoms of ectopic pregnancy to apply the combined diagnosis, improve the diagnostic accuracy. [ABSTRACT FROM AUTHOR]