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Background Non-alcoholic fatty liver disease has showed a high prevalence and a increasing trend especially towards younger age. It is of great public health significance to reduce damage through early detection of NAFLD in physical examination and intervention in time. Objective To investigate the detection rate of NAFLD in the Beijing physical examination population from 2018 to 2021, and analyze its related influencing factors. Methods People who received physical examinations at the Beijing Physical Examination Center from 2018-01-01 to 2021-12-31 were selected based on the inclusion criteria, the results of physical examination, laboratory examination, and liver ultrasonography were collected for analysis. Univariate analysis was performed using t-test, Mann-Whitney U test and Chi-square test. Multivariate Logistic regression was used to explore the influencing factors of NAFLD. Results A total 325 726 people were included in the study, of which 108 512 cases of NAFLD were detected, with a detection rate of 33.31%. The results of liver ultrasonography revealed that the number of mild, moderate and severe NAFLD detections were 74 062, 33 281 and 1 169 cases, accounting for 68.25%, 30.67% and 1.08% of the detection population, respectively. The detection rate of NAFLD was higher in males than females (χ2=17 518.893, P420 μmol/L, SUAfemale>360 μmol/L: OR=2.067) were influencing factors for NAFLD (P

2-花生四烯酸单甘酯（2-AG）是一种内源性大麻素，在神经、心血管和免疫等系统中具有一系列的生理活性。为实现2-AG的绿色高效制备，探究了脂肪酶催化醇解富含花生四烯酸的微生物油制备2-AG的方法。以2-单甘酯（2-MAG）含量为指标，通过单因素实验对酶法催化醇解反应条件进行了优化，并采用溶剂萃取法对产物进行纯化。结果表明：最佳反应条件为以Lipozyme 435脂肪酶为醇解脂肪酶、酶添加量4%（以油质量计）、油与无水乙醇物质的量比1∶ 40、叔丁醇为溶剂、油溶比2∶ 3、反应温度35 ℃、反应时间8 h，在最佳条件下粗产物中2-MAG含量为3363%；经溶剂萃取纯化后2-MAG的纯度达到了94.79%，其中2-AG含量为40.70%。 综上，酶法醇解富含花生四烯酸的微生物油可以获得高2-AG含量的2-MAG。2-Arachidonoylglycerol (2-AG) is an endogenous cannabinoid and exhibits a variety of biological activities in the central nervous, cardiovascular, and immune systems. To prepare 2-AG in a greener and efficient way, a lipase-catalyzed alcoholysis of microbial oil rich in arachidonic acid was used to synthesize 2-AG. With the 2-monoacylglycerol (2-MAG) content as an index, the reaction conditions of lipase-catalyzed alcoholysis were optimized by single factor experiment, and a solvent extraction method was employed to purify the product. The results showed that the optimal reaction conditions of lipase-catalyzed alcoholysis were as follows: Lipozyme 435 as alcoholysis enzyme, lipase dosage 4% (relative to oil mass), molar ratio of oil to anhydrous ethanol 1∶ 40, tert-butanol as solvent, ratio of oil to solvent 2∶ 3, reaction temperature 35 ℃ and reaction time 8 h. Under the optimal conditions, 2-MAG content in the crude product was up to 33.63%. The purity of 2-MAG after purification was up to 9479%, and the content of 2-AG was 40.70%. In conclusion, enzymatic alcoholysis of microbial oil rich in arachidonic acid can obtain 2-MAG with high 2-AG content.

In order to reveal the differences in the biosynthesis and metabolism of the major bioactive composition in sea buckthorn berry pulp during ripening, non-targeted metabolomics based on ultra-high performance liquid chromatography coupled to mass spectrometry (UPLC-MS) was used to analyze the metabolites of sea buckthorn berry pulp from two strains at different developmental stages (green and orange pulp). The results showed that the four sample groups had significant metabolic differences. A total of 124 significantly differential metabolites were detected among the four groups based on variable importance in the projection (VIP) > 1 and t-test P < 0.05, including organic acids, carbohydrates, lipids, flavonoids and secondary metabolites. According to Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, 15, 7 and 4 significantly differential metabolites associated with lipid, flavonoid and serotonin metabolism were identified, respectively, and eight significantly differential metabolites involved in anticancer function were selected. The significant up-regulation of phosphatidylcholine (PC) (16:0/16:0) and glycerophosphocholine could be the reason for the high accumulation of lipids in sea buckthorn berry pulp. The significant upregulation of isorhamnetin was key for the high flavonoid content in sea buckthorn berry pulp. Relatively high contents of N-acetylserotonin, capecitabine, γ-aminobutyric acid (GABA) and other bioactive composition involved in anticancer function were shown in sea buckthorn berry pulp during its development. These results provide a scientific basis for revealing the metabolic mechanism of bioactive composition of sea buckthorn berries and developing related functional products.

为寻找与中国人乳脂脂质组成高相似的天然人乳替代脂，分析比较了3种鱼油(金鲳鱼油、银鲳鱼油和巴沙鱼油)的总脂肪酸、sn-2位脂肪酸、甘油三酯组成和含量。结果表明：金鲳鱼油中棕榈酸、油酸和亚油酸含量分别为24.93%、25.61%和26.52%，其中sn-2位棕榈酸的含量为39.71%，占总棕榈酸比例为53.10%；在3种鱼油中，金鲳鱼油总脂肪酸组成最接近中国人乳脂；甘油三酯组成分析结果证实，金鲳鱼油中富含1-油酸-2-棕榈酸-3-亚油酸甘油三酯（OPL,24.36%），其含量显著高于其他两种鱼油，且其1,3-二油酸-2-棕榈酸甘油三酯（OPO）的含量（16.79%）接近报道的中国人乳脂的平均含量（15.84%）。因此，金鲳鱼油是理想的中国婴儿配方奶粉专用油脂基料油，在人乳替代脂中具有良好的发展前景。To find natural human milk fat substitute with high similarity to the lipid composition of Chinese human milk fat, the composition and content of total fatty acid, sn-2 fatty acid, and triglyceride of three types of fish oil (gold pomfret oil, silver pomfret oil, and barramundi oil) were analyzed and compared. The results showed that in gold pomfret oil, the contents of palmitic acid, oleic acid and linoleic acid were 24.93%, 25.61% and 26.52%, respectively. The content of sn-2 palmitic acid was 39.71%, accounting for 53.10% of the total palmitic acid. Among the three fish oils, gold pomfret oil exhibited the closest total fatty acid composition to Chinese human milk fat. The results of triglyceride composition analysis confirmed that golden pomfret fish oil was rich in 1-oleoyl-2-palmitoyl-3-linoleoylglycerol (OPL,24.36%), which was significantly higher than the other two fish oils, and its 1,3-dioleoy1-2-palmitoylglyecrol (OPO) content (16.79%) was close to the average content of reported Chinese human milk fat (15.84%). Therefore, golden pomfret fish oil is an ideal lipid base oil for Chinese infant formula, which has a good development prospect in human milk fat substitute.

Objective: To analyze the clinical features and genetic changes of 3 children in short stature with ACAN gene mutation. Methods: The clinical data, laboratory examinations, and genetic testing results of 3 children with ACAN gene mutations diagnosed with short stature at our pediatric endocrine disease clinic from 2018 to 2020 were collected, and the literature was reviewed for analysis and summary. Results: All the three children had a short family history, and their clinical manifestations were short stature. One patient had a slight limitation of the flexion activity of the thoracolumbar spine, and no other system abnormalities were found. Among them, the oldest of the 3 children was 5 years and 1 month, and the bone age was roughly consistent with or slightly advanced than the actual age, and the peak growth hormone challenge in 2 cases was less than 10 μg/L. The variations in the ACAN gene are c.G1877A and c.7360, respectively_ 7361del and c.7038_ 7039insCGGTGT, case 1 and case 2 are novel mutations that have not been reported in major databases. After the application of recombinant human growth hormone, the height of all three children improved. Reviewing the literature at home and abroad, we found that there were 120 children and 216 relatives reported at present. Among them, there were 80 ACAN gene variants related to short stature registered in HGMD, of which short stature was the most important clinical manifestation, followed by skeletal dysplasia. Conclusions: Mutations of ACAN gene mainly lead to short stature and skeletal dysplasia in children, and their clinical bone phenotypes are diverse, which can also only be manifested as short stature. For children with short stature, especially those with short stature family history, no matter whether they have skeletal abnormalities, they should be alert to this gene mutation.

Mass traffic stations are key nodes in integrated traffic networks. The scientific definition of station types is of great significance for the refined management of stations and network operations. Using the Xiamen BRT track double-mode network system as the research object, this study analyzed the characteristics and hierarchical relationships of the station network and used complex network analysis to classify stations within the network. By constructing a Space-L-directed weighted complex network model based on station passenger flows, this study proposes four indicators: node strength, weighted betweenness centrality, weighted closeness centrality, and weighted PageRank. A system-clustering method was used to classify the stations. The results are as follows: (1) In the complex network model, the network sites can be divided into six types: core-hub type, local connection, network transition, strong network conduction, weak network conduction, and network-end. The important sites of the network are gathered at the center of Xiamin island, and the secondary sites of the network are distributed on the periphery of the regular spatial network. The important sites of the network outside the island are distributed in mature urban construction areas, and the secondary sites are scattered in preliminary urban construction development areas. (2) All transfer station types have different characteristics. Single-mode transfer stations have the ability to adjust network passenger flow and accommodate the transfer capacity of passenger flow between various regions of the city, whereas double-mode transfer stations have the ability to attract network passenger flow, and the station and other stations on the network. It is closely connected and has high accessibility; single-mode and double-mode combined transfer stations have the ability to promote network passenger flow, and have high passenger flow connection strength and global passenger flow influence ability. (3) Among the single-mode stations in the BRT-metro transit network, the BRT stations perform better than the metro stations. This feature is more obvious in the island area owing to the unbalanced development of the east and west areas of the island. The station classification index and method proposed in this study can reveal the characteristics of station networks, which can improve the operational efficiency of urban BRT-rail network systems.

Objective To investigated when and how to retraining in peritoneal dialysis(PD) patients and its role in decreasing the incidence of peritonitis according to analysis of the characteristics of peritonitis in the PD center. Methods In a retrospective study, 2 years of data from 2019 before continuous quality improvement(CQI) and 2020 after CQI in our PD center were analyzed. According to analyzing the characteristics of peritonitis before CQI, when and how to retrain PD patients were put forward. The incidence and the characteristics of peritonitis were calculated and analyzed before and after CQI. Results There were 27 episodes of peritonitis in 22 out of total 99 PD patients in 2019. Totally 17 cases with peritonitis occurred for the first time and 11 of them (64. 71%) occurred in their first 6 months after PD initiate. Culture-positive was in 12 episodes (among them, 7 episodes of Coagulase-negative Staphylococcus or Staphylococcus Aureus). The whole year peritonitis rate was 1 episode every 35. 2 months in 2019 before CQI. The first retraining was taken in the third month after PD initiate and redirecting their behavior was made. There were 11 episodes of peritonitis in 10 patients out of 101 patients after CQI in 2020. There were 9 episodes of peritonitis occurred for the first time and 2 of them (22. 22%) occurred in their first 6 months after PD initiate. The rate of culture-positive peritonitis was increased to 63. 64%. In the 7 culture-positive episodes, 3 were Staphylococcus Aureus and 4 were Escherichia coli. The whole year peritonitis rate decreased to 1 episode every 108. 5 months in 2020 after CQI. Conclusion First retraining in the third month after PD initiate and redirecting their behavior to reduce the risk of peritonitis was an effective program in PD center. (目的 分析医院腹膜透析中心腹膜透析相关性腹膜炎发生原因、特点, 探讨再培训的时机、内容及实施效果。方法 选择河北医科大学第三医院腹膜透析中心因终末期肾脏病而行腹膜透析治疗并能规律随访的患者。分析2019年本中心腹膜炎发生率及特点, 根据持续质量改进的原则, 提出再培训的时机、内容、护理流程, 并观察实施效果, 与2020年腹膜透析患者腹膜炎发生率及特点进行比较。结果 2019年99例腹膜透析患者中22例患者发生27例次腹膜炎。全年腹膜炎发生率为1/35. 2个病人月。其中有17例患者首次发生, 11(64. 71%)例发生于腹膜透析置管后的6个月内。12例次培养阳性, 其中凝固酶阴性葡萄球菌及金黄色葡萄球菌感染7例次。将第一次再培训时机设为开始腹膜透析后的第3个月, 主要内容为规范操作。实施再培训后, 2020年本中心101例腹膜透析患者共10例患者发生11例次腹膜炎, 全年腹膜炎发生率为1/108. 5个病人月, 9例首次发生腹膜炎的患者中2(22. 22%)例发生于置管术后6个月内。7(63. 64%)例次培养阳性, 其中金黄色葡萄球菌感染3例次, 大肠杆菌4例次。结论 开展再培训计划, 可使医院腹膜透析中心的腹膜透析相关性腹膜炎的发生率明显减少。)

Objective To explore the influence of paracrine function of recurring and metastatic cervical cancer tissues on the spread of cancer cells. Methods Surgical specimens （cancerous and para-cancerous tissues） were obtained from 22 patients with metastatic cervical squamous cancer. Serum specimens were collected from 22 patients with metastatic cervical squamous cancer and 22 healthy volunteers， respectively. The expression levels of miR-21-5p in the cancerous and para-cancerous tissues were determined by quantitative real-time PCR （RT-qPCR）. SiHa cell were transferred with miR-21-5p mimics/inhibitors， respectively. The differences between two groups were analyzed by RT-qPCR， colony formation test， Transwell migration test， MTT， western blotting and dual luciferase reporter assay. Serum exosomes were extracted by high-speed centrifugation. The exosome characterization was performed by nanoparticle tracking analysis （NTA）， western blotting and transmission electron microscopy （TEM）. The differences in the expression levels of miR-21-5p in serum exosomes between cervical squamous cancer patients and healthy volunteers were assessed by RT-qPCR. The diagnostic efficiency of miR-21-5p in serum exosomes was evaluated by the receiver operating characteristic （ROC） curve. Results The expression level of miR-21-5p was up-regulated in cervical cancerous tissues compared with para-cancerous tissues. And over-expressed miR-21-5p could significantly promote SiHa cell colony formation， cell proliferation and migration （all P

Objective： Improve the dynamic performance of palletizing robot and reduce energy consumption. Methods： By static and dynamic analysis to determine to use minimal mass, maximizing the first natural frequency, minimizing the maximal stress and minimizing the maximal deformation as the optimization objectives, taking the structure parameters as design variables, the approximation models of objective functions and constraint functions were established by the Box-Behnken and the RSM. Based on the results of finite element analysis, an Analytic hierarchy process based on the results of finite element analysis was proposed. The process （AHP-FEA） was proposed to allocate the weight coefficients, and the comprehensive objective function was taken as the evaluation index. NSGA-II algorithm was used to solve the problem. The optimized model of the waist turntable was obtained based on AHP-FEA method, which was compared with the initial model. Results： The results showed that the mass of the waist turntable was reduced by 9.6% under the condition of ensuring the structural strength, stiffness and vibration stability. Conclusion： Compared with the common average allocation method and empirical weighting method, the comprehensive objective function value of optimization under the weight coefficient of AHP-FEA is the smallest, and its comprehensive optimization effect is better.

Objective: To explore the genotype and clinical phenotype of congenital generalized lipodystrophy type 1(CGL1), and to improve awareness of the disease. Methods: A patient with severe acanthosis nigricans was diagnosed as having CGL1, and the clinical information and results of laboratory and gene tests were analyzed. Five Chinese cases with CGL1 in the database were literaturally reviewed. Results: The patient was a girl(10 years and 11 months), who had significantly acanthosis nigricans and body subcutaneous fat loss. The examination of the girl showed hyperinsulinemia, impaired glucose tolerance, advanced bone age, low adiponectin and polycystic ovary. The compound heterozygous mutations were identified, which was c.646A>T:p.K216*(PVS1_Strong+ PM2+PM3 ( inherited from her father) and c.406G>A:p.G136R(PM3_Strong+PM1+PM2+PP3 (inherited from her mother) in AGPAT2 gene. The mutation of two gene loci could be pathogenic, which had not been reported in CNKI database. All 5 Chinese cases in CNKI database were reported before (including 2 males and 3 females, and age was between 66 days and 26 years old) showed the absence of adipose tissue, in which two patients presented severe acanthosis nigricans. Conclusions: The CGL1 is rare in Chinese population, and it should be considered as the patients present the acanthosis nigricans and absence of adipose tissue, and its diagnosis depends gene detection.

Airway remodeling refers to the structural and functional changes of airway tissues caused by repeated chronic inflammatory stimulation injury and incomplete repair. It is commonly seen in chronic airway inflammatory diseases, such as asthma and COPD, which is an important cause of irreversible airway stenosis and restricted airflow. MicroRNA （miRNA） molecules are involved in almost all pathophysiological processes in the human body, and they are excellent functional gene regulators. Recent studies have found that miRNA affects airway smooth muscle cell proliferation and migration, epithelial cell proliferation and adhesion, fibroblast proliferation, airway angiogenesis, goblet cell secretion and airway inflammation through different pathways and targets, thus further affecting airway remodeling. In this article, the research progresses on miRNA in airway remodeling were reviewed.

From August 2010 to August 2020, there were 3 cases of pathologically diagnosed alveolar adenoma (AA) were reported in Peking Union Medical College Hospital so far, which was a rare benign neoplasm of the lung. The clinical manifestations and radiological characteristics on computer tomography of AA were heterogenous among these patients and lacked specificities. The difficulty in predictive differentiation of benign or malignant characteristic of the lesion led to some confusions in clinical practices. This paper reported 2 cases of AA and reviewed the literature of AA. Its clinical, radiographical and pathological characters were analyzed, so to provide more knowledge and improve the differential diagnosis of this disease.

Surgery, radiotherapy, and chemotherapy are inevitable for most cancer patients, but these treatments also cause great damage to the body of humans.However fluorescent nanomaterials have the advantages of high fluorescence stability, low biotoxicity, and good biocompatibility, the most important thing is that it can perform non-invasive targeted therapy through its own peculiarity to avoid the harm of the above therapy to the human body. Therefore, fluorescent materials will be particularly important in biological applications. As a new type of carbon nanomaterial, carbon dot has excellent light stability and fluorescence performance, good biocompatibility, low toxicity and so on,which can be applied to biosensors, bioimaging and biomedical applications. This review will express the preparation of carbon dots, the mechanism of luminescence and the application of biology, and focus on the application of carbon dots in biological diagnosis and treatment, and discusses the combination of carbon dots with specific targeting molecules to form carbons that detect fluorescent signals, by means of advanced optical imaging technology, which can perform real-time dynamic monitoring of intracellular and biological molecules, perform rapid immunofluorescence analysis of major infectious disease sources, and provide new technologies and methods for disease occurrence, diagnosis, and treatment research.

In view of the poor flow pattern such as bias flow and vortex in the inlet building of the expansion pump station project, the method of arranging diversion piers is adopted to optimize the flow pattern in the project, but its structural parameters are usually adjusted according to experience, which cannot easily achieve the optimal effect.In order to determine the optimal structural opening parameters of the diversion pier, this study uses the opening length, width, height and spacing of the diversion pier as design variables. The test scheme is designed based on the central composite design method. The axial velocity uniformity is used as the evaluation index. The response surface model is constructed for optimization analysis, and the optimal parameter combination for the opening of the diversion pier is determined. Numerical simulation is carried out under the optimal parameter combination. It is found that the error between the actual value and the predicted value of the response surface model is only 0.33%, and the axial velocity uniformity increases by 11.17% compared with the original scheme, which has significantly improved the flow pattern of the forebay. The results indicate that the established response surface model can reflect the relationship between the evaluation index and the design variables, and the method can be applied to the structural parameter optimization of the rectification measures. [ABSTRACT FROM AUTHOR]

Double disks controller was used to constrain the size of spray plume. The flow field characteristics of the constrained spray technology under different gas inlet pressures were simulated by the computational fluid dynamics (CFD) software "Fluent", and the simulation result was experimentally verified. The results show that with the increase of atomization gas inlet pressure, the speed of reverse gas flow increases, and thus, the temperature of the nozzle tip decreases. In this case, solidification of the melt in the nozzle occurs. When the inlet pressures of the gas and metal are 2.5×105Pa and 2.0×104Pa respectively, the pressure acting on the melt decreases to minimum value of about 8.99×103Pa.At this condition, the molten metal flows out smoothly and no apparent oxidation phenomena appear in the deposition billet. Moreover, the effect of atomization is the best and the width of the deposition billet is exactly consistent with the width of the wheel groove of continuous extrusion machine.

In order to investigate the application of high temperature resistant profragrances in the aromatic modification of polyester, three POSS-based profragrances (M1, M2 and M3) were successfully synthesized by Schiff reaction using different fragrance aldehyde molecules and octa (γ-chloroaminopropyl) polyhedral oligomeric silsesquioxane (OCAP-POSS) as raw materials based on molecular hybridization method. The structure of the profragrances was characterized by nuclear magnetic resonance spectrum, infrared spectrum and ultraviolet-visible spectrum. We investigated the fragrance release kinetics characteristics of the profragrances in the environments, including simulated human acidic sweat, neutral and alkaline soap solutions. The results show that the thermal decomposition temperature of all the three profragrances exceeds 285 °C, indicating their good thermal stability. The structure of profragrances has significant effect on their release performance, with M1 reaching an equilibrium release rate of 57.86%, but M3 only 33.32%, and the sustained release time is in the order of M1(29 h)>M2 (16 h)>M3 (12 h). The profragrances are relatively stable in the soap environment, but exhibit a slow release in acidic sweat. The release behaviors follow the first-order reaction kinetics characteristics. [ABSTRACT FROM AUTHOR]

BackgroundThe measurement and analysis of γ ray spectrum are important means of qualitative identification and quantitative analysis of radionuclides. The analysis of overlapping peaks in complex spectra has always been a difficult problem. The traditional fitting method has greater uncertainty when processing data with high complexity and high statistical fluctuations.PurposeThis study aims to propose an improved method to achieve more accurate overlapping peak analysis.MethodsFirst of all, an overlapping peak analysis method based on constrained nonlinear optimization was proposed by using system calibration data, hence the peak width constraint was added to the conventional nonlinear least squares fitting of overlapping peaks, making the results more physically consistent. Then a simple iterative method was designed to solve the constrained optimization problem by transforming the constraints into real-time updates of peak width and weight coefficients, and its performance was investigated by simulated data under different statistical fluctuations, peak distance and peak area ratio. Finally, the method was verified by the spectra of 152Eu and 133Ba point sources measured by LaBr3(Ce) and NaI(Tl) spectrometers.ResultsThe results show that the errors of peak parameters such as peak position, full width at half maximum (FWHM) and peak area obtained by the proposed method are significantly lower than those of the unconstrained method. For spectra with high statistical fluctuations, the relative error of the analytic peak area can be reduced by more than 50%.ConclusionsMaking full use of known information such as FWHM calibration can constrain the results of nonlinear fitting in a more accurate range, effectively improving the accuracy of overlapping peak analysis. This method is suitable for complex spectrum analysis.

Iteration is repetition of same function. Iteration with different functions, called nonautonomous iteration, is a more complex one. In this paper, we consider a class of functional equations with linear combination of nonautonomous iterations, namely polynomial-like nonautonomous iterative equations, Based on some known results, the existence, uniqueness and continuous dependence of the convex solutions on the iterations and coefficients are studied. [ABSTRACT FROM AUTHOR]

To address the low-efficiency problem for query privacy protection on big data,parallel CPIR-V (PCPIR-V),which had a high level of privacy protection for nearest neighbor query,was presented and implemented based on spark.Two parallel strategies for PCPIR-V,Row strategy and Bit strategy,were proposed.To avoid redundant multiplications,the repeated products were cached based on a clustering technique while computing CPIR on Spark.According to the evaluation results of PCPIR-V on three datasets,the scalablity of PCPIR-V is good until the number of core is larger than 40.The cost of PCPIR-V with the method of caching partial multiplication results is reduced by 20% averagely.

Hexamethyldisilazane (HMDS) has been widely used in photolithography and coating process, film preparation, electrochemistry, organic synthesis and other fields. The research progress of HMDS in organic synthesis was reviewed, and its development trend was predicted. [ABSTRACT FROM AUTHOR]

In view of problems of difficult location for fault section and low efficiency of rush-repair in traditional manual patrolling mode when distribution network happens fault, a fault location and rapid repair system of distribution network based on pole fault location monitoring terminal was designed. The system uses pole fault location monitoring terminal to real-timely measure data of distribution network, and uses instantaneous over-current method to judge short-circuit fault and uses total current method to judge grounding fault. When fault happens, pole fault location monitoring terminal sends fault data to monitoring host through GPRS wireless communication module, monitoring host uses improved matrix location algorithm to realize accurate location for fault section. The fault type and position is noticed to related working personnel by message way and is displayed on interface of monitoring host to realize rapid repair for fault. The simulation result validates feasibility of the system.

In view of problems of high packet loss rate and bad expandability existed in traditional network monitoring and control system because of adopting centralized control way, the paper put forward a design scheme of network monitoring and control system based on SOPC technology. It introduced hardware platform and software design of the system in details. The testing data validated feasibility of the system.

As the size of microchannels of the microffuidic system becomes smaller and smaller, the traditional external force driving method has encountered great difficulties. The surface-tension-driven microffuid does not require any external power source, which is very advantageous for miniaturization and integration of microffuidic devices. By setting the baffle in the micro-mixing channel and changing the structural parameters of the baffle, the influence of the structural parameters of the baffle driven by the surface tension on the mixing effect was studied by numerical simulation. The results show that the mixing effect of the microchannels with baffle is significantly improved. At the same time, with the change of the baffle structure parameters, the mixing effect of microchannel also presents a certain variation law. The setting of baffle disturbs the flow of the microfluids, making the interface contact of the fluids more and improving the mixing performance. [ABSTRACT FROM AUTHOR]

Objective · To explore the relationship between serum interleukin-6 (IL-6) level and depressive symptoms in schizophrenia. Methods · A total of 239 patients with schizophrenia treated with olanzapine alone for more than 2 years were enrolled. Calgary Depression Scale for Schizophrenia (CDSS) was used to evaluate the depression level of the patients, and they were divided into depression group and non-depression group. Positive and Negative Syndrome Scale (PANSS) was used to evaluate the mental symptoms of patients. Serum IL-6 levels were measured by enzyme linked immunosorbent assay (ELISA), and the differences between the two groups were compared. Pearson correlation analysis was used to analyze the relationship between serum IL-6 level and CDSS score. Results · According to the results of CDSS, the patients were divided into depression group (119 cases) and non-depression group (120 cases). Compared with the non-depression group, the PANSS negative symptom subscale score and serum IL-6 level of patients in the depression group were higher (P=0.028, P=0.000). Pearson correlation analysis showed that serum IL-6 level was positively correlated with CDSS score in the depression group patients (r=0.42, P=0.000). Conclusion · The increase of serum IL-6 level may be related to the occurrence of schizophrenia with depression symptoms. [ABSTRACT FROM AUTHOR]

Zein is the major storage protein of corn and comprises 45%-50% of total protein in corn, and possesses good property of forming film in virtue of abundant sulphur amino acids. High content of hydrophobic amino acid grants hydrophobicity to zein film, but film made of natural casting retains its crispness. In order to improve the flexibility of zein film, plasticizers are added into the film solution. Though plasticizers can significantly enhance mechanical properties of zein film, they affect their security and edibility. Equipments such as pulsed electric field used in processing of casting can improve the properties of zein film by taking appropriate measures, without affecting the security and edibility of zein film. But the popularization of these equipments is hindered for their high price. In this paper, the combination of DC power (DYY-8C, Beijing) and conducting glass coated with indium tin oxide was used to set up paralleled uniform electric field, and then the electric field was introduced into the processing of zein film. This method was of simple equipment, easy operation and good selectivity. Coupled with the paralleled uniform electric field (1-5 A/m²), the soft zein films with complete shape were obtained by casting. The properties of zein film such as tensile strength, elongation at break, water vapor permeability and water absorption were measured and analyzed to evaluate the influence of the paralleled uniform electric field on zein film. Meanwhile, thermostability difference between films before and after treatment was studied by differential scanning calorimetry. By analyzing the data, tensile strength and elongation at break increased with the increase of electric current density while water vapor permeability and water absorption decreased. When electric current density was at 4 A/m², properties of zein film were optimal. Tensile strength and elongation at break reached the maximum value (73.09 MPa and 9.68%, respectively); water absorption and water vapor permeability reached the minimum value (14.87% and 2.54*10-8 g-m/(m².h.Pa), respectively). Contact angle declined slightly (within 5°), and tended towards stability when electric current density was above 2 A/m². Experiments indicated that the presence of electric field force facilitated interaction between zein molecules, and these molecules were organized in a network pattern contributing to the improvement of mechanical properties. Meanwhile, polar amino acid residues tended to move forward to the topside of the network, resulting in the slight decline of contact angle. There existed significant difference among the data obtained from the experiments by Duncan analysis (P<0.01). During the processing of zein film, no hazardous substance was added into the film solution. By adjusting the electric current density, film or edible packing material with flexibility, fixed shape, mechanical strength, certain mechanical properties or contact angle can be obtained, which are biodegradable, edible and non-toxic toward humans and environment. [ABSTRACT FROM AUTHOR]

A multiple criteria decision model addressing the comparison of both subjective and objective evaluation results is proposed. Firstly, based on the cluster analysis, a method for selecting representative sample data set from all alternatives under evaluation is designed. Next, experts are invited to review these sample data and the dominance-based rough set theory is used to analyze expert decisions, thus formatting a set of decision rules. Then, these trained decision rules are applied to all alternatives, and hence an objective-oriented result can be obtained and compared with the alternatives' self-evaluation results which contain subjective orientation. Finally, the method is used to analyze the leaning ability of graduate to demonstrate its feasibility. [ABSTRACT FROM AUTHOR]

In order to reduce an engineering quantity of the gas drainage borehole in low permeability seam and to improve the gas drainage efficiency, a study was conducted on the permeability improvement theory and technology application in a low permeability seam. Based on the controlled hydraulic fracturing conception of the seam, a hydraulic fracturing numerical simulation in the underground mine and the optimized design software were developed and a sealing method of a high pressurized upward borehole and horizontal borehole was provided. Thus the key technology to detect the fracturing water distribution scope was developed and the site application was conducted. The results showed that with a target, orientation and regional fracturing to realize a permeability improvement of the target regional seam, in comparison with the before and after the controlled hydraulic fracturing, the single borehole gas drainage volume was improved over five times, the gas drainage borehole engineering workload was reduced by 1/3 in some coal mining face, a single day coal production and driving rate of the gateway driving face was highly improved. The controlled hydraulic fracturing in the underground mine was an improvement and innovation of the conventional hydraulic fracturing technology and could effectively promote the seam permeability improvement in the target region and could improve the gas control effect. [ABSTRACT FROM AUTHOR]

With the development of internet technology, many application tools based on the internet have become popular. In addition, the media used by tourists has been abundant and diversified. Through internet, more and more tourists acquire tourism information, make tourism plans, purchase tourism services and exchange their experiences. The network channels such as official websites, micro-blogs, and e- commerce platforms of tourism destinations construct a network interface for tourists to communicate with the destinations. The information diffused by these network interfaces may greatly affect tourist perceptions of the destination image. Based on desk research and interviews of tourists, this research defines the characteristics of tourism destination network interface as 3 factors: information value, friendly interface and interactive interface. This research aimed to investigate the internet users such that all the survey questionnaires were all carried out through the internet. We issued the questionnaire on a famous Chinese internet investigation/information? platform (http://www.sojump.com). By snowball sampling, we sent the web link to the frequent tourism web surfers through our Sina microblog, Tencent microblog, and other tourism online communities (such as http://www.8264.com) and invited the members to fill in and forward to their friends. A total of 653 questionnaires were obtained over a three-month period. After eliminating incomplete and non-valid responses, 422 questionnaires remained for analysis in this study, with an acceptable effective rate of 65 percent. To explore the effect of tourism destination network interface on tourist experience and brand image, this research constructed a structural equation model (SEM) for characteristics of tourism destination network interface, tourist experience, and tourism destination brand image. We used AMOS17.0 software to estimate the model, test the fit index, path coefficient and T-value. The results suggest that the 3 factors of tourism destination network interface affect the destination brand image through functional experience and emotional experience, but the effect of information value on emotional experience is not significant. As a result, compared to the traditional environment, there are more factors of tourism destination affecting tourists'conceptions to tourism destinations within an internet context and the mechanism of image building is more complex. Based on these findings, this paper proposes some strategic suggestions for tourism destinations to optimize their network interfaces, improve tourist experiences, and enhance the destination brand image. The tourism destination marketers should (1) choose a suitable network interface and promote proper information to enhance the attractiveness of the interface; (2) have a clear mind on the positioning of the brand image through the internet and make sure the brand image is built consistently by different network platforms; (3) improve design technology of the network interface to enhance the appearance of network interface, optimize the content expression and to increase the tourists' stickiness; (4) strengthen the interaction of the network interface to help tourists to understand internet information and to communicate with each other. These initiatives will be of great help for improving the destination brand image. [ABSTRACT FROM AUTHOR]

Objective To explore the significance of the combing serum levels of gamma globulin and Indocyanine green clearance test in evaluating hepatic functional reserve. Methods 60 male SD rats were randomly divided into experimental group and control group. The model of liver cirrhosis in rats was established and the serum levels of gamma globulin and Indocyanine green retention rate in 15 minutes (ICG R15) were tested and their correlation was analyzed. Furthermore, the liver pathological examination was performed to estimate degree of liver fibrosis. Results As time went on, the liver fibrosis degree of SD rats aggravated gradually, both serum levels of gamma globulin and ICG R15 increased significantly (P< 0.05), and the correlation analysis showed that they had obvious correlation (r = 0.841) . The single factor linear regression analysis obtained a equation of regression:Y=0.715X+3.783 (Y is ICG R15, X is serum levels of gamma globulin) . Conclusion During the forming process of liver cirrhosis, the increase of serum levels of gamma globulin and ICG R15 have obvious correlation, so testing serum levels of gamma globulin would be a good approach to complement Indocyanine green clearance test in evaluating hepatic functional reserve. [ABSTRACT FROM AUTHOR]

Data in some emerging applications, such as sensor networks, real-time monitoring systems, etc., are always time-varying, uncertain, and continuously arriving. These data need to be quickly processed. However, some important operations are costly, such as the real-time window joins over data streams. The requirement is a high challenge for a data streams processing system. Currently, most of the algorithms use software optimization to accelerate the processing speed, yet the results are unsatisfactory. GPU (graphic processing unit) has a high processing performance as it uses multi-thread and high-bandwidth to process data in parallel. This paper presented a co-processing method with hardware and software to accelerate the window join operation over data streams. In CUDA (compute unified device architecture) architecture, CPU (central processing unit) transfers data to memory of GPU to be processed in parallel. Experiment results show that this method can greatly improve the processing speed with about 50 times faster than software implementation. [ABSTRACT FROM AUTHOR]

Network anomaly behavior detection is the important section of the intrusion detection, and it is hard for single security measure to attain good detection result. According to the evidence combination problem of highly conflict evidences, the paper applies an improved combination method based on weight to network anomaly behavior detection, and builds an intrusion detection model with multiple SVM classifiers. The method uses average evidences and weight value to distinguish the importance among all evidences, and thus it can deal with the conflicting evidences. Simulation results show that, compared with the traditional D-S theory, the proposed model can effectively improve the integration efficiency, thereby improving detection performance. [ABSTRACT FROM AUTHOR]

An abstract of the article "Human daily activity recognition method based on BSN and neural network" by Chen Ye and colleagues is presented.

"The value of interest and virtue" is one of important issues, debate the "interest" and "virtue" is not only academic question, also is the behavior of individual and moral principles. In the western thoughts of the China social impact, "The value of interest and virtue" content changes, but the shift is not without foundation, scholars still followed Chinese traditional academic ideas. Originally internalizes individual moral ethic "The value of interest and virtue" , in the old and new different interpretation under, into the external behavior and the judgment standard, thus profound impact on the Chinese people thinking about the problems of Chinese society [ABSTRACT FROM AUTHOR]

The introduction of technology integration theory and the emergence of more alternative advanced manufacturing technology (AMT) provide objective conditions for the innovation activities of domestic enterprises, which may even lead to technological leap. At the same time the diversity of technology market makes technical choices become a question to be resolved. Because of the imperfection of the AMT selection methods, this paper intends to establish an AMT selection model using binary-logit-discrete-choice theory with binary trend panel data. The random effect structure of the model and the probability distribution of the random trend disturbance term of utility model are also given. It discussed the estimation of the random utility model, presented and proved two theorems of eliminating random accidents and random disturbance items of the mode. A panel data processing method is given to handle the random preference variables of the model, eventually transform the multi-period panel data model to a cross-sectional data model that can be estimated. The paper thus presents a theoretical approach to choose multi-technology integrated AMT resources. An example is given to verify the theoretical approach is effective and feasible at last. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of raloxifene HCL (RLX) on serum biochemistry, bone markers, and bone mineral density (BMD) in women with postmenopausal osteoporosis. Methods A total of 90 patients with postmenopausal osteoporosis, who were hospitalized in our department from January 2010 to January 2010, were selected. All the patients took 600 mg calcium and 0.5 μg active vitamin D every day as the basic supplements. The patients also took 60 mg RLX every week for 12 months. The obvervational indexes included BMD of the lumbar vertebrae and the hip, bone markers, and serum biochemical indexes. BMD was detected using dual-energy X-ray absorptiometry. Bone markers were determined using enzyme-linked immunosorbent method. Serum biochemical indexes were detected using enzymic method. Results BMD of the lumbar vertebrae and the Ward's triangle was 0.848 ±0.167 and 0.536 ± 0.126, respectively, which was higher than that before the treatment (0.842 ± 0.181 and 0.500 ± 0.112, respectively), and the difference was statistically significant (P < 0.05). The serum levels of CTX and BGP decreased significantly than those before the treatment, while the serum PTH level was higher than that before the treatment. No significant difference of the serum levels of blood lipids between two groups was observed. Conclusion Raloxifene hydrochloride increases BMD of the lumbar vertebrae and the hip in women with postmenopausal osteoporosis, and reduces the bone turnover significantly. So, it has good therapeutic effect for postmenopausal osteoporosis. [ABSTRACT FROM AUTHOR]

Objective: To analyze the mutant spectrum of clonal hematopoiesis of indeterminate potential (CHIP) related mutations and clinical characteristics and to explore the correlation and the possible mechanism between CHIP-related mutations and cardio-cerebrovasculars events (CCEs) in patients with myeloproliferative neoplasms (MPNs)., Methods: The clinical data and next-generation sequencing results of 73 MPN patients in Beijing Anzhen Hospital from August 2019 to July 2022 were retrospectively analyzed. Statistical analyses were conducted by multivariate logistic regression for the effects of CHIP-related mutations and inflammatory cytokines on CCEs for MPNs patients., Results: Fifty-five cases of MPN (75.3%) showed positive in CHIP-related genes. There was no significant difference in variant allele frequency of CHIP-related gene between essential thrombocythemia (ET) and polycythemia vera (PV). CHIP-related gene mutations were mainly single gene mutations, with mutation rate from high to low as JAK2V617F (63.0%, 46/73), ASXL1 (16.4%, 12/73), TET2 (11.0%, 8/73), DNMT3A (9.6%, 7/73), SRSF2 (6.9%, 5/73), SF3B1 (4.1%, 3/73), TP53 (1.4%, 1/73) and PPM1D (1.4%, 1/73). The mutation rate of CHIP-related genes in MPN patients >60 years old was significantly higher than that in the patients ≤60 years old ［91.7%(33/36) vs 59.5%(22/37)］. CCEs occurred in 27 MPNs patients (37.0%, MPNs/CCEs), and 5 had recurrent CCEs, all of which were arterial events. Age (62.8±12.8 years vs 53.9±15.8 years, P =0.015), IL-1β level (17.7±26.0 vs 4.3±8.6, P =0.012), IL-8 level (360.7±598.6 vs 108.3±317.0, P =0.045), the proportion of the patients with thrombosis history (29.6% vs 2.2%, P =0.020), and the detection rate of CHIP-related mutations (88.9% vs 67.4%, P =0.040) in the group with CCEs were higher than those in the group without CCEs. Multivariate Logistic regression analysis showed that age（ OR =0.917， 95% CI ：0.843-0.999, P =0.047）, thrombosis history ( OR =34.148， 95% CI ：2.392-487.535, P =0.009), any CHIP-related mutations( OR =16.065， 95% CI ：1.217-212.024， P =0.035), and elevated level of IL-1β ( OR =0.929， 95% CI ：0.870-0.992， P =0.027) were independent risk factors for MPNs/CCEs. CHIP-related gene mutations were not associated with CCEs in MPN patients, but DNMT3A ( OR =88.717， 95% CI ：2.690-292.482， P =0.012) and ASXL1 ( OR =7.941， 95% CI ：1.045-60.353， P =0.045) were independent risk factors for CCEs in PV., Conclusion: There is a higher mutation rate of CHIP-related genes in MPN patients, especially those over 60 years old. Older age, thrombosis history, CHIP-related mutations and IL-1β elevated levels are independent risk factors for CCEs in MPN. DNMT3A and ASXL1 mutations are independent risk factors for CCEs in PV patients. CHIP-related gene mutations and inflammatory cytokine IL-1 β elevated levels may be the novel risk factors for CCEs in MPN.

Objective: To investigate the clinical characteristics and maternal and fetal prognosis of pregnant women with acute fatty liver of pregnancy (AFLP). Methods: The clinical data of 86 AFLP pregnant women admitted to the Third Affiliated Hospital of Guangzhou Medical University from September 2017 to August 2022 were collected, and their general data, clinical characteristics, laboratory tests and maternal and fetal outcomes were retrospectively analyzed. Results: (1) General information: the age of the 86 pregnant women with AFLP was (30.8±5.4) years, and the body mass index was (21.0±2.5) kg/m 2 . There were 50 primiparas (58.1%, 50/86) and 36 multiparas (41.9%, 36/86). There were 64 singleton pregnancies (74.4%, 64/86) and 22 twin pregnancies (25.6%, 22/86). (2) Clinical characteristics: the main complaints of AFLP pregnant women were gastrointestinal symptoms, including epigastric pain (68.6%, 59/86), nausea (47.7%, 41/86), anorexia (46.5%, 40/86), vomiting (39.5%, 34/86). The main non-gastrointestinal symptoms were jaundice of skin and/or scleral (54.7%, 47/86), edema (38.4%, 33/86), fatigue (19.8%, 17/86), bleeding tendency (16.3%, 14/86), polydipsia or polyuria (14.0%, 12/86), skin itching (8.1%, 7/86), and 17.4% (15/86) AFLP pregnant women had no obvious symptoms. (3) Laboratory tests: the incidence of liver and kidney dysfunction and abnormal coagulation function in AFLP pregnant women was high, and the levels of blood ammonia, lactate dehydrogenase and lactic acid were increased, and the levels of hemoglobin, platelet and albumin decreased. However, only 24 cases (27.9%, 24/86) of AFLP pregnant women showed fatty liver by imageology examination. (4) Pregnancy outcomes: ① AFLP pregnant women had a high incidence of pregnancy complications, mainly including renal insufficiency (95.3%, 82/86), preterm birth (46.5%, 40/86), hypertensive disorders in pregnancy (30.2%, 26/86), gestational diabetes mellitus (36.0%, 31/86), fetal distress (24.4%, 21/86), pulmonary infection (23.3%, 20/86), disseminated intravascular coagulation (16.3%, 14/86), multiple organ dysfunction syndrome (16.3%, 14/86), hepatic encephalopathy (9.3%, 8/86), and intrauterine fetal death (2.3%, 2/86). ② Treatment and outcome of AFLP pregnant women: the intensive care unit transfer rate of AFLP pregnant women was 66.3% (57/86). 82 cases were improved and discharged after treatment, 2 cases were transferred to other hospitals for follow-up treatment, and 2 cases (2.3%, 2/86) died. ③ Neonatal outcomes: except for 2 cases of intrauterine death, a total of 106 neonates were delivered, including 39 cases (36.8%, 39/106) of neonatal asphyxia, 63 cases (59.4%, 63/106) of neonatal intensive care unit admission, and 3 cases (2.8%, 3/106) of neonatal death. Conclusions: AFLP is a severe obstetric complication, which is harmful to mother and fetus. In the process of clinical diagnosis and treatment, attention should be paid to the clinical manifestations and laboratory tests of pregnant women, early diagnosis and active treatment, so as to improve maternal and fetal outcomes.