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Copyright of Diagnostic Imaging & Interventional Radiology is the property of Editorial Office of Diagnostic Imaging & Interventional Radiology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Kunming Medical University / Kunming Yike Daxue Xuebao is the property of Kunming Medical Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the value of 64 slice spiral CT (SCT) low-dose chest scanning at full inspiration and full expiration for lung density measurement in assessing the pulmonary function in patients with chronic obstructive pulmonary disease (COPD)., Methods: Totally 36 COPD patients (the COPD group) underwent pulmonary function tests (PFT) and were essentially verified COPD; 30 healthy people (the control group) were selected whose 64 slice SCT chest scanning was normal. The 2 groups underwent chest 64 slice SCT low-dose scanning at full inspiration and full expiration. After the scanning, the lung was measured by CT Pulmo software. The lung was divided into 3 regions by scanning layers. We measured and calculated the density indexes of each region (including the upper, middle, lower field, and the total lung) of the 2 groups. All density indexes were lung density at full inspiration and full expiration (Din, Dex), density difference (Dex-Din), density ratio (Dex/ Din), density variation percentage (Din-Dex)/Din. All patients underwent PFT and 64 slice SCT within 3 days, whose pulmonary function was tested by Master Lab ( Jaeger, Germany). The indexes were the percentage of actual value and expected value of forced expiratory volume at the first second (FEV1%) and the ratio of first second forced expiratory volume to forced vital capacity (FEV1/FVC). Then we compared with the CT indexes between the COPD group and the control group. The relevant indicators of lung densities were analyzed in comparison with the indicators of FEV1% and FEV1/FVC by Pearson correlation analysis., Results: The density indexes of each region and total lung, and the Din in the control group and the COPD group were compared. The difference between them was statistically significant (P<0.05). The difference among other indexes was also statistically significant (P<0.01). Excellent correlation was found between Dex, Dex-Din, Dex/ Din and (Din-Dex)/ Din indexes with FEV1% and FEV1/FVC (r=0.566, 0.686, 0.568, 0.580, -0.565, -0.598, 0.565 and 0.598; P<0.01), Conclusion: Sixty-four slice SCT low-dose two-phase scanning density indexes are closely related to the indicators (FEV1% and FEV1/FVC) of clinical lung function tests, which can be used to evaluate the lung function in COPD patients conventiently and accurately.

Objective: To study the correlation between the lung pixel indexes of multi-slice spiral CT (MSCT) and pulmonary function test (PFT), and to explore the CT features of histograms of lung attenuation., Methods: MSCT scan and pulmonary function test (PFT) were separately performed in 127 subjects within one week. The total lung was scanned with MSCT at full inspiration, full expiration, and normal respiration. The lung pixel indexes were measured by Pulmo pulmonary quantitative software. These indexes include PI(-910Huin), PI(-960HUEX), PI(-910Huin), PI(-960Huex), PI(-910(Hun), PI(-960Hun), PI(910Huex/in), and the histograms of lung attenuation., Results: Correlation existed between all the lung pixel indexes of MSCT and PFT. PI(-910Huex/in showed the best correlation with FEV1/FVC (r = 0.901, P < 0.01). Three distribution patterns were found in the histograms of lung attenuation of total lung, including double-peak distribution (n = 28), similar normal distribution (n = 81), and partial distribution (n = 18)., Conclusion: The lung pixel indexes of MSCT have significant correlation with PFT and can be used to assess the pulmonary function.

Objective: To compare the effectiveness of high resolution CT, CT pulmonary functional imaging, and pulmonary function test (PFT) in the quantitative evaluation of emphysema and obstructive pulmonary disease., Methods: The study included 37 patients with obstructive ventilatory defect and 20 normal controls. CT and pulmonary function test were performed in all subjects in one week. Correlation between and differences among HRCT visual scoring, parameters of CT pulmonary functional imaging and the result of pulmonary function test were compared., Results: (1) Emphysema was detected by CT in 23 of the 37 patients with obstructive ventilatory defect. (2) HRCT visual scoring was correlated only with D(L)CO% (r = -0.731, P < 0.001) among other pulmonary function parameters. (3) HRCT visual scoring in patients with enrphysema was correlated with pixel indices (PI) at full inspiration and expiration. Visual scoring showed the best correlation with PI(-910in) (r = 0.506, P < 0.001) and PI(-910ex) (r = 0.610, P < 0.001). (4) The grading of pulmonary function based on PI(-910in) and PI(-910ex) showed no difference from the grading by pulmonary function tests (chi(2) = 0.527, P = 0.913; chi(2) = 3.645, P = 0.302). The grading of emphysema based on PI(-910in) accorded with the grading by pulmonary function tests (chi(2) = 2.59, P = 0.459)., Conclusions: HRCT is more sensitive than conventional CT in diagnosing emphysema. However, in terms of slice thickness and radiation dose, it cannot be used in the evaluation of both lungs. CT functional imaging is easily performed, and the results are objective and correlated with the result of HRCT visual scoring and PFTs. It may be, therefore, more useful in diagnosing early emphysema and evaluating lung function.