1. Expression of RhoE in lung and breast cancer and its clinical significance
- Author
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Feng BI, Boquan JIN, Meng QIU, Deyun LUO, Juan HUANG, Surui LIU, Jitao ZHOU, Yajie ZHU, and Feng XU
- Subjects
Human RND-3 protein ,Breast neoplasms ,Lung meoplasms ,Tumor suppressor gene ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background and Objective Rho family is closely related with the growth , differentiation and metastasis of tumer cells. The objective of this work is to investigate the expression of RhoE in lung and breast carcinoma and their corresponding adjacent tissues, as well as its relationship between the expression and clinical pathological grades. The results of this study provide evidences for exploring the biological functions and clinical significance of RhoE. Methods The expression of RhoE was detected by immunohistochemistry in 62 lung carcinoma samples and 34 breast carcinoma samples, and their corresponding adjacent tissues were taken as control.Results RhoE was generally expressed in normal tissues, but the expression level of RhoE in carcerous tissueswas decreased or absent. The stained value of breast carcinoma was 3.65+/-0.62, but the adjacent cancerous tissueswas 10.53+/-0.44, significantly higher than that of the adjacent cancerous tissues (t=12.402, P
- Published
- 2008