1. [Cytokine production by MTSC 4 cells, an established mouse thymic dendritic cell line].
- Author
-
Liu ZG, Chen WF, Cao LX, Pang XW, Zhang PX, and Yu Q
- Subjects
- Animals, Cell Line, Dendritic Cells cytology, Interferons metabolism, Interleukin-6 metabolism, Mice, Mice, Inbred BALB C, Cytokines metabolism, Dendritic Cells metabolism, Thymus Gland cytology
- Abstract
The cytokine production by MTSC 4 cells, a murine thymic dendritic cell line established in our laboratory, has been investigated. Without exogenous stimulation, the MTSC 4 cells constitutively produce multiple types of cytokines, including IL-1, IL-6, IL-7, CSF, IFN and Chemotactic factor (CF). Of which, IL-6 and IFN were abundant: IL-1 and Chemokine, moderate: IL-7 and CSF at low level. MTSC4 cells could not produce detectable either IL-3 of TNF alpha. The establishment of MTSC 4 may be useful in the analysis of the mechanism of thymus selection, and in the study of the network regulation of autocrined cytokines.
- Published
- 1994