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Your search keyword '"Agranulocytosis drug therapy"' showing total 6 results
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6 results on '"Agranulocytosis drug therapy"'

4. [Comparative study of domestic and import vancomycin in the treatment of agranulocytosis complicated with infection in patients with acute leukemias].

Author

Tang XW, Ouyang J, and Zhou M

Subjects
Adolescent, Adult, Aged, Agranulocytosis complications, Anti-Bacterial Agents administration & dosage, Child, Female, Humans, Leukemia complications, Leukemia drug therapy, Male, Middle Aged, Treatment Outcome, Vancomycin administration & dosage, Young Adult, Agranulocytosis drug therapy, Anti-Bacterial Agents therapeutic use, Vancomycin therapeutic use
Published
2011

5. [Blood stream infections during agranulocytosis period after hematopoietic stem cell transplantation in one single center].

Author

Han TT, Huang XJ, Liu KY, Liu DH, Chen H, Han W, Zhang XH, Wang Y, Chen YH, Wang FR, Zhao T, Chen Y, and Xu LP

Subjects
Adolescent, Adult, Agranulocytosis drug therapy, Bacteremia drug therapy, Bacteria drug effects, Bacteria isolation & purification, Child, Child, Preschool, Communicable Diseases epidemiology, Drug Resistance, Microbial, Female, Fungi drug effects, Fungi isolation & purification, Humans, Male, Middle Aged, Retrospective Studies, Young Adult, Agranulocytosis microbiology, Bacteremia epidemiology, Hematopoietic Stem Cell Transplantation adverse effects, Infections epidemiology
Abstract

Objective: To analyze the epidemiologic features of blood stream infection (BSI) during the period of agranulocytosis after hematopoietic stem cell transplantation (HSCT) in our hospital, and provide the basis for the empirical therapy., Methods: The consecutive hematopoietic stem cell transplantation recipients conducted between January 2008 and October 2010 were studied retrospectively, to identify the current incidence, etiology for BSI and associated mortality during the period of agranulocytosis., Results: Totally 75 patients were diagnosed as BSI. The incidence of BSI was 9.6% (75/784) in HSCT during the period of agranulocytosis, 17.0% (75/441) in febrile patients. The pathogen testing showed that 64.4% were G(-) bacteria, 30.1% were G(+) bacterial and 5.5% were fungi. All G(-) bacteria except one were sensitive to carbapenems; all G(+) bacteria except one were sensitive to vancomycin. Among the 75 patients, 9 (12.0%) experienced septic shock and 5 (6.7%) died., Conclusions: The pathogens of the BSI in the cohort are G(-) bacteria, followed by G(+) bacteria and fungi. Carbapenems and vancomycin are the first drugs for the experiential therapy.

Published
2011

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