1. 对1 049 例寻常型银屑病患者病程证候、证素演变规律的回顾性研究.
- Author
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Jiayue, WANG, Ping, LI, Dongmei, ZHOU, Yanping, BAI, Xingwu, DUAN, Haibing, LAN, Yiding, ZHAO, Jingxia, ZHAO, Yan, WANG, Tingting, DI, Yujiao, MENG, and Zhaoxia, CHEN
- Subjects
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CHINESE medicine , *ELECTRONIC health records , *RECORD collecting , *DATABASES , *DISEASE progression - Abstract
Objective The study aimed to elucidate the evolution of the syndromes in Traditional Chinese Medicine ( TCM ) and TCM syndrome elements in different chronic stages of psoriasis vulgaris. Methods A database was constructed using electronic medical records collected from July 2019 to March 2024 from 1, 049 patients with psoriasis vulgaris. The study used Sankey diagrams and network association graphs to analyze the evolution of TCM syndromes and their elements in patients at the different stages: initial diagnosis, progressive stage (Week 2-3), progressive stage (Week 4-5), skin lesion improvement stage ( Week 6 - 7 ), and remission stage. The syndrome elements network was constructed using community detection algorithms, and the association rules between local skin lesion syndrome difierentiation and overall syndrome difierentiation were displayed using heatmaps. Results ( i) Initial diagnosis. In the syndrome differentiation of local skin lesions, blood heat syndrome was the most common (79.79%); among the disease location of TCM syndrome elements (called " disease location, , ), liver was the most prevalent ( 35.62%); and among the pathological factors of TCM syndrome elements ( called " pathological factors " ), fire (heat) was the most common (75. 48%). ( ii) Active stage (Week 2-3). In the syndrome differentiation of local skin lesions, blood heat syndrome remained the most prevalent (73. 13%) ; among the disease location, liver was still the most prevalent (31.71%); and among the pathological factors, fire ( heat) continued to be the most common (82. 11%), while dampness (22. 26%) and qi stagnation (8. 39%) began to increase. ( 111) Active stage ( Week 4-5). The syndrome differentiation of local skin lesions was dominated by blood heat syndrome (45. 91%) and blood dryness syndrome (37. 19%) ; among disease location, the interior was the most prevalent ( 15. 25%) ; and among the pathological factors, fire (heat) remained the most common ( 50. 66%), with an increase in yin deficiency ( 34. 26%). ( iv) Skin lesion improvement stage (Week 6 - 7 ). In the syndrome differentiation of local skin lesions, both blood dryness syndrome (49.44%) and blood stasis syndrome ( 33.33%) increased; among the disease location, meridians increased most significantly and became the most prevalent (13.44%); and among the pathological factors, blood stasis increased most significantly and became the most prevalent (28.20%). ( V ) Remission stage. In the syndrome difierentiation of local skin lesions, blood stasis syndrome became the primary (55.69%), while the percentage of blood dryness syndrome decreased ( 21. 16%) ; meridians (25.71%) and blood stasis ( 62. 34%) remained the most predominant syndrome elements related to disease location or pathological factors. Conclusion The overall pattern of TCM syndromes in psoriasis vulgaris evolved from excess to deficiency. From the initial diagnosis to the active phase (Week 2-3), heat syndrome dominated ; during the active phase ( Week 4-5), heat syndrome coexisted with damp syndrome or yin deficiency syndrome; changes in the syndrome element network were the most significant during the lesion improvement phase, with blood stasis gradually increasing and peaking during the remission phase. Blood stasis, dampness, and qi stagnation were pervasive throughout psoriasis vulgaris ; qi stagnation and blood stasis may be the main elements causing further deterioration and prolonged course of the disease during the active phase in patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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