1. [Mechanisms underlying the expression regulation of HOXB4 transcription in hematopoietic stem cells - review].
- Author
-
Li J and Chen H
- Subjects
- CCAAT-Binding Factor metabolism, Genes, Homeobox genetics, Homeodomain Proteins metabolism, Homeodomain Proteins physiology, Humans, Transcription Factors metabolism, Transcription Factors physiology, Upstream Stimulatory Factors metabolism, Wnt Proteins metabolism, Wnt3 Protein, Wnt3A Protein, Gene Expression Regulation, Genes, Homeobox physiology, Hematopoietic Stem Cells metabolism, Homeodomain Proteins genetics, Transcription Factors genetics
- Abstract
As a member of the hox gene family, hoxB4 gene encodes a class of DNA-dependent homeobox domain nucleoprotein, which is a specific transcription factor, playing an important role in regulating the balance between self-renewal and differentiation of hematopoietic stem cells (HSCs). Therefore, it is important to understand the mechanisms involved in regulating expression of hoxB4 in the HSC. Previous studies have suggested that some hoxB4 upstream regulatory factors, such as USF-1 (upstream activating factor -1), USF-2 (upstream activating factor -2) and NF-Y complex, as well as hematopoietic cytokines, such as platelet growth factor (TPO) and Wnt3a protein, play important regulatory roles in the expression of hoxB4 in hematopoietic stem cells. In this review the structure and biological characteristics of hoxB4, mechanisms involved in regulating expression of hoxB4 in the HSC are summarized.
- Published
- 2008