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Access of large-scale distributed power supply to the distribution network brings dimensionality disaster to the optimal dispatching of the distribution network. Therefore, it is necessary to cluster the distributed power supply to reduce the difficulty of regulation and control, and a reasonable division of distributed power supply cluster is very important. However, the incomplete real-time measurement data of the distribution network has caused difficulty and low time efficiency in real-time cluster division of the distribution network. Therefore, this paper proposes a distributed power cluster division strategy based on the smart local moving (SLM) algorithm and the radial basis function (RBF) neural network. First, the range of active power and reactive power regulation and the sensitivity of active power and reactive power to voltage are selected as the indexes of cluster division. By constructing a similarity matrix, the SLM algorithm is used to form the historical strategy library of cluster division of distributed power sources. Then, a voltage fitting model is established offline, which can observe the relationship between the power and voltage of buses in real time. Meanwhile, a voltage-division result model is established offline, and the real-time division result is obtained through the voltage online, which solves the problem that cluster division cannot be performed when the power flow model is missing, and improves the real-time performance of cluster division. Finally, the rationality and superiority of the algorithm are verified by simulation on MATLAB platform.

Environmental regulation, as an effective means to protect the environment, has important reference value for marine fishery management in China. This paper takes marine fisheries as the research object, uses the SBM model based on non-expected output to measure the marine fishery ecological efficiency in nine coastal provinces of China during 2011-2020, and uses the standard deviation ellipse method to analyze the temporal and spatial characteristics of marine fishery ecological efficiency. Finally, Tobit regression model was used to explore the impact of environmental regulation and other factors on the ecological efficiency of marine fisheries. The findings are as follows: (1) The ecological efficiency of marine fisheries showed a downward trend, and the regional gap was not significantly reduced, showing a trend of polarization. (2) The center of gravity of marine fishery eco-efficiency moved to the southwest as a whole, showing a northeast-southwest spatial development pattern. (3) Environmental regulation is negatively correlated with marine fishery eco-efficiency, regional development level and industrial structure of other influencing factors are negatively correlated with marine fishery eco-efficiency, and the level of opening to the outside world and scientific and technological support are not significantly correlated with marine fishery eco-efficiency. Finally, based on the research conclusions, this paper puts forward relevant policy recommendations.

Distributed Raman Fiber Amplifier (DRFA) is widely used in modern communication systems because it has a series of excellent features. Considering the existing problems of DRFA gain control, this paper studies and improves a method of Automatic Gain Control (AGC) of DRFA by Amplifying Spontaneous Emission (ASE) out of band. In view of the fact that DRFA gain is greatly affected by the performance of optical fiber link, this paper firstly theoretically analyzes the influence of the joint loss at the position 0 away from the pump source in the optical fiber link on the Raman gain control. Then the splice loss at different positions from the pump source is set to be equivalent to the splice loss at position 0. The relationship between Raman gain and out-of-band ASE power is modified so that the AGC of DRFA can be realized more accurately. The Optical Time Domain Reflectometer (OTDR) function is integrated in the DRFA module to detect the distance between the joint loss and the pump source and the loss value in the engineering optical fiber link. Experimental results show that the proposed AGC method can control the influence of joint loss on DRFA gain within 0.2 dB.

The access to droop-controlled components makes the operation of the power system more complicated,and also brings new challenges to the power system analysis. Power flow calculation is the most basic and important type of calculation in power system analysis. When performing power flow calculations for power systems with droop control components,it is necessary to consider new problems that are not considered in conventional power flow calculations. The basic theory of droop control is introduced and the research on power flow calculation of power systems with droop control is summarized. Firstly,the principle of droop control,the types of main components,and the application scenarios of power flow calculation with droop control are briefly introduced. Secondly,the processing methods of droop-controlled components in power flow calculation are listed. Then,the questions of alternating current (AC) system power flow calculation with droop control are considered. In addition,the domestic and foreign solutions are also presented. Finally,combined with the new requirements of power flow calculation in power system,it is proposed that the power flow calculation considering droop control needs to establish a unified calculation model in modeling,and the mathematical programming method can be used for the algorithm,but it needs to be further improved according to the actual scene.

Objective To investigate the expression and correlation of pigment epithelium derived factor (PEDF) and androgen receptor (AR) in bladder cancer tissues. Methods The expression of PEDF and AR in 30 cases of bladder cancer tissues were detected by immunohistochemical staining. The relation between PEDF expression and AR was analyzed by Pearson correlation. We detected the expression levels of PEDF and AR in bladder cancer TCCSUP cell line and the expression of PEDF after lentivirus-mediated AR interference by Real-time PCR and Western blot. Results PEDF expression was negatively correlated with AR expression(P=0.003). Androgen could significantly upregulate AR expression and inhibit PEDF expression. At the same time, interfering AR expression could upregulate the expression of PEDF. Conclusion The expression of PEDF may be inhibited by AR expression in bladder cancer tissues.

Reciprocating compressor vibration signal is typical nonlinear and non-stationary,and the vibration information interference coupling, owing to this problem,a fault diagnosis method of reciprocating compressor on the resonance-based sparse signal decomposition with optimal Q-factor was proposed.The method use resonance sparse decomposition to find the low resonance component which its kurtosis is maximum, optimize Q-factor with genetic algorithm and particle swarm optimization to get the optimal Q-factor;then use resonance sparse decomposition to decompose reciprocating compressor vibration signal by the optimal Q-factor;the result shows that this method can diagnose the oversized bearing clearance fault effectively.

The risk management in workplace is an important measure to effectively prevent and control the harm of hand-transmitted vibration. Based on the relevant developments at home and abroad, this paper expounds the risk of manual vibration operation in workplace by taking contact assessment and hazard assessment as an example. On this basis, the limit management and hierarchical management related to risk management are discussed, and the existing problems are analyzed.

Laryngeal carcinoma is one of the most common malignant tumors in the area of head and neck, and the main pathological type is laryngeal squamous cell carcinoma. Due to the fact that the disease usually have no overt clinical symptoms at the early stage and easy to relapse, it has a poor prognosis and low five-year survival rate. microRNA is a class of endogenous, non-coding RNA with a length of 19-25 nucleotides. microRNAs, mainly regulate the expression of target genes at the post-transcriptional level after complementing and pairing with the 3'-UTR area of the target gene. Studies have shown that the abnormal expression of microRNA is closely related to the occurrence, development, metastasis and prognosis of various cancers including laryngeal carcinoma. In this article, the research progress of microRNA in laryngeal squamous cell carcinoma is reviewed., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)

Objective: To investigate the effect of bone marrow mononuclear cell transplantation on the expression of miRNA-21 and miRNA-155 in mice with ulcerative colitis(UC). Methods: Healthy and clean KM mice aged 6-8 weeks were randomly divided into transplantation group, model group and normal control group with 15 mice in each group. In the transplantation group and model group, dextran sodium sulfate (DSS) was used to establish the model for 24 h. The mice in the transplantation group were injected with 0.4 ml of 4 ', 6-diaminol-2-phenylindole (DAPI) -labeled P3-BM-MNCs cell suspension (3.2×10(6) cells/ml), and the mice in the model group and the normal control group were injected with 0.4 ml phosphate buffer (PBS).UC disease activity index (DAI) was used to test the general condition of mice; HE staining was used to observe the pathological changes of colon tissue; Real-time quantitative PCR was used to detect the expression of miRNA-21 and miRNA-155 mRNA. Results: DAI scores of normal control group, model group and transplantation group were 0 (0,1), 3.1 (2.8,3.3) and 2.7 (2.4,3.1),respectively. Compared with normal control group, the DAI score of model group and transplantation group was higher ( P< 0.05), and the DAI score of transplantation group was lower than that of model group ( P< 0.05). The gross scores of tissue injury in normal control group, model group and transplantation group were 0 (0, 1), 3 (3, 4) and 1 (1, 2), respectively,and the pathological scores of tissue injury were 0 (0, 1), 16 (12, 16) and 6 (6, 8), respectively,compared with the normal control group. The tissue injury score of the model group and the transplantation group was higher ( P< 0.05), and the tissue injury score of the transplantation group was lower than that of the model group ( P< 0.05). The expression levels of miRNA-21 mRNA in normal control group, model group and transplantation group were 0.87±0.15, 2.38±0.29 and 1.59±0.32, respectively, and the expression levels of miRNA-155 mRNA were 1.87±0.46, 7.38±1.97 and 3.92±0.84, respectively, compared with the normal control group, the expression of miRNA-21 and miRNA-155 mRNA in the model group and transplantation group was higher ( P< 0.01), the expression of miRNA-21 and miRNA-155 mRNA in the transplantation group was lower than that of the model group ( P< 0.05). Conclusion: Bone marrow mononuclear cell transplantation can improve the histopathological and DAI scores of mice with UC, which may be related to the down-regulation of miRNA-21 and miRNA-155 mRNA expression.

Objective: To investigate the cinical value of FAM19A4promoter methylation in cervicalexfoliated cells for triage of cervical cancer. Methods: A total of 162 high-risk HPV-infected patients who were pathologically confirmed as different cervical lesions from August 2017 to December 2017 were collected in Guangdong Women and Children Hospital. Taqman probe-based quantitative PCR (qPCR) was used to detect the methylation of FAM19A4 promoterin different grades of cervical lesions, and the value of FAM19A4 methylation in predicting cervical HSIL and the above lesions was calculated by diagnostic test. Results: (1)The positive rates of FAM19A4 methylation in cervical exfoliated cells increased with the severity of cervical lesions, which were 7.69% (4/52) , 34.62% (9/26) , 55.56% (20/36) , 95.83% (46/48) in normal cervix/cervicitis, cervical LSIL, HSIL, and cervical cancer, respectively( P< 0.05).(2)There was no significant difference in the detection rates of FAM19A4 methylation between different age groups, pathological types, clinical stage, tumor size and lymph node metastasis status ( P> 0.05). (3) The specificity and positive predictive value of FAM19A4 methylation in detecting cervical HSIL alone and ≥HSIL lesions were the optimal, with the AUC of 0.69 and 0.84, respectively. When combined with HPV16/18 genotyping, the sensitivity was significantly improved. Conclusions: The detection of FAM19A4 promoter methylation in cervical exfoliated cells has a high clinical value of discriminating ≥HSIL lesions; and the cotest of methylated FAM19A4 and HPV16/18 genotyping can identify ≥HSIL lesions more sensitively.

Objective: To analyze the ultraviolet-screening of the n-butanol extracts of mangosteen pericarp and alpha-mangostin, compare the ultraviolet-screening effect of the extracts with rutin and ultramicro-titanium dioxide (TiO2)., Methods: The samples (n-butanol extract from mangosteen pericarp, alpha-mangostin, rutin and TiO2) were scanned at different wavelength and Pan-wavelength by ultraviolet spectrophotometry., Results: The n-butanol extracts and alpha-mangostin had relatively satisfactory effects on ultraviolet-screening when the concentration was over 0.40 mg/ml and the effects on ultraviolet-screening was better than TiO2., Conclusion: The n-butanol extracts and alpha-mangostin had a positive ultraviolet-screening activity which was better than TiO2.

Objective: To detect the expression of RhoC and Rho kinase 1 (ROCK-1) in prostate carcinoma, and explore the possible mechanism of RhoC/ROCK-1 in the pathogenesis of prostate carcinoma., Methods: Tissue specimens from 73 patients with prostate carcinoma and corresponding paracancerous tissues were obtained by prostate cancer biopsy or radical prostatectomy. The expression of RhoC/ROCK-1 mRNA was detected by RT-PCR. Western blot and immunohistochemistry were performed to dertect the expression of RhoC/ROCK-1 protein. Eukaryotic expression plasmids of RhoC were constructed and transfected into PC-3M-2B4 cells. p-MAPK and p-Akt were detected by Western bolt., Results: The expression levels of RhoC and ROCK-1 mRNA in the prostate carcinomas were significantly higher than those in corresponding paracancerous tissues [72.6% (53/73) vs. 34.2% (25/73); 68.5% (50/73) vs. 38.4% (28/73), P < 0.01], respectively. The results indicated that RhoC/ROCK-1 mRNA expression had no significant correlation with Gleason grade. However, the expression of RhoC/ROCK-1 mRNA showed a significant positive correlation with distant metastasis. The RhoC/ROCK-1 protein expression in prostate cancer was also higher than corresponding paracancerous tissues, and showed a significant positive correlation with p-MAPK and p-Akt expression levels. In addition, p-MAPK and p-Akt expression levels were up-regulated in the transcripts., Conclusion: Expression levels of RhoC and ROCK-1 in prostate carcinoma are higher than those in corresponding paracancerous tissues, showing a significant positive correlation with distant metastasis. RhoC/ROCK-1 may be involved in the development, invasion and metastasis of prostate carcinoma.

Objective: This clinical study was designed to evaluate the efficacy and toxicity of the combined regimen of docetaxel, 5-Fu and DDP (TPF) in the treatment of advanced or relapsed nasopharyngeal carcinoma (NPC)., Methods: Fifty-six patients with newly diagnosed or recurrent/metastatic NPC following chemotherapy or radiotherapy were enrolled. Both docetaxel and DDP were administered intravenously for 6 hours at the dose of 70 mg/m2 on D1. 5-Fu was given at a dose of 400-500 mg/m2 for 6 hours from D1 to D5. Dexamethasone was routinely administered before injection of docetaxel. This combination was repeated every 3 to 4 weeks, and continued for 4-6 cycles or until PD for the responders., Results: Fifty-one (91.1%) patients were evaluable for response assessment. The response rate for whole group was 72.5% (37/51) with a CR rate of 9.8% (5/51). The stable disease accounted for 17.6% (9/51). There were 17(30.4%) chemotherapy-naïve patients. The overall response rate in those was 82.4% with a CR rate of 29.4%. However, the response rate for previously treated patients was 64.7% without CR. Twelve patients had progressed disease, including 5 (8.9%) died of disease progression with a median follow-up of 11 month (ranged from 1 to 19 months). Totally, 196 courses of chemotherapy were administered. The major toxicity was myelosupression, nausea/vomiting. The incidence of leucopenia was 48% with 22.2% of these in NCI grade II or IV. But only 2 patients (3.6%) experienced leucopenia with a fever. Other mild toxicities including alopecia, asthenia, mucositis and diarrhea were also observed., Conclusion: Our preliminary outcome shows docetaxel, 5-Fu and DDP combination is effective and safe for the patients with advanced or relapsed nasopharyngeal carcinoma. But further clinical study is warranted.

Background & Objective: The prognosis of relapsed or refractory T-cell non-Hodgkin's lymphoma (T-NHL) is poor. There is no definite prognostic factors and standard regimens for these patients. This study was to explore the prognostic factors and effective regimens for relapsed or refractory T-NHL., Methods: Clinical records of 45 patients with relapsed or refractory T-NHL, treated in Cancer Center of Sun Yat-sen University from Jan. 1997 to Mar. 2003, were analyzed in terms of response, long-term survival and prognostic factors., Results: By the end of Jul. 2006, 5 patients still alive; the median follow-up time was 30 (2-70) months. The median survival time after relapse was 22 (2-62) months. Of the 45 patients, 42 (93.3%) received salvage regimen, the response rate was 61.9% (26/42); for those received second-line chemotherapy, the response rate was 52.4% (22/42). The 1-, 3-, and 5-year overall survival rates were 75.6%, 17.8%, and 4.4% for the whole group, 82.1%, 25.0%, and 5.8% for low risk group and 64.7%, 6.5%, and 6.5% for high risk group, respectively (P=0.026). Multivariate analysis showed that serum lactate dehydrogenase (LDH) level (P=0.010), second-line Ann Arbor stage (P=0.009), second-line IPI score (P=0.015), autologous stem cell transplantation (P=0.026), performance status (P=0.002), and IMVP-16 regimen (P=0.026) were independent prognostic factors of relapsed or refractory T-NHL., Conclusions: Second-line IPI score, autologous stem cell transplantation, and so on, may be independent prognostic factors for relapsed or refractory T-NHL. The prognosis of this disease is poor and the addition of intensive treatments, such as stem cell transplantation, should be considered when alleviated after chemotherapy.

Objective: The aim of this study is to analyse the efficacy and toxicity of CEOP regimen in the treatment of non-Hodgkin's lymphoma (NHL)., Methods: From January 1995 to December 2000, 121 patients with NHL were treated by CEOP regimen with or without radiotherapy for the involved field. The clinical characteristics, response, toxicity and long-term survival results were analysed retrospectively., Results: Of these 121 patients, 83 (68.6%) had B-cell NHL and 38(31.4%) peripheral T or NK-cell NHL; 55. 4% (67/121) had early disease (stage I or II), and 89.3% (108/121) had IPI score 0-2. The median age was 53 years (range: 7-79 yr). All patients were treated by CEOP regimen (totally, 471 cycles) with or without radiotherapy. The overall response (OR) rate in this series was 90.9% (110/121) with a complete remission (CR) rate of 71.9% (87/121); whereas the response rate of chemotherapy alone was 88.4% (107/121) with a CR rate of 67.8% (82/121). Major toxicity consisted of grade III-IV myelosuppression (11.9%), neutropenia (1.9%) and thrombocytopenia and anemia (1.1%). Alopecia was observed in 46.3%. However, cardiotoxicity was mild and reversible. Median follow-up duration in this series was 63 months (range: 2-116 months). The overall 1-, 3- and 5-year survival rate was 84.8%, 62.7% and 55.9%, respectively, with a median survival time of 85 months (2-118 months)., Conclusion: Our data show that CEOP regimen combined with or without radiotherapy for the involved field is effective and well tolerated by the patients with non-Hodgkin's lymphoma.

Background & Objective: The incidence of mucositis caused by autologous hematopoietic stem cell transplantation (AHSCT) is relatively high. The severe painful mucositis can reduce the quality of life of patients obviously. Transdermal fentanyl is efficient in treating chronic pain of cancer, and also can relieve the severe pain of mucositis resulted from chemotherapy. This study was to investigate the efficacy and safety of transdermal fentanyl for the severe painful mucositis caused by AHSCT., Methods: A total of 22 malignant tumor patients suffered from severe mucositis caused by high dose chemotherapy combined AHSCT. The analgesic degree before and after treatment was evaluated by the scores of Visual Analogue Scale (VAS) (range 0-10). The median VAS scores of all patients were above 4 (moderate to severe pain) before the administration of transdermal fentanyl. The quality of life before and after treatment was evaluated by the Standard of Quality of Life drew up in China in 1990. The adverse events after treatment were evaluated by Common Toxicity Criteria formulated by National Cancer Institute of the USA., Results: The median VAS score has been decreased from baseline at 6 (4-9) to 3.5 (0-9) on Day 3, 2 (0-6) on Day 5, 0.5 (0-8) on Day 7, 0 (0-6) on Day 10, and 0 (0-5) on Day 15 after treatment (P<0.001). The overall response rate was 100%, while the complete response rate was 45.5%. The quality of life of the patients was improved significantly (P<0.01). The adverse events after treatment of transdermal fentanyl included dizziness, somnolence, dysuria, mild and transient nausea, vomiting, discomfort of stomach, and so on. All the adverse events disappeared within several days after proper managements. Neither severe adverse event nor drug addiction was found., Conclusions: Transdermal fentanyl has good analgesic effect on painful severe mucositis induced by AHSCT. It is convenient and well tolerated, and could improve quality of life significantly.

Background & Objective: The prognosis of relapsed or refractory B-cell lymphoma is poor, with a short-term survival after conventional second-line chemotherapy. Rituximab, a chimeric anti-CD20 antigen, in combination with CHOP or CHOP-like chemotherapy may improve both disease-freely survival and overall survival of naive patients, but it's role in the second-line treatment for relapsed non-Hodgkin's lymphoma (NHL) is uncertain. This study was to evaluate the efficacy of rituximab-containing salvage regimens on relapsed or refractory NHL, and observe the toxicities., Methods: Clinical data of 35 patients with relapsed or refractory NHL, treated in Cancer Center of Sun Yat-sen University, were analyzed retrospectively. Of the 35 patients, 19 were man, and 16 were women, with a median age of 53.5 years (ranged from 21 to 77); for ECOG performance status, 33 (94.3%) scored 0-1; for international prognostic index (IPI), 20 (57.1%) scored 0-1, 7 (20%) scored 2, 4 (11.4%) scored 3, and 4 (11.4%) scored 4-5; 23 cases of diffuse large B-cell lymphoma (DLBL) accounted for 65.7% among all subtypes. Rituximab (375 mg/m2) was administered intravenously at the day before each chemotherapy cycle. The second-or third-line salvage regimens included EPOCH, CHOP, DHAP, DICE, IVAC, IMVP-16, and FND., Results: Of the 35 patients, 30 received rituximab-combined regimens, and 5 received rituximab alone. A total of 102 cycles of rituximab-containing salvage regimens were administered. The objective response rate of the 32 evaluable cases was 68.8%, with a complete remission (CR) rate of 40.6%; 3 patients achieved CR after radiotherapy following rituximab-based regimens, and 3 achieved CR after autologous hematopoietic stem cell transplantation. The most frequent adverse events were nausea, leukopenia, and alopecia. The addition of rituximab to chemotherapy only elevated the occurrence of mild infusion-related reactions, such as chills, fever, and pruritus. The median follow-up time was 12.5 months (ranged from 3 to 69 months); 2 patients were lost, 10 were died (9 died of lymphoma, and 1 died of severe hepatitis), the other patients remained alive. The median progression-freely survival was 11.8 months (ranged from 3 to 33 months). The overall 1-, 2-, and 3-year survival rates were 72.9%, 62.8%, and 62.8%, respectively., Conclusion: Rituximab-containing salvage regimens are effective and well tolerated, even in extensively pretreated patients with relapsed or refractory B-cell NHL.

Questionnaires were sent through mail to study the epidemiology of drowning in 56 towns and townships in Wujin. Results showed that the prevalence of drowning in Wujin reached 11.14 per 10(5) of which the males out-numbered females. Children aged 1-9 years and people above 60 years old were more than the other age groups. The main causes were due to accidental falls in elderly, children swimming in waters, followed by falling into the river as the result of disease fulmination and suicidal among adults. Measures should be taken to strengthen the care of children, people with mental diseases and the elderly.