In order to determine the optimal scheme for the introduction of Zhuhai-Zhaoqing High-speed Railway into Zhuhai Railway Hub, the paper analyzed the functional status of Zhuhai-Zhaoqing High-speed Railway, the current situation of existing railways in Zhuhai Railway Hub, the general layout of the hub, the overall urban planning, the passenger operation volume and traffic flow characteristics in the hub. It is concluded that the existing and under-construction stations in the hub cannot meet the requirements of the introduction of new lines. It is urgent to build a new hub passenger station at a different location, and introduce Zhuhai-Zhaoqing High-speed Railway and planned lines into the new Zhuhai Hezhou Station. In this paper, through the investigation of the Hezhou Island topography, using the method of comprehensive economic and technical comparison and selection, the route conditions of each scheme, including the impact on urban planning, project investment, project implementation difficulty, were studied respectively. Location schemes including the south of Xianghai highway, the west of Jiangzhu highway, Xianghai highway to the north, Jiangzhu highway to the west, Xianghai Highway to the north, adjacent to Jiangzhu Highway and Xianghai Highway to the north, Jiangzhu Highway to the east, were analyzed. The research shows that, the scheme of setting up stations in the south of Xianghai Expressway and the west of Jiangzhu Expressway on Hezhou Island has straight alignment and better introduction conditions. The comprehensive layout of the station and the EMU station is more reasonable and better integrated with urban planning; the implementation of the project is less difficult and the project investment is the most economical, so it is recommended. [ABSTRACT FROM AUTHOR]