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BackgroundPrevious studies have shown that bisphenol A exposure is associated with the risk of hypertension; however, most of them are cross-sectional and the conclusions are not consistent. ObjectiveTo evaluate the association between bisphenol A exposure and the incident risk of hypertension. MethodsBased on a nested case-control design involving 1990 subjects derived from the Dongfeng-Tongji cohort, a total of 1080 subjects were included in this study after excluding 887 hypertensive cases at baseline and 23 subjects with missing blood pressure data in follow-up visits. Epidemiological information was collected through questionnaire survey, and serum bisphenol A concentration was detected by high performance liquid chromatography tandem mass spectrometry. Logistic regression model was used to analyze the potential association between serum bisphenol A level and the risk of hypertension incidence, and linear regression model was used to analyze the association between serum bisphenol A level and blood pressure changes between baseline and follow-up. ResultsThe average age of the 1 080 participants was (62.03±7.45) years, of which 41.1% were male. During the follow-up period, a total of 477 (44.2%) developed hypertension. The median serum concentration of bisphenol A in the total population was 3.15 μg·L−1, and the baseline bisphenol A concentration in the new case group (3.24 μg·L−1) was higher than that in the control group (2.98 μg·L−1) (P0.05). ConclusionBisphenol A exposure is positively associated with the risk of hypertension.

Objective To analyze the effects of homocysteine （Hcy） on blood pressure, blood glucose and blood lipid in a longitudinal cohort study, so as to provide basis knowledge for the prevention and treatment of related chronic diseases. Methods 987 physical examination personnel with complete data in the annual physical examination survey during the two-year period after the 2017 baseline survey were selected as study subjects to construct a longitudinal study cohort. We collected demographic characteristics, homocysteine, blood pressure, blood glucose and blood lipid, and based on the homocysteine change, divided them into three groups: the non-change group （normal-normal; abnormal-abnormal）, normal-abnormal group, abnormal-normal group. Generalized linear regression model was used to analyze the relationship between homocysteine change and the changes in blood pressure, blood glucose and blood lipid. Results The average age of participants in baseline survey was （43.63±11.4） years with a range of 23 to 85 years. During the three-year period, there were 50.25%（496）, 14.39%（142）, 35.36%（349） people with non-change group （normal-normal;Abnormal-abnormal）, normal-abnormal group, abnormal-normal group, The Hcy change was taken as the dependent variable for analysis. Univariate analysis showed that, compared with the non-changed group, systolic blood pressure in the abnormally normal group was significantly reduced （P < 0.05）, and there were no statistical differences in other indicators. Based on generalized linear model, after adjustment for age, gender, baseline BMI, drinking, smoking, results show that when compared with the non-change group, the systolic blood pressure, total cholesterol, blood sugar of anomaly-normal group were significantly decrease （P < 0.05）, and the drop-out value were 2.132, 0.203, 0.182 respectively. There was no significant difference in the change of diastolic blood pressure, triglyceride, High-density lipoprotein and low-density lipoprotein. Conclusion The change of Hcy is related to the change of systolic blood pressure, total cholesterol and blood glucose, and the decrease of Hcy is conductive to the improvement of blood glucose, blood pressure and lipid levels. [ABSTRACT FROM AUTHOR]