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Objective To explore the application effect of risk management based on nursing quality sensitive indicators in elderly patients with severe pneumonia. Methods A total of 94 elderly patients with severe pneumonia admitted to the Respiratory Department of Zhengzhou Yihe Hospital from May 2021 to May 2023 were selected as the study subjects. The 94 elderly patients with severe pneumonia were divided into the control group and the observation group using a random number table method, with 47 cases in each group. The patients in the control group were given routine nursing care, while the patients in the observation group were given risk management based on sensitive indicators of nursing quality. Both groups continued to receive care until the patients were discharged. The nursing management effects of the two groups were compared. Results The indexes of blood gas analysis in the two groups after nursing were better than those before nursing, and the partial pressure of carbon dioxide in the observation group was lower than that in the control group, with statistical significances（P＜0. 05). The arterial oxygen partial pressure, oxygen and index in the observation group were higher than those in the control group after nursing, but the differences were not statistically significant（P＞0. 05). The duration of mechanical ventilation and hospitalization in the observation group were shorter than those in the control group, and the total incidence of nursing adverse events such as ventilator-associated pneumonia and falling off the bed was lower than that in the control group. The scores of SF-36 and the scores of nursing satisfaction were higher than those in the control group, with statistical significances（P＜0. 05). Conclusion After risk management intervention based on nursing quality sensitive indicators, elderly patients with severe pneumonia can improve their blood gas analysis indicators, further shorten their mechanical ventilation time, reduce hospital stay, reduce nursing adverse events such as ventilator-associated pneumonia and falls, promote the improvement of patient quality of life, and achieve satisfactory nursing outcomes. [ABSTRACT FROM AUTHOR]

Objective By screening and passaging G0 generation Wistar rats, we obtained hypoxiasensitive and hypoxia-tolerant G1 generation rats, and then the differences in hypoxia sensitivity among these rats were preliminarily explored. Methods 200 Wistar rats (half male and half female) were selected as G0 generation and placed in a controlled oxygen concentration system. The hypoxia tolerance time, which refers to the time from placement to near death, was recorded for the G0 generation rats at an oxygen volume fraction of 3%. 30 rats (half male and half female) with the shortest hypoxia tolerance time were selected for mating and passage to obtain G1 generation hypoxia-sensitive rats. Similarly, 30 rats (half male and half female) with the longest hypoxia tolerance time were selected for mating and passage to obtain G1 generation hypoxia-tolerant rats. An additional 24 standard Wistar rats were randomly divided into two groups: a control group and a model group, with 12 rats in each group (half male and half female). The control group was kept in a normoxic environment, while the model group, along with the G1 generation hypoxia-sensitive rats (G1 sensitive group) and G1 generation hypoxia-tolerant rats (G1 tolerant group), were placed in a hypobaric hypoxia chamber (simulating an altitude of 5 000 m). After 12 hours, various indicators, including blood gas, complete blood count, blood biochemistry, pathological sections, and hypoxia-related genes were detected or observed to compare the differences in hypoxia sensitivity among the 4 groups. Results Compared with the G0 genera3tion standard rats, the hypoxia tolerance time of G1 generation rats was significantly prolonged (P<0.01). Compared with the model group, the oxygen saturation (SatO2) in G1 tolerant group was significantly higher (P<0.05). In the G1 sensitive group, the levels of white blood cell (WBC) count, neutrophil (NEUT) count, hemoglobin (HGB) concentration, hematocrit (HCT), red blood cell distribution width (RDW), platelet (PLT), and creatinine (Cr) significantly increased (P<0.05 or P<0.01), while actual bicarbonate (AB) content significantly decreased (P<0.05), and the brain and lung coefficients were significantly elevated (P<0.05). In addition, pathological section results showed that the brain and lung tissues in the model group, G1 sensitive group, and G1 tolerant group all suffered from significant damage, with no evident differences in the gene expression levels of hypoxia-inducible factor-1 α (HIF-1α) and vascular endothelial growth factor A (VEGFA) in brain tissues among the three groups (P>0.05). Conclusion Compared with standard rats, G1 generation hypoxia-sensitive/tolerant rats exhibit good signs of hypoxia sensitivity/tolerance traits, but further screening and passage are still needed to purify them. [ABSTRACT FROM AUTHOR]

Objective By screening and passaging G0 generation Wistar rats, we obtained hypoxia-sensitive and hypoxia-tolerant G1 generation rats, and then the differences in hypoxia sensitivity among these rats were preliminarily explored. Methods 200 Wistar rats (half male and half female) were selected as G0 generation and placed in a controlled oxygen concentration system. The hypoxia tolerance time, which refers to the time from placement to near death, was recorded for the G0 generation rats at an oxygen volume fraction of 3%. 30 rats (half male and half female) with the shortest hypoxia tolerance time were selected for mating and passage to obtain G1 generation hypoxia-sensitive rats. Similarly, 30 rats (half male and half female) with the longest hypoxia tolerance time were selected for mating and passage to obtain G1 generation hypoxia-tolerant rats. An additional 24 standard Wistar rats were randomly divided into two groups: a control group and a model group, with 12 rats in each group (half male and half female). The control group was kept in a normoxic environment, while the model group, along with the G1 generation hypoxia-sensitive rats (G1 sensitive group) and G1 generation hypoxia-tolerant rats (G1 tolerant group), were placed in a hypobaric hypoxia chamber (simulating an altitude of 5 000 m). After 12 hours, various indicators, including blood gas, complete blood count, blood biochemistry, pathological sections, and hypoxia-related genes were detected or observed to compare the differences in hypoxia sensitivity among the 4 groups. Results Compared with the G0 generation standard rats, the hypoxia tolerance time of G1 generation rats was significantly prolonged (P0.05).ConclusionCompared with standard rats, G1 generation hypoxia-sensitive/tolerant rats exhibit good signs of hypoxia sensitivity/tolerance traits, but further screening and passage are still needed to purify them.

Objective To investigate the effect of using pulmonary surfactant (PS) during different time periods of mechanical ventilation in the treatment of neonatal respiratory distress syndrome (NRDS) on blood gas and lung function indicators in children. Methods A total of 80 children with NRDS who received treatment at Neonatal Intensive Care Unit, Nanjing Jiangbei Hospital from February 2021 to February 2023 were selected and divided into observation group A, observation group B, observation group C and control group randomly (n=20, each). All the children received routine mechanical ventilation and comprehensive treatment for 72 hours. In the observation group A, B and C, the same dose of PS (70 mg/kg) was slowly injected into the intake pipe intubation within 0.5 h, 2-4 h and 4-6 h after mechanical ventilation, respectively. The blood gas indexes, lung function indexes, clinical efficacy and complications of the four groups before mechanical ventilation and 6 hours after PS treatment were compared. Results The improvement of blood gas indexes (PaO2, PaCO2, pH value) in the observation group A, B and C were significantly better than those in the control group at 6 h after PS (P＜0.05). The pulmonary function indexes, spontaneous breathing times, lung compliance and blood oxygen saturation recovery time of children in observation group A, B and C after using PS were prolonged in turn, but they were significantly better than those in control group (P＜0.05). The total efficiency of the observation group was significantly higher than that of the control group (98.33% vs 80.00%, χ2=5.760, P=0.016). The incidence of complications in the observation group during treatment was significantly lower than that in the control group (3.33% vs 25.00%, χ2=6.314, P=0.012). Conclusion The combination of mechanical ventilation and PS treatment can improve the prognosis of children with NRDS. The earlier the use of PS, the better the effect.

Objective: To observe the effect of acupoint application and acupuncture therapy combined with treatment on blood gas analysis indicators, diaphragm function, and inflammatory immune indicators in patients with acute respiratory failure undergoing mechanical ventilation. Methods: 92 patients with acute respiratory failure who underwent mechanical ventilation at Lu'an Hospital Affiliated to Anhui University of Traditional Chinese Medicine from November 2021 to December 2022 were selected, and they were randomly divided into control group (46 cases for routine treatment) and study group (46 cases for acupuncture therapy combined with acupoint application treatment on the basis of the control group) by random number table method. The blood gas analysis indicators, diaphragm function, inflammatory immune indicators, and gastrointestinal function between the two groups were compared, and the incidence of complications between the two groups were recorded. Results: The oxygenation index (OI), pH, and arterial partial pressure of oxygen (PaO2) before weaning in the study group were higher than those in the control group, while the arterial blood partial pressure of carbon dioxide (PaCO2) was lower than that in the control group (P<0.05). The right diaphragmatic end expiratory thickness (Tdi-ee), inspiratory end thickness (Tdi-ei), and diaphragmatic thickening fraction (TFdi) before weaning in the study group were lower than those in the control group(P<0.05). High sensitivity C-reactive protein (hs-CRP), calcitonin (PCT) and white blood cell count (WBC) before weaning in the study group were lower than those in the control group, and CD4+ was higher than that in the control group (P<0.05). The gastrointestinal function score of the study group before weaning was lower than that of the control group (P<0.05). There was no statistically significant difference in the incidence of complications between the two groups(P>0.05). Conclusion: Acupuncture therapy combined with acupoint application has good application value in improving blood [ABSTRACT FROM AUTHOR]

Background Noninvasive positive pressure ventilation (NPPV) is a major respiratory support technique for patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and carbon dioxide (CO2) retention. However, the obvious dead space in available masks used for NPPV could easily lead to repeated CO2 inhalation, which affects the correction of CO2 retention. Objective To develop a face mask with two channel and constant leakage (TCCL) used for NPPV, and to examine its value in NPPV treatment of AECOPD patients with CO2 retention. Methods Thirty patients with AECOPD and typeⅡ respiratory failure treated with NPPV were recruited from the ICU, the First Affiliated Hospital of Chongqing Medical University from 2020 to 2021, and equally randomized into an experimental group (using the TCCL mask) and an control group (using the traditional mask with an exhalation valve on the side for NPPV) . Treatment effectiveness was assessed using arterial partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) monitored at baseline, and at the end of 4, 8, 24, and 48 hours of NPPV treatment as well as 24 hours after NPPV cessation. Results The two-way repeated measures ANOVA indicated that treatment time and treatment approach had no interactive effects on PaO2 (P>0.05) . Treatment time produced significant main effects on PaO2 (P0.05) . Treatment time and treatment approach had no interactive effects on PaCO2 (P>0.05) . Treatment time produced significant main effect on PaCO2 (P

Objective To observe the effects of different sedatives on hemodynamics and blood gas analysis in patients with heart failure with noninvasive positive pressure ventilation (NPPV) .Methods A total of 90 patients with heart failure diagnosed and treated with NPPV in this hospital from January 2020 to January 2022 were selected as research objects, and randomly divided into groups A,B and C, with 30 patients in each group.The group A was given dexmedetomidine, the group B was given midazolam, and the group C was given propofol. The NPPV time, ICU treatment time, endotracheal intubation rate, mortality within 28 days, incidence of adverse reactions, central venous pressure (CVP),changes of heart rate (HR),N-terminal B-type natriuretic peptide (Nt-proBNP),mean arterial pressure (MAP),arterial oxygen partial oxygen saturation (SpO2),and arterial partial carbon dioxide pressure (PaCO2) at 6,24 and 48 hours after sedation were observed and recorded in each group. Results The NIPPV time, endotracheal intubation rate, ICU treatment time and wake time after drug withdrawal in the group A were significantly shorter than those in groups B and C, the differences were statistically significant (P<0.05),but there were no statistical significances in NIPPV time, endotracheal intubation rate, ICU treatment time and wake time after drug withdrawal between groups B and C (P>0.05) .The levels of HR, CVP, Nt-proBNP and MAP in group A were significantly lower than those in groups B and C at 6,24 and 48 hours after sedation, the differences were statistically significant (P<0.05) .However, there were no statistical significances in the levels of HR, CVP, Nt-proBNP and MAP between groups B and C at 6,24 and 48 hours after sedation (P>0.05) .SpO2,PaO2 in the group A were significantly higher than those in groups B and C at 6,24 and 48 hours after sedation, and PaCO2 was significantly lower than those in groups B and C, the differences were statistically significant (P<0.05),but there were no statistical significances in SpO2,PaO2 and PaCO2 between groups B and C at 6,24 and 48 hours after sedation (P>0.05) .There was no significant difference in the incidence of complications between the group A (16.67%),group B (26.67%) and group C (30.00%) (P>0.05) .Conclusion Dexmedetomidine, midazolam and propofol have the same incidence of adverse reactions during sedation in patients with NPPV heart failure, but dexmedetomidine is more effective in reducing the duration of NPPV, endotracheal intubation rate, ICU treatment time and wake time after drug withdrawal, and can improve hemodynamic status and cardiac function faster, and correct hypoxemia more significantly. [ABSTRACT FROM AUTHOR]

Objective To analyze the clinical characteristics and related influencing factors of obstructive sleep apnea (OSA) combined with obesity-related sleep hypoventilation (ORSH) and to identify indicators that can predict the OSA combined with ORSH population. Methods A total of 185 obese patients (body mass index ≥30 kg/m2 ) who were admitted to hospital due to snoring were selected. All patients underwent daytime awake arterial blood gas analysis, pulmonary function examination, polysomnography monitoring and percutaneous carbon dioxide monitoring at least 7 hours. According to the above examination results, patients were divided into the OSA group (n=109), the OSA combined with ORSH group (n= 46) and the OSA combined with obesity hypopnea syndrome (OHS) group (n=30). The general clinical characteristics, pulmonary function, arterial blood gas and polysomnography monitoring indexes were compared and analyzed in the three groups. Multivariate Logistic regression analysis was conducted to analyze the risk factors of OSA combined with ORSH. A model was established and receiver operating characteristic (ROC) curve was drawn to analyze the prediction efficiency. Results Waist circumference, BMI and proportion of stroke patients were higher in the OSA combined with OHS group than those in the OSA group and the OSA combined with ORSH group, while the percentage of forced expiratory volume in the first second in the predicted value (FEV1%) and the percentage of forced vital capacity in the predicted value (FVC%) were significantly lower in the OSA combined with OHS group than those in the OSA group and the OSA combined with ORSH group (P＜0.05). Arterial partial pressure of oxygen [p(O2)] was significantly lower in the OSA combined with OHS group than that in the OSA group, while arterial partial pressure of carbon dioxide [p(CO2)] and bicarbonate ion (HCO3 - ) were significantly higher than those in the OSA group and the OSA combined with ORSH group (P＜0.05). P(CO2) and HCO3 - were significantly higher in the OSA combined with ORSH group than those in the OSA group (P＜0.05). Compared with the OSA group, the Epworth sleepiness scale score (ESS) was higher in the OSA combined with OHS group, and the oxygen reduction index (ODI), apnea hypopnea index (AHI), micro-arousal index (MAI), apnea index (AI), mean apnea time (MAT), longest apnea time (LAT), the percentage of time with blood oxygen saturation less than 90% of the total time (T90) and the treatment proportion of bi-level positive airway pressure (BI-PAP) ventilation mode were increased in the OSA combined with ORSH group and the OSA combined with OHS group, while the minimum oxygen saturation (minSpO2) and mean blood oxygen saturation (meanSpO2) decreased (P＜0.05). Compared with the OSA combined with ORSH group, the proportion of continuous positive airway pressure (CPAP) treatment mode was decreased in the OSA combined with OHS group, and the proportion of BI-PAP ventilator treatment was increased (P＜0.05). Multivariate Logistic regression analysis indicated that prolonged LAT and increased HCO3 -were independent risk factors for OSA combined with ORSH. The area under the curve predicted by LAT and HCO3 - was 0.784, the sensitivity was 0.913, and the specificity was 0.541. Conclusion The combined detection of LAT and HCO3 - has a certain predictive value for OSA combined with ORSH. [ABSTRACT FROM AUTHOR]

Objective: To explore the value of circ&#95;0054633 in early diagnosis and prognosis prediction of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in children with severe pneumonia., Methods: A retrospective case-control study was conducted on children with diagnosed severe pneumonia admitted to Tianjin Children's Hospital from July 1, 2022, to February 29, 2024. The clinical data was collected by electronic medical record system and clinical follow-up, including gender, age, lung injury prediction score (LIPS), pediatric critical illness score (PCIS), serum circ&#95;0054633, interleukin-6 (IL-6), the indicators of the arterial blood-gas analysis, oxygenation index (PaO 2 /FiO 2 ) within 24 hours of admission and the survival status of 28 days. According to whether ALI/ARDS occurred, they were divided into the ALI/ARDS group and the non-ALI/ARDS group. The differences of clinical data between the two groups were compared, and multivariate Logistic regression was used to analyze the risk factors for ALI/ARDS in children with severe pneumonia. The receiver operator characteristic curve (ROC curve) will be used to explore the early diagnostic value of ALI/ARDS in children with severe pneumonia. The patients of ALI/ARDS were divided into mild group, moderate group and severe group according to the level of PaO 2 /FiO 2 . The levels of serum circ&#95;0054633 and IL-6 in various severity ALI/ARDS were compared. The differences of serum circ&#95;0054633, IL-6 levels, PCIS score and LIPS score were compared between the two groups of ALI/ARDS patients according to different prognoses in 28 days, as well as the correlation between various risk factors and circ&#95;0054633., Results: A total 74 children with severe pneumonia were included, with 34 cases in the ALI/ARDS group and 40 cases in the non-ALI/ARDS group. In ALI/ARDS group, there were 9 cases in the mild group, 15 cases in the moderate group and 10 cases in the severe group; while 12 cases died and 22 cases survived after 28 days. The serum circ&#95;0054633, IL-6 level and LIPS score were higher in the ALI/ARDS group than the non-ALI/ARDS group, while the PCIS score was lower, and the two groups had significant difference. Multivariate Logistic regression analysis showed that circ&#95;0054633 was independent predictors of ALI/ARDS in children with severe pneumonia [odds ratio (OR) = 3.853, 95% confidence interval (95%CI) was 1.912-7.805, P = 0.017]. ROC curve analysis showed that the cut-off values for circ&#95;0054633 in the diagnosis of ALI/ARDS were 3.955, sensitivity was 79.4%, specificity was 92.5%, area under the ROC curve (AUC) was 0.892. The serum circ&#95;0054633 and IL-6 levels were higher in the children who died in 28 days than the children who were survived, while the PCIS score was lower, and the two groups had significant difference. Spearman correlation analysis showed that the level of circ&#95;0054633 in children with ALI/ARDS was positively correlated with 28-day mortality and IL-6 (r value was 0.675, 0.763, respectively, all P < 0.001), but negatively correlated with PCIS score (r = -0.626, P < 0.001), while no significant correlation with LIPS score (r = 0.389, P = 0.023)., Conclusions: The level of serum circ&#95;0054633 has a better value in early diagnosis and prognosis prediction of ALI/ARDS caused in children with severe pneumonia.

To investigate the guiding effect of noninvasive monitoring of cardiac output (CO) and central venous oxygen saturation (ScvO2) on early goal - directed fluid resuscitation in patients with hyperlipidemic severe acute pancreatitis. Methods A total of 84 patients with hyperlipidemic severe acute pancreatitis who were admitted to the People's Hospital of Huadu District from January 2018 to December 2020 were enrolled as subjects and randomly divided into research group and control group, with 42 patients in each group. In the control group, goal - directed fluid resuscitation was performed by monitoring mean arterial pressure and central venous pressure, and in the research group, goal - directed fluid resuscitation was guided by the dynamic monitoring of CO through a bedside Doppler noninvasive hemodynamic detector and the monitoring of ScvO2 through PreSep central venous catheter. The two groups were compared in terms of time to early volume reaching standard ( hour), time to relief of abdominal pain (day), time to gastrointestinal function recovery (day), time to triglyceride (TG) recovery (day), lactate clearance rate at 6 hours after treatment, change of Acute Physiology and Chronic Health Evaluation II (APACHE - II) score from before treatment to days 3 and 7 after treatment, and early complications of acute pancreatitis. The t - test was used for comparison of continuous data between groups, and the chi - square test was used for comparison of categorical data between groups. Results Compared with the control group, the research group had significantly shorter time to volume reaching standard (8.7 ± 1.6 hours vs 19.6 ±2.1 hours, t = -18.86, P <0.05), time to relief of abdominal pain (3.4 ± 1.2 days vs 5.8 ± 1.5 days, t = -16.74, P < 0.05), time to gastrointestinal function recovery (5.6 ± 2.3 days vs 8.2 ± 2.5 days, t = - 11.74, P < 0.05), and time for TG to decrease to the normal level (5.5 ± 1.6 days vs 9.7 ± 1.7 days, t = 10.76, P < 0.05). Compared with the control group, the research group had a significantly lower APACHE - II score on days 3 and 7 (day 3: 11.86 ± 1.88 vs 20.75 ± 1.63, t = - 17.36, P < 0.05; day 7: 6.21 ± 1.13 vs 14. 36 ± 1.53, t = - 18. 41, P < 0.05), a significantly lower arterial blood lactate level at 6 hours after admission (4. 24 ± 0.23 mmol/L vs 5.07 ± 0.17 mmol/L, t = - 17.76, P < 0.05 ), and a significantly higher arterial blood lactate clearance rate at 6 hours (23.74% ± 0. 44% vs 10.74% ± 0.67%, t = - 17.73, P < 0.05). The comparison of early complications showed that compared with the control group, the research group had significantly lower incidence rates of peripancreatic acute necrotic collection ( 4.76 % vs 19.05 %, x2 = 16.63, p <0. 05), pulmonary infection (9.52% vs 38.10%, χ² = 15.78, p < 0.05), pleural effusion (35.71 % vs 88.10%, χ² = 8.96, p < 0.05), gastrointestinal bleeding (7.14% vs 16.67%, χ² =7.45, p < 0.05), and organ failure ( 11. 90% vs 30.95%, χ² = 7.96, P < 0.05). Conclusion Noninvasive monitoring of CO and ScvO2 in clinical practice has an important guiding significance for early goal - directed fluid resuscitation in patients with hyperlipidemic severe acute pancreatitis and can significantly improve the clinical treatment outcome of hyperlipidemic severe acute pancreatitis. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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Copyright of Journal of Modern Laboratory Medicine is the property of Journal of Modern Laboratory Medicine Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Clinical Healthcare is the property of Chinese Journal of Clinical Healthcare and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the application of 6-minute walk test (6MWT) in evaluation of elderly patients with pulmonary tuberculosis, and to analyze the correlation of 6MWT with blood gas indexes of pulmonary tuberculosis patients. Methods: A total of 200 elderly patients with pulmonary tuberculosis, who were treated in Affiliated Hospital of Hebei University from January 2019 to December 2019, were chosen as experimental group, and 50 healthy individuals, who received physical examination in the hospital at the same time, as the control group. The 6MWT experiment was carried out on two groups of patients. The walking distance and SpO2 before and after experiment of two groups of individuals were measured and calculated. The lung function experiment was carried out on the patients of experimental group; the correlation of 6MWT with lung function-related indicators of pulmonary tuberculosis patients was evaluated. Results: (1) 6MWT, SpO2 and PaO2 in the experimental group were significantly lower than those in the control group, and PaCO2 was higher than that in the control group (P<0.05). (2) The SpO2 and PaO2 of the experimental group after experiment were lower than those before experiment, and the PaCO2 was higher than that before experiment (P<0.05). (3) The 6MWT of the experimental group was positively correlated with FEV1, FEV1/FVC (P<0.05). (4) The correlation analysis showed that the 6MWT of the experimental group was positively correlated with SpO2 and PaO2, but negatively correlated with PaCO2 (P<0.05). Conclusions: 6MWT is obviously correlated with pulmonary function and blood gas related indexes in elderly patients with pulmonary tuberculosis. 6MWT can be used as one of the indicators to evaluate the condition of elderly patients with pulmonary tuberculosis. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of rivaroxaban and low molecular weight heparin on the symptom relief, blood gas analysis indexes and coagulation function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）. Methods: A total of 72 elderly patients with AECOPD admitted to our hospital from August 2016 to November 2019 were selected, and were randomly divided into control group（n=36, low molecular weight heparin treatment） and study group（n=36,rivaroxaban treatment） by lottery. The efficacy, symptom relief, blood gas analysis index and coagulation function of the two groups were compared, and adverse reactions during the treatment were recorded. Results: The total effective rate of the study group 10 days after treatment was higher than the control group（P<0.05）. There were no significant differences in the relief time of cough, sputum, fever and dyspnea between the two groups（P>0.05）. 10 days after treatment, the oxygen partial pressure（PaO2）, oxygen saturation（SaO2） of the two groups increased, while the partial pressure of carbon dioxide（PaCO2） of the two groups decreased（P<0.05）. 10 days after treatment,PaO2 and SaO2 of the study group were higher than the control group, while PaCO2 was lower than those of the control group（P<0.05）.10 days after treatment, fibrinogen（Fib） of the two groups increased, D-Dimer（D-D）, activated partial thromboplastin time（APTT）,plasma prothrombin time（PT） and thrombin time（TT） decreased（P<0.05）. 10 days after treatment, D-D of the study group was lower than the control group（P<0.05）. There were no significant differences between Fib, APTT, TT and PT of the two groups（P>0.05）. There was no significant difference in the incidence of adverse reactions between the two groups（P>0.05）. Conclusion: Elderly patients with AECOPD treated with rivaroxaban and low molecular weight heparin can improved their clinical symptoms and showed better safety, but those treated with rivaroxaban had better efficacy, and better improvement in blood gas analysis indicators and coagulation function. [ABSTRACT FROM AUTHOR]

Objective: To summarize the strategy and method for the treatment of critically ill patients with self-made extracorporeal membrane oxygenation (ECMO) system., Methods: A observative study was conducted. Fifty-six patients with ECMO assisted support in Fuwai Central China Cardiovascular Disease Hospital from December 2020 to December 2021 were enrolled. According to the clinical situation of the patients and the wishes of the family, conventional ECMO package (conventional group) or self-made ECMO package (self-made group) was chosen. In the conventional group, the disposable ECMO package was used to install the machine, pre charge and exhaust the air. In the self-made group, the disposable consumables commonly used in extracorporeal circulation during cardiac surgery (including centrifugal pump heads, membrane oxygenation, tubes, connectors, etc.) were used to create a self-made ECMO system. Based on the patient's situation, personalized tube model selection and length control were carried out. The preparation time, auxiliary time, auxiliary method, total pre charge volume, free hemoglobin (FHb) levels after 2 hours of ECMO operation and operating costs, as well as changes in hemodynamics, arterial blood gas analysis, and blood indicators within 48 hours after ECMO placement in the two groups were recorded. The occurrence of adverse events related to the ECMO system during ECMO adjuvant therapy in two groups was simultaneously observed., Results: Fifty-six patients were enrolled finally, with 28 cases in the conventional group and 28 cases in the self-made group, and all successfully completed the operation of ECMO. There was no statistically significant difference in ECMO system preparation time, auxiliary time, auxiliary method, and FHb levels after 2 hours of ECMO operation between the conventional group and the self-made group [preparation time (minutes): 13±4 vs. 15±5, auxiliary time (hours): 287±34 vs. 276±42, veno-arterial ECMO (cases): 22 vs. 24, veno-venous ECMO (cases): 6 vs. 4, FHb after 2 hours of ECMO operation (mg/L): 226±67 vs. 253±78, all P > 0.05]. However, the total pre charge volume and operating costs in the self-made group were significantly lower than those in the conventional group [total pre charge volume (mL): 420±25 vs. 650±10, operating costs (ten thousand yuan): 3.8±0.4 vs. 6.7±0.3, both P < 0.01]. The hemodynamics, arterial blood gas analysis, and blood indicators of patients in the two groups were relatively stable within 48 hours after ECMO operation, and most of the indicators between the two groups showed no statistically significant differences. The hemoglobin (Hb) levels at 12, 24, and 48 hours after the machine transfer in the self-made group were significantly higher than those in the conventional group (g/L: 128.5±23.7 vs. 117.5±24.3 at 12 hours, 121.3±31.3 vs. 109.6±33.2 at 24 hours, 118.5±20.1 vs. 105.2±25.7 at 48 hours, all P < 0.05). Both groups of patients did not experience any adverse event related to the ECMO system, such as membrane pulmonary infiltration, joint detachment, and massive hemolysis, during the ECMO assisted treatment process., Conclusions: When implementing ECMO for critically ill patients in clinical practice, a self-made ECMO system with disposable consumables commonly used in extracorporeal circulation during cardiac surgery can be used for cardiopulmonary function assistance support, thereby saving patients medical costs and alleviating their dependence on disposable ECMO package in clinical practice.

A pulse and respiration synchronous detection system is designed to explore the changes of physiological signals in different situations. The system obtains the corresponding signal through STM32 control pulse and respiratory acquisition circuit, calculates and displays real-time parameters such as heart rate and respiratory rate, and transmits the data to the upper computer for storage in the database. The experimental test results show that the system can monitor pulse and respiratory waveform in different situations, and the waveform is in good condition. Compared with medical pulse oximeter, the error of measured heart rate and blood oxygen concentration is less than 3%, and the error of respiratory rate is less than 5% compared with the actual value, which verifies the accuracy of system signal acquisition. The system is small in size, low in cost, and comfortable to wear, and can be applied in experimental research related to pulse and respiratory signals.

Objectives: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) combined with severe type II respiratory failure have a high probability of ventilation failure using conventional non-invasive positive pressure ventilation (NPPV). This study aims to investigate the clinical efficacy of high intensity NPPV (HI-NPPV) for the treatment of AECOPD combined with severe type II respiratory failure., Methods: The data of patients with AECOPD combined with severe type II respiratory failure (blood gas analysis pH≤7.25) treated with NPPV in the Second Affiliated Hospital of Chongqing Medical University from July 2013 to July 2023 were collected to conduct a retrospective case-control study. The patients were divided into 2 groups according to the inspired positive airway pressure (IPAP) used during the NPPV treatment: a NPPV group (IPAP<20 cmH 2 O, 1 cmH 2 O=0.098 kPa) and a HI-NPPV group (20 cmH 2 O≤IPAP< 30 cmH 2 O). Ninety-nine and 95 patients were included in the NPPV group and the HI-NPPV group, respectively. A total of 86 pairs of data were matched using propensity score matching (PSM) for data matching. The primary outcome indexes (mortality and tracheal intubation rate) and secondary outcome indexes [blood gas analysis pH, arterial partial pressure of oxygen (PaO 2 ) and arterial partial pressure of carbon dioxide (PaCO 2 ), adverse reaction rate, and length of hospitalization] were compared between the 2 groups., Results: The tracheal intubation rates of the NPPV group and the HI-NPPV group were 6.98% and 1.16%, respectively, and the difference between the 2 groups was statistically significant ( χ 2 =4.32, P <0.05); the mortality of the NPPV group and the HI-NPPV group was 23.26% and 9.30%, respectively, and the difference between the 2 groups was statistically significant ( χ 2 =11.64, P <0.01). The PaO 2 at 24 h and 48 h after treatment of the HI-NPPV group was higher than that of the NPPV group, and the PaCO 2 of the HI-NPPV group was lower than that of the NPPV group, and the differences were statistically significant (all P <0.05). The differences of pH at 24 h and 48 h after treatment between the 2 groups were not statistically significant (both P >0.05). The differences between the 2 groups in adverse reaction rate and hospitalization length were not statistically significant (both P >0.05)., Conclusions: HI-NPPV can reduce mortality and tracheal intubation rates by rapidly improving the ventilation of patients with AECOPD combined with severe type II respiratory failure. This study provides a new idea for the treatment of patients with AECOPD combined with severe type II respiratory failure.

Objective To explore the effect of nurse -patient communication skills on disease outcomes and blood gas indices of children with bronchial pneumonia treated by atomization inhalation. Methods A total of 120 children with bronchopneumonia treated in the Department of Pediatrics of Kaiping Central Hospital from January 2019 to June 2020 were collected and randomly divided into a control group (n =60) and an observation group (n =60). Both groups of children were treated with atomization inhalation. The control group was given routine nursing, and the observation group was given nursing care through nurse -patient communication skills. The clinical eeficacy, disease outcomes, pulmonary function, blood gas indices and adverse reactions of the two groups were observed and compared. Results The total eefective rate of the observation group was 95.00%, which was higher than 75.00% of the control group (P < 0-05). The disappearance time of clinical symptoms (fever, asthma, cough, pulmonary rates) and hospitalization time in the observation group were shorter than those in the control group (all P <0. 05). After nursing, the peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1), forced vital capacity ( FVC), FEV1 /FVC, partial pressure of oxygen ( Pa02) and arterial oxygen saturation (SaO2) of the two groups were both significantly higher than those before nursing (all P < 0. 05), and those of the observation group were significantly higher than those of the control group (all P <0. 05). The partial pressure of carbon dioxide (PaCO2) in the two groups was lower than that before nursing, and the observation group was lower than the control group (both P < 0. 05 ). The incidence of adverse reactions in the observation was 8.33%, lower than 25.00% in the control group (P <0.05 ). Conclusion Nurse-patient communication skills can effectively improve the clinical efficacy of atomization inhalation, improve pulmonary function, blood gas indicators, promote the prognosis of diseases and reduce the situation of adverse reactions in the treatment of children with bronchopneumonia, which can be promoted. [ABSTRACT FROM AUTHOR]

Objective To analyze the clinical efficacy of high flow nasal cannula oxygen (HFNC) therapy in acute mild to moderate type I respiratory failure. Methods A total of 68 patients with acute mild to moderate type I respiratory failure who hospitalized in the department from June 2017 to June 2019 were selected as subjects. They were divided into 2 groups, 34 cases in each group. The observation group was given HFNC, while the control group was given face mask oxygen inhalation therapy. The medical research council scale (MRC) and changes of blood gas analysis were observed before and 24 h after treatment in both groups. Results There were no significant differences in pH, arterial partial pressure of carbon dioxide (PaCO2) , arterial partial pressure of oxygen (Pa02) and MRC scores between the two groups before treatment (P > 0. 05) . Compared with before treat m ent, there were no significant differences in pH and PaC02 between the two groups after 24 h treatment (P >O. 05) ; but Pa02 in creased, and MRC scores decreased after 24 h treatment, the differences were statistically significant (P < 0. 05) . The Pa02 was higher, and MRC was lower in the observation group than those in the control group after 24 h treatment, the differences were sta tistically significant(P< 0. 05) . Conclusion HFNC can effectively alleviate hypoxia and dyspnea in patients with acute mild to moderate type I respiratory failure, and can improve comfort of patients with effective airway management. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of different aerosol inhalation of salbutamol and budesonide combined with cefoperazone sodium and sulbactam sodium on blood gas index and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: 210 AECOPD inpatients who were admitted to our hospital from January 2015 to October 2018 were selected as the study subjects. They were randomly divided into control group (cefoperazone sodium sulbactam sodium treatment), continuous atomization group (salbutamol, budesonide continuous atomization treatment+cefoperazone sodium sulbactam sodium), and successive atomization group (salbutamol atomization, budesonide atomization treatment+cefoperazone sodium sulbactamsodium). 70 cases in each group. The clinical efficacy, blood gas index, lung function and adverse reactions of the three groups were compared. Results: The total effective rate of successive atomization group was 91.43%, which was higher than that of continuous atomization group (78.57%) and control group (67.14%) (P<0.05). The partial pressure of oxygen (PaO2) and oxygen saturation (SaO2) in the successive atomization group were higher than those in the continuous atomization group and the control group at 5 days after treatment, and that in the continuous atomization group was higher than that in the control group (P<0.05). The partial pressure of carbon dioxide (PaCO2) in the successive atomization group at 5 days after treatment was lower than that in the continuous atomization group and the control group, and that in the continuous atomization group was lower than that in the control group (P<0.05). The first second forced expiratory volume (FEV1), forced vital capacity (FVC), the percentage of forced expiratory volume occupied by the first second forced expiratory volume (FEV1/FVC), and the percentage of forced expiratory volume occupied by the first second forced expiratory volume (FEV1%) in the successive atomization group were higher than those in the continuous atomization group and the control group. Those in the continuous atomization group were higher than those in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05). Conclusion: Salbutamol, budesonide atomization inhalation combined with cefoperazone sodium and sulbactam sodium in the treatment of AECOPD patients is effective, it can improve the lung function of patients, improve blood gas related indicators. [ABSTRACT FROM AUTHOR]

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Copyright of CT Theory & Applications is the property of Editorial Department of CT Theory & Applications and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objectives: To explore the effects of hypoxic and hypobaric conditions on blood gas and erythrocyte-related indicators in rats., Methods: SD male rats were exposed to low-pressure hypoxic conditions simulating an altitude of 6500 m in a small or a large experimental cabin. Abdominal aortic blood samples were collected and blood gas indicators, red blood cells (RBCs) count, and hemoglobin (Hb) content were measured. The effects of exposure to different hypoxia times, different hypoxia modes, normal oxygen recovery after hypoxia, and re-hypoxia after hypoxia preconditioning on blood gas indicators, RBCs count and Hb content were investigated., Results: The effect of blood gas indicators was correlated with the length of exposure time of hypoxia and the reoxygenation after leaving the cabin. Hypoxia caused acid-base imbalance and its severity was associated with the duration of hypoxia; hypoxia also led to an increase in RBCs count and Hb content, and the increase was also related to the time exposed to hypoxia. The effects of reoxygenation on acid-base imbalance in rats caged in a small animal cabin were more severe that those in a large experimental cabin. Acetazolamide alleviated the effects of reoxygenation after leaving the cabin. Different hypoxia modes and administration of acetazolamide had little effect on RBCs count and Hb content. Normal oxygen recovery can alleviate the reoxygenation and acid-base imbalance of hypoxic rats after leaving the cabin and improve the increase in red blood cell and hemoglobin content caused by hypoxia. The improvement of hypoxia preconditioning on post hypoxia reoxygenation is not significant, but it can alleviate the acid-base imbalance caused by hypoxia in rats and to some extent improve the increase in red blood cell and hemoglobin content caused by hypoxia., Conclusions: Due to excessive ventilation and elevated RBCs count and Hb content after hypoxia reoxygenation, oxygen partial pressure and other oxygenation indicators in hypoxic rats are prone to become abnormal, while blood gas acid-base balance indicators are relatively stable, which are more suitable for evaluating the degree of hypoxia injury and related pharmacological effects in rats.

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Objective: Ex vivo lung perfusion (EVLP) is significant for lung transplantation but is costly. In this research, the EYLP system of pig model was established by using domestic economic materials to maintain the efficacy of the system while reducing the cost. Methods: We first configured the lung perfusate and assemble chambers via reasonably priced materials to established the EVLP system. Then we surgically obtained the lungs of three domestic pigs, perfused the lung perfusate, and stored them for 6 horns at low temperature. Finally, the lungs were connected to the EVLP system, and blood gas analysis and lung functional examination were used to assess the physiological function of the lungs over time. Results: By using this relatively low-priced EVLP system, we successfully obtained pig lungs and stored them for 6 hours at low temperature. Within 2 hours, the modified lung perfusion system maintained good oxygenation function and lung physiological indexes. Pulmonary arterial pressure, peak inflation pressure, platform pressure, pulmonary oxygen partial pressure and carbon dioxide partial pressure, and left atrial oxygen partial pressure and carbon dioxide partial pressure were all stable, while the lungs had normal color and elasticity without significant edema and functional damage. Conclusions: The EVLP system we established can effectively acquire and store the physiological functions of the donor pig lungs. Besides such systems could reduce costs greatly. Together, what we done provided research basis for optimizing the ex vivo lung perfusion techniques for the application of lung transplantation. [ABSTRACT FROM AUTHOR]

Objective To explore the correlation of Apgar score in neonatal umbilical artery. Methods A total of 93 neonates delivered in obstetrics department of Medical College of Shihezi University from June 2017 to June 2018 were collected. According to Apgar score 0—<4,4—<8,8 — ≤10 points, the group was divided into the medium-risk group(24 cases), the low-risk group (39 cases )and the control group(30 cases). The correlation of age, gestational age, pH value and BE value among three groups of mothers was compared and analyzed, and analyzed the influence of different delivery modes on newborns, the correlation between BE value and 1,5 min Apgar score. Results There were significant differences in BE values of umbilical artery blood gas analysis between the three groups(P<0.05). There were statistically significant differences in cesarean section rate between the three groups (P<0.05). The BE values in umbilical artery blood gas analysis were correlated with the 1,5 min Apgar score, and more significantly with the 5 min Apgar score(P<0. 05). The pH value in umbilical arterial blood gas was correlated with Apgar score of 5 min. Conclusion Apgar score is correlated with umbilical arterial blood gas, among which BE, pH and 5 min Apgar score are more significantly correlated. For newborns, we should be done well perinatal health care should be done well, reduced high-risk factors, and early recovery should be completed actively after birth, and regular spontaneous breathing should be established as soon as possible, and ensure the safety of lives. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of high-flow nasal cannula oxygen therapy on blood gas analysis， reintubation rate and comfort degree of patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） . Methods 72 patients with AECOPD were divided into observation group and control group according to random number table method， 36 cases in each group. The patients in the two groups were given routine basic treatment. On this basis， the control group was given conventional oxygen therapy and the observation group was given high-flow nasal cannula oxygen therapy. The proportion of patients with reintubation and hospital stays were statistically analyzed. The saturation of blood oxygen （SpO2）， partial pressure of arterial oxygen （PaCO2） and partial pressure of carbon dioxide （PaCO2） before treatment and at 2 h，24 h，48 h after treatment were measured. The comfort degrees of patients during treatment were compared. Results The intubation rate of the observation group was significantly lower than that of the control group. The hospital stays were significantly shorter than those of the control group （ P＜0.05）. PaCO2 and SpO2 were significantly increased in the two groups after treatment （ P＜0.05）， while PaCO2 were decreased （ P＜0.05） . The increase or decrease in the observation group was significantly higher than that in the control group （ P＜0.05） . The scores of symptom such as nasal discom-fort，throat discomfort and chest discomfort in the observation group were significantly lower than those in the control group on the 3th and 5th day of treatment （ P＜0.05） . Conclusion High-flow nasal cannula oxygen therapy can improve the oxygenation status of AECOPD patients， reduce the rate of reintubation， improve comfort degree. [ABSTRACT FROM AUTHOR]

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In June 2022, a carbon monoxide poisoning accident with hidden source occurred in a bonded gold/silver wire manufacturing enterprise in Guangzhou, causing 10 people to be poisoned, of which 1 was caused by carbon monoxide poisoning and 9 by carbon monoxide contact reaction. The symptoms were dizziness, fatigue and vomiting. After 5 to 7 h, the saturation of carboxyhemoglobin in finger pulse was 4% to 10%, and the saturation of carboxyhemoglobin in blood gas biochemical analysis was 1.9% to 5.8%. The concentration of carbon monoxide detected in the carbon borne purification plant of the enterprise was 34.46-37.26 mg/m(3). It was judged that the accident was carbon monoxide poisoning caused by carbon monoxide gas being transported to the work post along the gas transmission pipeline due to abnormal operation of the carbon borne purification plant. By investigating the source and cause of poison, this paper provides a warning for the similar process to prevent similar events, and provides a new idea for the identification of chemical poisoning risk. At the same time, it is warned that similar enterprises should fully consider the risk of poisoning under specific circumstances, strengthen equipment maintenance and repair, and prevent the occurrence of similar incidents.

Objective: To investigate the application value of ROX index in evaluating the effect of high-flow nasal cannula oxygen therapy (HFNC) on patients diagnosed with respiratory failure, and to find a simpler and more effective method to observe the efficacy of HFNC., Methods: A retrospective cohort study was conducted. Patients who were admitted to department of critical care medicine of the Tianjin Third Central Hospital from April 2020 to August 2022, diagnosed with type I respiratory failure, and treated with HFNC after failure of conventional oxygen therapy were enrolled. Oxygenation index (PaO 2 /FiO 2 ), fraction of inspired oxygen (FiO 2 ), gas flow rate at the initial time of admission, and pulse oxygen saturation (SpO 2 ), FiO 2 and respiratory rate (RR) at 2, 4, 6, 8, 10 and 12 hours of HFNC were collected, and ROX index was calculated. The patients with symptoms and PaO 2 /FiO 2 improved after HFNC treatment and without higher respiratory support lately were defined as HFNC success, while other patients with symptoms worsening and needing follow-up non-invasive positive pressure ventilation (NIPPV) or invasive positive pressure ventilation (IPPV) were defined as HFNC failure. The tendency of changes in the ROX index at each time point was observed. Receiver operator characteristic curve (ROC curve) was plotted to obtain the optimum cut-off value of ROX index for predicting HFNC outcome and the optimal monitoring time point for HFNC., Results: A total of 142 patients were eventually enrolled, among whom 96 patients (67.61%) were in treated with HFNC successfully, while 46 patients (32.39%) were recorded as HFNC failure (39 patients and 7 patients received NIPPV or IPPV, respectively), with an overall intubation rate of 4.93% (7/142). Compared with the HFNC success group, the HFNC failure group had lower PaO 2 /FiO 2 [mmHg (1 mmHg ≈ 0.133 kPa): 208.8±37.3 vs. 235.7±48.3, P < 0.01] and higher initial gas flow rate (L/min: 46.4±3.9 vs. 42.3±4.9, P < 0.01). However, there was no significant difference in gender, age, primary diagnosis, severity of disease, hemoglobin (Hb), C-reactive protein (CRP), and brain natriuretic peptide (BNP) between the two groups. In the HFNC failure group, there were 12 patients (26.09%) received progressive oxygen therapy within 12 hours of HFNC, of which 3 patients (6.52%) occurred within 6 hours, while the other 9 patients (19.57%) occurred after 6 hours. The initial ROX index was not statistically significant between the two groups. Both groups showed a continuous increasing ROX index with longer treatment duration of HFNC, and the ROX index at all of the time points of the HFNC failure group was significantly lower than that of the HFNC success group with statistically significant difference (2 hours: 9.39±2.85 vs. 10.91±3.51, 4 hours: 8.62±2.29 vs. 11.40±3.18, 6 hours: 7.62±1.65 vs. 11.85±3.45, 8 hours: 7.79±1.59 vs. 11.62±3.10, 10 hours: 7.97±1.62 vs. 12.44±2.75, 12 hours: 8.84±2.51 vs. 12.45±3.03, all P < 0.05). The ROC curve analysis showed that the areas under the ROC curve (AUC) of ROX index assessing the effect of HFNC at the time of treating 6, 8 and 10 hours were better than 2, 4 and 12 hours (0.890, 0.903, 0.930 vs. 0.585, 0.738 and 0.829), indicating that the ROX index could determine the efficacy at the early stage of HFNC (within 6 hours). When the optimum cut-off value of ROX index was 8.78, the sensitivity was 90.6%, and the specificity was 76.5%., Conclusions: The ROX index at 6 hours of HFNC has a certain predictive value for the efficacy of HFNC with an optimum cut-off value of 8.78, which can provide clinical health care personnel a method for observing the efficacy of HFNC, and guide the correct selection of oxygen therapy modality at an early stage and timely adjustment of oxygen therapy strategy.

Objective To explore the relationship between SpO2/FiO2 (S/F) and PaO2/FiO2(P/F) so as to determine the possibility of ARDS severity identification based on noninvasive parameters. Methods The physiological parameters of corresponding patients were acquired from Medical Information Mart for Intensive Care (MIMIC-III)，and then divided into a training set and a test set randomly. In the training set the linear relationship between lg(S/F) and lg(P/F) was established with generalized linear regression model, and a log linear regression model was formed with the optimal regression equation; the linear relationship between lg(S/F) and lg(P/F) was compared with that between S/F and P/F. In the test set, the two models were compared on the identification of ARDS in case P/F values were 100 (mild ARDS), 200 (moderate ARDS) and 300 (severe ARDS) respectively. Results In the training set (n=61 634) the linear relationship between lg(S/F) and lg(P/F) was deduced as lg(S/F)=1.277+0.437 x lg(P/F) (r=0.66, P<0.000 1) , and the S/F thresholds in case P/F values were 100, 200 and 300 respectively were 131, 201 and 271. In the test set (n =26 758) the identification effect was verified with the acquired S/F thresholds, which proved better than that of traditional regression model. Conclusion Noninvasive parameter SpO2/FiO2 can replace PaO2/FiO2 for the auxiliary diagnosis of ARDS in case the result of blood gas analysis is absent. [ABSTRACT FROM AUTHOR]

Objective： To investigate the clinical value of plasma brain natriuretic peptide （BNP）, C-reactive protein （CRP） and blood gas analysis in the clinical classification of pulmonary embolism, and to provide the theoretical basis for clinical classification and treatment. Methods： 112 inpatients diagnosed as pulmonary embolism from january 2015 to december 2016 were selected, who were divided into high risk pulmonary embolism group （49 cases） and middle and low risk pulmonary embolism group （63 cases） according to clinical manifestation, the results of plasma BNP, CRP and blood gas analysis between the two groups were compared, the sensitivity and specificity ofBNP, CRP, arterial partial pressure of carbon dioxide （PaCO2） and arterial oxygen partial pressure （PaO2） in the diagnosis of high-risk pulmonary embolism were analyzed. Results： The combination of high risk pulmonary embolism, right ventricular dysfunction and fatality rate were significantly higher than those in middle and low risk pulmonary embolism group, the difference was statistically significant （P〈0.05）. The levels of plasma BNP, CRP and PaCO： in the high risk pulmonary embolism group were significantly higher than those in the middle and low risk pulmonary embolism group （P〈0.05）; and the PaO2 in the high risk pulmonary embolism group was significantly lower than that in the middle and low risk pulmonary embolism group （P〈0.05）. The positive rates of plasma BNP, PaCO2 and PaO2 in high risk pulmonary embolism group were significantly higher than those in middle and low risk pulmonary embolism group （P〈0.05）, and there was no significant difference in CRP positive rate between the two groups （P〉0.05）. The sensitivity of BNP, CRP and blood gas analysis in diagnosis of high risk pulmonary embolism was 97.96% and specificity was 77.78%. Conclusion： Pulmonary embolism of plasma BNP, CRP, blood gas analysis is abnormal, the combination of the three test is valuable in the diagnosis and clinical classification of pulmonary embolism, which have a important clinical significance for the formulation and prognosis of the optimal treatment. [ABSTRACT FROM AUTHOR]

Chronic obstructive pulmonary disease (COPD) is a respiratory disease, complications, mortality is high. In acute exacerbation of COPD, endotoxin, inflammatory mediators and cytokines first vascular endothelial injury, caused systemic coagulopathy and negative nitrogen balance. As in vivo coagulation State and fibrinolysis molecular marker of hyperthyroidism, d-dimer is d-dimer is the cross-linking of fibrin in the fibrinolytic enzyme producing a specific degradation product, which reflects the fibrinolytic activity in the secondary meaning. Several studies showed that d-dimer levels in the treatment of chronic obstructive pulmonary evaluation of the effects and prognosis is important. This paper will summarize the d-dimer structure, age and smoking, arterial blood gas analysis and pulmonary function, and so on, instead of an aperture in d-dimer correlation with COPD, and d-dimer in the treatment of COPD and its relevance to the prognosis of chronic obstructive pulmonary. [ABSTRACT FROM AUTHOR]

Objective: To analyze the influence of naloxone on inflammatory factors and blood gas analysis of patients with chronic obstructive pulmonary diseasecopd（COPD） and type Ⅱ respiratory failure. Methods: 106 patients with COPD and type Ⅱrespiratory failure were selected and randomly divided into the control group and the research group with 53 cases in each group. The patients in the control group were treated with the conventional method, while the patients in the research group were treated with naloxone on the basis of the control group. Then the TLC, forced expiratory volume at the end of 1 second（FEV1）, maximal oral expiratory pressure（PEMAX）, blood oxygen saturation（SaO2）, arterial blood oxygen partial pressure（PaO2）, CO2 partial pressure（PaCO2）, maximum oxygen consumption（VO2）, oxygen uptake rate（ERO2）, IL-10, IL-18, tumor necrosis factor-α（TNF-α）, c-reactive protein（CRP）, glutathione peroxidase（GSH-Px）, superoxide dismutase（SOD）, lipid peroxide（LPO） and adverse reactions between two groups were observed and compared before and after the treatment. Results: After treatment, the TLC, FEV1, PEMAX, SaO2, PaO2, CaO2, IL-10, GSH-Px and SOD in the research group were higher than those of the control group, and the differences were statistically significant（P<0.05）. The PaCO2, VO2, ERO2, IL-18, TNF-α, CRP and LPO in the research group were lower than those of the control group, and the differences were statistically significant（P<0.05）. There was no statistically significant difference on the adverse reactions between the two groups（P>0.05）. Conclusions: Naloxone in the treatment of COPD and type Ⅱ respiratory failure can reduce inflammatory mediators, improve the blood gas analysis index. [ABSTRACT FROM AUTHOR]

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Objective To retrospectively analyze the anesthetic management of infant and young child liver transplanta-tion. Methods Seven pediatric patients(including 1 cases of living donor liver transplantation) with liver transplantation due to congenital biliary atresia and end-stage liver disease in our hospital from July 21, 2013 to May 20, 2014 were included in this retrospective study. The patients entered into the operation room without venous access. The peripheral vein was opened after intra-muscular injection of ketamine 2-5 mg/kg and atropine 0.02 mg/kg. Anesthesia were rapidly induced by intravenous midazolam0.05-0.20 mg/kg, propofol 2-3 mg/kg, vecuronium 0.1-0.2 mg/kg and fentanyl 5 μg/kg. Then intubation was visually performed through mouth. The anesthetic maintenance adopted 2%-3% sevoflurance inhalation combined with 0.2-0.3 μg/(kg·min)remifentanil and 2-3 μg/(kg·min)cis-atracurium by venous pump. The indexes including general situation, operation time, time of anhepatic phase, amount of bleeding, urine volume and intravenous infusion amount were observed; the changes of respiration, circulation, blood gas and coagulation indicators were recorded immediately before occlusion of the portal vein, immediately after occlusion of the portal vein, 20 min during the anhepatic phase, immediately after reperfusion, 1 h during the neohepatic phase and end of operation. Results All of the seven patients were successfully extubated without obvious anesthesia related compli-cations. HR immediately after occlusion of the portal vein was significantly increased compared with that immediately before oc clusion, and the difference was statistically significant[(129.00±4.38)bpm/min vs.(114.14±11.65)bpm/min, P<0.05], but MAP and CVP at these two time points had no statistically significant(P<0.05); MAP immediately before occlusion of the portal vein and at 1 h during the neohepatic phase were[(45.14±6.49), (54.57±6.50)mm Hg(1 mm Hg=0.133 k Pa), which were significantly decreased compared with(69.57±5.97)mm Hg before occlusion, the differences were statistically signioficant(P<0.05), but HR and CVP had no statistical differences among these 3 time points(P<0.05); blood sodium level at the end of operation was significantly increased compared with that immediately before occlusion[(139.5±3.51)mmol/L vs.(133.00±6.03)mmol/L], blood glucose levels immediately after reperfusion and at 1 h during the neohepatic phase were(11.21±3.90)mmol/L and(13.91±4.48)mmol/L respectively, which were significantly higher than(6.39±2.45)mmol/L immediately before occlusion, the differences were statistically significant(P<0.05); the lactic acid level at 1 h during the neohepatic phase was significantly increased compared with that imme-diately before occlusion[(4.40±1.54)mmol/L vs. 2.50±2.16)mmol/L], blood p H value was significantly decreased(7.32±0.04 vs.7.40±0.07), the difference was statistically significant(P<0.05). Conclusion Anesthesia in infant and young child liver transplantation is more elaborate and special. Respiration, circulation and internal environment should be closely monitored in order to conduct timely intervention and actively improve the prognosis of infant and young child liver transplantation. [ABSTRACT FROM AUTHOR]

Objective By measuring the level of fetal hemoglobin（HbF）in neonates at 31~42 weeks gestational ages， it is aimed to know how HbF levels change at different gestational ages for normal neonates and asphyxia neonates. This prelimi- nary study provides both reference data on HbF levels for neonates at different gestational ages and possible basis for clinical identification of high-risk neonates. Methods The blood samples from 523 neonates hospitalized in the department from January 2016 to March 2017 were collected.According to the age of neonatal orthodontic treatment on the day of blood sampling，all specimens were grouped，the specimens of 31 weeks 0 d to 31 weeks 6 d were included in 31 weeks group，and so on. The 378 blood samples in normal neonates group，the 145 blood samples in asphyxial neonates group.Due to the insufficient sample size of the asphyxial neonates at 41，42 weeks，the final asphyxial neonates group only collected samples from 31 to 40 weeks. Mea- suring HbF percentage by ABL90 Radiometer Corperation. Results There was a gradual decrease in HbF levels for normal neo- nates with increasing gestational ages，while no obvious decrease for asphyxia neonates. The asphyxia neonates at 34~40 weeks gestational ages showed much higher HbF levels than that normal neonates of the same gestational age，the differences were sta- tistically significant（P<0.05）. Conclusion Asphyxia is a high-risk element causing elevated HbF levels. It is therefore of po- tential clinical significance by observing HbF levels at different gestational ages，which could possibly provide an early identifi- cation of high-risk neonates. [ABSTRACT FROM AUTHOR]

Objective To discuss the clinical significance of arterial pressure-based cardiac output(APCO) monitoring in the fluid management of critically ill patients.Methods The clinical data in critically ill patients admitted to ICU of Chongqing Southwest Aluminum Hospital from April 2014 to June 2016 were retrospectively analyzed.The hemodynamic param-eters in critically ill patients were monitored by APCO,moreover which was combined with the stroke volume variation(SVV)monitoring,passive leg-raising test(PLR) and respiratory variations in superior vena cava peak velocity measured by transthoracic echocardiography for conducting the patient′s fluid management.Results The heart rate,MAP,SVV,arterial blood lactic acid,CVP and 24 h urine volume at 24 h after implementing APCO monitoring in the effective group were improved compared with be-fore implementation,the difference were statistically significant(P<0.05),while which in the ineffective group had no statistical difference between before and after treatment(P>0.05).Conclusion SVV monitored by APCO is a good indicator for monitoring the volume responsiveness,combining with PLR and TTE can serve as an important reference basis for implementing the fluid management [ABSTRACT FROM AUTHOR]

Objective: To analyze the correlation of pulmonary thromboembolism area with clinical characteristics. Methods: 78 patients with pulmonary thromboembolism who were treated in the respiratory medicine of the Second Affiliated Hospital of Harbin Medical University from January 2007 to December 2011 were taken as the research object. According to the embolization area, the paitients were divided into large embolization group (38 cases) and small embolization group (40 cases). Then the clinical symptoms, clinical signs, risk factors, blood gas analysis results and the two D-dimer level of patients in the two groups were observed and analyzed. Results: Dyspnea, palpitations, syncope in the large area group has a significantly higher incidence than in small area group, the incidence of shortness of breath, cyanosis were significantly higher than those in patients with small area group, PaO2 and PaCO2 were significantly lower than those in small area group, The difference was statistically significant (P<0.05). There is no significant difference in D-dimer values of two groups, which to be measured with Semi quantitative latex aggregation method. The D-dimer values in large area group, which to be measured with turbidmetric method, are significantly higher than that in small area group , and there is statistical difference (P<0.05). Conclusion: (1) The dyspnea, palpitations, syncope, shortness of breath, blood pressure drops, and cyanosis can prompt a massive pulmonary thromboembolism occurred.(2) The values of PaO2 and PaCO2, which are low significantly, suggesting that it may be is a large area of pulmonary embolism. (3) D- dimer could prompt pulmonary embolism size or not, may be related to the measurement method ofD- dimer, which need further study, but there is an important significance for Excluding Pulmonary embolism. [ABSTRACT FROM AUTHOR]

Oxygen reserve index (ORI) is a novel dimensionless index used for noninvasive, real-time, and continuous monitoring of oxygenation, and ORI value ranges from 0 to 1, which reflects the range of 100-200 mmHg for arterial partial pressure of oxygen. ORI combined with pulse oximetry may help to accurately adjust the concentration of inspired oxygen and prevent hyperoxemia and hypoxemia. ORI is suitable for various clinical situations, and the medical staff should master this novel parameter and use it properly to assess the oxygenation of patients. In addition, several limitations of ORI should be noticed during clinical application.

Objective To investigate the application of dexmedetomidine combined with sevoflurane in pediatric bron-chofiberscope examination. Methods One hundred children who were diagonsed by bronchofiberscope in our hospital from October 2015 to May 2016 were selected and divided into the observation group and the control group,50 cases in each group. The control group was given sevoflurane while the observation group was given dexmedetomidine combined with sevoflurane. The anesthetic effect, vital signs changes,onset time of anesthesia,awakening time and adverse reaction were compared between two groups. Results The ratio of excellence in the control group (80.00%) was obviously lower than that in the observation group (96.00%) ,the difference was statistically significant(P<0.05) ；from the end of 10 min pump injection to bronchofiberscope en­tering the bronchus, HR and BP of control group were significantly higher than those in the observation group(P<0.05) ；from in­serting into the throat to bronchofiberscope getting into bronchus, SpO2 of control group was lower than that in the observation group with statistically significant difference (P<0.05 ) ； the onset time and awakening time had no significal difference be­tween the two groups (P>0.05) ；the adverse reaction rate of the control group (48.00%) was higher than that in the observation group(10.00%) with statistically significant difference (P<0.05). Conclusion Dexmedetomidine combined with sevoflurane can obviously improve the anesthetic effect in pediatric bronchofiberscope examination, decrease the adverse reaction and pain with­out obvious influence on vital signs,and has high-security. [ABSTRACT FROM AUTHOR]

Objective: To establish a stable fragment-induced penetrating liver injury model in landrace pigs and evaluate the characteristics of deep tissue injury., Methods: According to the different positioning methods of aiming points, twelve healthy adult landrace pigs were divided into group A (the relative height "h" of the aiming point and the highest point of the body surface on the tracing line was set to 5 cm) and group B ("h" was set to 6 cm). Ultrasonography was used to determine the direction of fragment projection, and an experimental ballistic gun was used to project high-velocity fragments to cause injury to animals. The vital signs of the two groups were monitored, and whole blood cell count, blood gas analysis, and liver and renal function were tested. Damages to the liver and adjacent organs, as well as the amount of bleeding and survival time were analyzed., Results: For the overall analysis of the two groups, the liver hit rate of fragment simulating projectiles was 100% (right anterior lobe and right lateral lobe injury), the hit rate of other organs in the abdominal cavity was 25% (3/12), and the incidence of hemothorax or pneumothorax was 8% (1/12). The wounds were mainly characterized by liver lacerations, with total or partial disconnection of the distal liver lobe. There was no significant difference in wound length and bleeding amount between groups A and B [wound length (cm): 9.8±1.7 vs. 11.2±3.8, bleeding amount (g): 597.0±477.1 vs. 1 032.0±390.3, both P > 0.05]. The depth of liver parenchymal laceration in group B with the aiming point closer to the anterior median line was significantly longer than that in group A (cm: 2.8±0.4 vs. 1.9±0.6, P = 0.015). Mean arterial pressure (MAP), pH value, residual arterial blood base (BE), hemoglobin (Hb) and hematocrit (HCT) levels decreased after the fragment-induced injury, and then reached a trough level [MAP (mmHg, 1 mmHg ≈ 0.133 kPa): 87.0±33.6, pH: 7.26±0.15, BE (mmol/L): -6.65±8.48, Hb (g/L): 9.86±1.10, HCT: 0.309±0.029, all P < 0.05] in the first hour. Blood lactate (Lac), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels increased over time, and reached a peak level [Lac (mmol/L): 10.21±4.40, LDH (U/L): 1 417.0±223.3, AST (U/L): 234.5 (162.5, 357.5), both P < 0.05] at 1 hour after injury. Pearson's correlation analysis showed that the total amount of bleeding was correlated with the depth of liver parenchyma laceration (r = 0.684,P = 0.014). The Kaplan-Meier survival curve showed that the 3 hours survival rate in group A was higher than that in group B, but the difference was not statistically significant [83.3% (5/6) vs. 33.3% (2/6), P > 0.05]., Conclusions: The high-velocity fragment-induced penetrating liver injury model established by striking landrace pigs closer to the anterior median line with fragment simulating projectiles is reproducible and the degree of damage is controllable, and the model is applicable to further relevant research of hepatic ballistic trauma.

Objective: To analyze the correlation between blood routine-derived inflammation indicators and respiratory function in patients with pneumoconiosis. Methods: In January 2021, 492 male pneumoconiosis patients hospitalized in Hefei Institute of Occupational Disease Control and Prevention from 2012 to 2020 were randomly selected as the case group, 492 dust exposed non pneumoconiosis workers who underwent occupational health examination at the same time were taken as the control group. The occupational history and clinical examination data of the two groups of subjects were collected, the correlation between blood routine-derived inflammatory indexes and pulmonary function and blood gas analysis was analyzed retrospectively. Results: Compared with the control group, the lymphocyte monocyte ratio (LMR) in the case group was decreased, and the neutrophil lymphocyte ratio (NLR) was increased, and the difference was statistically significant ( P <0.05) . There were significant differences in forced vital capacity as a percentage of the predicted value (FVC) , forced expiratory volume in the first second as a percentage of the predicted value (FEV(1)%) , one second rate (FEV(1)/FVC) , partial pressure of oxygen (PaO(2)) , partial pressure of carbon dioxide (PaCO(2)) , and pH among pneumoconiosis patients at different stages ( P <0.05) . FVC%, FEV(1)%, FEV(1)/FVC, and PaO(2) decreased with the increase of the stage, the trend test was statistically significant (tau-b=-0.24, -0.34, -0.37, -0.17, P <0.05) , PaCO(2) and pH increased with the increase of the stage, and the trend test was statistically significant (tau-b=0.10, 0.08, P <0.05) . There were statistically significant differences in LYM, LMR, NLR, platelet lymphocyte ratio (PLR) in patients with pneumoconiosis at different stages ( P <0.05) , and LYM and LMR decreased with the increase of stage, trend test showed that there was statistically significant (tau-b=-0.11, -0.13, P <0.05) . There were significant differences in FVC%, FEV(1)%, FEV(1)/FVC, PaO(2), pH, LMR, NLR, PLR among patients with different types of pneumoconiosis ( P <0.05) . LMR in pneumoconiosis patients was significantly positively correlated with FVC%, FEV(1)%, FEV(1)/FVC and PaO(2) ( r (s)=0.342, 0.324, 0.203, 0.207, P <0.05) , NLR was significantly negatively correlated with FVC%, FEV(1)%, FEV(1)/FVC and PaO(2) ( r (s)=-0.193, -0.202, -0.164, -0.177, P <0.05) , PLR was significantly negatively correlated with FVC%, FEV(1)%, FEV(1)/FVC and PaO(2) ( r (s)=-0.194, -0.193, -0.106, -0.113, P <0.05) . Multiple linear regression analysis showed that LMR in pneumoconiosis patients was positively related with FVC%, FEV(1)% and PaO(2) ( P <0.05) . Conclusion: LMR in patients with pneumoconiosis has a certain correlation with lung function and blood gas analysis, LMR is expected to become a sensitive indicator for evaluating pneumoconiosis.

Objective To observe the effect and security of Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in the adjuvant therapy of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty patients with AECOPD in the Second Affiliated Hospital of Chongqing Medical University from October to Decem-ber 2015 were selected as the research subjects and randomly divided into the conventional treatment group (32 cases) and the Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration group (experimental group, 28 cases). The effect and safety of the Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in treating AECOPD were analyzed. The clinical curative effect and occurrence rate of adverse reactions were compared between the two groups. The efficacy and safety of Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration in treating this disease were analyzed. Results The hospitalization time and disappearance time of clinical symptoms and signs in the experimental group were shorter than those in the conventional treatment group, moreover the treatment total effective rate was 96.43%(27/28),which was higher than 78.13%(25/32) in the conventional treatment group;in the comparison of the sputum character on 1,2 3 d after treatment in the two groups, the sputum expectoration volume in the experimental group was increased compared with the conventional treatment group, sputum dry mass/wet mass and viscosity were decreased compared with the con-ventional treatment group, the differences were statistically significant(P<0.05);PaCO2 and PaO2 on 3,7 d after treatment in the experimental group were significantly improved compared with the conventional treatment group, the difference was statistically significant(P<0.05);the two groups had no adverse reactions occurrence during the treatment process. Conclusion The Chinese medicine sonophoresis combined with mechanical vibration sputum expectoration as an adjuvant therapy of AECOPD has definite effect, safety and reliability. [ABSTRACT FROM AUTHOR]

Objective To explore the risk factors causing tetany in patients with hyperventilation syndrome. Methods A total of 103 patients with hyperventilation syndrome treated in our hospital were included in this study. According to whether there was tetany, patients were divided into tetany group and non-tetany group. Values of gender, age, electrolyte, pH and p(CO2) were analysed between two groups. The factors of P < 0.1 were engaged in binary Logistic regression. Logistic regression (Forward Wald) was used to analyze the risk factors of tetany in patients with hyperventilation syndrome. Results In 103 patients there were 70 patients with tetany (68%), 33 patients without tetany(32%). The serum K+, serum phosphorus and p(CO2) values were significantly lower in tetany group than those of non-tetany group (P < 0.01), while the pH value was significantly higher in tetany group than those of non-tetany group (P < 0.01). There were no significant differences in gender, age, serum Na+, serum Cl-, serum calcium (bound calcium and ionized calcium), ionized calcium and serum Mg2+ levels between two groups (P > 0.05). It was revealed that the younger age, the lower level of the serum K+, serum phosphorus and p(CO2) were the risk factors of tetany through binary Logistic regression analysis. Conclusion The risk factors of tetany in patients with hyperventilation syndrome include younger age, lower level of serum K+ and serum phosphorus and reduced p(CO2). [ABSTRACT FROM AUTHOR]

Objective To investigate the influyence of early opening artificial airway on the curative effect, neural functional recovery and living quality. Methods A total of 76 cases of severe stroke in the intensive care medicine department of our hospital from June 2014 to June 2015 were selected as the research subjects and divided into the observation group and control group based on the time of opening artificial airway,38 cases in each group. The levels of blood gas analysis, neurological impair ment scores(NDS) and quality of life(MBI) scores before treatment and after treatment were compared between the two groups.Results Pa O2 after treatment in the two groups was increased, while PaCO2 and heart rate after treatment were both decreased to different degrees, but the observation was more obvious than the control group, the difference was statistically significant (P<.05). The NDS scores after treatment in the two groups were decreased to different degrees,while the MBI and FCA scores after treatment were increased to different degrees compared with before treatment, but the observation was more obvious than the control group, the difference was statistically different(P<.05). The scores of role function,psychological function, physical function and social function after treatment in the two groups were all increased,while the observer group was more obvious than the control group with statistical difference(P<.05). Conclusion The early opening artificial airway in the patients with severe stroke can effectively improve hypoxemia, reduces the degree of brain damage, is conducive to the recovery of neurological function, and can effectively improve the quality of life of patients. [ABSTRACT FROM AUTHOR]

Objective: To explore the application effects of feedforward control theory in the rollover bed treatment of mass patients with burn-explosion combined injury. Methods: A retrospective observational research was conducted. From June 13 to 14, 2020, 15 patients with severe burn-explosion combined injury caused by liquefied natural gas tank car explosion and conforming to the inclusion criteria were admitted to the Second Affiliated Hospital of Zhejiang University School of Medicine. There were 13 males and 2 females, aged 33-92 (66±17) years. All the patients were treated with rollover bed from 48 h post admission, and the feedforward control theory was introduced, including establishing a special feedforward control management team for rollover bed, clarifying the duties of the medical staff in the rollover bed treatment of patients, implementing the cooperation strategy of multidisciplinary physician, training and examining for 80 nurses in the temporarily organized nurse team in the form of "rollover bed workshop", and formulating the checklist and valuation list of rollover bed treatment for continuous quality control. The frequency and the total number of turning over, and successful rate of one-time posture change with the rollover bed of patients within 30 days of admission were recorded, the occurrences of adverse events caused by improper operation for the rollover bed during the treatment were observed, including respiratory and cardiac arrests, treatment interruption, unplanned extubation, bed falling, and skin graft displacement. The lowest levels of arterial partial pressure of oxygen (PaO 2 ) and arterial partial pressure of carbon dioxide (PaCO 2 ), the number of patients with oxygenation index>300 mmHg (1 mmHg=0.133 kPa), and the occurrence of acute respiratory distress syndrome (ARDS) of patients within 2 days of admission and on the 30 th day of admission were recorded. Results: Within 30 days of admission, the patients were turned over with the rollover bed for 2 to 6 times each day, with a total of 1 320 turning over operations, the successful rate of one-time posture change reached 99.9% (1 319/1 320), and no adverse event occurred. Within 2 days of admission, the lowest levels of PaO 2 and PaCO 2 of the patients were (100±19) and (42±4) mmHg, respectively, and the number of patients with mild, moderate, and severe ARDS were 10, 2, and 3, respectively, and none of the patients had oxygenation index>300 mmHg. On the 30 th day of admission, the lowest levels of PaO 2 and PaCO 2 of the patients were (135±28) and (37±8) mmHg, respectively, 3 patients developed moderate ARDS, 1 patient developed severe ARDS, and 11 patients had oxygenation index>300 mmHg. Conclusions: The introduction of feedforward control theory in the treatment of rollover bed of mass patients with burn-explosion combined injury can ensure safe and successful completion of turning over with the rollover bed, promote the repair of burn wound, and improve respiratory function, and therefore improve the treatment quality of patients.