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Objective: To observe the effects of Tongdu Tiaoshen acupuncture combined with citicoline on cognitive function, hemorheology and cerebral hemodynamics in patients with vascular dementia (VD) after cerebral infarction. Methods: 98 cases of VD after cerebral infarction who were treated in The Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from March 2018 to March 2021 were selected. They were randomly divided into control group (49 cases, citicoline combined with traditional acupuncture) and observation group (49 cases, Tongdu Tiaoshen acupuncture combined with citicoline). The efficacy, cognitive function,dementia symptoms, activities of daily living, hemorheology and cerebral hemodynamics were compared between the two groups.Results: The total clinical effective rate of the observation group was higher than that of the control group (P<0.05). After treatment, the scores of a ctivity of Daily Living Scale (ADL) and hasegawa dementia correction scale (HDS-R), mini-Mental State Examination (MMSE) in the observation group were higher than those of the control group (P<0.05). The hematocrit, plasma viscosity, whole blood high shear viscosity and whole blood low shear viscosity in the observation group was lower than those of the control group (P<0.05).The peak systolic velocity (Vmax) and pulsatility index (PI) in the observation group were higher than those of the control group. The peak diastolic velocity (Vmin) and resistance index (RI) were lower than those of the control group (P<0.05). Conclusion: Citicoline-combined with Tongdu Tiaoshen acupuncture are effective in the treatment of patients with VD after cerebral infarction. It can improve dementia symptoms, cognitive function and activities of daily living, which may be related to the regulation of hemorheology and cerebral hemodynamics. [ABSTRACT FROM AUTHOR]

Objective: To study the effect of piracetam combined with citicoline on cognitive and neurological functions in patients with acute cerebral infarction. Methods: 150 patients with acute cerebral infarction from January 2014 to January 2018 were randomly divided into two groups. The control group was treated with piracetam, and the observation group was treated with piracetam combined with citicoline. Using the National Institutes of Health Stroke Scale (NIHSS), the Montreal Cognitive Assessment Scale (Mo CA), and the Activities of Daily Living (ADL) rating scale, coomparison of neurological function, cognitive function and daily living ability before and after treatment in the two groups. Results: In the observation group, 15 cases were basically cured, 30 cases were markedly effective, 26 cases were effective, 4 cases were ineffective and 1 case was deteriorated. The total effective rate was 94.67%, which was higher than that in the control group (P<0.05). After treatment, the ADL, Mo CA and NHISS scores of the two groups increased significantly, and the ADL, Mo CA and NHISS scores of the observation group were significantly better than those of the control group (allP<0.05). After treatment, the levels of serum Caspase-3 and HIF-1alpha in two groups were significantly decreased, and the levels of serum Caspase- 3 and HIF-1alpha in the observation group were lower than those in the control group (all P<0.05). The control group had 1 case of retching (1.33%), 2 cases of nausea (2.67%), 1 case of headache (1.33%) and 1 case of dizziness (1.33%), the observation group had 1 case of retching (1.33%), 1 case of nausea (1.33%), 1 case of headache (1.33%) and 1 case of haemorrhage (1.33%), there was no difference between the two groups (P>0.05). Conclusion: Piracetam combined with citicoline can significantly improve cognitive and neurological functions in patients with acute cerebral infarction. Miracles may be related to the expression of Caspase-3 and HIF-1a. [ABSTRACT FROM AUTHOR]