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Objective：To explore the relationship between carotid intima ⁃media thickness（cIMT）and subclinical left ventricular function in population of Danyang community. Methods：The study subjects were recruited in 2021 from the Station Community of Danyang City，Jiangsu Province. cIMT was measured and analyzed by GE Vivid E90 ultrasound instrument. Two ⁃ dimensional（2D） speckle tracking technology was used to collect left ventricular global longitudinal strain（LVGLS）of the left ventricle as an indicator for assessing subclinical systolic function. The e’and E/e’ratio were obtained from mitral valve blood flow spectra and tissue Doppler imaging，serving as indicators for evaluating subclinical diastolic function. Results：A total of 561 participants with an average age of （58.2 ± 11.7）years were enrolled，among whom 339（60.4% ）were females. Using tertiles of cIMT as a categorical variable，in univariate analysis，LVGLS，E/A ratio，and e’decreased as cIMT tertiles increased，while the E/e’ratio increased（all Ptrend ≤ 0.002）， except for left ventricular ejection fraction. However，after further multivariate adjustment，only LVGLS continued to decrease with increasing cIMT tertiles（P < 0.05）. Continuous variable analysis after natural logarithm transformation of cIMT yielded results similar to categorical variable analysis，with only LVGLS showing a significant negative correlation with cIMT（r=- 0.087，P=0.041），and similar findings were observed in regression analysis（β =- 1.12，P=0.041）. Conclusion：In the Danyang community population in Jiangsu，increased cIMT is independently correlated with decreased GLS. [ABSTRACT FROM AUTHOR]

Background In recent years, studies have demonstrated the use of ultrasound speckle tracking techniques for the early evaluation of subclinical left ventricular (LV) systolic function in patients with type 2 diabetes mellitus (T2DM). In addition, long-term exposure to hyperglycemia severely damages the microvascular system. However, the interaction between diabetic microvascular complications and subclinical LV systolic function has not been fully understood. Objective To investigate the relationship between subclinical LV systolic function and diabetic microvascular complications in patients with T2DM. Methods A total of 150 patients with T2DM who were admitted to the Department of Endocrinology, the First Affiliated Hospital of Air Force Medical University from June to December 2021 were selected in the cross-sectional study and all underwent conventional echocardiography, pulsed tissue Doppler echocardiography and two-dimensional speckle tracking echocardiography (2D STE). The 2D global longitudinal strain (GLS) of LV was obtained to assess the subclinical LV systolic function. Diabetic microvascular complications were defined as combined diabetic retinopathy, diabetic kidney disease or peripheral neuropathy. The subjects were divided into the T2DM alone group (T2DM alone group, n=76), the T2DM with 1 complication group〔T2DM+C (1) group, n=37〕 and the T2DM with 2 to 3 complications group〔T2DM+C (2 to 3) group, n=37〕 according to the cumulative number of microvascular complications. The general demographic characteristics and biochemical indices of patients in the three groups were compared. The relationship between microvascular complications and subclinical LV systolic function was assessed by using Spearman correlation analysis and Logistic regression analysis. Results GLS was lower in the T2DM+C (1) and T2DM+C (2 to 3) groups than in the T2DM alone group (P

Background and purpose: Breast cancer has overtaken lung cancer as the most common malignant tumor in women. Early breast cancer patient can achieve a long survival time after comprehensive treatment, however the cardiotoxicity caused by radiotherapy may affect its long-term prognosis. Therefore, early monitoring of radiation-induced heart disease is important for improving the survival of breast cancer patients. Speckle-tracking echocardiography (STE) is a new technique to study myocardial deformation. Global longitudinal strain (GLS) is a good parameter for evaluating early cardiotoxicity caused by radiotherapy. The purpose of this study was to evaluate the value of GLS in evaluating radiotherapy-induced early cardiotoxicity in breast cancer. Methods: PubMed, EMBASE, Web of Science, Cochrane Library, Wanfang and China National Knowledge Infrastructure (CNKI) databases were searched by computer from January 2010 to March 2022. According to the pre-set inclusion and exclusion criteria, screening studies was performed using GLS and left ventricular ejection fraction (LVEF) to evaluate myocardial function changes during and after radiotherapy for breast cancer. Two researchers independently conducted literature screening and data extraction. Review Manager5.4 analysis software was used for data analysis. Results: Finally, 9 studies were included, involving a total of 543 patients. Meta-analysis results showed that LVEF of patients with left breast cancer decreased slightly immediately after radiotherapy, and WMD was -0.98. LVEF of those patients increased at 6 months after radiotherapy, and the WMD was -0.83, which was still lower than baseline. LVEF was almost unchangeable after radiotherapy for right breast cancer. GLS of left-sided breast cancer patients decreased significantly immediately after radiotherapy, at 6 weeks, 6 months and 12 months after radiotherapy, and WMD was 1.57, 1.84, 1.04 and 1.69, respectively. The differences were statistically significant. There was no significant heterogeneity among the studies. However, there was no significant change in GLS after radiotherapy for right breast cancer. There was no significant difference in GLSr between breast cancers of different sides. Conclusion: GLS may be a good predictor of radiation-induced heart disease in patients with left-sided breast cancer. [ABSTRACT FROM AUTHOR]

Objective: To evaluate the predictive value of global longitudinal strain (GLS) measured by cardiac magnetic resonance (CMR) feature-tracking technique for left ventricular remodeling (LVR) after percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI)., Methods: A total of 403 patients undergoing PCI for acute STEMI were prospectively recruited from multiple centers in China.CMR examinations were performed one week (7±2 days) and 6 months after myocardial infarction to obtain GLS, global radial strain (GRS), global circumferential strain (GCS), ejection fraction (LVEF) and infarct size (IS).The primary endpoint was LVR, defined as an increase of left ventricle end-diastolic volume by ≥20% or an increase of left ventricle end-systolic volume by ≥15% from the baseline determined by CMR at 6 months.Logistic regression analysis was performed to evaluate the predictive value of CMR parameters for LVR., Results: LVR occurred in 101 of the patients at 6 months after myocardial infarction.Compared with those without LVR ( n =302), the patients in LVR group exhibited significantly higher GLS and GCS ( P < 0.001) and lower GRS and LVEF ( P < 0.001).Logistic regression analysis indicated that both GLS (OR=1.387, 95% CI : 1.223-1.573; P < 0.001) and LVEF (OR=0.951, 95% CI : 0.914-0.990; P =0.015) were independent predictors of LVR.ROC curve analysis showed that at the optimal cutoff value of-10.6%, GLS had a sensitivity of 74.3% and a specificity of 71.9% for predicting LVR.The AUC of GLS was similar to that of LVEF for predicting LVR ( P =0.146), but was significantly greater than those of other parameters such as GCS, GRS and IS ( P < 0.05);the AUC of LVEF did not differ significantly from those of the other parameters ( P >0.05)., Conclusion: In patients receiving PCI for STEMI, GLS measured by CMR is a significant predictor of LVR occurrence with better performance than GRS, GCS, IS and LVEF.

Objective To explore the effectiveness of β receptor blockers on subclinical cardiotoxicity (AIC)induced by anthracyclines (ANT) and the clinical value of global longitudinal strain(GLS) on monitoring subclinical AIC measured by two-dimensional speckle tracking technology (2D-STI). Methods The electronic databases such as PubMed, Web of science, Embase, Cochrane library, Wanfang, CNKI and VIP from the database establishment to September 2020 were retrieved. All the clinical controlled trials of β receptor blockers for preventive treatment of AIC were selected. Two investigators independently screened the literature according to the established inclusion and exclusion criteria, extracted data and evaluated the methodological quality of the included studies. The RevMan5. 3 statistical software was used for meta-analysis. Results A comprehensive search yielded 179 relevant articles. Finally, 4 articles with a total of 290 patients were included. The sample size of the intervention group using β receptor blocker was 140 cases, and of the blank or placebo control group was 150 cases. Meta-analysis results indicated those the final value of GLS, ΔGLS had a statistically significant differences (SMD= —0. 42,95 %CI —0. 66--0. 19, P

OBJECTIVE: To compare the efficacy and safety of Sacubitril valsartan sodium tablets and Benazepril hydrochloride tablets in the treatment of chronic heart failure with reduced ejection fraction, so as to explore effective medication regimens for clinical treatment. METHODS: Totally 102 chronic heart failure with reduced ejection fraction patients admitted into Changshu No. 2 People's Hospital from Dec. 2018 to Dec. 2019 were extracted to be divided into the ARNI group and the ACEI group via the random number table and opaque envelope method, with 51 cases in each group. Patients in the ARNI group received Sacubitril valsartan sodium tablets, while the ACEI group was given Benazepril hydrochloride tablets. Clinical efficacy, cardiac function indicators [left ventricular posterior wall thickness (LVPWD), left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD), left ventricular global longitudinal strain (GLS), radial strain (GRS) and circumferential strain (GCS) during diastole], myocardial injury markers [N-terminal precursor brain natriuretic peptide (NT-ProBNP), serum troponin I (cTn I)], inflammatory mediators and myocardial fibrosis markers [soluble growth stimulating expression gene 2 protein (sST2) levels, interleukin (IL)-1 and IL-6] before and after treatment, adverse drug reactions during medication in two groups were observed and compared. RESULTS: The total effective rate in the ARNI group was 90. 20% (46 / 51), significantly higher than that in the ACEI group (74. 51%,38 / 51), with statistically significant difference (P<0. 05). After treatment, the absolute values of LVEF, GLS and GCS of all patients were significantly higher than those before treatment, and LVPWD, LVEDD, NT-ProBNP, cTnⅠ, IL-1, IL-6 and sST2 were significantly lower than those before treatment; meanwhile, the increase of LVEF in the ARNI group was greater, and the decrease of LVPWD, LVEDD, NT-proBNP, IL-1, IL-6, cTnⅠ and SST2 was greater, with statistically significant difference (P<0. 05). After 12 months of follow-up, 1 patient developed hypotension, 1 patient developed cough, and 1 patient was readmitted to hospital, but no hyperkalemia or death was observed in the ARNI group. In the ACEI group, 1 patient developed hypotension, 1 patient developed cough, 4 patients were readmitted to hospital, and 1 patient death, but no hyperkalemia was observed. CONCLUSIONS: Compared with Benazepril hydrochloride tablets, Sacubitril valsartan sodium tablets are more effective in improving heart function, inflammatory factors and myocardial injury markers in chronic heart failure with reduced ejection fraction patients, with better clinical efficacy and similar safety. [ABSTRACT FROM AUTHOR]