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Objective: To explore the effects of maternal sound stimulation combined with non-nutritive sucking on oral feeding of premature infants. Premature infants (200 cases) hospitalized in the neonatal ward of our hospital from January 2018 to December 2018 were selected as the study objects and randomly divided into the control group (70 cases), study group A (65 cases) and study group B (65 cases). The control group was routinely managed according to the routine management of neonatology. Study group A was given pure maternal sound stimulation on the basis of routine management, while study group B was given non-nutritive sucking management on the basis of routine management and pure maternal sound stimulation. The feeding process, feeding performance, body mass growth and feeding intolerance score of each group were compared. The PMA at beginning of oral feeding and transition time of study group A and study group B were significantly shorter than that of the control group, and study group B was significantly shorter than that of study group A, with statistically significant differences (P<0.05). The feeding efficiency at beginning of oral feeding and feeding efficiency at full oral feeding of study group A and study group B were significantly higher than that of the control group, and study group B was significantly higher than that of study group A, with statistically significant differences (P<0.05). The body mass at full oral feeding and body mass at discharge of study group A and study group B were significantly lower than that of the control group, and study group B was significantly lower than study group A, with statistically significant differences (P<0.05). The difference of feeding intolerance scores between study group B and control group was statistically significant (P<0.05). Maternal sound stimulation combined with non-nutritive sucking can promote the process of oral feeding, improve the oral feeding performance, reduce the incidence of feeding intolerance, and speed up the time of recovery to birth body mass. [ABSTRACT FROM AUTHOR]