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Objective: To study Analysis of the Correlation between serum il-2, il-16 levels and CD4 cell counts in hiv-infected patients. Methods: 50 patients with HIV infection admitted to our hospital from March 2017 to March 2018 were selected as the observation group and 40 healthy people who underwent physical examination in our hospital during the same period as the control group, the serum il-2, il-16 and CD4 cell counts in the two groups were detected and compared, and the correlation between serum il-2, il-16 and CD4 cell counts in the observation group was analyzed. Results: Serum il-2, il-16 levels and CD4 cell counts in the observation group were significantly lower than those in the control group, with statistically significant differences(P<0.05). Pearson correlation analysis showed that serum il-2 and il-16 levels in the observation group were significantly positively correlated with CD4 cell count(r=0.514,r=0.499, P<0.05). Conclusion: Serum il-2 and il-16 levels of hiv-infected patients were significantly down-regulated and positively correlated with CD4 cell count, which can reflect the severity of HIV infection to some extent. [ABSTRACT FROM AUTHOR]