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Objective To establish a pig model of inguinal penetrating injury combined with femoral artery hemorrhage, and verify the hemostatic effect of chain-based sponge for the model. Methods The model of inguinal penetrating injury complicated with femoral artery hemorrhage was established with 8 adult Bama mini pigs by muscle transection in inguinal region and perforation of 6 mm femoral artery. The 8 model pigs were randomly and equally divided into two groups. Chain-based hemostatic device (consisted of a disposable push pipe and a compressed polyvinyl alcohol resin sponge) was used for hemostasis of pigs in experimental group. The chain-based sponge were injected into the wound, and the bleeding was compressed after expansion. While in the control group, ordinary gauze was used to fill the wound in a shingle way to stop bleeding. After 3 hours, the hemostatic materials in the two groups were taken out, the survival status of animals in the two groups, the amount of modeled bleeding, the bleeding amount from the start to the end of hemostasis, the time of hemostasis, the total bleeding amount, the time of hemostatic materials removal, and the histopathological findings of muscle tissue at the bottom of the wound and the proximal femoral artery were observed in the two groups. Results The model of inguinal penetrating injury combined with femoral artery hemorrhage was successfully established. All animals in the two groups survived. The hemostasis time was shorter in experimental group than that in control group [(44.3±7.0) s vs. (380.3±23.2) s, P0.05] and the time of hemostatic materials removal between the two groups [(26.3±6.4) s vs. (26.5±5.1) s, P>0.05]. No obvious fracture or necrosis was observed in the muscle tissue of the two groups. The endometrial, medial and outer membranes of the proximal vascular tissue were relatively complete and no obvious necrosis was observed. Conclusions The Bama mini pig model of inguinal penetrating injury combined with femoral artery hemorrhage has the advantages of reliability, efficiency and high repeatability, and can be used for the application research of different hemostatic materials. The chain-based sponge is superior to ordinary gauze in hemostatic time and blood loss, and cause no damage to tissue, so is a good hemostatic device. DOI: 10.11855/j.issn.0577-7402.2019.12.03