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Background Stigma in adolescents with type 1 diabetes mellitus (T1DM) is closely associated with their health outcomes. Currently, there is a lack of stigma assessment tools for this population. Objective To translate the Type 1 Diabetes Stigma Assessment Scale (DSAS-1) and test its reliability and validity in Chinese adolescents with T1DM. Methods A total of 194 patients with T1DM admitted to the First Affiliated Hospital with Nanjing Medical University and Children's Hospital of Nanjing Medical University were selected as the study subjects by using the convenient sampling method from March 2022 to March 2023. The English version of DSAS-1 was directly translated, back-translated and culturally adapted by using Brislin's classical back translation model to form a Chinese version. The Self-designed General Information Questionnaire, the Chinese version of the DSAS-1, the Diabetes Strengths and Resilience Measure for Adolescents, the Parent-child Relationship Scale, and the Quality of Life Scale was used to conduct investigation. Exploratory factor analysis and confirmatory factor analysis were used to test the structural validity of the scale, and the internal consistency of the version was evaluated by calculating the Cronbach's α coefficients. Correlation analyses with the Diabetes Strengths and Resilience Measure for Adolescents, the Parent-child Relationship Scale, and the Quality of Life Scale were conducted to confirm the effect of the Chinese version of DSAS-1 in detecting stigma among adolescents. Results A total of 194 valid questionnaires were recovered. The exploratory factor analysis and confirmatory factor analysis results showed that the Chinese version of DSAS-1 for adolescents was categorized into three dimensions of differential treatment, complaints and comments and identity concerns, with good structural validity (all factor load>0.55, cumulative variance=67.98%), convergent validity (AVE>0.5), and discriminant validity (correlation coefficients of each dimension less than the square root of AVE). The reliability test results showed good internal consistency of the scale (Cronbach's α coefficient of 0.930). The total score of the Chinese version of DSAS-1 for adolescents was negatively correlated with the total scores of the Diabetes Strengths and Resilience Measure for Adolescents (r=-0.425, P

Background Benign prostatic hyperplasia (BPH) is a major cause of lower urinary tract symptoms in middle-aged and elderly men, while abnormal blood glucose can also lead to functional and organic changes in urinary system. However, there is still a lack of relevant research on the effect of abnormal blood glucose on urodynamic parameters of BPH patients. Objective To explore the impact of elevated fasting blood glucose (FBG) on urodynamic parameters of BPH patients. Methods The clinical data of 95 older male patients with BPH who were hospitalized in Department of Urology, Second Affiliated Hospital of Dalian Medical University from January to December, 2021 were analyzed retrospectively. They were divided into hyperglycemic group (n=11) and normal FBG group (n=84) according to the admission FBG level to compare clinical indicators. Results We found that the two groups had no statistically significant differences in average age, BMI, total prostate-specific antigen (tPSA), the volume, length, width and height of the prostate, and glycosylated hemoglobin (P>0.05). It was noticed that the mean course of diabetes in the hyperglycemic group was longer〔2 (0, 10) years vs 0 (0, 0) years, u=705.500, P=0.025〕. The average FBG level of the hyperglycemic group was significantly higher than that of the normal FBG group 〔 (8.9±2.1) mmol/L vs (5.4±0.7) mmol/L, t=-11.263, P0.05). However, the average scores on IPSS-storage〔 (13.7±1.4) scores vs (11.4±3.3) scores, t=-2.316, P=0.023〕 and bladder first sensation volume〔 (147.8±76.9) ml vs (100.2±48.0) ml, t=-2.532, P=0.014〕in the hyperglycemic group were significantly higher. Conclusion We demonstrated that elevated FBG has significant adverse effects on subjective and objective urodynamic parameters of BPH patients, which may lead to impaired first sensation volume of bladder and more severe storage symptoms. These patients often have a long course of diabetes, so more clinical attention should be given to their blood glucose control. It is of prominent significance to take active comprehensive intervention for symptomatic management of BPH.