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Objective: To investigate the relationship between serum tumor markers and pathological features of cervical cancer and the prediction of postoperative recurrence. Methods: 82 patients with cervical cancer who came to our hospital from January 2015 to December 2017 were selected as the observation group, and 50 healthy women who came to our hospital for physical examination during the same period were selected. The serum levels of CA125, CA153, CA199 and CEA in both groups were detected by electrochemical luminescence immunoassay. Patients in the observation group were followed up until December 2022. The serum CA125, CA153, CA199, CEA levels of the two groups were compared, and the relationship between the serum CA125, CA153, CA199, CEA levels and clinicopathological characteristics of the observation group was analyzed. The recurrence of patients in the observation group was analyzed after the postoperative follow-up, and the univariate and multivariate Cox regression results of the recurrence of patients after radical resection of cervical cancer were analyzed. Prognostic value of serum CA125, CA153, CA199 and CEA levels for recurrence of cervical cancer after radical resection. Results: The levels of serum CA125, CA153, CA199 and CEA in observation group were significantly higher than those in control group (P<0.05). The levels of serum CA125, CA153, CA199 and CEA among patients with cervical cancer at different FIGO stages, depth of interstitial invasion and presence of lymph node metastasis were statistically significant (P<0.05). The follow-up time of 82 patients was 13-60 months, and the median survival time was 39 months. By the end of December 2022, 18 of 82 patients (21.95%) had relapse after surgery. Univariate and multivariate Cox regression analysis showed that FIGO stage in stage Ⅱ A, interstitial infiltration depth ≥ 1/2, lymph node metastasis, CA125 ≥ 307.41U/mL, CA153 ≥ 185.89U/mL, CA199 ≥ 153.23U/mL, CEA≥ 30.15ng/mL are independent risk factors for postoperative recurrence of cervical cancer.ROC curve showed that the AUC value of CA125+CA153+CA199+CEA in predicting postoperative recurrence of cervical cancer was significantly higher than that of CA125, CA153, CA199 and CEA alone (P<0.05). Conclusion: Serum CA125, CA153, CA199 and CEA are highly expressed in patients with cervical cancer, which is related to the depth of interstitial infiltration, FIGO stage, lymph node metastasis and postoperative recurrence. The combination of the four can be used as a predictor of postoperative recurrence of cervical cancer. [ABSTRACT FROM AUTHOR]