1. [Effects of induction of anti-embryonation and anti-fecundity immunity on liver granuloma formation in mice infected with Schistosoma japonicum].
- Author
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Wang S, Zhou M, and Zhang S
- Subjects
- Animals, Antigens, Helminth, Granuloma, Foreign-Body prevention & control, Mice, Mice, Inbred BALB C, Granuloma, Foreign-Body immunology, Liver Diseases parasitology, Ovum, Schistosoma japonicum immunology, Schistosomiasis japonica immunology
- Abstract
Objective: To investigate the effect of anti-fecundity and anti-embryonation immunity on liver granuloma formation in mice immunized with soluble immature egg antigen (SIEA) of schistosoma japonicum., Method: BALB/c mice were immunized with the crude SIEA or 26,000-28,000 molecular antigen derived from SIEA and compared the size in schistosoma japonicum egg granulomas in the liver after challenge infection both the immunized mice and unimmunized controls., Results: The number and size of egg granuloma were significantly decreased in mice immunized with SIEA and SIEA 26-28,000, by 29.26% and 49.64%, respectively. The inhibitive effects on granuloma formation and spleen weights in the group immunized with SIEA 26-28,000 were stronger than those in the group immunized with the crude SIEA. However, mean granuloma size and spleen weights in the group immunized with SEA or SIEA-1 fraction were not different from unimmunized control., Conclusion: SIEA and SIEA 26-28,000 antigenic molecule play an important role in inhibition on liver granuloma formation through their anti-embryonation and anti-fecundity immunity effects.
- Published
- 1997