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As a high-risk industry, coal mining enterprises have a complex record of violations.In order to efficiently, accurately and intelligently retrieve and manage an enterprise's illegal record and reduce the occurrence of illegal behaviors.A database of 13, 935 violations in a mine in recent three years is taken as a sample.The illegal actions are divided into 3 categories and 23 subcategories.And based on the computer text classification technology, the illegal text data classifier is built.Its process includes text preprocessing of Jieba word segmentation, vector space model construction, feature value selection of TF-IDF model, and similarity calculation process.Finally, a visual classification statistics and presentation system was constructed in Python environment, and the classified statistics were carried out.The results showed that the proportion of illegal operation is 64 %, which is the highest among all illegal behavior, followed by illegal action, and illegal command accounted for the smallest proportion.At the same time, the key subcategories of high frequency, medium frequency and low frequency were analyzed to provide quantitative support for accident prevention.

A strategy based on grafting organocatalytic units as side-chain on the organic linkers, a TEMPO radical decorated terphenyl-dicarboxylic acid linker was synthesized. By employing acetic acid as modulator, TEMPO radical decorated UiO-68-TEMPO nanocrystals were synthesized by using H2tpdc-TEMPO as organic linker and ZrOCl2 as metal source under solvothermal conditions. UiO-68-TEMPO are monodispersed nanocrystals with side in the range of 800-1200 nm, with high BET areas (up to 1320 m2/g), and contain a large number of TEMPO radicals as evidenced by solid-state EPR spectrum. UiO-68-TEMPO nanocrystals enable selective oxidation of a broad range of alcohols, including primary aromatic alcohols, secondary aromatic alcohols, and heterogeneous atomic alcohols, with high efficiency and selectivity. The catalytic activity of UiO-68-TEMPO nanocrystals remains 75% after catalysis for four cycles. Finally, a plausible catalytic mechanism for the oxidation of benzyl alcohol by UiO-68-TEMPO was proposed, that is the TBN co-catalyst produces NO2/NO redox mediator, which enables the oxidation of TEMPO radicals to oxoammonium cations by O2, and finally oxidize benzyl alcohol to benzaldehyde.

AIM: To examine the effects of borneol on inflammation and myocardial remodeling after myocardial infarction (MI) in mice, and to investigate the underlying mechanisms. METHODS: Eight-week-old wild-type (WT) C57BL/6 mice and transient receptor potential cation channel subfamily M member 8 (TRPM8) gene knockout ( TRPM8-/-) mice were randomly divided into sham and MI groups, and were subsequently treated with normal saline (control group) or borneol (borneol group) via gavage. Survival curves were plotted for WT and TRPM8mice with MI treated with or without borneol. After 28 d, cardiac function of the mice was assessed through echocardiography, and haemodynamic indexes were evaluated using a multi-channel physiological instrument. Infarct size, myocardial hypertrophy and interstitial fibrosis were assessed via pathological staining. In addition, inflammatory response in the peri-infarct region was detected. RESULTS: The TRPM8 expression was up-regulated in the peri-infarct region of the mice with MI (P<0. 05), and borneol had no effect on TRPM8 expression (P>0. 05). Borneol increased the survival rate, reduced the infarct size, inhibited cardiac remodeling and improved cardiac function in WT mice with MI (P<0. 05 or P<0. 01). However, it did not affect the survival rate, infarct size, myocardial hypertrophy, myocardial fibrosis or cardiac function in TRPM8mice (P>0. 05). Furthermore, borneol reduced inflammatory cell infiltration and the expression of inflammatory cytokines, tumor necrosis factor-α (TNF-α ), interleukin-1β (IL-1β), IL-6 and monocyte chemotactic protein-1 (MCP-1), in WT mice (P<0. 05 or P<0. 01) but not in TRPM8-/- mice (P>0. 05). CONCLUSION: Borneol attenuates inflammation, inhibits cardiac remodeling and improves cardiac function in mice with MI via TRPM8. [ABSTRACT FROM AUTHOR]

The iron salts (ferric and ferrous salts) play a critical role for the synthesis of morphology and size controllable, and highly crystalline MIL-100(Fe). The use of ferrous salt results in octahedral, highly crystalline MIL-100(Fe) with high surface areas. In contrast, the use of ferric salt only results in smaller Fe-BTC metal-organic polymers with low crystallinity. The crystal structure, morphology, photo-absorption property, absorption and photocatalytic-degradation properties of MIL-100(Fe) and Fe-BTC toward RhB, were fully characterized by XRD, SEM, FT-IR, UV-Vis DRS, and UV-Vis spectroscopy. The results indicate that the slow oxidation of Fe2+ to Fe3+ is key to the synthesis of highly crystalline MIL-100(Fe) since this process facilitates the formation of μ3-OFe(Ⅲ)O6, which is inorganic secondary building unit (SBU) of MIL-100(Fe). When FeCl3 used as iron source, the fast dynamic reaction of Fe3+ with BTC3- is not beneficial to the formation of μ3-OFe(Ⅲ)O6 SBU; therefore, Fe-BTC nanoparticle polymer is obtained. The smaller size of Fe-BTC nanoparticless, and meso-/macroporous structure in the aggregated nanoparticle surface, which facilitates the diffusion of RhB as well as the photodegradated forms. Fe-BTC shows better absorption capacity and photocatalytic activity toward RhB compared to MIL-100(Fe).

In order to prepare highly crystalline and stable metal-organic frameworks (MOFs) nanoparticles in a straightforward and low cost method, trimesic acid was depronated by three equivalent NaOH in water, and mixed with ferrous salts (e.g. FeCl2 and Fe(OAc)) solution under vigorous stirring for 24h at room temperature. The morphology and photocatalytic activity of the obtained MIL-100(Fe) nanoparticles were fully characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), UV-Vis diffuse reflectance spectroscopy (UV-Vis DRS) and UV-Vis spectroscopy. The results demonstrate that the MIL-100(Fe) nanoparticles exhibit excellent photocatalytic performance toward high concentrated Rhodamine B (RhB) and methyl orange (MO) organic dyes in the presence of H2O2 as a co-catalyst under UV light irradiation.

Objective To investigate the association between the serum CXC chemokine ligand 17 (CXCL17) and type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods This was a cross-sectional study. Newly diagnosed T2DM patients hospitalized at the Department of Endocrinology of the First Affiliated Hospital of Soochow University from April 2021 to December 2022 and the healthy volunteers in the physical examination center during the same period were selected as the control group. Height and weight of the participants were collected, body mass index (BMI) was calculated, CXCL17, low-density lipoprotein-cholesterol (LDL-C) and glutamic pyruvic transaminase (ALT) were detected, and hepatic fat fraction (HFF) was measured. According to HFF, patients with T2DM but without NAFLD were assigned to T2DM group (HFF≤5.5%), and patients with T2DM and NAFLD were assigned to T2DM+NAFLD group (HFF> 5.5%). One-way analysis of variance (ANOVA), Kruskal-Wallis H test and χ² test were used for comparisons between groups, Spearman correlation analysis was used to analyze the correlation between HFF and other variables, and binary logistic regression analysis was used to analyze the independent influencing factors of T2DM patients with NAFLD. Results Two hundred and seventy patients were enrolled. Of these, 88 were in T2DM group, 92 in T2DM+NAFLD group and 90 in control group. The level of serum CXCL17 in T2DM+NAFLD group [(95.62±6.83) ng/L] was higher than that in T2DM group [(56.49±9.45) ng/L] and control group [(21.59±5.12) ng/L] (P<0.05). Spearman correlation analysis showed that HFF was positively correlated with CXCL17 (r=0.672), BMI (r=0.481), ALT (r=0.447), LDL-C (r=0.253), respectively (all P<0.001). Binary logistic regression showed that CXCL17(OR=0.949,95%CI 0.926-0.973), BMI(OR=0.773,95%CI 0.678-0.882), ALT(OR= 0.943, 95%CI 0.918-0.968), LDL-C(OR=0.632, 95%CI 0.432-0.923) were independent influencing factors of NAFLD (P<0.05). Conclusion The increase of serum CXCL17 might be an independent risk factor of NAFLD. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between the expression of OX40 on circulating follicular helper T cells (cTfh) in newly diagnosed type 2 diabetes and insulin resistance. Methods The newly diagnosed T2DM patients hospitalized in the First Affiliated Hospital of Soochow University from November 2020 to December 2021 were selected, and the healthy volunteers in the physical examination center during the same period were selected as the control. The height and weight of the subjects were measured, and the body mass index (BMI) was calculated. The subjects' fasting plasma glucose (FPG) and fasting serum insulin (FINS) were collected, and the area under the serum insulin curve (AUCINS) and homeostasis model assessment of insulin resistance (HOMA-IR) were calculated. The proportion of cTfh cells in the peripheral blood and the expression of OX40 on the surface of cTfh cells were detected. T-test or χ² test was used to compare the indexes between the two groups. Pearson correlation analysis was used to analyze the correlation between HOMA-IR and clinical indicators, and multiple linear regression was used to analyze the influencing factors of HOMA-IR. Results A total of 160 subjects were included. There were 96 cases in T2DM group and 64 cases in control group. The expression of OX40 on cTfh cells in T2DM (7.51±5.32)% was significantly higher than that in control group (3.95±1.62)%, and the difference was statistically significant (t=4.29, P=0.006). Pearson correlation analysis showed that HOMA-IR was positively correlated with the ratio of OX40+Tfh cells (r=0.569), BMI (r=0.450) and AUCINS (r=0.341), (P<0.001), respectively. Multiple linear regression showed that the increase of OX40+Tfh cells (B=0.284, 95%CI 0.029-0.538, P=0.017) and BMI (B=0.249, 95%CI 0.030-0.486, P= 0.022) had independent positive effects on the degree of insulin resistance in newly diagnosed T2DM. Conclusions OX40 was up-regulated on the surface of cTfh in T2DM patients. Moreover, the increase of OX40+Tfh cells might be an independent risk factor of insulin resistance in patient with newly diagnosed type 2 diabetes. [ABSTRACT FROM AUTHOR]

Due to the immaturity of intelligent technology in universality, robustness and security, intelligent interactive products were prone to "behavior conflict" due to the mismatch with user behavior patterns in intention expression, information processing, decision logic, interaction timing and action intensity. Unified modeling and optimization of multi domain behavior processes of human-machine environmental systems were the key to realize behavior characteristic regulation and forward design of intelligent interactive products. This paper systematically reviewed the research progresses of multi domain behavior process representation model, modeling language and tool, model validation and behavior process optimization of human-machine environmental systems from four dimensions: how to represent, what to represent, how to verify and how to optimize. The existing problems and limitations in this field were analyzed, and the future research focus and development trend were prospected. [ABSTRACT FROM AUTHOR]

The effect of retinoic acid (RA) on renal interstitial fibrosis (RIF) is important. Notch signaling is known to play an important role in the pathological injury of RIF. This study summarized recent research progress of the effect of RA on RIF and Notch signaling. Interruption of Notch signaling by RA might be a potential anti-fibrotic strategy in RIF. [ABSTRACT FROM AUTHOR]

With sufficient consideration about temperature load, mechanical load, expansion cone hardness with hard coating and casing hardness, the computational equation was deduced to calculate yield collapse pressure between expansion cone and casing by fractal theory and contact mechanics. Digital analyses show that yield collapse pressure between expansion cone and casing adds with the increasing final temperature, fractal roughness, linear expansion coefficient, Brinell hardness of expansion cone with hard coating, intermediate principal stress coefficient and casing wall thickness. Yield collapse pressure between expansion cone and casing decreases with the increase in fractal dimension from 1. Yield collapse pressure between expansion cone and casing enhances with the augment in fractal dimension close to 2. Yield collapse pressure between expansion cone and casing reduces due to the increase in tensile- to-compressive strength ratio. Relative errors between calculable values for yield collapse pressure and experimental measurement ones lie within the range from -8.9253% to -0.9901%. [ABSTRACT FROM AUTHOR]

Excessive application of chemical fertilizer has caused many problems in Angelica dahurica var. formosana planting, such as yield decline and quality degradation. In order to promote the green cultivation mode of A. dahurica var. formosana and explore rhizosphere fungus resources, the rhizosphere fungi with nitrogen fixation, phosphorus solubilization, potassium solubilization, iron-producing carrier, and IAA-producing properties were isolated and screened in the rhizosphere of A. dahurica var. formosana from the genuine and non-genuine areas, respectively. The strains were identified comprehensively in light of the morphological characteristics and ITS rDNA sequences, and the growth-promoting effect of the screened strains was verified by pot experiment. The results showed that 37 strains of growth-promoting fungi were isolated and screened from the rhizosphere of A. dahurica var. formosana, mostly belonging to Fusarium. The cultured rhizosphere growth-promoting fungi of A. dahurica var. formosana were more abundant and diverse in the genuine producing areas than in the non-genuine producing areas. Among all strains, Aspergillus niger ZJ-17 had the strongest growth promotion potential. Under the condition of no fertilization outdoors, ZJ-17 inoculation significantly promoted the growth, yield, and accumulation of effective components of A. dahurica var. formosana planted in the soil of genuine and non-genuine producing areas, with yield increases of 73.59% and 37.84%, respectively. To a certain extent, it alleviated the restriction without additional fertilization on the growth of A. dahurica var. formosana. Therefore, A. niger ZJ-17 has great application prospects in increasing yield and quality of A. dahurica var. formosana and reducing fertilizer application and can be actually applied in promoting the growth of A. dahurica var. formosana and producing biofertilizer.

In recent years, the MYB-related gene family has been found pivotal in plant growth and development. MYB-related gene family in Angelica dahurica var. formosana was systematically investigated based on &quot;Chuanzhi No. 2&quot; through transcriptome database search and bioinformatics and the temporal and spatial expression patterns were analyzed through real-time fluorescence-based quantitative polymerase chain reaction(PCR). The results showed that 122 MYB-related proteins family were identified, mainly including the unstable hydrophilic proteins with good thermal stability. Most of the proteins were located in nuclei. The majority of the proteins had the structures of random coil and α-helix. Five MYB-related proteins family of A. dahurica var. formosana had membrane-binding domains. The conserved domain analysis of MYB-related proteins family of A. dahurica var. formosana showed that the MYB domains of genes in five subgroups, similar to 2 R-, 3 R-, and 4 R-MYB proteins, contained three evenly distributed Trp(W) residues in the MYB repeat sequence. The phylogenetic analysis of MYB-related proteins family in A. dahurica var. formosana and Arabidopsis thaliana showed that the MYB-related members were unevenly distributed in five subgroups, and A. thaliana and A. dahurica var. formosana had almost the same number of genes in the CCA1-like subgroup. There were differences in the number, type, and distribution of motifs contained in 122 encoded proteins. Transcription factors with similar branches had similar domains and motifs. The expression pattern analysis showed that the transcription factors AdMYB53, AdMYB83, and AdMYB89 responded to hormones to varying degrees, and they were highly expressed in leaves and responded quickly in roots. This study lays a foundation for further investigating the function of MYB-related transcription factors of A. dahurica var. formosana and solving the corresponding biological problems such as bolting early.

Artemisinin, one of the most powerful new generation antimalarial drugs, is an unique sesquiterpene lactone compound extracted from traditional Chinese drug Artemisa annua L, which contains specific endoperoxide bridge. In this study, the Raman scattering of artemisinin in the spectral range of 100～3 500 cm-1 has been investigated. The analysis suggests that the phonon mode at 724 cm-1 would be directly correlated with a representative vibrational mode of the ring containing endoperoxide bridge, thus it can be applied for Raman detection of endoperoxide bridge in artemisinin. The phonon mode at 1 734 cm-1 would be directly correlated with a representative vibrational mode of the lactone ring, thus can be applied for further identification of artemisinin with Raman spectroscopy. Also both of these two phonon modes can be easily observed by Raman experiment; therefore they are good representative phonon modes for quick qualitative analysis of artemisinin by Raman spectroscopy. In addition, by investigating the relative intensity ratio of the two representative phonon modes at 724 and 1 734 cm-1, the Raman method can be applied for quantitative analysis of artemisinin purity. Compared with the commonly used high performance liquid chromatography method, the Raman method is much more powerful: it is faster, more convenient, more accurate, and can be applied for the analysis of homogeneity of purity for artemisinin samples. Furthermore, the qualitative and quantitative analysis of artemisinin purity would be very helpful for quantitative analysis of the quality of Chinese drug Artemisa annua L with Raman spectroscopy.

Objective: To investigate the prevalence and risk factors of mild vision loss in adult patients with type 2 diabetes in Beixinjing Community, Shanghai, China., Methods: A population-based, cross-sectional survey among 2 216 Chinese Han adult patients with type 2 diabetes was conducted from October 2014 to January 2015.Random cluster sampling was used to enroll diabetic patients based on the local Chronic Diseases Prevention and Control System data.The survey was preceded by a pilot study in which operational methods were refined and quality assurance evaluation was carried out.Eligible participants underwent a comprehensive eye examination, including the best corrected visual acuity (BCVA) test using the logarithm of the minimum angle resolution charts.Mild vision loss was defined as BCVA <20/32 to ≥20/63 following the International Council of Ophthalmology (ICO) 2002 definitions.The primary causes of visual impairment and blindness were determined.The prevalence and causes of monocular and binocular mild vision loss were investigated.Logistic regression analysis was used to determine the related risk factors of binocular mild vision loss., Results: Among 2 582 patients, 2 216 were examined, and the response rate was 85.8%.Monocular mild vision loss was found in 591 patients with a prevalence rate of 26.7%.Binocular mild vision loss was detected in 650 patients, with a prevalence rate of 29.3%.Totally 1 891 eyes were confirmed as mild vision loss.Diabetic retinopathy (27.3%, 517/1 891) were the second leading cause of mild vision loss, after cataract (31.3%, 591/1 891). Binocular mild vision loss of unknown reasons happened in 201 persons.Old age, female gender, lower educational level, higher glycosylated hemoglobin A1c level and longer duration of diabetes were associated with the prevalence of total binocular mild vision loss and binocular mild vision loss of unknown reasons., Conclusion: The prevalence of mild vision loss is higher among adult patients with type 2 diabetes in Beixinjing Community.Intensive glucose control is recommended to prevent and slow mild vision loss in Chinese Han patients with type 2 diabetes.

Objective: To analyze pathological characteristics of organs recovered during forensic autopsy submitted by legal medicine experts., Methods: From Baoji city, 358 cases of forensic autopsy specimens from a series of routine exams were collected. And histopathological diagnoses were reviewed., Results: Majority of the 358 cases were young men. The major causes of death were trauma, sudden death and poisoning. The cause of death was determined with histology in 250 cases. No typical histological changes were noted in 101 cases. The tissue autolysis and decomposition were present in 7 cases. The major pathological diagnosis was cardiovascular disease, followed by diseases in respiratory, nervous, and digestive systems., Conclusion: Forensic autopsy with its professional characteristics, is different from regular autopsy. When diagnosing cause of death by histopathological examination, pathologists should collaborate with legal medicine experts to know the details of the cases, circumstances surrounding the death, and specific forensic pathological characteristics.

Developing emission inventory for nonroad mobile equipments is the initiating step of nonroad mobile source emission control. NONROAD model developed by U. S. EPA was studied, and methods based on actual fuel consumption rate were established to calculate fuel consumption and emission inventory of excavators and loaders in China. Surveys were conducted on key emission parameters of typical construction equipments in China, including equipment inventory, annual activity, actual fuel consumption rate, and emission factor. Results show that diesel consumption of excavators and loaders was 1.21 x 10(7) t, accounting for 9.7% of total consumption of all sectors in China in 2007. Total emissions of NO, and PM from excavators and loaders were 6.81 x 10(5) t and 5.31 x 10(4) t, respectively. The data indicates construction equipments are important emission sources compared with motor vehicles. According to the results, it is necessary to tighten limits of exhaust pollutants for construction equipments in China and to bring them into effect.

Objective: To investigate the expression of T cell receptor (TCR) Vgamma genes in patients with graft-versus-host disease (GVHD) after allogenic hematopoietic stem cell transplantation (allo-HSCT)., Methods: The expression levels of the TCR Vgamma I-III genes in peripheral blood mononuclear cells (PBMNCs) from 18 patients with GVHD following allo-HSCT were determined using real-time fluorescence quantitative PCR, with 12 healthy individuals serving as the normal controls., Results: The expression level of TCR Vgamma II gene in the PBMNCs from patients with GVHD was significant lower than that in the normal controls. The expression patterns of TCR Vgamma I-III subfamilies also underwent alterations in patients with GVHD, and the expression level of TCR Vgamma II gene was significantly lower than that of TCR Vgamma I gene or TCR Vgamma III gene., Conclusion: The low expression of TCR Vgamma II subfamily might be related to the pathogenesis of GVHD in patients receiving allo-HSCT.

Objective: To explore the role of monitoring sex chromosome chimeric status by fluorescence in situ hybridization (FISH) in the identification of leukemic extramedullary relapse and post-transplant lymphoproliferative disease (PTLD) in acute lymphocytic leukemia (ALL) after allogeneic hematopoietic stem cell transplantation (allo-HSCT)., Methods: Six ALL patients who received sex-mismatched allo-HSCT and manifested extravisceral lymphadenectasis or local lump were investigated. The sex chromosome chimeric status in tumor tissues and bone marrows (BM) were monitored by FISH, and EBV-RNA in the tumor tissues were detected by in situ hybridization (ISH)., Results: The sex chromosomes in BM of all 6 patients were 100% donor-derived. Among the sex chromosome chimeric status of tumor tissues, three patients were mainly recipient-derived, and the percentage of sex chromosomes derived from recipients were 100%, 100% and 98.0%, respectively, and then they were diagnosed leukemic extramedullary relapse. The other 3 patients were donor-derived, the percentage was 98.5%, 96.0% and 91.5%, respectively, and were diagnosed PTLD. EBV-RNA and latent membrane protein (LMP-1) were positive in 2 patients with PTLD and negative in the other 4 patients. One patient with extramedullary relapse obtained partial remission, one with PTLD gained complete remission, and the others died eventually after therapy., Conclusion: Monitoring the sex chromosome chimeric status by FISH is an effective method to distinguish leukemic extramedullary relapse from PTLD in ALL received sex-mismatched donor HSCT.

Objective: To evaluate the role of human leukocyte antigen G (HLA-G) in the better effect of allogenetic bone marrow transplantation than that of peripheral blood stem cell transplantation., Methods: Flow cytometry was used to detect the expression of membrane-bound HLA-G (mHLA-G) on donor peripheral blood (PBC) or bone marrow (BM) mononuclear cells. The levels of soluble HLA-G (sHLA-G) in the plasma and bone marrow fluid were determined using enzyme-linked immunosorbent assay (ELISA) before and after granulocyte colony-stimulating factor (G-CSF) mobilization., Results: The mean levels of mHLA-G after G-CSF mobilization in the PBC and BM were significantly higher than that before G-CSF mobilization (P=0.001 and 0.000), but the plasma levels of sHLA-G showed no significant changes after the mobilization (P=0.279). The mean levels of sHLA-G in the BM fluid significantly increased (P=0.002) to a level higher than that in the PBC after G-CSF mobilization (P=0.004)., Conclusion: HLA-G plays an important role in immune tolerance after hematopoietic stem cell transplantation with G-CSF mobilization.

Emission from 7 typical light-duty vehicles under actual driving conditions was monitored using a portable emission measurement system to gather data for characterization of the real world vehicle emission in Shenzhen, including the effects of driving modes on vehicle emission, comparison of fuel consumption based emission factors (g x L(-1) with mileage based emission factors (g x km(-1)), and the average emission factors of the monitored vehicles. The acceleration and deceleration modes accounted for 66.7% of total travel time, 80.3% of traveling distance and 74.6%-79.2% of vehicle emission; the acceleration mode contributed more than other driving modes. The fuel based emission factors were less dependent on the driving speed; they may be utilized in building macro-scale vehicle emission inventory with smaller sensitivity to the vehicle driving conditions. The effect of vehicle technology on vehicle emission was significant; the emission factors of CO, HC and NO(x) of carbureted vehicles were 19.9-20.5, 5.6-26.1 and 1.8-2.0 times the more advanced vehicles of Euro II, respectively. Using the ECE + EUDC driving cycle would not produce the desired real-world emission rates of light duty vehicles in a typical Chinese city.